Journal
BMJ OPEN
Volume 9, Issue 4, Pages -Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/bmjopen-2018-025222
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Funding
- National Science Foundation of China [81330016, 81630038, 81771634]
- Major State Basic Research Development Program [2017YFA01042000]
- Ministry of Education of China [IRT0935]
- Science and Technology Bureau of Sichuan Province [2016TD0002]
- Grant of clinical discipline program (Neonatology) from the Ministry of Health of China [1311200003303]
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Objectives Our study aimed to synthesise and analyse the early diagnostic value of neutrophil CD11b (nCD11b) for neonatal sepsis. Design Systematic review and meta-analysis. Methods Pubmed, Embase, the Cochrane Library and Web of Science Databases were searched up to June 2018. We used Stata software (V.14.0) to conduct the pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic OR (DOR), pretest probability, post-test probability and summary receiver operating characteristic (SROC) curve for diagnostic efficiency of n CD11b. Results Nine studies, accounting for 843 neonates, were included. The overall pooled sensitivity, specificity, PLR, NLR, DOR, post-test positive probability and post-test negative probability and the area under the SROC curve were 0.82 (95% CI 0.71 to 0.90), 0.93 (95% CI 0.62 to 0.99), 11.51 (95% CI 1.55 to 85.62), 0.19 (95% CI 0.10 to 0.36), 59.50 (95% CI 4.65 to 761.58), 74%, 5% and 0.90, which had accuracy in diagnosing neonatal sepsis. Conclusion The present evidence indicated that nCD11b is a promising biomarker for the early diagnosis of neonatal sepsis.
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