Stem Cell Based Drug Delivery for Protection of Auditory Neurons in a Guinea Pig Model of Cochlear Implantation

Inner ear drug delivery: Recent advances, challenges, and perspective

(2018) Jinsong Hao et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Controlled drug release to the inner ear: Concepts, materials, mechanisms, and performance

(2018) Karsten Mäder et al.   HEARING RESEARCH

Pharmacokinetic principles in the inner ear: Influence of drug properties on intratympanic applications

(2018) Alec N. Salt et al.   HEARING RESEARCH

The feasibility of an encapsulated cell approach in an animal deafness model

(2018) Anette Fransson et al.   JOURNAL OF CONTROLLED RELEASE

Hearing Preservation Outcomes After Cochlear Implantation Depending on the Angle of Insertion

(2018) Silke Helbig et al.   OTOLOGY & NEUROTOLOGY

Intracochlear administration of steroids with a catheter during human cochlear implantation: a safety and feasibility study

(2018) Nils K. Prenzler et al.   Drug Delivery and Translational Research

Chronic intracochlear electrical stimulation at high charge densities results in platinum dissolution but not neural loss or functional changes in vivo

(2018) Robert K Shepherd et al.   Journal of Neural Engineering

Drug discovery for hearing loss: Phenotypic screening of chemical compounds on primary cultures of the spiral ganglion

(2017) Donna S. Whitlon   HEARING RESEARCH

Encapsulated cell device approach for combined electrical stimulation and neurotrophic treatment of the deaf cochlea

(2017) W.S. Konerding et al.   HEARING RESEARCH

Evolution of impedance field telemetry after one day of activation in cochlear implant recipients

(2017) Hao-Chun Hu et al.   PLoS One

Local inner ear application of dexamethasone in cochlear implant models is safe for auditory neurons and increases the neuroprotective effect of chronic electrical stimulation

(2017) Verena Scheper et al.   PLoS One

Recent advances in therapeutics and drug delivery for the treatment of inner ear diseases: a patent review (2011-2015)

(2016) Kim Nguyen et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Impedance Changes and Fibrous Tissue Growth after Cochlear Implantation Are Correlated and Can Be Reduced Using a Dexamethasone Eluting Electrode

(2016) Maciej Wilk et al.   PLoS One

Viral Vectors: The Road to Reducing Genotoxicity

(2016) Rhiannon M. David et al.   TOXICOLOGICAL SCIENCES

Recent advances in local drug delivery to the inner ear

(2015) Naila El Kechai et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Cell-based neurotrophin treatment supports long-term auditory neuron survival in the deaf guinea pig

(2015) Lisa N. Gillespie et al.   JOURNAL OF CONTROLLED RELEASE

Temporary Neurotrophin Treatment Prevents Deafness-Induced Auditory Nerve Degeneration and Preserves Function

(2015) D. Ramekers et al.   JOURNAL OF NEUROSCIENCE

The pre- and post-somatic segments of the human type I spiral ganglion neurons – Structural and functional considerations related to cochlear implantation

(2015) W. Liu et al.   NEUROSCIENCE

Within-Subject Comparison of Word Recognition and Spiral Ganglion Cell Count in Bilateral Cochlear Implant Recipients

(2014) Mohammad Seyyedi et al.   OTOLOGY & NEUROTOLOGY

In Vitro and In Vivo Evaluation of a Hydrogel Reservoir as a Continuous Drug Delivery System for Inner Ear Treatment

(2014) Mareike Hütten et al.   PLoS One

Spiral ganglion neuron quantification in the guinea pig cochlea using Confocal Laser Scanning Microscopy compared to embedding methods

(2013) Antonina Wrzeszcz et al.   HEARING RESEARCH

Effects of Brain-Derived Neurotrophic Factor (BDNF) and Electrical Stimulation on Survival and Function of Cochlear Spiral Ganglion Neurons in Deafened, Developing Cats

(2013) Patricia A. Leake et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

UHV-Alginate as Matrix for Neurotrophic Factor Producing Cells—A Novel Biomaterial for Cochlear Implant Optimization to Preserve Inner Ear Neurons From Degeneration

(2013) Mareike Hütten et al.   OTOLOGY & NEUROTOLOGY

Biocompatible Coating of Encapsulated Cells Using Ionotropic Gelation

(2013) Friederike Ehrhart et al.   PLoS One

Gene transfer in inner ear cells: a challenging race

(2012) R Sacheli et al.   GENE THERAPY

Stable release of BDNF from the fibroblast cell line NIH3T3 grown on silicone elastomers enhances survival of spiral ganglion cells in vitro and in vivo

(2012) Athanasia Warnecke et al.   HEARING RESEARCH

Lipidic nanocapsule drug delivery: neuronal protection for cochlear implant optimization

(2012) Verena Scheper et al.   International Journal of Nanomedicine

Inner Hair Cells Are Not Required for Survival of Spiral Ganglion Neurons in the Adult Cochlea

(2012) Y. Zilberstein et al.   JOURNAL OF NEUROSCIENCE

The overlooked difference between human endogenous and recombinant erythropoietins and its implication for sports drug testing and pharmaceutical drug design

(2011) Christian Reichel   Drug Testing and Analysis

Principles of inner ear sustained release following intratympanic administration

(2011) Xiaobo Wang et al.   LARYNGOSCOPE

Combining Cell-Based Therapies and Neural Prostheses to Promote Neural Survival

(2011) Andrew K. Wise et al.   Neurotherapeutics

Enhanced Auditory Neuron Survival Following Cell-Based BDNF Treatment in the Deaf Guinea Pig

(2011) Lisa N. Pettingill et al.   PLoS One

Chronic electrical stimulation does not prevent spiral ganglion cell degeneration in deafened guinea pigs

(2010) Martijn J.H. Agterberg et al.   HEARING RESEARCH

Spiral ganglion cell survival after round window membrane application of brain-derived neurotrophic factor using gelfoam as carrier

(2010) Sarah Havenith et al.   HEARING RESEARCH

Brain-derived neurotrophic factor promotes cochlear spiral ganglion cell survival and function in deafened, developing cats

(2010) Patricia A. Leake et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Enhanced Survival of Spiral Ganglion Cells After Cessation of Treatment with Brain-Derived Neurotrophic Factor in Deafened Guinea Pigs

(2009) Martijn J. H. Agterberg et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Encapsulated living choroid plexus cells: potential long-term treatments for central nervous system disease and trauma

(2009) S J M Skinner et al.   Journal of Neural Engineering

Effects of delayed treatment with combined GDNF and continuous electrical stimulation on spiral ganglion cell survival in deafened guinea pigs

(2008) Verena Scheper et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Schwann cells genetically modified to express neurotrophins promote spiral ganglion neuron survival in vitro

(2008) L.N. Pettingill et al.   NEUROSCIENCE

Glial cell line-derived neurotrophic factor and antioxidants preserve the electrical responsiveness of the spiral ganglion neurons after experimentally induced deafness

(2007) Jun Maruyama et al.   NEUROBIOLOGY OF DISEASE