Article
Multidisciplinary Sciences
Pei-Ying Peng, Lei Xu, Gu-Xian Wang, Wen-Yuan He, Ting-Liang Yan, Xian-Guo Guo
Summary: This study aimed to understand the characteristics of scrub typhus in Yunnan province and assist in public health prevention and control measures. The results showed that the incidence of scrub typhus in Yunnan is high and has been increasing steadily in recent years.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Ana Maria Humanes-Navarro, Zaida Herrador, Lidia Redondo, Israel Cruz, Beatriz Fernandez-Martinez
Summary: Leishmaniasis has been a mandatory reporting disease in Spain since 1982, but surveillance was decentralized between 1996 and 2014. A capture-recapture study was conducted to estimate the incidence of leishmaniasis and assess underreporting, which found a significant proportion of cases were not reported. The study highlights the importance of improving surveillance systems to reduce underreporting in Spain.
Article
Public, Environmental & Occupational Health
Hannah Tappis, Marwa Ramadan, Josep Vargas, Vincent Kahi, Heiko Hering, Catrin Schulte-Hillen, Paul Spiegel
Summary: This study examined neonatal mortality burden and trends in refugee camps using routine health information system data from 2006 to 2017. Findings showed that refugee camp neonatal mortality rates were lower than that of the immediate host community in most countries and years with national population-based surveys available. The study highlights the importance of improving data reporting systems to monitor and improve neonatal health in refugee populations.
Article
Public, Environmental & Occupational Health
Emily Raquel Nunes Vidal, Livia Carla Vinhal Frutuoso, Elisabeth Carmen Duarte, Henry Maia Peixoto
Summary: The study aims to describe CHIKF cases and estimate its burden in Brazil from 2016 to 2017. The disease burden in 2016 was estimated to be 77,422.61 DALY, with the incidence rate at 114.70 per 100,000 inhabitants. Deaths from CHIKF accounted for approximately 10% of the total DALY value.
TROPICAL MEDICINE & INTERNATIONAL HEALTH
(2022)
Article
Oncology
Huang Lin, Lei Shi, Jiachi Zhang, Jinchan Zhang, Chichen Zhang
Summary: This study investigated the epidemiological characteristics of breast cancer in Shantou and developed ETS and ARIMA models for predicting its incidence. The study provides valuable data and scientific references for local government and future breast cancer research.
Article
Medicine, General & Internal
Chen Peng, Xin Xu, Wenjuan Chen, Xingzi Li, Xuemei Yi, Yangfeng Ding, Ning Yu, Jiajing Lu
Summary: Psoriasis's health burden globally exhibits significant disparities in terms of geography, gender, age, and socioeconomic status. Despite some improvement in inequality over the past 27 years, disparities still exist. Policy planning for psoriasis services on a global scale is crucial based on the findings of this study.
FRONTIERS IN MEDICINE
(2021)
Article
Nutrition & Dietetics
Teresa Shamah-Levy, Lucia Cuevas-Nasu, Martin Romero-Martinez, Ignacio Mendez Gomez-Humaran, Marco Antonio Avila-Arcos, Juan A. Rivera
Summary: This study utilized the National Health and Nutrition Surveys data in Mexico to analyze the nutrition status of children, teenagers, and adults, emphasizing the importance of maintaining systematic, reliable, and timely anthropometric data in the population to inform nutrition-related public policy and track trends.
FRONTIERS IN NUTRITION
(2021)
Article
Public, Environmental & Occupational Health
Stefan David Baral, Katherine Blair Rucinski, Jean Olivier Twahirwa Rwema, Amrita Rao, Neia Prata Menezes, Daouda Diouf, Adeeba Kamarulzaman, Nancy Phaswana-Mafuya, Sharmistha Mishra
Summary: In regions with pronounced influenza seasonality, COVID-19 epidemics have largely followed trends similar to those seen for influenza from 2017 to 2019. Regions with less influenza activity have shown more heterogeneity in COVID-19 epidemics.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2021)
Article
Pediatrics
Anju Sinha, Reynold Washington, Rajeev Sethumadhavan, Rajaram Subramanian Potty, Shajy Isac, Vasantha Thavraj, Ravindra Mohan Pandey
Summary: This study aims to estimate the disease burden of pediatric HIV among children in a high HIV prevalence district in India. With an innovative three-pronged strategy, the study calculated the overall burden of pediatric HIV by multiplying detected cases by a net inflation factor. The prevalence of HIV among children in the district is higher than national estimates and other state estimates.
Article
Dermatology
Hsin- Shih, Yi-Ting Huang, Chi-Jung Wu
Summary: This study used the Taiwan National Health Insurance Research Database to depict the disease burden and demographics of mucormycosis in Taiwan and compared it with aspergillosis. The study found that mucormycosis is a rare fungal disease in Taiwan, occurring mostly in diabetic patients.
Review
Health Care Sciences & Services
Daniel Mendoza-Quispe, Silvana Perez-Leon, Christoper A. Alarcon-Ruiz, Andrea Gaspar, Maria Sofia Cuba-Fuentes, Joseph R. Zunt, Victor M. Montori, Juan Carlos Bazo-Alvarez, J. Jaime Miranda
Summary: This study aims to identify, assess, and summarize the measures to assess burden of treatment in patients with multimorbidity (BoT-MMs) and their measurement properties. The evidence for the use of existing BoT-MMs is insufficiently developed and there are limitations and issues that need attention in research and clinical practice.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Review
Gastroenterology & Hepatology
Mayo Hirabayashi, Damien Georges, Gary M. Clifford, Catherine de Martel
Summary: In this study, the proportion of Epstein-Barr virus (EBV)-positive gastric cancer was systematically explored. The prevalence of EBV in gastric tumors was 7.5%, higher in men, diffuse type, and proximal region. Developing an effective EBV vaccine could potentially prevent 81,000 EBV-associated gastric cancer cases annually.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Dermatology
Nipun Verma, Shreya Singh, Manvi Singh, Anil Chauhan, Pranita Pradhan, Nishant Jaiswal, Arunaloke Chakrabarti, Meenu Singh
Summary: Fungal infections have significant implications in cirrhosis, especially in patients with advanced liver disease. There are remarkable geographic variations in the types and sites of fungal infections in cirrhotics globally, with pulmonary infections having the highest prevalence.
Article
Public, Environmental & Occupational Health
Julia Moreira Pescarini, Camila Silveira Silva Teixeira, Nivea Bispo da Silva, Mauro Niskier Sanchez, Marcio Santos da Natividade, Laura Cunha Rodrigues, Maria Lucia Fernandes Penna, Mauricio Lima Barreto, Elizabeth B. Brickley, Gerson Oliveira Penna, Joilda Silva Nery
Summary: The study revealed a decreasing trend in the new case detection rate (NCDR) of leprosy in Brazil from 2006 to 2017, but there are still a significant number of cases with multibacillary leprosy, physical disabilities, or without proper evaluation, especially among children.
CADERNOS DE SAUDE PUBLICA
(2021)
Review
Public, Environmental & Occupational Health
Javier Munoz Laguna, Milo A. Puhan, Fernando Rodriguez Artalejo, Robby De Pauw, Grant M. A. Wyper, Brecht Devleesschauwer, Joao V. Santos, Cesar A. Hincapie
Summary: This study describes and assesses the risk of bias of the primary input studies for low back pain, neck pain, and knee osteoarthritis in the Global Burden of Disease Study 2019. It also evaluates the certainty of the modelled prevalence evidence in the GBD study.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2023)
Article
Parasitology
Caty Carrera Vargas, Luis Solorzano, Doris Guale, Claudia Herrera, Eric Dumonteil
Summary: Chagas disease, caused by Trypanosoma cruzi, is a vector-borne disease with a major disease burden in the Americas. A study in Ecuador found a seroprevalence of 0.77% among 516 schoolchildren in the Napo province, indicating ongoing transmission of the parasite and the need for strengthened epidemiological surveillance and patient care.
ACTA PARASITOLOGICA
(2021)
Article
Immunology
Abel Ramos-Vega, Elizabeth Monreal-Escalante, Eric Dumonteil, Bernardo Banuelos-Hernandez, Carlos Angulo
Summary: Plant-made vaccines have been shown to be a cost-effective and successful platform for producing and delivering vaccines against parasitic diseases. The technology has the potential to play a significant role in fighting neglected tropical diseases like Chagas disease.
EXPERT REVIEW OF VACCINES
(2021)
Article
Parasitology
G. E. Benitez-Villa, A. Lopez-Monteon, E. Waleckx, E. Dumonteil, A. J. Marquez-Fernandez, M. J. Rovirosa-Hernandez, F. Orduna-Garcia, D. Guzman-Gomez, A. Ramos-Ligonio
Summary: This study aimed to identify risk factors associated with house infestation by Triatomadimidiata and Trypanosomacruzi infection in two rural communities in Catemaco, Veracruz, Mexico. Blood samples from 116 humans and 34 dogs were collected and tested, with a prevalence of 5.1% T. cruzi infection in humans and 50% in dogs. The presence of animals and certain house construction characteristics were identified as key risk factors for infestation and infection. Further studies are needed for better understanding of transmission dynamics and implementation of control programs in Veracruz, Mexico.
ACTA PARASITOLOGICA
(2022)
Review
Parasitology
Marc Desquesnes, Alireza Sazmand, Marisa Gonzatti, Alain Boulange, Geraldine Bossard, Sophie Thevenon, Geoffrey Gimonneau, Philippe Truc, Stephane Herder, Sophie Ravel, Denis Sereno, Etienne Waleckx, Vincent Jamonneau, Philippe Jacquiet, Sathaporn Jittapalapong, David Berthier, Philippe Solano, Laurent Hebert
Summary: Reliable diagnostic tools are necessary to effectively treat and control animal trypanosomoses, which can be pathogenic. This review emphasizes the implementation of previously reviewed diagnostic methods in complex scenarios, and highlights the need for an integrative approach that combines parasite detection, DNA/RNA/antigen detection, antibody detection, and epizootiological information. While antibody detection tests have high sensitivity, DNA-based methods are more specific. Further developments are required to address gaps in current diagnostic methods and to improve prevention and control of animal trypanosomoses.
PARASITES & VECTORS
(2022)
Editorial Material
Public, Environmental & Occupational Health
Brice Rotureau, Etienne Waleckx, Vincent Jamonneau, Philippe Solano, Sophie Molia, Patrice Debre, Koussay Dellagi, Serge Morand
Article
Parasitology
Lopez-Dominguez Jaime, Lopez-Monteon Aracely, Ochoa-Martinez Paulina, Eric Dumonteil, Christian Barnabe, Etienne Waleckx, Ruben Gustavo Hernandez-Giles, Angel Ramos-Ligonio
Summary: This study aimed to characterize Mexican isolates of T. cruzi and evaluate their susceptibility to NFX. The results showed a high variability in the susceptibility to NFX of the T. cruzi isolates in Central and Southeastern Mexico, suggesting the presence of naturally resistant isolates circulating in the country. These findings have important implications for treatment policies for Chagas disease patients.
ACTA PARASITOLOGICA
(2022)
Article
Immunology
Eric Dumonteil, Claudia Herrera, Preston A. Marx
Summary: This study tested the safety and efficacy of a therapeutic DNA vaccine for preventing cardiac alterations in experimentally infected macaques. The results showed that the vaccine was safe and prevented the onset of cardiac alterations.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Genetics & Heredity
Hans Desale, Pierre Buekens, Jackeline Alger, Maria Luisa Cafferata, Emily Wheeler Harville, Claudia Herrera, Carine Truyens, Eric Dumonteil
Summary: The study assessed the epigenetic effects of in utero exposure to maternal Trypanosoma cruzi infection. By comparing the DNA methylation patterns of umbilical cord blood cells from uninfected babies with chagasic and uninfected mothers, a differential DNA methylation signature was identified. The genes affected are related to hematopoietic cell differentiation, immune response, and developmental disorders.
Article
Parasitology
Irving J. J. May-Concha, Maryrose J. J. Escalante-Talavera, Jean-Pierre Dujardin, Etienne Waleckx
Summary: This study investigated the effect of Trypanosoma cruzi infection on the antennal phenotype of Triatoma dimidiata vectors. The results showed significant differences in sensilla patterns between infected and non-infected insects in sylvatic and domestic populations, suggesting that T. cruzi infection may lead to changes in antennal phenotype. Furthermore, infected insects in sylvatic and domestic populations tended to exhibit increased sexual dimorphism.
PARASITES & VECTORS
(2022)
Article
Veterinary Sciences
Juan Mena, Christian Hidalgo, Daniela Estay-Olea, Nicole Sallaberry-Pincheira, Antonella Bacigalupo, Andre V. Rubio, Diego Penaloza, Carolina Sanchez, Javiera Gomez-Adaros, Valeria Olmos, Javier Cabello, Kendra Ivelic, Maria Jose Abarca, Diego Ramirez-Alvarez, Marisol Torregrosa Rocabado, Natalia Duran Castro, Martina Carreno, Gabriela Gomez, Pedro E. Cattan, Galia Ramirez-Toloza, Sofia Robbiano, Carla Marchese, Eduardo Raffo, Paulina Stowhas, Gonzalo Medina-Vogel, Carlos Landaeta-Aqueveque, Rene Ortega, Etienne Waleckx, Daniel Gonzalez-Acuna, Gemma Rojo
Summary: This study aimed to conduct molecular surveillance in wildlife rehabilitation centers and wildlife associated institutions in Chile to assess the transmission risk of SARS-CoV-2 in wild animals. A total of 185 samples from 83 individuals belonging to 15 different species were tested, and the results showed that all samples were negative for SARS-CoV-2.
VETERINARY QUARTERLY
(2023)
Article
Multidisciplinary Sciences
Evan M. Teal, Claudia M. Herrera, Eric M. Dumonteil
Summary: This study investigated the differences in gut microbiota between nymph and adult Triatoma sanguisuga, a major vector of Trypanosoma cruzi in the southeastern US. The results showed significant differences in microbiota composition and diversity between the two developmental stages. Laboratory-raised nymphs had a higher taxonomic diversity, while field-caught adults had a lower bacterial diversity. These differences in composition were associated with differences in metabolism, with nymphs metabolizing a limited diversity of carbon sources and producing lactic acid, while adults had a broader diversity of carbon sources and produced a variety of products. These findings provide insights into the metabolic interactions between triatomines and their gut microbiota, potentially leading to new vector control strategies.
Article
Infectious Diseases
Alheli Flores-Ferrer, Gerardo Suzan, Etienne Waleckx, Sebastien Gourbiere
Summary: Urbanization is a global trend that requires effective control measures to prevent the transmission of infectious diseases in urban areas. This study focuses on the risk of West Nile Virus (WNV) outbreaks in Merida, Mexico, due to changes in the bird community. The researchers developed a mathematical model and found that urbanization can significantly increase the duration and daily risk of WNV outbreaks, with the increase in Quiscalus mexicanus abundance having the largest impact. To mitigate the risks, reducing the mosquito population is crucial, and epidemiological monitoring combined with preemptive measures targeting both mosquitoes and birds is recommended.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Infectious Diseases
Alvaro Proano, Eric Dumonteil, Claudia Herrera
Summary: Chagas disease is a major public health problem in the Americas, affecting 7 million people with at least 65 million at risk. Our study in New Orleans, Louisiana found a low level of disease surveillance and a need for increased awareness and education among healthcare workers.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Microbiology
Eric Dumonteil, Hans Desale, Weihong Tu, Nora Hernandez-Cuevas, Monica Shroyer, Kelly Goff, Preston A. Marx, Claudia Herrera
Summary: In this study, the dynamics and pathogenesis of Trypanosoma cruzi parasite in naturally infected rhesus macaques were assessed over a 2.5-year period. It was found that parasite diversity influenced the progression of the disease, with individuals controlling parasite levels having a greater diversity of parasite strains. Additionally, the rate of parasite multiplication decreased with increasing parasite diversity, suggesting competition or a stronger immune response in multiple infections. The study also observed significant differences in electrocardiographic profiles between Chagasic macaques and uninfected controls, with changes in ECG patterns over time only occurring in macaques with increasing parasite levels and lower parasite diversity. Disease progression was associated with plasma fibronectin degradation, which may serve as a biomarker. These findings provide a new framework for understanding the pathogenesis of Chagas disease.
MICROBIOLOGY SPECTRUM
(2023)
Review
Parasitology
David E. Gorla, Zhou Xiao-Nong, Lileia Diotaiuti, Pham Thi Khoa, Etienne Waleckx, Rita de Cassia Moreira de Souza, Liu Qin, Truong Xuan Lam, Hector Freilij
Summary: The complexity of Chagas Disease is determined by the multiplicity of epidemiological scenarios resulting from various transmission routes and geo-ecobiosocial settings. These scenarios have evolved over time and geography due to new understandings of the disease, policy changes, and human movements. The multiple scenarios have shattered previous paradigms and expanded our knowledge of Trypanosoma cruzi infection.
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2022)