Article
Materials Science, Ceramics
Ib Holzmeister, Jan Weichhold, Juergen Groll, Hala Zreiqat, Uwe Gbureck
Summary: The study investigated the hydraulic reactivity and cement formation of baghdadite (Ca3ZrSi2O9), revealing that the material exhibited reduced particle and crystallite size and partial amorphization after being mechanically activated. Cement formation resulted in high compressive strengths, with a preferred dissolution of calcium and marginal release of zirconium ions. Alkaline conditions were found to be crucial for cement formation.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2021)
Article
Materials Science, Ceramics
Zilgma Irbe, Dagnija Loca
Summary: Premixed calcium phosphate cement pastes have been proposed as biomaterials for bone tissue repair and regeneration, with alpha-Tricalcium phosphate (alpha-TCP) based cements setting to form calcium deficient hydroxyapatite. The use of mixture of basic and acidic potassium phosphate salts showed the best overall results in terms of cohesion, pH value, hydrolysis, and compressive strength of the cement.
CERAMICS INTERNATIONAL
(2021)
Article
Biotechnology & Applied Microbiology
Lijuan Sun, Tongyang Li, Sen Yu, Mengmeng Mao, Dagang Guo
Summary: A novel strontium-substituted calcium phosphate bone cement (Sr-CPC) was developed and its physicochemical properties and hydration mechanism were intensively investigated. The compressive strength of Sr-CPC tended to increase with the extension of hydration time, while cytocompatibility was favorable at low strontium contents. The effect of strontium ions on cytocompatibility of Sr-CPC was not significant.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Ceramics
Yeeun Kim, Jiyoung Bae, Emi Uyama, Kazumitsu Sekine, Fumiaki Kawano, Kenichi Hamada
Summary: Injectable calcium phosphate cements can be improved in strength and injectability through mechano-chemically modification and the addition of zirconia powder, respectively. This study found that the changes in cement powder properties affected injectability, while zirconia abrasion powder contamination impacted strength.
CERAMICS INTERNATIONAL
(2021)
Article
Nanoscience & Nanotechnology
Marcin Wekwejt, Maryia Khamenka, Anna Ronowska, Uwe Gbureck
Summary: This paper reports the preparation of a novel cement based on magnesium phosphate cement (MPC) and poly-(2-hydroxyethyl methacrylate) (pHEMA). The addition of HEMA has been found to improve the formability, setting time, and mechanical strengths of the cement. The developed cement shows promising properties for various biomedical applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Ceramics
Min Wei, Yufei Tang, Lei Chen, Bo Zhang, Shitong Zhang, Kang Zhao, Zixiang Wu
Summary: This study successfully introduced montmorillonite (MMT) into calcium phosphate cement (CPC) to prepare CPC/MMT composite bone cement. The compressive strength of the composite cement was significantly enhanced, and the anti-washout ability was improved as well. The composite bone cement also exhibited outstanding cell adhesion and proliferation abilities.
CERAMICS INTERNATIONAL
(2022)
Article
Construction & Building Technology
Robbie M. Damiani, Paramita Mondal, David A. Lange
Summary: The reuse of waste tires in the form of waste rubber in concrete has been attempted to address environmental concerns, but it results in a drastic decrease in compressive strength. This study investigates the effect of expansive cement on the performance of rubberized cement samples and the interfacial transition zone, showing that the use of expansive cement can decrease the interfacial gap at the rubber-paste interface and improve mechanical performance. The experimental results support the hypothesis that expansive cement enhances the mechanical properties of rubberized concrete samples.
CONSTRUCTION AND BUILDING MATERIALS
(2021)
Review
Construction & Building Technology
Xiangrui Meng, Yu Jiang, Bing Chen, Liyan Wang
Summary: This paper provides a comprehensive literature review of 146 papers published from 1970 to 2023 on the solidification and hardening of magnesium phosphate cement (MPC). It analyzes the effects of raw material properties and ratios, temperature variations, retarder and admixture contents on the setting time of MPC-based materials, and summarizes the approaches to regulating the solidification and hardening. The paper also focuses on the mechanism of the effects of mixing proportion and admixtures on the solidification and hardening of MPC.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Materials Science, Ceramics
H. Mabroum, H. Noukrati, H. Ben Youcef, B. Lefeuvre, H. Oudadesse, A. Barroug
Summary: Novel composite cement based on CPC, BG, and Alg shows advantages in setting time and rheological properties, with improved mechanical performance by adding BG and Alg, which may have potential clinical applications.
CERAMICS INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Hailiang Xu, Lei Zhu, Fang Tian, Chengwen Wang, Weidong Wu, Botao Lu, Liang Yan, Shuaijun Jia, Dingjun Hao
Summary: In this study, a novel strontium-modified calcium phosphate cement (SMPC) was developed by introducing tristrontium silicate, which showed better injectability and a shorter setting time compared to traditional calcium phosphate cement (CPC). SMPC also promoted cell proliferation and differentiation, and facilitated bone regeneration in vivo. Therefore, 5% SMPC is a promising substitute material for bone repair with excellent physicochemical properties and biological activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Construction & Building Technology
Ting Zhang, Baoguo Ma, Hongbo Tan, Huahui Qi, Tao Shi
Summary: This study found that sodium carbonate and sodium phosphate have different effects on the hydration of cement based on the structure of the precipitates formed, where calcium carbonate precipitate accelerated cement hydration while calcium phosphate precipitate retarded it. The composition and structure of the precipitates were responsible for these effects, with calcium carbonate providing interspace for easier ion dissolution and calcium phosphate forming a more compact layer structure that hindered the transport of water molecules and ions.
JOURNAL OF BUILDING ENGINEERING
(2022)
Article
Endocrinology & Metabolism
Young Jung No, Tien Nguyen, Zufu Lu, Mohammad Mirkhalaf, Frank Fei, Matthew Foley, Hala Zreiqat
Summary: The study investigated the effects of incorporating bismuth ions into the crystalline structure of baghdadite, with Bi0.1-BAG showing promising results for treating bone defects due to its homogeneity and increased radiopacity.
Article
Construction & Building Technology
Chinedu A. Ajoku, Anaclet Turatsinze, Ariane Abou-Chakra
Summary: Calcium phosphate cement is a room-temperature hardening inorganic cement with low fracture behavior. By incorporating recycled rubber aggregates and corrosion-resistant fibers into the cement matrix, high-strength composites with improved strain capacities can be produced. The addition of inert inclusions improves the fracture properties of the plain cement.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Green & Sustainable Science & Technology
Yue Ma, Yunlong Luo, Hongyan Ma, Xintao Zhou, Zhongqiu Luo
Summary: This study utilized steel slag powder (SSP) as the raw material to prepare iron-calcium phosphate cement (ICPC) by reacting with ammonium dihydrogen phosphate (ADP). The effects of the raw material mass ratios on the properties and microstructures of ICPC pastes were investigated. The study found that the compressive strengths of ICPC pastes initially increased and then decreased with the increase of SSP/ADP, and the ratio of 6.0 gave the highest strength. Crystalline mundrabillaite and amorphous phases were formed as the main binding phases through reactions between calcium-containing compounds in the steel slag and ADP, and ADP also reacted with free FeO in the steel slag to yield amorphous iron phosphate phase. BSE analysis showed that hydration products formed and grew on the surface of steel slag particles, forming a continuous, dense microstructure of ICPC paste. The utilization of high-volume steel slag as the base component can bring significant economic and environmental benefits in the manufacture of phosphate cement.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Chemistry, Physical
David Yong, Joanne Jung Eun Choi, Peter Cathro, Paul R. Cooper, George Dias, Jeffrey Huang, Jithendra Ratnayake
Summary: The aim of this study was to develop an endodontic cement using bovine bone-derived hydroxyapatite (BHA), Portland cement (PC), and a radiopacifier. The results showed that the addition of 10% and 20% BHA improved the mechanical strength of the cement while maintaining similar radiopacity and biocompatibility to ProRoot MTA. This study is important for enhancing the properties of endodontic cements.
Article
Engineering, Biomedical
Ellen T. Newsom, Ameneh Sadeghpoura, Ali Entezari, Joan Lace U. Vinzonsa, Ralph E. Stanfordc, Mohammad Mirkhalafb, Daniel Chone, Colin R. Dunstanb, Hala Zreiqat
Summary: We have developed a bioceramic material, Sr-HT-Gahnite, which has the potential to be a fusion device material that mimics the biological and mechanical performance of natural bone. In a study conducted on sheep, it has been shown that this material is safe for systemic use over a period of 26 weeks, indicating the systemic safety of the Sr-HT-Gahnite fusion device.
ACTA BIOMATERIALIA
(2023)
Review
Engineering, Biomedical
Mohammad Mirkhalaf, Yinghui Men, Rui Wang, Young No, Hala Zreiqat
Summary: 3D printed bone scaffolds have the potential to replace autografts and allografts due to their ability to customize the scaffolds' properties and the unlimited supply. Progress has been made in 3D printing bone grafts, but challenges remain in replicating the mechanical and biological functions of native bones. This review outlines the recent progress and challenges in engineering synthetic bone scaffolds and provides suggestions for overcoming these challenges.
ACTA BIOMATERIALIA
(2023)
Article
Geriatrics & Gerontology
ZuFu Lu, Liting Jiang, Pooria Lesani, WenJie Zhang, Ning Li, Danyang Luo, Yusi Li, Yulin Ye, Ji Bian, Guocheng Wang, Colin R. Dunstan, XinQuan Jiang, Hala Zreiqat
Summary: This study shows that nicotinamide mononucleotide (NMN) could partially reverse the negative effects of tumor necrosis factor-alpha (TNF-α) on osteoblasts, including inducing senescence, reducing differentiation ability, and affecting mitochondrial function. In addition, NMN can protect cells from aging damage by increasing mitophagy activity.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Editorial Material
Engineering, Biomedical
Khoon S. Lim, Hala Zreiqat, Debby Gawlitta
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Kai Peter Sommer, Adrian Krolinski, Mohammad Mirkhalaf, Hala Zreiqat, Oliver Friedrich, Martin Vielreicher
Summary: The goal of bone tissue engineering is to build artificial bone tissue that closely resembles human bone and supports its integration into the body. This study used two types of 3D-printed scaffolds to seed and differentiate osteoblastic cells, and tested different assays and imaging methods to monitor these processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Lena Scheller, Stephanie Bachmann, Theresa Zorn, Simon Hanio, Uwe Gbureck, Dimitrios Fatouros, Ann-Christin Poppler, Lorenz Meinel
Summary: In this study, the solidification of drug-loaded microemulsion preconcentrates with the acid-sensitive metal-organic framework ZIF-8 was detailed using various analytical techniques. Nile Red, Vitamin K1, and Lumefantrine were used as model compounds to analyze the adsorption and desorption dynamics. The loaded preconcentrates and drugs were successfully preserved in the crystal structure of ZIF-8, which could be pressed into tablets or 3D-printed into oral dosage forms. The stimuli-responsive metal organic frameworks have the potential to form colloidal microemulsions in solid dosage forms for oral delivery of lipid-based formulations.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Review
Materials Science, Multidisciplinary
Iman Roohani, Ellen Newsom, Hala Zreiqat
Summary: Bioceramics are highly sought after for their biocompatibility and bone regenerative properties, making them a multibillion-dollar industry in orthopaedic and dental implants. However, traditional manufacturing methods have limitations in creating complex geometries customized for specific bone defects. Vat-photopolymerization 3D printing has emerged as a precise and high-resolution technique for fabricating complex bioceramic parts with strong, ultralight, energy-absorbing, and tough materials. Despite their potential, regulatory and reimbursement obstacles hinder the clinical translation of 3D-printed bioceramic implants. This review analyzes recent advances in vat-photopolymerization printing of bioceramics, highlighting technical challenges and the potential of nanoscale printing to enhance implant mechanical and biological functions. The review also provides recommendations for regulatory frameworks, envisioning a future with successful clinical translation of advanced 3D architectures.
INTERNATIONAL MATERIALS REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Peter L. H. Newman, Queenie Yip, Pierre Osteil, Tim A. Anderson, Jane Q. J. Sun, Daryan Kempe, Mate Biro, Jae-Won Shin, Patrick P. L. Tam, Hala Zreiqat
Summary: Multicellular patterning in stem-cell-derived tissue models is often achieved through self-organizing activities triggered by external morphogenetic stimuli. However, these tissue models exhibit stochastic behavior, leading to limited reproducibility and non-physiological structures. To improve multicellular patterning, researchers have developed a method for creating complex tissue microenvironments with programmable mechano-chemical cues. These cues, including peptides, proteins, morphogens, and defined stiffness, spatially guide tissue patterning processes, such as mechanosensing and cell differentiation. By designing niches, the authors successfully engineered bone-fat assembly and germ layer tissues. Microstructured cell niches enable the spatial programming of tissue patterning processes, enhancing the organization and composition of engineered tissues.
Article
Materials Science, Biomaterials
Zhengjiang Xu, Yuan Zhang, Danping Lu, Guofang Zhang, Yang Li, Zufu Lu, Fei Wang, Guocheng Wang
Summary: Accumulation of senescent cells in the elderly has a negative impact on bone homeostasis, and it is important to mitigate cell senescence and reduce oxidative stress for improved bone fracture healing in elderly patients. This study developed a nanoformulation of resveratrol (RSV) using a biocompatible zeolitic imidazolate framework-8 (ZIF-8) nanoparticle, which effectively addressed the issues of oxidation and bioavailability. The ZIF-8/RSV nanoformulation showed promising results in alleviating cellular senescence and enhancing cell functions, suggesting its potential for bone fracture treatment in the elderly.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Engineering, Biomedical
Charenpreet Virdi, Zufu Lu, Hala Zreiqat, Young Jung No
Summary: This study demonstrates that high-water content polyvinyl alcohol hydrogels can achieve a tensile strength exceeding 1.0 MPa through a combination of physical crosslinking, mechanical drawing, freeze drying, and hierarchical design.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Engineering, Biomedical
Yassine Ouhaddi, Baptiste Charbonnier, Juliette Porge, Yu-Ling Zhang, Isadora Garcia, Uwe Gbureck, Liam Grover, Mirko Gilardino, Edward Harvey, Nicholas Makhoul, Jake Barralet
Summary: In this study, we investigated the response of blood vessels to surgical injury or placement of an inorganic construct, and found that only calcium phosphate induced a significant angiogenic response. We also identified changes in macrophage and smooth muscle cell populations, as well as the activation of NLRP3 inflammasome and sustained expression of IL-1 beta. These findings suggest a potential role of sterile inflammation in biomaterial-induced angiogenesis, and provide a new strategy for creating better pro-regenerative biomaterials.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Andreas Fuchs, Michael Bartolf-Kopp, Hartmut Boehm, Anton Straub, Alexander C. C. Kuebler, Christian Linz, Uwe Gbureck
Summary: Composite grafts made of self-setting and oil-based calcium phosphate cement (CPC) pastes, reinforced with 3D-printed polycaprolactone (PCL) fiber mats, can be adapted to various bony defects in oral and maxillofacial surgery. The PCL-reinforced CPC samples have good processability and a high precision of fit, with increased clinical handling properties.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Engineering, Biomedical
Tobias Renner, Paul Otto, Alexander C. Kuebler, Stefanie Hoelscher-Doht, Uwe Gbureck
Summary: A bone adhesive for use in surgeries is currently not available. Phosphoserine modified cements (PMC) based on mixtures of OPLS and calcium phosphates, as well as chelate setting magnesium phosphate cements, have gained popularity. New mineral-organic bone cements based on phosphoserine and magnesium phosphates or oxides were investigated for their adhesive properties. The novel adhesives demonstrated excellent bond strength to bone and outperformed currently available adhesives.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2023)