Article
Chemistry, Multidisciplinary
Elena Martinez-Plaza, Ainhoa Molina-Martin, David P. Pinero
Summary: The study compared the agreement between Medmont E300 and Visionix VX120+ systems in measuring NIBUT and TMH and found significant differences, suggesting that they are not interchangeable for diagnosing dry eye.
APPLIED SCIENCES-BASEL
(2022)
Article
Ophthalmology
Takashi Itokawa, Takashi Suzuki, Shizuka Koh, Yuichi Hori
Summary: The study compared fluorescein tear break-up time (BUT) and noninvasive BUT measured using interferometry and corneal topography. The results showed that there was a significant correlation between fluorescein BUT and noninvasive BUT, with the noninvasive BUT values being higher. Thus, noninvasive methods can be used as an effective tool for diagnosing dry eye.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2023)
Article
Medicine, General & Internal
Mazyar Yazdani, Jorgen Fiskadal, Xiangjun Chen, Oygunn A. Utheim, Sten Raeder, Valeria Vitelli, Tor P. Utheim
Summary: The study found that tear film break-up time can effectively differentiate pathological scores for other clinical tests and is associated with other parameters. Significant differences were observed between parameters at different TFBUT levels, with OPI showing the strongest discriminative power and association with TFBUT.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Stephen Pflugfelder, Lauren Nakhleh, Yasushi Kikukawa, Shin Tanaka, Takuya Kosugi
Summary: This study compares visual and software detection of non-invasive tear break-up using the KOWA DR-1 alpha tear interferometer and investigates the relationship between non-invasive tear break-up time (NIBUT) and dry eye clinical severity. The results show that software-detected NIBUT is a clinically relevant measure of dry eye clinical severity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Ophthalmology
Swati Singh, Pragnya Rao Donthineni, Saumya Srivastav, Christina Jacobi, Sayan Basu, Friedrich Paulsen
Summary: Lacrimal and meibomian glands contribute to tear film components, and their evaluation is essential for diagnosing and managing dry eye disease. This review discusses the differences and reliability of diagnostic tests and devices used for DED diagnosis. Various tests, both direct and machine-based, are available, but results should be interpreted considering repeatability and environmental factors.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Samrat Chatterjee, Deepshikha Agrawal
Summary: The prevalence of short tear film break-up time (TBUT) dry eye disease in India is 5.4%, with similar symptom severity to aqueous tear-deficient dry eyes but different characteristics. Risk factors associated with short TBUT dry eye disease include meibomian gland dysfunction and female sex.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Noemi Toth, Eszter Szalai, Tibor Rak, Veronika Lillik, Attila Nagy, Adrienne Csutak
Summary: The study aimed to investigate the reliability and clinical applicability of a modern tear film imaging tool by comparing the inter- and intragrader difference. Results showed excellent variability in measuring lower tear meniscus height, while there were larger differences in MeibI and MeibS measurements between graders. The agreement between NIBUT and TBUT was also found to be slight.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Swati Singh, Saumya Srivastav, Ashik Mohamed, Sayan Basu
Summary: This study investigated age- and sex-related differences in tear film parameters of a normal Indian population and examined their interparametric relationships. The findings suggest that tear meniscus height is minimally affected by age and independent of sex, non-invasive tear breakup time, and tear osmolarity. Tear breakup time and osmolarity show no significant age- and sex-related variation.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Yuzhou Wang, Zhiqiang Xu, Qianwen Gong, Wenjun Ren, Lin Chen, Fan Lu, Liang Hu
Summary: This study compared the diagnostic power of strip meniscometry, Schirmer test, and tear meniscus in mild dry eye disease and found that strip meniscometry was the most relevant factor to Dry Eye Disease Index scores and tear film break-up time. Additionally, measurements obtained by optical coherence tomography had better diagnostic power than Schirmer test.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Review
Biology
Robinson T. Barrientos, Fernando Godin, Carlos Rocha-De-Lossada, Matias Soifer, Jose-Maria Sanchez-Gonzalez, Esteban Moreno-Toral, Ana-Luisa Gonzalez, Mike Zein, Pablo Larco, Carolina Mercado, Maria-Adelaida Piedrahita
Summary: This article provides a systematic and critical review of scientific publications on dry eye disease and SS, summarizing their conceptualization, prevalence, risk factors, etiopathogenesis, clinical manifestations, diagnosis, and treatment.
Article
Veterinary Sciences
Youngsam Kim, Seonmi Kang, Sunhyo Kim, Jaeho Shim, Seokmin Go, Kangmoon Seo
Summary: This study establishes reference values for dry eye tests (DETs) in dogs and analyzes the correlation between DETs, providing useful information for diagnosing and further researching dry eye disease in dogs.
JOURNAL OF VETERINARY SCIENCE
(2022)
Article
Ophthalmology
Swati Singh, Saumya Srivastav, Minal Thacker, Kiran K. Bokara, Vivek Singh, Sayan Basu
Summary: The current study examined the normative data values and repeatability of non-invasive tear film tests using Oculus Keratograph 5M in rabbit eyes. The results showed that the non-invasive tear film parameters measured with K5M have good repeatability and can be used as an objective parameter for rabbit ocular surface experiments.
CURRENT EYE RESEARCH
(2023)
Article
Ophthalmology
Shaopan Wang, Xin He, Jiezhou He, Shuang Li, Yuguang Chen, Changsheng Xu, Xiang Lin, Jie Kang, Wei Li, Zhiming Luo, Zuguo Liu
Summary: This study proposes a novel automatic artificial intelligence (AI) system for evaluating tear meniscus height, which is essential for the accurate diagnosis of dry eye. The developed system showed strong correlation with manual calculations by ophthalmologists, indicating its potential for clinical practice.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Tanya Cross, Reidun Ovstebo, Berit Sletbakk Brusletto, Anne-Marie Siebke Troseid, Ole Kristoffer Olstad, Trude Aspelin, Catherine Joan Jackson, Xiangjun Chen, Tor Paaske Utheim, Kari Bente Foss Haug
Summary: Currently, diagnosing and stratifying dry eye disease require multiple tests. This study investigates the potential of using tear fluid extracellular vesicle-RNA as a single definitive test for dry eye disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Shaopan Wang, Xin He, Jiezhou He, Shuang Li, Yuguang Chen, Changsheng Xu, Xiang Lin, Jie Kang, Wei Li, Zhiming Luo, Zuguo Liu
Summary: In this study, a fully automated and reliable AI system was developed to accurately measure the height of the tear meniscus. After large-scale clinical testing, this method can be used for screening dry eye in clinical practice.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)