From Probiotics to Psychobiotics: Live Beneficial Bacteria Which Act on the Brain-Gut Axis

Finding the needle in the haystack: systematic identification of psychobiotics

(2018) Aisling Bambury et al.   BRITISH JOURNAL OF PHARMACOLOGY

Genetic risk, dysbiosis, and treatment stratification using host genome and gut microbiome in inflammatory bowel disease

(2018) Ahmed Moustafa et al.   Clinical and Translational Gastroenterology

Probiotics in Celiac Disease

(2018) Fernanda Cristofori et al.   Nutrients

Interactions between the microbiota, immune and nervous systems in health and disease

(2017) Thomas C Fung et al.   NATURE NEUROSCIENCE

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

(2017) Glenn R. Gibson et al.   Nature Reviews Gastroenterology & Hepatology

Intrinsic functional connectivity between amygdala and hippocampus during rest predicts enhanced memory under stress

(2017) Lycia D. de Voogd et al.   PSYCHONEUROENDOCRINOLOGY

Prebiotic Effect of Fructooligosaccharides from Morinda officinalis on Alzheimer’s Disease in Rodent Models by Targeting the Microbiota-Gut-Brain Axis

(2017) Diling Chen et al.   Frontiers in Aging Neuroscience

Neurophysiology of the “Celiac Brain”: Disentangling Gut-Brain Connections

(2017) Manuela Pennisi et al.   Frontiers in Neuroscience

Prebiotic administration normalizes lipopolysaccharide (LPS)-induced anxiety and cortical 5-HT2A receptor and IL1-β levels in male mice

(2016) Helene M. Savignac et al.   BRAIN BEHAVIOR AND IMMUNITY

Neural circuitry of emotion regulation: Effects of appraisal, attention, and cortisol administration

(2016) Sean T. Ma et al.   COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE

Adult microbiota-deficient mice have distinct dendritic morphological changes: differential effects in the amygdala and hippocampus

(2016) Pauline Luczynski et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Chitosan oligosaccharides alleviate cognitive deficits in an amyloid-β1–42-induced rat model of Alzheimer's disease

(2016) Shiliang Jia et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Oral supplementation of 2′-fucosyllactose during lactation improves memory and learning in rats

(2016) Elena Oliveros et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Neurodevelopment of Preterm Infants at 24 Months After Neonatal Supplementation of a Prebiotic Mix

(2016) Jolice P. van den Berg et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

(2016) Rachel J. Perry et al.   NATURE

Microglia development follows a stepwise program to regulate brain homeostasis

(2016) O. Matcovitch-Natan et al.   SCIENCE

Neonatal prebiotic (BGOS) supplementation increases the levels of synaptophysin, GluN2A-subunits and BDNF proteins in the adult rat hippocampus

(2016) Sarah Williams et al.   SYNAPSE

Psychobiotics and the Manipulation of Bacteria–Gut–Brain Signals

(2016) Amar Sarkar et al.   TRENDS IN NEUROSCIENCES

Adult Hippocampal Neurogenesis Is Regulated by the Microbiome

(2015) Ebere S. Ogbonnaya et al.   BIOLOGICAL PSYCHIATRY

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

Alterations in the Vaginal Microbiome by Maternal Stress Are Associated With Metabolic Reprogramming of the Offspring Gut and Brain

(2015) Eldin Jašarević et al.   ENDOCRINOLOGY

60 YEARS OF NEUROENDOCRINOLOGY: Redefining neuroendocrinology: stress, sex and cognitive and emotional regulation

(2015) Bruce S McEwen et al.   JOURNAL OF ENDOCRINOLOGY

Effects of a human milk oligosaccharide, 2′-fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents

(2015) Enrique Vázquez et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Collective unconscious: How gut microbes shape human behavior

(2015) Timothy G. Dinan et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Effect of a Gluten-Free Diet on Cortical Excitability in Adults with Celiac Disease

(2015) Rita Bella et al.   PLoS One

Neural control of the immune system

(2014) Eva Sundman et al.   ADVANCES IN PHYSIOLOGY EDUCATION

Microglia Development and Function

(2014) Debasis Nayak et al.   Annual Review of Immunology

The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents

(2014) A Psichas et al.   INTERNATIONAL JOURNAL OF OBESITY

Amygdala Inputs to the Ventral Hippocampus Bidirectionally Modulate Social Behavior

(2014) A. C. Felix-Ortiz et al.   JOURNAL OF NEUROSCIENCE

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

(2014) Colin Hill et al.   Nature Reviews Gastroenterology & Hepatology

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Possible additional antidepressant-like mechanism of sodium butyrate: Targeting the hippocampus

(2014) Arum Han et al.   NEUROPHARMACOLOGY

Changes in Intestinal Glucocorticoid Sensitivity in Early Life Shape the Risk of Epithelial Barrier Defect in Maternal-Deprived Rats

(2014) Nabila Moussaoui et al.   PLoS One

Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers

(2014) Kristin Schmidt et al.   PSYCHOPHARMACOLOGY

Serotonin receptors and their role in the pathophysiology and therapy of irritable bowel syndrome

(2014) C. Stasi et al.   Techniques in Coloproctology

Microbiota and neurodevelopmental windows: implications for brain disorders

(2014) Yuliya E. Borre et al.   TRENDS IN MOLECULAR MEDICINE

Optogenetic insights on the relationship between anxiety-related behaviors and social deficits

(2014) Stephen A. Allsop et al.   Frontiers in Behavioral Neuroscience

Psychobiotics: A Novel Class of Psychotropic

(2013) Timothy G. Dinan et al.   BIOLOGICAL PSYCHIATRY

Microbial genes, brain & behaviour - epigenetic regulation of the gut-brain axis

(2013) R. M. Stilling et al.   GENES BRAIN AND BEHAVIOR

The circadian clock and glucocorticoids – Interactions across many time scales

(2013) Thomas Dickmeis et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Innate immune recognition of the microbiota promotes host-microbial symbiosis

(2013) Hiutung Chu et al.   NATURE IMMUNOLOGY

Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets

(2013) Gary M. Mawe et al.   Nature Reviews Gastroenterology & Hepatology

Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-d-aspartate receptor subunits and d-serine

(2013) Helene M. Savignac et al.   NEUROCHEMISTRY INTERNATIONAL

Differential Control of Learning and Anxiety along the Dorsoventral Axis of the Dentate Gyrus

(2013) Mazen A. Kheirbek et al.   NEURON

Neurodevelopmental Outcome during the First Year of Life in Preterm Infants after Supplementation of a Prebiotic Mixture in the Neonatal Period: A Follow-Up Study

(2013) Natalie LeCouffe et al.   NEUROPEDIATRICS

Stress-System Genes and Life Stress Predict Cortisol Levels and Amygdala and Hippocampal Volumes in Children

(2013) David Pagliaccio et al.   NEUROPSYCHOPHARMACOLOGY

Galactooligosaccharide improves the animal survival and alleviates motor neuron death in SOD1G93A mouse model of amyotrophic lateral sclerosis

(2013) L. Song et al.   NEUROSCIENCE

Gut–brain axis: how the microbiome influences anxiety and depression

(2013) Jane A. Foster et al.   TRENDS IN NEUROSCIENCES

A Dialogue between the Immune System and Brain, Spoken in the Language of Serotonin

(2012) Nicole L. Baganz et al.   ACS Chemical Neuroscience

Activation of Colonic Mucosal 5-HT4 Receptors Accelerates Propulsive Motility and Inhibits Visceral Hypersensitivity

(2012) Jill M. Hoffman et al.   GASTROENTEROLOGY

Rethinking inflammation: neural circuits in the regulation of immunity

(2012) Peder S. Olofsson et al.   IMMUNOLOGICAL REVIEWS

γ-Aminobutyric acid production by culturable bacteria from the human intestine

(2012) E. Barrett et al.   JOURNAL OF APPLIED MICROBIOLOGY

Stimulation of Dopamine Receptor D5 Expressed on Dendritic Cells Potentiates Th17-Mediated Immunity

(2012) C. Prado et al.   JOURNAL OF IMMUNOLOGY

VSL#3 probiotics exerts the anti-inflammatory activity via PI3k/Akt and NF-κB pathway in rat model of DSS-induced colitis

(2012) Cong Dai et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology

(2012) Isaac M Chiu et al.   NATURE NEUROSCIENCE

The interplay between the intestinal microbiota and the brain

(2012) Stephen M. Collins et al.   NATURE REVIEWS MICROBIOLOGY

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

(2012) John F. Cryan et al.   NATURE REVIEWS NEUROSCIENCE

Microbes and the gut-brain axis

(2012) P. Bercik et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Regulation of the stress response by the gut microbiota: Implications for psychoneuroendocrinology

(2012) Timothy G. Dinan et al.   PSYCHONEUROENDOCRINOLOGY

Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Disease

(2012) Kirsty Brown et al.   Nutrients

A mitochondrial etiology of Alzheimer and Parkinson disease

(2011) Pinar Coskun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Probiotics function mechanistically as delivery vehicles for neuroactive compounds: Microbial endocrinology in the design and use of probiotics

(2011) Mark Lyte   BIOESSAYS

The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice

(2011) Premysl Bercik et al.   GASTROENTEROLOGY

Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis

(2011) D A Rossignol et al.   MOLECULAR PSYCHIATRY

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Amygdala circuitry mediating reversible and bidirectional control of anxiety

(2011) Kay M. Tye et al.   NATURE

Gut feelings: the emerging biology of gut–brain communication

(2011) Emeran A. Mayer   NATURE REVIEWS NEUROSCIENCE

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

(2011) J. A. Bravo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal GPCR Controls Innate Immunity by Regulating Noncanonical Unfolded Protein Response Genes

(2011) J. Sun et al.   SCIENCE

Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit

(2011) M. Rosas-Ballina et al.   SCIENCE

Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation

(2010) Michael T. Bailey et al.   BRAIN BEHAVIOR AND IMMUNITY

Chronic Gastrointestinal Inflammation Induces Anxiety-Like Behavior and Alters Central Nervous System Biochemistry in Mice

(2010) Premysl Bercik et al.   GASTROENTEROLOGY

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

(2010) Y. K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proximal Small Intestinal Microbiota and Identification of Rod-Shaped Bacteria Associated With Childhood Celiac Disease

(2009) Gangwei Ou et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Cortagine, a CRF1 agonist, induces stresslike alterations of colonic function and visceral hypersensitivity in rodents primarily through peripheral pathways

(2009) Muriel Larauche et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mood and gut feelings

(2009) Paul Forsythe et al.   BRAIN BEHAVIOR AND IMMUNITY

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

The Relationship Between Intestinal Microbiota and the Central Nervous System in Normal Gastrointestinal Function and Disease

(2009) Stephen M. Collins et al.   GASTROENTEROLOGY

The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

(2009) Valérie Gaboriau-Routhiau et al.   IMMUNITY

Role of Gut Commensal Microflora in the Development of Experimental Autoimmune Encephalomyelitis

(2009) J. Ochoa-Reparaz et al.   JOURNAL OF IMMUNOLOGY

Principles and clinical implications of the brain–gut–enteric microbiota axis

(2009) Sang H. Rhee et al.   Nature Reviews Gastroenterology & Hepatology

Effects of stress throughout the lifespan on the brain, behaviour and cognition

(2009) Sonia J. Lupien et al.   NATURE REVIEWS NEUROSCIENCE

Differential stress-induced alterations of colonic corticotropin-releasing factor receptors in the Wistar Kyoto rat

(2009) d. o'malley et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Chronic peripheral administration of corticotropin-releasing factor causes colonic barrier dysfunction similar to psychological stress

(2008) Aaron A. Teitelbaum et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL

Gut flora, Toll-like receptors and nuclear receptors: a tripartite communication that tunes innate immunity in large intestine

(2008) Annelie Lundin et al.   CELLULAR MICROBIOLOGY

Enhanced Intracellular Calcium Induced by Urocortin Is Involved in Degranulation of Rat Lung Mast Cells

(2008) Yuqing Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Pathophysiological Mechanisms of Stress-Induced Intestina Damage

(2008) Melanie Gareau et al.   CURRENT MOLECULAR MEDICINE

Commensal microbiota is fundamental for the development of inflammatory pain

(2008) F. A. Amaral et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA