Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells

Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource

(2018) Piero Marchetti et al.   DIABETOLOGIA

Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes

(2018) Mijke Buitinga et al.   DIABETES

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

(2017) Miriam Cnop et al.   Molecular Metabolism

Peptide Binding Glucose Regulated Protein 78 Improves Type 1 Diabetes by Preventing Pancreatic β Cell Apoptosis

(2016) A. Raiter et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Inherent ER stress in pancreatic islet β cells causes self-recognition by autoreactive T cells in type 1 diabetes

(2016) Meghan L. Marré et al.   JOURNAL OF AUTOIMMUNITY

Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms

(2015) Flora Brozzi et al.   DIABETOLOGIA

Characterization and Mechanism of Stress-induced Translocation of 78-Kilodalton Glucose-regulated Protein (GRP78) to the Cell Surface

(2015) Yuan-Li Tsai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Translocation of ER Chaperones to the Cell Surface and Immunomodulatory Roles in Cancer and Autoimmunity

(2015) Valerie R. Wiersma et al.   Frontiers in Oncology

Absence of BiP Co-chaperone DNAJC3 Causes Diabetes Mellitus and Multisystemic Neurodegeneration

(2014) Matthis Synofzik et al.   AMERICAN JOURNAL OF HUMAN GENETICS

GRP78 Secreted by Colon Cancer Cells Facilitates Cell Proliferation via PI3K/Akt Signaling

(2014) Rong Fu et al.   Asian Pacific Journal of Cancer Prevention

Citrullinated Glucose-Regulated Protein 78 Is an Autoantigen in Type 1 Diabetes

(2014) Dieter Rondas et al.   DIABETES

Foodborne Cereulide Causes Beta-Cell Dysfunction and Apoptosis

(2014) Roman Vangoitsenhoven et al.   PLoS One

ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death

(2013) Abhishek D. Garg et al.   Autophagy

Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis

(2013) R. Liu et al.   CLINICAL CANCER RESEARCH

A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice

(2012) Gustaaf G. de Ridder et al.   MELANOMA RESEARCH

Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting

(2011) Min Ni et al.   BIOCHEMICAL JOURNAL

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

(2011) Philippe Ravassard et al.   JOURNAL OF CLINICAL INVESTIGATION

Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells

(2010) Uma K. Misra et al.   CANCER BIOLOGY & THERAPY

Cell Surface Relocalization of the Endoplasmic Reticulum Chaperone and Unfolded Protein Response Regulator GRP78/BiP

(2010) Yi Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligation of Prostate Cancer Cell Surface GRP78 Activates a Proproliferative and Antiapoptotic Feedback Loop

(2010) Uma K. Misra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER Stress in Pancreatic   Cells: The Thin Red Line Between Adaptation and Failure

(2010) D. L. Eizirik et al.   Science Signaling

Role of the Unfolded Protein Response Regulator GRP78/BiP in Development, Cancer, and Neurological Disorders

(2009) Miao Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

GRP78: A Multifunctional Receptor on the Cell Surface

(2009) Mario Gonzalez–Gronow et al.   ANTIOXIDANTS & REDOX SIGNALING

Patterns of GRP78 and MTJ1 expression in primary cutaneous malignant melanoma

(2009) John A Papalas et al.   MODERN PATHOLOGY

Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis

(2009) U. K. Misra et al.   MOLECULAR CANCER THERAPEUTICS

Golgicide A reveals essential roles for GBF1 in Golgi assembly and function

(2009) José B Sáenz et al.   Nature Chemical Biology

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology