Journal
ASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume 8, Issue 7, Pages 1097-1101Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.201900190
Keywords
C-H activation; chemodivergence; pyridones; rhodium; synthetic methods
Categories
Funding
- JSPS KAKENHI [JP 15H05485, 18K19078, JP 17H06092]
Ask authors/readers for more resources
A solvent-controlled rhodium-catalyzed C6-selective alkenylation and alkylation of 2-pyridones with acrylates via a pyridine-directed C-H cleavage was developed. Using DMF as solvent, the C-H alkenylation with acrylates selectively occurs to deliver the corresponding C6-alkenylated 2-pyridones in good yields. On the other hand, the C6-alkylated products are predominantly formed in a more polar and protic solvent, HFIP. Thus, a single set of starting substrates can be divergently transformed to C6-functionalized 2-pyridones, which are of potent interest in medicinal and pharmaceutical chemistry.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available