Article
Biochemistry & Molecular Biology
Youjia Du, Carla G. Taylor, Harold M. Aukema, Peter Zahradka
Summary: DHA induces apoptosis of confluent endothelial cells through both intrinsic and extrinsic pathways, involving activation of p38 MAPK, JNK, caspase-9, caspase-8, and caspase-3. p38 MAPK plays a crucial role in apoptosis induction, with MAP kinases and caspases having differential roles in endothelial cell apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Biochemistry & Molecular Biology
Lili Sun, Chen Yao, Xiaojiao Li, Yuxing Wang, Ru Wang, Molin Wang, Qiao Liu, Denise J. Montell, Changshun Shao, Yaoqin Gong, Gongping Sun
Summary: This study reveals that cells can survive executioner caspase activation through a process called anastasis, and these surviving cells have enhanced migration and pro-angiogenic capacity. The activation of p38 MAPK plays a crucial role in anastasis and is essential for the elevated migratory and angiogenic capacity in these cells.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Environmental Sciences
Won-Young Lee, Hyun-Jung Park
Summary: T-2 toxin induces reproductive toxicity and germ cell damage. It reduces testicular germ cell number and downregulates their corresponding markers, but increases Sertoli cell markers and steroidogenic enzyme expression. T-2 toxin also decreases cell viability, increases apoptosis, and triggers ROS-mediated JNK/p38-MAPK signaling pathway, leading to mitochondrial dysfunction and apoptotic cell death in germ cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Oncology
Siting Li, Yuexin Hu, Ouxuan Liu, Xiao Li, Bei Lin
Summary: The study found that MCP-4 is highly expressed in ovarian cancer tissues and is associated with patient prognosis. MCP-4 overexpression promotes cell migration and invasion in ovarian cancer, inhibits apoptosis, and activates the p38 MAPK signaling pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Moran Sun, Jinling Qin, Yingying Kang, Yixin Zhang, Mengyu Ba, Hua Yang, Yongtao Duan, Yongfang Yao
Summary: Multi-target drugs design has advantages in cancer treatment. In this study, a new hybrid molecule combining HDAC inhibitors pharmacophore and 2ME2 was synthesized and evaluated for its anticancer activities. Compound 4s exhibited dual inhibition and high selectivity against multiple cancer cell lines, as well as anti-angiogenic and anti-metastasis activities.
BIOORGANIC CHEMISTRY
(2022)
Article
Cell Biology
Qi Yan, Linxin Pan, Shunli Qi, Fang Liu, Zhen Wang, Cheng Qian, Lijian Chen, Jian Du
Summary: The up-regulation of RNF2 in liver fibrosis enhances HSC activation and exerts fibrogenic effects by inhibiting the ERK/p38 signaling pathway induced by TGF-beta 1. The inhibition of RNF2 may be a promising therapeutic target for liver fibrosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Weijue Liu, Sihao Li, Qing Zhou, Zhushan Fu, Pinya Liu, Xiyue Cao, Shuhua Xi
Summary: BDE-47 impairs placental angiogenesis by inhibiting cell migration and invasion, and induces placental toxicity by inhibiting proliferation, increasing apoptosis and autophagy. In vitro, activation of the p38 MAPK signaling pathway is involved in the processes of placental injury caused by BDE-47.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Plant Sciences
Zhu Zhang, Wen-qing Chen, Shi-qing Zhang, Jing-xuan Bai, Bin Liu, Ken Kin-Lam Yung, Joshua Ka-Shun Ko
Summary: The study revealed that isoliquiritigenin (ISL) inhibited the progression of pancreatic cancer by blocking autophagy through the p38 MAPK signaling pathway.
Article
Biochemistry & Molecular Biology
Yuan Hu, Ling Lin, Kehong Liu, Enshuo Liu, Shumin Han, Zhihua Gong, Wenjun Xiao
Summary: With the current trend of global warming, the impairment of heat stress on human health is a serious concern. L-Theanine, a non-protein amino acid found in tea, has various biological activities, including immunoregulatory, anti-anxiety, and anti-oxidation effects. This study investigated the effect of l-theanine on heat stress-induced changes in immune function and its underlying mechanism using male BALB/c mice. The results indicated that l-theanine treatment attenuated heat stress-induced damage, inhibited inflammatory factors, and improved immune function. It is suggested that l-theanine may act through the P38 signaling pathway and regulate HSP27, PPAR-gamma, and Foxp3 proteins.
Article
Pharmacology & Pharmacy
Jiaxuan Tang, Chaofan Liu, Shiying Liu, Xing Zhou, Jinghao Lu, Ming Li, Lubing Zhu
Summary: 2-Methoxyestradiol (2-ME) has shown significant inhibition on proliferation, angiogenesis, and inflammation, making it a promising therapeutic agent for psoriasis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Applied
M. T. Ngo Njembe, E. Dormal, C. Gardin, E. Mignolet, C. Debier, Y. Larondelle
Summary: This study showed that supplementing laying hens' feeds with flaxseeds combined with oil from Ricinodendron heudelotii or Punica granatum seeds can increase the egg content of beneficial fatty acids, without affecting the conversion rate of ALA to DHA. Both oils efficiently converted into RmA, with Punica granatum seed oil having a higher accumulation of PunA in eggs.
Article
Cell Biology
Pinaki Chaudhuri, Priya Putta, Michael A. Rosenbaum, Linda M. Graham
Summary: Endothelial cell migration is crucial for repairing monolayer disruption after angioplasties, but it is inhibited by lipid oxidation products like lysophosphatidylcholine (lysoPC). LysoPC activates phospholipase A2 to release arachidonic acid (ArA), which then activates arachidonic acid-regulated calcium (ARC) channels formed by STIM1, Orai1, and Orai3 proteins.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Multidisciplinary Sciences
El-Shaimaa A. Arafa, Mohamed S. Refaey, Omnia A. M. Abd El-Ghafar, Emad H. M. Hassanein, Ahmed M. Sayed
Summary: Research has shown that certain ginsenosides have therapeutic potential in downregulating p38 MAPK signaling, leading to their pharmacological benefits in various ailments. Studies on individual ginsenosides have focused on their specific molecular mechanisms of action, rather than the effects of whole-plant extracts.
Article
Multidisciplinary Sciences
Wei Zhao, Yongxia Lao, Yang Liu, Jiqin Niu, Zhihui Xiao, Palanisamy Arulselvan, Jian Shen
Summary: This study demonstrated that escin possesses potent antioxidant capacity and inhibits the viability of OC A2780 cells by increasing lipid peroxidation, promoting ROS accumulation and apoptotic cell death, while suppressing the p38 MAPK/ERK signaling pathway.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Environmental Sciences
Jing Tang, Chenjuan Yao, Yingqi Liu, Jiaming Yuan, Li Wu, Kazuo Hosoi, Shali Yu, Chunyan Huang, Haiyan Wei, Gang Chen
Summary: In this study, it was elucidated that BCL-2, as a pro-apoptotic factor, plays a role in As2O3-induced apoptosis in BEAS-2B cells through NF-kappa B and p38 MAPK signaling pathways. The upregulation, nuclear localization, and phosphorylation of BCL-2 during apoptosis were found to be crucial factors in As2O3-induced cell death.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Aayatti Mallick Gupta, Purab Pal, Sukhendu Mandal
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2016)
Review
Veterinary Sciences
Purab Pal, Kara Nicole Starkweather, Karen Held Hales, Dale Buchanan Hales
Summary: Ovarian cancer, often referred to as the silent killer, is the most lethal gynecologic malignancy with no known early detection biomarkers. The laying hen model has emerged as a valuable tool in studying ovarian cancer, providing insights into the pathology and potential prevention strategies for this disease. Studies in this model have shown associations between decreased ovulation, inflammation, and decreased incidence of ovarian cancer development.
COMPARATIVE MEDICINE
(2021)
Meeting Abstract
Oncology
Purab Pal, Alec Millner, Ekin Atilla-Gokcumen, Jonna Frasor
Article
Oncology
Purab Pal, Alec Millner, Svetlana E. Semina, Rosemary J. Huggins, Logan Running, Diana S. Aga, Debra A. Tonetti, Rachel Schiff, Geoffrey L. Greene, G. Ekin Atilla-Gokcumen, Jonna Frasor
Summary: Endocrine therapy resistance is a critical problem in estrogen receptor-positive breast cancer. This study investigated how alterations in sphingolipids promote cell survival in ET-resistant breast cancer. Through targeted sphingolipidomics analysis, the researchers found that tamoxifen-resistant cells have lower levels of ceramides compared to their sensitive counterparts. They also identified that CERK inhibition induces ceramide-mediated cell death in tamoxifen-resistant cells. These findings suggest that ET-resistant breast cancer cells rely on CERK activity to maintain lower ceramide levels, making CERK a potential therapeutic target.
Review
Biochemistry & Molecular Biology
Purab Pal, G. Ekin Atilla-Gokcumen, Jonna Frasor
Summary: The imbalance between cell proliferation and cell death is a classic hallmark of cancer, and ceramide, a bioactive sphingolipid, is implicated in cancer. In addition to its effects on cell death and therapeutic efficacy, ceramide turnover to downstream sphingolipids plays an equally important role in driving pro-tumorigenic phenotypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Svetlana E. Semina, Purab Pal, Nidhi S. Kansara, Rosemary J. Huggins, Elaine T. Alarid, Geoffrey L. Greene, Jonna Frasor
Summary: The NF kappa B+ cell population expands during endocrine therapy (ET), and this population has clinical relevance. A gene signature based on the preexisting NF kappa B+ cell population is predictive of tumor relapse. The integrated stress response (ISR) occurs during ET and contributes to clonogenic growth under the selective pressure of ET.
BREAST CANCER RESEARCH
(2022)
Meeting Abstract
Oncology
Purab Pal, Karen Hales, Dale Buchanan Hales
CLINICAL CANCER RESEARCH
(2020)