Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 61, Issue 3, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.02107-16
Keywords
Pseudomonas aeruginosa; SOS response; ciprofloxacin; recA
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Brazil (FAPESP) [2014/15982-6]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil CNPq [407259/2013-9]
- postdoctoral fellowship from CNPq [151264/2014-7]
- Plan Nacional de
- Instituto de Salud Carlos III, Subdireccion General de Redes y Centros de Investigacion Cooperativa, Ministerio de Economia y Competitividad, Spanish Network for Research in Infectious Diseases [REIPI RD12/0015]
- European Regional Development Fund (ERDF) [FIS PI13/00063]
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Resistance to antibiotics is a global health problem. Activation of the SOS response, and the subsequent elevation in mutagenesis, contributes to the appearance of resistance mutations. Among currently used drugs, quinolones are the most potent inducers of the SOS response. In the present study, we show that amikacin inhibits ciprofloxacin-mediated SOS induction and mutagenesis in Pseudomonas aeruginosa.
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