Review
Medicine, General & Internal
Katarzyna Rutka, Adam Garkowski, Katarzyna Karaszewska, Urszula Lebkowska
Summary: Systemic sclerosis is a connective tissue disease characterized by fibrosis in skin and internal organs, vascular obliteration, and autoantibody production. Diagnostic imaging plays a crucial role in diagnosing and monitoring patients, with MRI and ultrasonography being important tools in the evaluation process.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Mislav Radic, Hana Dogas, Andrea Gelemanovic, Slavica Juric Petricevic, Ivan Skopljanac, Josipa Radic
Summary: This systematic review evaluated the advantages of lung ultrasonography (LUS) examination in assessing interstitial lung disease (ILD) in systemic sclerosis (SSc) patients. LUS using high-resolution computed tomography (HRCT) as a reference standard showed high sensitivity and low false-positive rate in determining the need for further scans. However, further studies are needed to reach a consensus on the evaluation methodology of LUS examination.
Article
Rheumatology
Aldo Carnevale, Mario Silva, Elisa Maietti, Gianluca Milanese, Marta Saracco, Simone Parisi, Elena Bravi, Fabio De Gennaro, Eugenio Arrigoni, Flavio Cesare Bodini, Enrico Fusaro, Carlo Alberto Scire, Nicola Sverzellati, Alarico Ariani
Summary: This study aimed to determine the correlation between functional and radiological changes in patients with SSc-ILD, and tested the OMERACT criteria's ability to predict ILD evolution. It was found that changes in radiological extent were correlated to functional decline in a limited time frame. Repeated HRCT every 12-24 months could detect early progression in SSc-ILD, even in patients with stable pulmonary function, and OMERACT criteria might overlook some cases of radiological progression.
CLINICAL RHEUMATOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lisa Jungblut, Andre Euler, Jochen von Spiczak, Thomas Sartoretti, Victor Mergen, Vanessa Englmaier, Anna Landsmann, Carmen-Marina Mihai, Oliver Distler, Hatem Alkadhi, Thomas Frauenfelder, Katharina Martini
Summary: Photon-counting detector computed tomography (PCD-CT) has the potential to reduce radiation dose by 66% compared to conventional energy-integrated detector CT (EID-CT) without compromising image quality and diagnostic performance in the assessment of interstitial lung disease (ILD) in systemic sclerosis (SSc) patients.
INVESTIGATIVE RADIOLOGY
(2022)
Article
Medicine, General & Internal
Elisa Baratella, Barbara Ruaro, Fabiola Giudici, Barbara Wade, Mario Santagiuliana, Francesco Salton, Paola Confalonieri, Michele Simbolo, Aldo Scarpa, Saverio Tollot, Cristina Marrocchio, Maria Assunta Cova, Marco Confalonieri
Summary: This study found significant differences in HRCT patterns at diagnosis between familial and sporadic IPF patients, with familial patients showing a slight increase in typical UIP pattern at two years. Genetic factors play a key role in IPF development, but further studies are needed to clarify their impact on clinical treatment decisions.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yann Gaillandre, Alain Duhamel, Thomas Flohr, Jean-Baptiste Faivre, Suonita Khung, Antoine Hutt, Paul Felloni, Jacques Remy, Martine Remy-Jardin
Summary: This study compared the impact of the ultra-high resolution (UHR) images of a photon-counting CT (PCCT) scanner with the high-resolution (HR) images of an energy-integrating detector CT (EID-CT) on lung parenchyma analysis. It found that using the UHR scanning mode improved the visibility and identification of ILD features, leading to the reclassification of ILD patterns, all while reducing radiation dose.
EUROPEAN RADIOLOGY
(2023)
Article
Immunology
Marcin Zietkiewicz, Natalia Buda, Ewa Wiesik-Szewczyk, Maciej Piskunowicz, Dominika Grzegowska, Karina Jahnz-Rozyk, Zbigniew Zdrojewski
Summary: This study aimed to evaluate lung lesions in patients with predominantly antibody deficiencies (PADs) using simultaneous lung ultrasonography (LUS) and high-resolution computed tomography (HRCT). The results showed that LUS is an effective alternative for evaluating and monitoring pulmonary lesions in adult patients with PADs, especially for pulmonary fibrosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Turkey Refaee, Zohaib Salahuddin, Anne-Noelle Frix, Chenggong Yan, Guangyao Wu, Henry C. Woodruff, Hester Gietema, Paul Meunier, Renaud Louis, Julien Guiot, Philippe Lambin
Summary: This study developed automated diagnostic tools based on handcrafted radiomics (HCR) and deep learning (DL) to differentiate between idiopathic pulmonary fibrosis (IPF) and non-IPF interstitial lung diseases (ILDs). The ensemble model showed better diagnostic performance than clinicians and identified texture features as the most important for IPF diagnosis.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, General & Internal
Maria Martin-Lopez, Patricia E. Carreira
Summary: Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by immune dysregulation and progressive fibrosis. Interstitial lung disease (ILD) is the leading cause of death in patients with SSc. The management of SSc-ILD has shifted to include targeted biologic and antifibrotic therapies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Luna Gargani, Cosimo Bruni, Daniele De Marchi, Chiara Romei, Serena Guiducci, Silvia Bellando-Randone, Giovanni Donato Aquaro, Alessia Pepe, Emanuele Neri, Stefano Colagrande, Fabio Falaschi, Alberto Moggi-Pignone, Alessandro Pingitore, Marco Matucci-Cerinic
Summary: This study found that lung MRI can detect SSc-related ILD, with STIR values able to independently predict worsening lung involvement. This suggests that in the near future, MRI could support the choice for an early treatment of SSc-related ILD, as well as a more appropriate use of HRCT.
CLINICAL RHEUMATOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nicholas Landini, Martina Orlandi, Mariaelena Occhipinti, Cosimo Nardi, Lorenzo Tofani, Silvia Bellando-Randone, Pierluigi Ciet, Piotr Wielopolski, Thomas Benkert, Cosimo Bruni, Silvia Bertolo, Alberto Moggi-Pignone, Marco Matucci-Cerinic, Giovanni Morana, Stefano Colagrande
Summary: The purpose of this study was to test the application of respiratory-triggered ultrashort echo-time (UTE) Spiral VIBE-MRI sequence in the assessment of systemic sclerosis-interstitial lung disease (SSc-ILD) compared with computed tomography (CT). The results showed that the UTE sequence had high reliability in assessing the extent of ILD and GGO.
JOURNAL OF THORACIC IMAGING
(2023)
Article
Medicine, General & Internal
Cosimo Bruni, Lavinia Mattolini, Lorenzo Tofani, Luna Gargani, Nicholas Landini, Nicola Roma, Gemma Lepri, Martina Orlandi, Serena Guiducci, Silvia Bellando-Randone, Chiara Romei, Yukai Wang, Marco Matucci-Cerinic
Summary: The study found that lung ultrasound (LUS) can be used as a tool to evaluate systemic sclerosis-related interstitial lung disease (SSc-ILD) and can be correlated with different methods of ILD evaluation.
Article
Cardiac & Cardiovascular Systems
Brittany N. Weber, Julie J. Paik, Ayaz Aghayev, Allan L. Klein, Sophie I. Mavrogeni, Paul B. Yu, Monica Mukherjee
Summary: Derangements in immune responses in systemic inflammatory syndromes contribute to increased risk of atherosclerosis and cardiovascular disease. Novel multimodality imaging techniques can improve diagnostic precision and disease activity monitoring. The integrated use of these technologies aids in early diagnosis and noninvasive monitoring of cardiac involvement, playing important roles in preclinical studies, patient selection, and clinical trials, thereby improving clinical outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Barbara Ruaro, Elisa Baratella, Paola Confalonieri, Marco Confalonieri, Fabio Giuseppe Vassallo, Barbara Wade, Pietro Geri, Riccardo Pozzan, Gaetano Caforio, Cristina Marrocchio, Maria Assunta Cova, Francesco Salton
Summary: Imaging, especially high-resolution computed tomography (HRCT), plays a crucial role in the evaluation of systemic sclerosis-associated interstitial lung disease (SSc-ILD). Most SSc patients with ILD show a non-specific interstitial pneumonia pattern on HRCT, while recent studies suggest that lung ultrasound (LUS) may be a valuable tool in SSc diagnosis and follow-up.
Article
Health Care Sciences & Services
Anja Ljilja Posavec, Stela Hrkac, Josip Tecer, Renata Huzjan Korunic, Boris Karanovic, Ivana Jezic, Ivan Skopljanac, Nevenka Piskac Zivkovic, Josko Mitrovic
Summary: This study evaluated diaphragmatic function in patients with systemic sclerosis using ultrasound and investigated the associations between ultrasonic parameters and important clinical parameters. The results showed that patients with interstitial lung disease had lower diaphragmatic mobility in deep breathing. Diaphragmatic mobility was negatively correlated with dyspnea, skin score, anti-Scl-70 antibodies, esophageal diameters, and positively correlated with lung function.
JOURNAL OF PERSONALIZED MEDICINE
(2023)