Article
Endocrinology & Metabolism
Jing Yang, Linlin Wang, Jingwen Ma, Lianghui Diao, Jiao Chen, Yanxiang Cheng, Longfei Li
Summary: This study identified four potential biomarkers (TPPP3, S100A13, HSD17B2, and AZGP1) associated with non-receptive endometrium using iTRAQ-based proteomics analysis. It was found that TPPP3 and HSD17B2 were downregulated in the endometrium of patients with poor endometrial receptivity. These findings provide new evidence for the diagnosis and treatment of non-receptive endometrium and recurrent implantation failure (RIF).
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Xizhao Chen, Mansheng Li, Songbiao Zhu, Yang Lu, Shuwei Duan, Xu Wang, Yong Wang, Pu Chen, Jie Wu, Di Wu, Zhe Feng, Guangyan Cai, Yunping Zhu, Haiteng Deng, Xiangmei Chen
Summary: We constructed a quantitative proteome atlas for IgA nephropathy (IgAN) and identified three subtypes based on proteomic profiles. We found differences in protein expression, subcellular injury, and extracellular accumulation among the subtypes. The complement mitochondrial extracellular (CME) pathway showed high diagnostic potential in distinguishing IgAN subtypes. Moreover, proteins related to glial cells, endothelial cells, and tubular interstitial fibrosis were highly expressed in certain subtypes and associated with worse prognosis.
Article
Biochemical Research Methods
Tianze Huang, Yuchen Wang, Zhonghai Wang, Qin Long, Ying Li, Di Chen
Summary: Proteomic analysis of corneal samples from myopic patients undergoing lenticule extraction surgery reveals that proteins associated with the complement system, extracellular matrix remodeling, and mitochondrial energy metabolism are involved in myopiagenesis. The findings provide new insights into the pathogenesis of myopia.
JOURNAL OF PROTEOMICS
(2023)
Article
Endocrinology & Metabolism
Shuanggang Hu, Zhe Sun, Boyu Li, Hanting Zhao, Yuan Wang, Guangxin Yao, Xinyu Li, Xuejiao Bian, Tin Chiu Li, Hugo Vankelecom, Yun Sun
Summary: Identification of key molecules involved in endometrial receptivity is crucial for understanding human implantation and improving pregnancy rates in assisted reproduction treatment. This study used proteomics to profile the proteomes of different phases of endometrial tissues and identified differentially expressed proteins. The findings contribute to the understanding of the mechanisms governing endometrial receptivity.
Article
Biochemical Research Methods
Jun Li, Xiaohua Jiang, Caihua Li, Huihui Che, Lin Ling, Zhaolian Wei
Summary: Impaired endometrial receptivity in patients with PCOS is caused by multiple proteins, pathways, systems, and abnormalities that interact with each other, making research on endometrial receptivity more challenging.
CLINICAL PROTEOMICS
(2022)
Article
Obstetrics & Gynecology
Tianli Yang, Jing Zhao, Feng Liu, Yanping Li
Summary: This review summarizes the impact of lipid metabolism on reproductive health, particularly on endometrial receptivity and embryonic implantation. It discusses the role of various lipids and lipid-derived mediators in the processes and highlights emerging methods for evaluating endometrial receptivity.
HUMAN REPRODUCTION UPDATE
(2022)
Article
Plant Sciences
Yi Zhang, Haoting Chen, Shuo Li, Yang Li, Mukesh Kumar Kanwar, Bin Li, Longqiang Bai, Jin Xu, Yu Shi
Summary: The study showed that exogenous BR can enhance chlorophyll metabolism and adjust osmotic stress responses in hydroponically grown tomatoes under Ca(NO3)(2) stress, thereby alleviating the impact of stress on plants.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Reproductive Biology
Xi Guo, Tin Chiu Li, Xiaoyan Chen
Summary: Embryo implantation is a complex process that requires competent embryos and receptive endometrium. Despite the recognized cause of infertility being the failure of the endometrium to achieve receptivity, the molecular mechanisms governing endometrial receptivity are still not fully understood.
BIOLOGY OF REPRODUCTION
(2021)
Article
Biochemical Research Methods
Mazen Abdulghani, Rasiqua Iram, Priti Chidrawar, Kajal Bhosle, Rubina Kazi, Rajendra Patil, Kiran Kharat, Gajanan Zore
Summary: In this study, proteomic analysis was used to understand the formation of Candida albicans biofilms. The results show that metabolism, gene expression, stress response, and cell wall composition are modulated during biofilm formation. It was also observed that oxidative phosphorylation and cell wall architecture play a role in the recalcitrance of biofilm cells. Further investigation is needed to explore these findings.
JOURNAL OF PROTEOMICS
(2022)
Article
Obstetrics & Gynecology
Laurentiu Craciunas, Oonagh Pickering, Justin Chu, Meenakshi Choudhary, Justina Zurauskiene, Arri Coomarasamy
Summary: This study characterized the endometrial transcriptomic profiles of women with recurrent miscarriage and aimed to develop an endometrial receptivity test for predicting subsequent pregnancy outcomes. Women with four or more miscarriages showed differential gene expression related to immunity, energy production, hormone secretion, adhesion, and cell proliferation. Women who achieved a subsequent live birth had enrichment of genes related to regulation of cell structure and proliferation, while those who suffered another miscarriage had enrichment of genes related to immunity, transmembrane transport, and coagulation.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Review
Immunology
Raffaella Parente, Valentina Possetti, Marco Erreni, Francesca D'Autilia, Barbara Bottazzi, Cecilia Garlanda, Alberto Mantovani, Antonio Inforzato, Andrea Doni
Summary: The ubiquitous mold Aspergillus fumigatus is the major cause of invasive aspergillosis, requiring coordinated action of cellular and humoral components of the innate immune system for effective disposal. The complement system and pentraxins form an integrated system with interactions, synergy, and regulation, playing a pivotal role in mounting antifungal immunity. Proteins like PTX3 and SAP target A. fumigatus through complement-dependent pathways, utilising different mechanisms of complement activation and receptor-mediated phagocytosis, adding complexity to the immune response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
Jigal Haas, Robert F. Casper
Summary: This brief review examines the investigation of the endometrial cavity before embryo transfer using various techniques, including hysteroscopy, endometrial biopsy, and ultrasound imaging. These investigative tools are currently controversial and require large prospective controlled trials for validation. Retained embryos during embryo transfer do not appear to have a negative impact on pregnancy outcome, and physical activity immediately after embryo transfer has no impact on pregnancy outcome, according to consistent data.
FERTILITY AND STERILITY
(2022)
Article
Plant Sciences
Ming He, Li Li, Xuecong Wei, Dandan Geng, Huabo Jiang, Gu Xiangxiang, Yu Zhang, Huilan Du
Summary: The study aimed to investigate the effect of XYP on pregnancy rates and endometrial angiogenesis, and to determine the potent mechanism associated with pro-angiogenic behavior, which improves endometrial receptivity. The results demonstrated that XYP can improve endometrial receptivity, leading to high pregnancy rates, by promoting angiogenesis through the p38 and JNK MAPK signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Immunology
Erin E. West, Nicolas S. Merle, Marcin M. Kaminski, Gustavo Palacios, Dhaneshwar Kumar, Luopin Wang, Jack A. Bibby, Kirsten Overdahl, Alan K. Jarmusch, Simon Freeley, Duck-Yeon Lee, J. Will Thompson, Zu-Xi Yu, Naomi Taylor, Marc Sitbon, Douglas R. Green, Andrea Bohrer, Katrin D. Mayer-Barber, Behdad Afzali, Majid Kazemian, Sabine Scholl-Buergi, Daniela Karall, Martina Huemer, Claudia Kemper
Summary: Induction of Arg1 expression in lung CD4+ T cells during mouse in vivo influenza infection accelerates the resolution of virus-specific Th1 effector responses, leading to efficient viral clearance and reduced lung pathology.
Article
Multidisciplinary Sciences
Shaza B. Zaghlool, Anna Halama, Nisha Stephan, Valborg Gudmundsdottir, Vilmundur Gudnason, Lori L. Jennings, Manonanthini Thangam, Emma Ahlqvist, Rayaz A. Malik, Omar M. E. Albagha, Karsten Suhre, Abdul Badi Abou-Samra
Summary: This study translates T2D subtypes previously identified in European individuals to an Arab population and identifies specific metabolic and proteomic signatures for each subtype, providing further understanding of the pathogenesis of these subtypes.
NATURE COMMUNICATIONS
(2022)