Preeclampsia link to gestational hypoxia

A novel rodent model of pregnancy complications associated with genetically determined angiotensin-converting enzyme (ACE) activity

(2018) Eugenia Mata-Greenwood et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Chronic Prenatal Hypoxia Down-Regulated BK Channel Β1 Subunits in Mesenteric Artery Smooth Muscle Cells of the Offspring

(2018) Bailin Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The large-conductance voltage- and Ca2+ -activated K+ channel and its γ1-subunit modulate mouse uterine artery function during pregnancy

(2018) Ramón A. Lorca et al.   JOURNAL OF PHYSIOLOGY-LONDON

Placental adaptation to early-onset hypoxic pregnancy and mitochondria-targeted antioxidant therapy in rat

(2018) Anna Maria Nuzzo et al.   AMERICAN JOURNAL OF PATHOLOGY

Alzheimer's Disease and the Quest for Causation

(2017)   FASEB JOURNAL

Prediction of Preeclampsia Using the Soluble fms-Like Tyrosine Kinase 1 to Placental Growth Factor RatioNovelty and Significance

(2017) Ulla Sovio et al.   HYPERTENSION

Placental growth factor and pre-eclampsia

(2017) K Chau et al.   JOURNAL OF HUMAN HYPERTENSION

Review: Placental derived biomarkers of pregnancy disorders

(2017) James S.M. Cuffe et al.   PLACENTA

Mitochondrial – Endoplasmic reticulum interactions in the trophoblast: Stress and senescence

(2017) G.J. Burton et al.   PLACENTA

MiR133b is involved in endogenous hydrogen sulfide suppression of sFlt-1 production in human placenta

(2017) Tian-Xiao Hu et al.   PLACENTA

Mitochondrial composition and function under the control of hypoxia

(2017) Dominik C. Fuhrmann et al.   Redox Biology

Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development

(2017) Tom J. Phillips et al.   Scientific Reports

Maternal vascular responses to hypoxia in a rat model of intrauterine growth restriction

(2016) Mais M. Aljunaidy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Restoring placental growth factor-soluble fms-like tyrosine kinase-1 balance reverses vascular hyper-reactivity and hypertension in pregnancy

(2016) Minglin Zhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Hydrogen sulfide in hypertension

(2016) Harry van Goor et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Placental Growth Factor Administration Abolishes Placental Ischemia-Induced HypertensionNovelty and Significance

(2016) Frank T. Spradley et al.   HYPERTENSION

Sildenafil therapy for fetal cardiovascular dysfunction during hypoxic development: studies in the chick embryo

(2016) Nozomi Itani et al.   JOURNAL OF PHYSIOLOGY-LONDON

The fetal brain sparing response to hypoxia: physiological mechanisms

(2016) Dino A. Giussani   JOURNAL OF PHYSIOLOGY-LONDON

Global, regional, and national levels and trends in maternal mortality between 1990 and 2015, with scenario-based projections to 2030: a systematic analysis by the UN Maternal Mortality Estimation Inter-Agency Group

(2016) Leontine Alkema et al.   LANCET

Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia

(2016) Harald Zeisler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Placental histological examination and the relationship with oxidative stress in preterm infants

(2016) Serafina Perrone et al.   PLACENTA

Placental Underperfusion in a Rat Model of Intrauterine Growth Restriction Induced by a Reduced Plasma Volume Expansion

(2016) Karine Bibeau et al.   PLoS One

Association Between Unintentional Injury During Pregnancy and Excess Risk of Preterm Birth and Its Neonatal Sequelae

(2015) Shiliang Liu et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

The Dahl salt-sensitive rat is a spontaneous model of superimposed preeclampsia

(2015) Ellen E. Gillis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Bioactive factors in uteroplacental and systemic circulation link placental ischemia to generalized vascular dysfunction in hypertensive pregnancy and preeclampsia

(2015) Dania A. Shah et al.   BIOCHEMICAL PHARMACOLOGY

Nitric Oxide and Reactive Oxygen Species in the Pathogenesis of Preeclampsia

(2015) Keiichi Matsubara et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Angiogenesis-Related Biomarkers (sFlt-1/PLGF) in the Prediction and Diagnosis of Placental Dysfunction: An Approach for Clinical Integration

(2015) Ignacio Herraiz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Morphological and molecular changes in the murine placenta exposed to normobaric hypoxia throughout pregnancy

(2015) Hannah Matheson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Placental phenotype and resource allocation to fetal growth are modified by the timing and degree of hypoxia during mouse pregnancy

(2015) J. S. Higgins et al.   JOURNAL OF PHYSIOLOGY-LONDON

Melatonin rescues cardiovascular dysfunction during hypoxic development in the chick embryo

(2015) Nozomi Itani et al.   JOURNAL OF PINEAL RESEARCH

Inflammation in maternal obesity and gestational diabetes mellitus

(2015) P. Pantham et al.   PLACENTA

Animal models of fetal growth restriction: Considerations for translational medicine

(2015) A.M. Swanson et al.   PLACENTA

Reduced uterine perfusion pressure induces hypertension in the pregnant mouse

(2014) Suttira Intapad et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Placenta-Derived Exosomes and Syncytiotrophoblast Microparticles and their Role in Human Reproduction: Immune Modulation for Pregnancy Success

(2014) Lucia Mincheva-Nilsson et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

High-Altitude Hypoxia and Echocardiographic Indices of Pulmonary Hypertension in Male and Female Chickens at Adulthood

(2014) Carlos E. Salinas et al.   CIRCULATION JOURNAL

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

Gestational Hypoxia Increases Reactive Oxygen Species and Inhibits Steroid Hormone–Mediated Upregulation of Ca 2+ -Activated K + Channel Function in Uterine Arteries

(2014) Ronghui Zhu et al.   HYPERTENSION

Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy

(2014) Suchismita Sarker et al.   Journal of Translational Medicine

Hypoxia-Mediated Soluble Fms-Like Tyrosine Kinase 1 Increase Is Not Attenuated in Interleukin 6-Deficient Mice

(2014) Sarah Appel et al.   Reproductive Sciences

A Comparison of the Histological Structure of the Placenta in Experimental Animals

(2014) Satoshi Furukawa et al.   Journal of Toxicologic Pathology

Global causes of maternal death: a WHO systematic analysis

(2014) Lale Say et al.   Lancet Global Health

Reduced Cystathionine γ-Lyase and Increased miR-21 Expression Are Associated with Increased Vascular Resistance in Growth-Restricted Pregnancies

(2013) Tereza Cindrova-Davies et al.   AMERICAN JOURNAL OF PATHOLOGY

Reactive Oxygen Species in Inflammation and Tissue Injury

(2013) Manish Mittal et al.   ANTIOXIDANTS & REDOX SIGNALING

Hypoxic Patterns of Placental Injury: A Review

(2013) Jerzy Stanek   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Linking Intrauterine Growth Restriction and Blood Pressure

(2013) Bettye Sue Hennington et al.   CIRCULATION

Dysregulation of Hydrogen Sulfide Producing Enzyme Cystathionine γ-lyase Contributes to Maternal Hypertension and Placental Abnormalities in Preeclampsia

(2013) Keqing Wang et al.   CIRCULATION

Gestational Hypoxia Induces Preeclampsia-Like Symptoms via Heightened Endothelin-1 Signaling in Pregnant Rats

(2013) Jianjun Zhou et al.   HYPERTENSION

Hydrogen Sulfide Attenuates sFlt1-Induced Hypertension and Renal Damage by Upregulating Vascular Endothelial Growth Factor

(2013) K. M. Holwerda et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Graduated effects of high-altitude hypoxia and highland ancestry on birth size

(2013) Rudy Soria et al.   PEDIATRIC RESEARCH

Chronic Hypoxia during Gestation Enhances Uterine Arterial Myogenic Tone via Heightened Oxidative Stress

(2013) Daliao Xiao et al.   PLoS One

Exosomal Signaling during Hypoxia Mediates Microvascular Endothelial Cell Migration and Vasculogenesis

(2013) Carlos Salomon et al.   PLoS One

Hypoxia-Induced Changes in the Bioactivity of Cytotrophoblast-Derived Exosomes

(2013) Carlos Salomon et al.   PLoS One

Low Birth Weight, Small for Gestational Age and Preterm Births before and after the Economic Collapse in Iceland: A Population Based Cohort Study

(2013) Védís Helga Eiríksdóttir et al.   PLoS One

Attenuation of VEGFR-2 Expression by sFlt-1 and Low Oxygen in Human Placenta

(2013) Ori Nevo et al.   PLoS One

Developmental programming of cardiovascular disease by prenatal hypoxia

(2013) D. A. Giussani et al.   Journal of Developmental Origins of Health and Disease

eNOS knockout mouse as a model of fetal growth restriction with an impaired uterine artery function and placental transport phenotype

(2012) Laura C. Kusinski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Hypoxia in early pregnancy induces cardiac dysfunction in adult offspring of Rattus norvegicus, a non-hypoxia-adapted species

(2012) David Hauton   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Evidence of endoplasmic reticulum stress and protein synthesis inhibition in the placenta of non-native women at high altitude

(2012) Hong Wa Yung et al.   FASEB JOURNAL

The Hypoxic Placenta

(2012) Martha C. Tissot van Patot et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Chronic Hypoxia Suppresses Pregnancy-Induced Upregulation of Large-Conductance Ca 2+ -Activated K + Channel Activity in Uterine Arteries

(2012) Xiang-Qun Hu et al.   HYPERTENSION

Endothelial NO Synthase Augments Fetoplacental Blood Flow, Placental Vascularization, and Fetal Growth in Mice

(2012) Shathiyah Kulandavelu et al.   HYPERTENSION

Placental Secretion of Interleukin-1 and Interleukin-1 Receptor Antagonist in Preeclampsia: Effect of Magnesium Sulfate

(2012) Alaa Amash et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Ascorbate prevents placental oxidative stress and enhances birth weight in hypoxic pregnancy in rats

(2012) H. G. Richter et al.   JOURNAL OF PHYSIOLOGY-LONDON

A role for xanthine oxidase in the control of fetal cardiovascular function in late gestation sheep

(2012) E. A. Herrera et al.   JOURNAL OF PHYSIOLOGY-LONDON

Developmental Programming of Cardiovascular Dysfunction by Prenatal Hypoxia and Oxidative Stress

(2012) Dino A. Giussani et al.   PLoS One

Endothelin-1: a key pathological factor in pre-eclampsia?

(2012) Arjun Jain   REPRODUCTIVE BIOMEDICINE ONLINE

High altitude hypoxia and blood pressure dysregulation in adult chickens

(2012) E. A. Herrera et al.   Journal of Developmental Origins of Health and Disease

The placenta in preeclampsia

(2012) James M. Roberts et al.   Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

The interaction between endothelin-1 and nitric oxide in the vasculature: new perspectives

(2011) Stephane L. Bourque et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy

(2011) Subash C. Gupta et al.   ANTIOXIDANTS & REDOX SIGNALING

MicroRNA-21 represses human cystathionine gamma-lyase expression by targeting at specificity protein-1 in smooth muscle cells

(2011) Guangdong Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role of Reactive Oxygen Species During Hypertension in Response to Chronic Antiangiogenic Factor (sFlt-1) Excess in Pregnant Rats

(2010) K. B. T. Tam et al.   AMERICAN JOURNAL OF HYPERTENSION

Trophoblast-Derived Exosomes Mediate Monocyte Recruitment and Differentiation

(2010) Safinur Atay et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Endothelin—Biology and disease

(2010) Al-karim Khimji et al.   CELLULAR SIGNALLING

Hydrogen sulfide as a gasotransmitter

(2010) Moataz M. Gadalla et al.   JOURNAL OF NEUROCHEMISTRY

The role of autocrine TGFβ1 in endothelial cell activation induced by phagocytosis of necrotic trophoblasts: a possible role in the pathogenesis of pre-eclampsia

(2010) Qi Chen et al.   JOURNAL OF PATHOLOGY

Melatonin and vitamin C increase umbilical blood flow via nitric oxide-dependent mechanisms

(2010) Avnesh S. Thakor et al.   JOURNAL OF PINEAL RESEARCH

Fractional Excretion of Tumor Necrosis Factor-α in Women With Severe Preeclampsia

(2010) Michael Cackovic et al.   OBSTETRICS AND GYNECOLOGY

Spreading endothelial cell dysfunction in response to necrotic trophoblasts. Soluble factors released from endothelial cells that have phagocytosed necrotic shed trophoblasts reduce the proliferation of additional endothelial cells

(2010) Q. Chen et al.   PLACENTA

Chronic hypoxia increases pressure-dependent myogenic tone of the uterine artery in pregnant sheep: role of ERK/PKC pathway

(2009) Katherine Chang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Augmented uterine artery blood flow and oxygen delivery protect Andeans from altitude-associated reductions in fetal growth

(2009) Colleen Glyde Julian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Magnetic resonance imaging of hypoxic injury to the murine placenta

(2009) Tracy M. Tomlinson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Human placental metabolic adaptation to chronic hypoxia, high altitude: hypoxic preconditioning

(2009) Martha C. Tissot van Patot et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Hydrogen Sulfide: The Third Gasotransmitter in Biology and Medicine

(2009) Rui Wang   ANTIOXIDANTS & REDOX SIGNALING

Effect of hypoxia and exogenous IL-10 on the pro-inflammatory cytokine TNF-α and the anti-angiogenic molecule soluble Flt-1 in placental villous explants

(2009) Caroline Royle et al.   CYTOKINE

Effect of Recombinant Placental Growth Factor 2 on Hypertension Induced by Full-Length Mouse Soluble fms-Like Tyrosine Kinase 1 Adenoviral Vector in Pregnant Mice

(2009) Hirotada Suzuki et al.   HYPERTENSION

Lack of Oxygen Deactivates Mitochondrial Complex I

(2009) Alexander Galkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxic Repression of Endothelial Nitric-oxide Synthase Transcription Is Coupled with Eviction of Promoter Histones

(2009) Jason E. Fish et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia Induces Dilated Cardiomyopathy in the Chick Embryo: Mechanism, Intervention, and Long-Term Consequences

(2009) Andrei Tintu et al.   PLoS One

The Neurodevelopmental Hypothesis of Schizophrenia, Revisited

(2009) S. H. Fatemi et al.   SCHIZOPHRENIA BULLETIN

Syncytial Knots, Sprouts, Apoptosis, and Trophoblast Deportation from the Human Placenta

(2009) Graham J. Burton et al.   Taiwanese Journal of Obstetrics & Gynecology

Cardiac and vascular disease prior to hatching in chick embryos incubated at high altitude

(2009) C. E. Salinas et al.   Journal of Developmental Origins of Health and Disease

Early fetal hypoxia leads to growth restriction and myocardial thinning

(2008) Margie Ream et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Lower uterine artery blood flow and higher endothelin relative to nitric oxide metabolite levels are associated with reductions in birth weight at high altitude

(2008) Colleen Glyde Julian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Maternal hypoxia activates endovascular trophoblast cell invasion

(2008) Gracy X. Rosario et al.   DEVELOPMENTAL BIOLOGY

Hypertension in Response to Chronic Reductions in Uterine Perfusion in Pregnant Rats

(2008) Babbette LaMarca et al.   HYPERTENSION

The hypoxia of high altitude causes restricted fetal growth in chick embryos with the extent of this effect depending on maternal altitudinal status

(2008) Arpan R. Mehta et al.   JOURNAL OF PHYSIOLOGY-LONDON

Effect of In Utero and Early-Life Conditions on Adult Health and Disease

(2008) Peter D. Gluckman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Circulating Microparticles in Normal Pregnancy and Pre-Eclampsia

(2008) C.W.G. Redman et al.   PLACENTA

H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine  -Lyase

(2008) G. Yang et al.   SCIENCE

Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunction

(2007) Jeffrey S. Gilbert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY