4.7 Article

The Resveratrol Rice DJ526 Callus Significantly Increases the Lifespan of Drosophila (Resveratrol Rice DJ526 Callus for Longevity)

Journal

NUTRIENTS
Volume 11, Issue 5, Pages -

Publisher

MDPI
DOI: 10.3390/nu11050983

Keywords

resveratrol; antiaging; lifespan; resveratrol rice DJ526; callus

Funding

  1. National Research Foundation of Korea (NRF) - Korean government (MSIP) [NRF-2017R1A4A1015594]
  2. NextGeneration BioGreen 21 Program, Rural Development Administration, Republic of Korea [PJ01369101]
  3. Rural Development Administration (RDA), Republic of Korea [PJ013691012019] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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Resveratrol has gained widespread scientific attention due to its ability to significantly extend the lifespan of yeast. However, research on the efficacy of resveratrol on lifespan extension has yielded mixed results in animal studies, making resveratrol a contentious subject. In our previous work, we reported that transgenic resveratrol rice DJ526 showed unusual health benefits beyond expectations. In this work, we established a callus culture of resveratrol rice DJ526, which contains 180 times more resveratrol than the grain, and found that resveratrol rice callus significantly extended the median lifespan of Drosophila melanogaster by up to 50% compared to the control. The resveratrol rice callus also ameliorated age-dependent symptoms, including locomotive deterioration, body weight gain, eye degeneration, and neurodegeneration of D. melanogaster with age progression. Considering that resveratrol is the most preferred antiaging compound due to its superior safety and proven mechanism against many serious adult diseases, the outstanding efficacy of resveratrol on the longevity of wild-type animals could cast a light on the development of antiaging therapeutic agents.

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