Article
Biotechnology & Applied Microbiology
Tiangang Ma, Yanbing Hu, Yinxue Guo, Qinghua Zhang
Summary: The study demonstrates that miR-203 carried by extracellular vesicles from endothelial cells can inhibit the malignant phenotypes of NSCLC cells and delay tumor growth by targeting DTL and promoting p21 protein stability.
CANCER GENE THERAPY
(2022)
Article
Medicine, Research & Experimental
Hui Ye, Sachin Mulmi Shrestha, Jie Zhu, Yan Ding, Ruihua Shi
Summary: The study revealed that LINC00491 was upregulated in ESCC tissues and its knockdown resulted in decreased cell proliferation and migration, and increased apoptosis rate. Therefore, LINC00491 may be a potential therapeutic target for ESCC.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Zihao Chen, Yong Li, Bibo Tan, Fang Li, Qun Zhao, Liqiao Fan, Zhidong Zhang, Xuefeng Zhao, Yu Liu, Dong Wang
Summary: This study revealed that Lnc_ASNR is highly expressed in gastric cancer and promotes cell proliferation, migration, and invasion by regulating the miR-519e-5p/FGFR2 pathway. Lnc_ASNR functions as a ceRNA targeting miR-519e-5p, and its effects are closely related to epithelial-mesenchymal transition (EMT) in gastric cancer development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Tiantian Du, Qinglun Gao, Yinghui Zhao, Jie Gao, Juan Li, Lili Wang, Peilong Li, Yunshan Wang, Lutao Du, Chuanxin Wang
Summary: The study revealed that the novel lncRNA LINC02474, as an oncogene, can promote metastasis and inhibit apoptosis in CRC by partially inhibiting GZMB expression. LINC02474 has the potential to be used as a biomarker for prognosis in CRC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
JinShan Tang, ZiQiang Zhu, Suwei Dong, YunQing Wang, JianQang Wang, HongLiang Chen, Gang Duan
Summary: This study found that LINC00641 can increase the drug resistance of DDP-resistant OS cells by mediating the miR-320d/MCL1 axis.
Article
Oncology
Ji Huang, Qiu-Ming He, Qi Wu, Wei-Min Zhou, Chao Hao, Gong-Xian Wang, Xin-Hua Tu
Summary: The long non-coding RNA 00858 (LINC00858) is found to be upregulated in bladder cancer tissues and cell lines, and its knockdown inhibits proliferation, migration, and invasion of bladder cancer cells by regulating the miR-3064-5p/CTGF axis.
Article
Oncology
Yanli He, Haiyan Nan, Linfeng Yan, Tao Ma, Minghao Man, Bo Tian, Shaochun Guo, Xingye Zhang
Summary: The study found that MIR22HG suppresses the development of glioma by inhibiting the miR-9/CPEB3 axis, providing a novel therapeutic strategy for glioma treatment.
Review
Biochemistry & Molecular Biology
Ali Gholami, Khosro Farhadi, Fatemeh Sayyadipour, Masoud Soleimani, Fakhredin Saba
Summary: This review summarizes the role of lncRNAs in lymphomas and their potential clinical value. It has been found that lncRNAs play a critical role in lymphoma carcinogenesis by affecting apoptosis, cell proliferation, invasion, and response to chemotherapy.
Article
Biotechnology & Applied Microbiology
Dezhang Zhu, Caifeng Shi, Yanan Jiang, Kongjuan Zhu, Xiangzhen Wang, Wei Feng
Summary: Cisatracurium inhibits ovarian cancer cell progression by upregulating lincRNA-p21 expression, which leads to inhibition of cell growth and invasion and induction of apoptosis. Moreover, lincRNA-p21 acts as a regulator by targeting miR-181b, further modulating the biological functions of cancer cells.
Article
Biotechnology & Applied Microbiology
Chaoyu Jiang, Xianbiao Shi, Dandan Yi, Ru Wang, Fazhan Xu, Wenxian Guan, Jianfeng Sang
Summary: The study revealed that lncRNA ANCR is downregulated in breast cancer, and exerts anti-tumor effects by targeting miR-331 to inhibit cell proliferation, invasion, and migration.
Article
Cell Biology
Yuqing Duan, Yunlong Jia, Jiali Wang, Tianxu Liu, Zishuo Cheng, Meixiang Sang, Wei Lv, Jing Qin, Lihua Liu
Summary: The study reveals that upregulated lncRNA DGCR5 promotes proliferation, migration, and invasion of ESCC cells while inhibiting apoptosis. DGCR5 directly binds to SRSF1, increasing its stability and initiating important isoform switch of Mcl-1. Cell-derived xenograft model confirms DGCR5's role in facilitating ESCC tumorigenesis.
CELL DEATH & DISEASE
(2021)
Article
Medicine, General & Internal
Feng Gao, Feng Xu
Summary: This study analyzed the role of LncRNA GAL1 in osteosarcoma cancer proliferation, migration and invasion of cancer cells. The results showed that GASL1 exhibits lower expression in osteosarcoma tissues and cell lines than normal surroundings tissues and osteoblasts respectively. GASL1 overexpression resulted in a decline of cancer cell viability and decreased migration and invasion of cancer cells.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Medicine, Research & Experimental
Zhibo Tan, Peitao Zhou, Zhenru Zhu, Ying Wang, Zeqin Guo, Mengying Shen, Yazhi Xiao, Weixi Shen, Dehua Wu
Summary: The study reveals that in esophageal squamous cell carcinoma (ESCC), long non-coding RNA LincIN is significantly overexpressed and exerts an oncogenic role through the regulation of the NF90/miR-7/HOXB13 axis. This suggests that LincIN may serve as a potential prognostic biomarker and therapeutic target for ESCC.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Plant Sciences
Marianne C. Kramer, Hee Jong Kim, Kyle R. Palos, Benjamin A. Garcia, Eric Lyons, Mark A. Beilstein, Andrew D. L. Nelson, Brian D. Gregory
Summary: This article investigates a previously unstudied group of lncRNAs, lncCOBRA, and demonstrates that one member, lncCOBRA1, shows tissue and developmental specific expression in Arabidopsis thaliana. It is shown that plants lacking lncCOBRA1 exhibit delayed germination and stunted growth, indicating the important role of lncCOBRA1 in plant development.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Medicine, Research & Experimental
Rui Zhang, Chunhong Niu, Yuhan Guan, Jianhua Wu, Liping Hu
Summary: The study suggests that LINC00963 may regulate the proliferation and migration of glucose-induced HRECs through interaction with miR-27b, and it could potentially serve as a therapeutic target for diabetic retinopathy.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)