Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 56, Issue -, Pages 21-32Publisher
ELSEVIER
DOI: 10.1016/j.jff.2019.02.044
Keywords
Lactobacillus fermentum; Inflammatory diseases; Immunomodulatory properties
Categories
Funding
- National Natural Science Foundation of Jiangsu Province [BK20160175]
- National Natural Science Foundation of China Program [31871773, 31530056, 31820103010]
- National First-Class Discipline Program of Food Science and Technology [JUFSTR20180102]
- Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province
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Lactobacillus fermentum has been used in industrial processes and food fermentation for a long time. Because it is of human origin, non-pathogenic, has high resistance to passing through the intestine, prevents pathogenic insults and promotes the maturation of the immune system, it has been identified as a potential probiotic. L. fermentum has been shown to interact with human immune cells and to modulate specific pathways involved in innate and adaptive immune processes in diverse inflammatory diseases. This review summarizes the immunomodulatory properties and regulatory mechanisms of L. fermentum identified in isolated immune cells, animal models and the human body in recent studies.
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