Blockade of HMGB1 signaling pathway by ethyl pyruvate inhibits tumor growth in diffuse large B-cell lymphoma

Lysophospholipids and Their Receptors Serve as Conditional DAMPs and DAMP Receptors in Tissue Oxidative and Inflammatory Injury

(2018) Ying Shao et al.   ANTIOXIDANTS & REDOX SIGNALING

Gene regulation and suppression of type I interferon signaling by STAT3 in diffuse large B cell lymphoma

(2018) Li Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HMGB1 promotes ERK-mediated mitochondrial Drp1 phosphorylation for chemoresistance through RAGE in colorectal cancer

(2018) Chih-Yang Huang et al.   Cell Death & Disease

Succeeding in Breaking the R-CHOP Ceiling in DLBCL: Learning From Negative Trials

(2017) Andre Goy   JOURNAL OF CLINICAL ONCOLOGY

Ly6G+ neutrophil-derived miR-223 inhibits the NLRP3 inflammasome in mitochondrial DAMP-induced acute lung injury

(2017) Zunyong Feng et al.   Cell Death & Disease

Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses

(2017) S. Dallari et al.   Nature Communications

HMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of human mesothelioma

(2017) Laura Pellegrini et al.   Oncotarget

Ethyl Pyruvate Administration Suppresses Growth and Invasion of Gallbladder Cancer Cells via Downregulation of Hmgb1-Rage Axis

(2017) M-L. Li et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

The T-cell Receptor Repertoire Influences the Tumor Microenvironment and Is Associated with Survival in Aggressive B-cell Lymphoma

(2016) Colm Keane et al.   CLINICAL CANCER RESEARCH

Ethyl pyruvate inhibits the acetylation and release of HMGB1 via effects on SIRT1/STAT signaling in LPS-activated RAW264.7 cells and peritoneal macrophages

(2016) Young Min Kim et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ethyl pyruvate is a novel anti-inflammatory agent to treat multiple inflammatory organ injuries

(2016) Runkuan Yang et al.   Journal of Inflammation-London

Subtype-specific addiction of the activated B-cell subset of diffuse large B-cell lymphoma to FOXP1

(2016) Joseph D. Dekker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD126 and Targeted Therapy with Tocilizumab in Chronic Lymphocytic Leukemia

(2015) F.-T. Liu et al.   CLINICAL CANCER RESEARCH

Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation

(2015) Xiaorong Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

Shikonin-enhanced cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP components

(2015) Tien-Jen Lin et al.   Molecular Cancer

Overexpression of HMGB1 A-box reduced lipopolysaccharide-induced intestinal inflammationviaHMGB1/TLR4 signalingin vitro

(2015) Fu-Cai Wang   WORLD JOURNAL OF GASTROENTEROLOGY

Innate sensing of microbial products promotes wound-induced skin cancer

(2015) Esther Hoste et al.   Nature Communications

Extracellular HMGB1 promotes differentiation of nurse-like cells in chronic lymphocytic leukemia

(2014) L. Jia et al.   BLOOD

Jun-regulated genes promote interaction of diffuse large B-cell lymphoma with the microenvironment

(2014) M. Blonska et al.   BLOOD

5-Fluorouracil causes leukocytes attraction in the peritoneal cavity by activating autophagy and HMGB1 release in colon carcinoma cells

(2014) Lucia Cottone et al.   INTERNATIONAL JOURNAL OF CANCER

Fas ligand–mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas

(2014) Shoukat Afshar-Sterle et al.   NATURE MEDICINE

Diallyl Disulfide Suppresses SRC/Ras/ERK Signaling-Mediated Proliferation and Metastasis in Human Breast Cancer by Up-Regulating miR-34a

(2014) Xiangsheng Xiao et al.   PLoS One

HMGB1–LPS complex promotes transformation of osteoarthritis synovial fibroblasts to a rheumatoid arthritis synovial fibroblast-like phenotype

(2014) Y Qin et al.   Cell Death & Disease

Activation of the STAT3 Signaling Pathway Is Associated With Poor Survival in Diffuse Large B-Cell Lymphoma Treated With R-CHOP

(2013) Xin Huang et al.   JOURNAL OF CLINICAL ONCOLOGY

p53 promotes inflammation-associated hepatocarcinogenesis by inducing HMGB1 release

(2013) He-Xin Yan et al.   JOURNAL OF HEPATOLOGY

The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics

(2013) R Kang et al.   ONCOGENE

Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A

(2012) M. Pulvino et al.   BLOOD

Tissue Damage-Associated "Danger Signals" Influence T-cell Responses That Promote the Progression of Preneoplasia to Cancer

(2012) Y. He et al.   CANCER RESEARCH

Increased expression of HMGB1 is associated with poor prognosis in human bladder cancer

(2012) Guo-Liang Yang et al.   JOURNAL OF SURGICAL ONCOLOGY

HMGB1 is overexpressed in tumor cells and promotes activity of regulatory T cells in patients with head and neck cancer

(2012) Clarissa A. Wild et al.   ORAL ONCOLOGY

Ethyl pyruvate, an anti-inflammatory agent, inhibits tumor angiogenesis through inhibition of the NF-κB signaling pathway

(2011) Shi-Young Park et al.   CANCER LETTERS

Inactivating mutations of acetyltransferase genes in B-cell lymphoma

(2011) Laura Pasqualucci et al.   NATURE

New pyrazolo[3,4-d]pyrimidine SRC inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization

(2011) P Indovina et al.   ONCOGENE

Targeting Src family kinases in anti-cancer therapies: turning promise into triumph

(2011) Siyuan Zhang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Immunotherapeutic Suppression of Indoleamine 2,3-Dioxygenase and Tumor Growth with Ethyl Pyruvate

(2010) A. J. Muller et al.   CANCER RESEARCH

High Erk activity suppresses expression of the cell cycle inhibitor p27Kip1 in colorectal cancer cells

(2010) Theresia R Kress et al.   Cell Communication and Signaling

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

(2010) R. Eric Davis et al.   NATURE

HMGB1 release and redox regulates autophagy and apoptosis in cancer cells

(2010) D Tang et al.   ONCOGENE

Toll-like receptor signaling in cell proliferation and survival

(2009) Xinyan Li et al.   CYTOKINE

Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis

(2009) Shaival H. Davé et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation

(2008) C. K. Sun et al.   CARCINOGENESIS

Increased expression of high mobility group box 1 (HMGB1) is associated with progression and poor prognosis in human nasopharyngeal carcinoma

(2008) D Wu et al.   JOURNAL OF PATHOLOGY

Stromal Gene Signatures in Large-B-Cell Lymphomas

(2008) G. Lenz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor- B pathways in subtypes of diffuse large B-cell lymphoma

(2007) L. T. Lam et al.   BLOOD