Article
Biochemistry & Molecular Biology
Dmitry S. Semenovich, Egor Y. Plotnikov, Elena P. Lukiyenko, Alexander A. Astrowski, Nina P. Kanunnikova
Summary: This study investigated the protective effect of D-panthenol in rhabdomyolysis-induced acute kidney injury (AKI). The results showed that D-panthenol protects the kidney tissue from pathological changes through antioxidant effects, normalization of mitochondrial metabolism, and modulation of glutathione-dependent signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Rami B. Kassab, Ahmed A. Elhenawy, Abdulrahman Theyab, Yousef M. Hawsawi, Osama M. Al-Amer, Atif Abdulwahab A. Oyouni, Ola A. Habotta, Hussam A. Althagafi, Fahad Alharthi, Maha S. Lokman, Khalaf F. Alsharif, Ashraf Albrakati, Ali O. Al-Ghamdy, Ehab Kotb Elmahallawy, Mohamed A. Elhefny, Kalid E. Hassan, Alaa Jameel A. Albarakati, Ahmed E. Abdel Moneim, Ahmed A. Moustafa
Summary: This study investigated the therapeutic potential and underlying mechanisms of daidzein, a dietary isoflavone, against glycerol-induced acute kidney injury (AKI) in male rats. The results demonstrated that daidzein pre-administration effectively improved kidney function, reduced kidney injury markers, enhanced antioxidant capacity, suppressed inflammation, and attenuated apoptosis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Food Science & Technology
Nahla E. El-Ashmawy, Eman G. Khedr, Ahmed S. Doghish, Mohammed S. Elballal
Summary: This study aimed to investigate the protective effects of carnosine and crocin on acute kidney injury caused by glycerol-induced rhabdomyolysis. The results showed that both carnosine and crocin could effectively prevent AKI by upregulating the expression of HO-1 and antioxidant system, and suppressing the generation of reactive oxygen species, lipid peroxidation, and inflammatory response.
Article
Cell Biology
Jun Muratsu, Fumihiro Sanada, Nobutaka Koibuchi, Kana Shibata, Naruto Katsuragi, Shoji Ikebe, Yasuo Tsunetoshi, Hiromi Rakugi, Ryuichi Morishita, Yoshiaki Taniyama
Summary: This study aimed to investigate the role of periostin (POSTN) in a rhabdomyolysis mice model of acute kidney injury (AKI). The study found that POSTN was highly expressed in the kidney after rhabdomyolysis and acted as a positive regulator of AKI. POSTN-null mice exhibited lower expression of inflammation-associated mRNAs and reduced tubular injury compared to wildtype mice. Targeting POSTN may provide a new therapeutic strategy against the development of AKI.
Article
Pharmacology & Pharmacy
Jiajia Li, Yupeng Jiang, Qin Dai, Yue Yu, Xin Lv, Yan Zhang, Xiaohua Liao, Liyun Ao, Gaoyun Hu, Jie Meng, Zhangzhe Peng, Lijian Tao, Yanyun Xie
Summary: In this study, the protective effect of Mefunidone on ischemia-reperfusion injury-induced acute kidney injury was investigated. The results showed that Mefunidone can protect the kidney by relieving kidney tubular injury, suppressing oxidative stress, and inhibiting cell apoptosis. Furthermore, Mefunidone reduced mitochondrial damage and protected mitochondrial function.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Chien-Wen Yang, Si Li, Yishan Dong, Nitpriya Paliwal, Yichen Wang
Summary: This study analyzed data from the HCUP database from 2016 to 2018 and found that rhabdomyolysis patients with AKI were more likely to be older, have Medicare insurance, and have a higher comorbidity index. AKI was associated with higher mortality, longer hospital stays, and higher hospital costs in patients with rhabdomyolysis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Bing-feng Hu, Qian Gong, Shi-qing Chen, Lin Yue, Wen-xian Ma, Fang Wang, Xiao-wen Feng, Jia-nan Wang, Chao Li, Ming-ming Liu, Xue-fu Wang, Xiao-ming Meng, Jun Li, Jia-gen Wen
Summary: Necroptosis plays a role in gentamicin-induced acute kidney injury, and suppressing necroptosis could be a promising strategy for prevention.
Article
Urology & Nephrology
Qinglian Wang, Guanghui Qi, Hongwei Zhou, Fajuan Cheng, Xiaowei Yang, Xiang Liu, Rong Wang
Summary: In this study, we investigated whether thymol, a main component of thyme species, could ameliorate rhabdomyolysis-induced acute kidney injury (AKI) and its related mechanism. The results showed that thymol treatment attenuated renal damage, oxidative stress, inflammatory damage, and PI3K/Akt pathway downregulation associated with glycerol-induced AKI.
Article
Pharmacology & Pharmacy
Wenli Guo, Yu Wang, Yuxuan Wu, Jiang Liu, Ying Li, Jing Wang, Santao Ou, Weihua Wu
Summary: The study demonstrated that NM can protect the kidneys from RIAKI by regulating glutathione metabolism, inflammatory response, ferroptosis-related pathways, and key DEGs. Targeting these DEGs might emerge as a potential molecular therapy for RIAKI.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Wenjun Lin, Xianfeng Wu, Jiejun Wen, Yang Fei, Junnan Wu, Xiaomei Li, Qunzi Zhang, Yang Dong, Tao Xu, Ying Fan, Niansong Wang
Summary: This study demonstrated the renal protective effect of nicotinamide on rhabdomyolysis-induced AKI, with Klotho preservation being essential for this effect. The study provided insight into the interaction between nicotinamide and Klotho, and proposed a new preventive strategy for rhabdomyolysis-induced AKI.
Article
Immunology
Zhe Jin, Meng-Yun Li, Lijuan Tang, Yufeng Zou, Kai Chen
Summary: This study found that ulinastatin (UTI) can effectively reduce acute lung injury (ALI) induced by diabetic sepsis in rats by inhibiting inflammatory response, reducing oxidative stress, regulating hypoxia response pathway, and improving pulmonary microvascular permeability.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jung-Yeon Kim, Hyo-Lim Hong, Gyun Moo Kim, Jaechan Leem, Hyun Hee Kwon
Summary: The study demonstrates that carnosic acid can ameliorate kidney injury induced by septic acute kidney injury (AKI) and exert its effects by inhibiting inflammation, oxidative stress, and cell apoptosis.
Article
Immunology
Sukkum Ngullie Chang, Jae Gyu Park, Sun Chul Kang
Summary: In this study, the therapeutic efficacy of ginsenosides Rg1 and Rg3 in glycerol-induced acute kidney injury (AKI) was investigated. The results showed that Rg1 and Rg3 significantly alleviated kidney damage by reducing the expression of kidney damage markers, decreasing tubular necrosis, and downregulating oxidative and ER stress markers. Additionally, Rg1 and Rg3 exhibited a protective effect against apoptotic cell death. Therefore, Rg1 and Rg3 could be considered as natural therapeutic remedies for AKI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Environmental Sciences
Bowen Yin, Xiao Zhang, Jingyi Ren, Fengge Chen, Jufeng Liang, Hanning Zhang, Huanting Pei, Zhaohui Hu, Yan Wang, Wei Xue, Xinyue Yu, Rui Zhang, Yuxia Ma
Summary: The study found that procyanidin supplementation effectively reduced oxidative stress and apoptosis in rat myocardial tissue caused by PM2.5 exposure. There were no significant differences in the protective effect of different doses of procyanidin.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Cell Biology
Jia-Long Tang, Meng Xin, Li -Chao Zhang
Summary: Astragalus membranaceus and its active monomer Astragaloside IV (AS-IV) can attenuate sepsis-induced kidney tubular injury by activating the PI3K/AKT pathway.
Article
Public, Environmental & Occupational Health
L. F. Almeida, H. D. C. Francescato, R. S. Silva, C. G. A. Silva, J. Antunes-Rodrigues, F. J. A. de Paula, T. M. Coimbra
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2019)
Review
Pediatrics
Lucas Ferreira de Almeida, Terezila Machado Coimbra
FRONTIERS IN PEDIATRICS
(2019)
Article
Nutrition & Dietetics
Lucas Ferreira de Almeida, Heloisa Della Coletta Francescato, Jose Antunes-Rodrigues, Francisco Jose Albuquerque de Paula, Cleonice Giovanni Alves da Silva, Roberto Silva Costa, Terezila Machado Coimbra
Review
Medicine, Research & Experimental
Lucas F. Almeida, Signe S. Tofteng, Kirsten Madsen, Boye L. Jensen
Meeting Abstract
Biochemistry & Molecular Biology
Luiz Navegantes, Natany Reis, Joao Turatti, Dawit Goncalves, Willian Silveira, Natalia Lautherbach, Lucas Almeida, Ana de Assis, Neusa Zanon, Lilian Heck, Isis Kettelhut
Article
Obstetrics & Gynecology
Lucas Ferreira de Almeida, Terezila Machado Coimbra
Summary: Premature birth or low birth weight can lead to a reduction in glomerular number, increasing the risk of hypertension and kidney injury in adulthood. Renal development is sensitive to hypoxia, but hyperoxia can negatively affect glomerular and tubular development. Preterm newborns often receive oxygen therapy, exposing them to an environment with high oxygen levels, which may have long-term effects on kidney development and adult health.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Natany G. Reis, Ana P. Assis, Natalia Lautherbach, Dawit A. Goncalves, Wilian A. Silveira, Henrique J. N. Morgan, Rafael R. Valentim, Lucas F. Almeida, Lilian C. Heck, Neusa M. Zanon, Tatiana E. Koike, Audrei R. Santos, Elen H. Miyabara, Isis C. Kettelhut, Luiz C. Navegantes
Summary: This study found that maternal vitamin D deficiency selectively affects the development of type-II muscle fibers in male offspring rats, leading to muscle atrophy. However, compensatory increase in vitamin D content in adult age may increase fiber size and fatigue resistance.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Biochemistry & Molecular Biology
Beatriz M. Oliveira, Lucas Ferreira de Almeida, Amanda L. Deluque, Claudia S. Souza, Ana Livia D. Maciel, Heloisa D. C. Francescato, Roberto S. Costa, Cleonice Giovanini, Francisco Jose A. de Paula, Terezila M. Coimbra
Summary: Cisplatin treatment is commonly used for cancer patients, but it often leads to acute kidney injury. This study found that bioactive vitamin D can attenuate the renal injury caused by cisplatin by reducing inflammation and vascular damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Susana Quiros Cognuck, Lucas Ferreira de Almeida, Wagner L. Reis, Marcia S. Silva, Gislaine Almeida-Pereira, Sandra V. Zorro, Andre S. Mecawi, Terezila Machado Coimbra, Lucila L. K. Elias, Jose Antunes-Rodrigues
Summary: Aging affects kidney structure, and the changes vary with sex in a stressful situation such as dehydration. Male rats at 18 months of age showed lower expression of Slc12a3 mRNA but higher expression of fibronectin and alpha-SMA compared to younger males. In females, only fibronectin expression was higher in the 18-month-old rats. Dehydration also influenced gene expression, with 3-month-old females showing lower Slc12a3 mRNA expression than males, and 18-month-old males showing higher fibronectin and alpha-SMA expression compared to females. Overall, aging, sex, and dehydration contribute to alterations in kidney structure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Amanda Lima Deluque, Beatriz Magalhaes Oliveira, Claudia Silva Souza, Ana Livia Dias Maciel, Heloisa Della Coletta Francescato, Cleonice Giovanini, Lucas Ferreira de Almeida, Francisco Jose Albuquerque de Paula, Roberto Silva Costa, Jose Antunes-Rodrigues, Terezila Machado Coimbra
Summary: By activating the vitamin D receptor, paricalcitol protects renal endothelial cells from ADR-induced injury, improves the structure and function of glomerulus and tubules, and maintains endothelial cell function and structure through regulating NO production, suppressing fibrotic marker expression, and modulating the angiopoietins and VEGF signaling pathways.
Article
Medicine, General & Internal
Amanda L. Deluque, Lucas F. de Almeida, Heloisa D. C. Francescato, Cleonice G. A. da Silva, Roberto S. Costa, Jose Antunes-Rodrigues, Terezila M. Coimbra
FRONTIERS IN MEDICINE
(2020)