Review
Biochemistry & Molecular Biology
Yoichiro Abe, Masato Yasui
Summary: The discovery of NMO-IgG in patients with neuromyelitis optica spectrum disorder (NMOSD) has highlighted the importance of the water channel aquaporin-4 (AQP4) in autoimmune diseases of the central nervous system. The unique structure of AQP4 and its subcellular localization may play a crucial role in the pathogenesis of NMOSD, in addition to the complement-dependent cytotoxic effects of NMO-IgG. Studies have also shown complement-independent cytotoxic effects of NMO-IgG, potentially involving antibody-induced endocytosis of AQP4.
Article
Immunology
Liang Wang, Lei Du, Qinying Li, Fang Li, Bei Wang, Yuanqi Zhao, Qiang Meng, Wenyu Li, Juyuan Pan, Junhui Xia, Shitao Wu, Jie Yang, Heng Li, Jianhua Ma, Jingzi ZhangBao, Wenjuan Huang, Xuechun Chang, Hongmei Tan, Jian Yu, Lei Zhou, Chuanzhen Lu, Min Wang, Qiang Dong, Jiahong Lu, Chongbo Zhao, Chao Quan
Summary: This study investigates the predictors of relapse, and severe visual or motor disability in patients with NMOSD and develops corresponding predictive models. Early identification of patients at risk of unfavorable outcomes is crucial for informing treatment decisions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Edgar Carnero Contentti, Jorge Correale
Summary: Neuromyelitis optica (NMO) is a chronic inflammatory autoimmune disease characterized by acute optic neuritis and transverse myelitis. It is caused by a pathogenic serum IgG antibody targeting the water channel aquaporin 4 (AQP4). Recent studies have shown significant progress in identifying new treatments for NMOSD.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Clinical Neurology
Tetsuya Akaishi, Toshiyuki Takahashi, Kazuo Fujihara, Tatsuro Misu, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Michiaki Abe, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima
Summary: NMOSD patients positive for AQP4-IgG have a higher association with Sjogren's syndrome, with a higher prevalence of comorbid SjS among female patients and a higher relapse rate.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Liang Wang, Hongmei Tan, Wenjuan Huang, Xuechun Chang, Jingzi ZhangBao, Lei Zhou, Chuanzhen Lu, Min Wang, Jiahong Lu, Chongbo Zhao, Chao Quan
Summary: This study evaluated the clinical characteristics and prognosis of late onset neuromyelitis optica spectrum disorder (LO-NMOSD) and compared them with early onset NMOSD (EO-NMOSD) and NMOSD with different antibody serostatuses. The study found that patients with LO-NMOSD, especially those with AQP4 antibodies, had a worse prognosis. Age at disease onset and antibody serostatus were predictors of blindness and motor dysfunction.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Koon-Ho Chan, Chi-Yan Lee
Summary: NMOSD is an autoimmune disorder that predominantly affects females, leading to serious CNS inflammatory disorders. The pathogenesis involves AQP4-IgG autoantibodies targeting aquaporin-4, triggering astrocytopathy and neuroinflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
Shabeer Paul, Gouranga Prasad Mondal, Ramesh Bhattacharyya, Kartik Chandra Ghosh, Imtiyaz Ahmad Bhat
Summary: Over the past two decades, the disease concept of NMOSD has significantly changed with the detection of MOG antibody and the understanding of immune astrocytopathy. The revised diagnostic criteria have widened the clinical spectrum of NMOSD, allowing for earlier diagnosis and prompt initiation of effective immunosuppression for better long-term outcomes. Challenges still remain in treating seronegative NMOSD due to limited treatment options.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Itay Lotan, Gabriela Romanow, Rebecca Salky, Negar Molazadeh, Anastasia Vishnevetsky, Monique Anderson, Phillipe-Antoine Bilodeau, Gary Cutter, Michael Levy
Summary: This study aimed to assess the mortality rate in patients with MOGAD and found a lower mortality rate compared to other neuroinflammatory diseases, similar to the age-adjusted mortality rates of the general population in the United States. Further studies are needed to confirm this observation.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Clinical Neurology
Laura Cacciaguerra, Paola Valsasina, Alessandro Meani, Gianna C. Riccitelli, Marta Radaelli, Maria A. Rocca, Massimo Filippi
Summary: The study revealed hippocampal atrophy in NMOSD patients associated with verbal and visual memory impairments. However, this damage did not explain the attention and executive function alterations, which were the most common cognitive deficits in this population.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Liang Wang, Lei Du, Qinying Li, Fang Li, Bei Wang, Yuanqi Zhao, Qiang Meng, Wenyu Li, Juyuan Pan, Junhui Xia, Shitao Wu, Jie Yang, Heng Li, Jianhua Ma, Jingzi ZhangBao, Wenjuan Huang, Xuechun Chang, Hongmei Tan, Jian Yu, Lei Zhou, Chuanzhen Lu, Min Wang, Qiang Dong, Jiahong Lu, Chongbo Zhao, Chao Quan
Summary: This study confirmed the superiority of deep learning in designing a predictive model for relapse in patients with AQP4-ab-positive NMOSD, with the LogisticHazard model showing the best predictive power in validation.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Liang Wang, Lei Zhou, Jingzi ZhangBao, Wenjuan Huang, Hongmei Tan, Yuxin Fan, Chuanzhen Lu, Jian Yu, Min Wang, Jiahong Lu, Chongbo Zhao, Tiansong Zhang, Chao Quan
Summary: This study aimed to investigate the causal associations between four herpesvirus infections (chickenpox, cold sores, mononucleosis and shingles) and NMOSD. The results showed significant associations between cold sores and shingles with AQP4-ab-positive NMOSD.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Laura Cacciaguerra, Paola Tortorella, Maria A. Rocca, Massimo Filippi
Summary: Advancements in the understanding of neuromyelitis optica spectrum disorder have led to the development of targeted drugs, particularly biologics that significantly reduce the risk of relapses in aquaporin-4-seropositive patients with mild to moderate adverse effects.
Review
Immunology
Ehab Harahsheh, Marcus Callister, Shemonti Hasan, David Gritsch, Cristina Valencia-Sanchez
Summary: Neuromyelitis optica spectrum disorder (NMOSD) is rarely reported following COVID-19 vaccination. This study identified 16 cases of NMOSD with positive aquaporin-4 IgG following vaccination. Transverse myelitis was the most common clinical presentation. Most patients received high dose steroids for acute treatment and maintenance therapy was started in 12 patients. The included cases share similar epidemiology and natural course to non-vaccine related cases. Clinicians should be aware of possible post-vaccination NMOSD for early diagnosis and treatment.
JOURNAL OF NEUROIMMUNOLOGY
(2022)
Article
Immunology
Shanchao Zhang, Shan Qiao, Haiyun Li, Ranran Zhang, Meiling Wang, Tao Han, Xuewu Liu, Yunshan Wang
Summary: This study aimed to investigate the risk factors for relapses in Chinese children with NMOSD, and to establish a risk score model and a predictive nomogram to help clinicians predict relapse risk and provide personalized treatment. The results showed that discharge EDSS score, mixed-lesion onset, counts of concomitant autoantibodies, and maintenance therapy were independent factors for relapse. The risk score model and predictive nomogram demonstrated good accuracy in predicting relapse. This study is of significant clinical importance for predicting relapse risk in children with NMOSD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Eleonora Virgilio, Domizia Vecchio, Marco Vercellino, Paola Naldi, Fabiana Tesser, Roberto Cantello, Paola Cavalla, Cristoforo Comi
Summary: AQP4-IgG neuromyelitis optica spectrum disorders are rare idiopathic autoimmune diseases with a potential association with tumors, and there is currently no consensus on treatment for paraneoplastic syndrome.
NEUROLOGICAL SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andreia Rocha, Bruna Bellaver, Debora G. Souza, Guilherme Schu, Igor C. Fontana, Gianina T. Venturin, Samuel Greggio, Fernanda U. Fontella, Manoela L. Schiavenin, Luiza S. Machado, Diogo Miron, Jaderson C. da Costa, Pedro Rosa-Neto, Diogo O. Souza, Luc Pellerin, Eduardo R. Zimmer
Summary: This study used FDG-PET imaging to investigate the impact of the antipsychotic drug clozapine on brain glucose metabolism in rats, and found that downregulation of GLT-1 resulted in astrocyte-dependent cortical hypometabolism, resembling the hypometabolic signature observed in people developing dementia.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Biochemistry & Molecular Biology
Leticia Rodrigues, Krista Mineia Wartchow, Michael Buchfelder, Diogo Onofre Souza, Carlos-Alberto Goncalves, Andrea Kleindienst
Summary: In this study, the researchers investigated the role of S100B, a neurotrophic protein, in brain injury and neuroregeneration. Using S100Btg mice with increased expression of the S100B gene, they found enhanced proliferation and migration of progenitor cells, as well as reduced levels of GFAP, ApoE, and BDNF in certain brain regions. The study highlights the importance of the S100Btg model in evaluating the role of S100B in neuroregenerative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Infectious Diseases
Natalie Duran Rocha, Sara Kvitko de Moura, Gabriel Aude Bueno da Silva, Rita Mattiello, Douglas Kazutoshi Sato
Summary: This systematic review and meta-analysis aimed to assess the prevalence and types of neurological sequelae in children after acute viral encephalitis caused by HSV. The study found that the general prevalence of neurological sequelae was 50.7%, with mental disability being the most frequent sequelae (42.1%), and visual impairment being the least frequent (5.9%).
BMC INFECTIOUS DISEASES
(2023)
Article
Clinical Neurology
Rosa Cortese, Marco Battaglini, Ferran Prados, Alessia Bianchi, Lukas Haider, Anu Jacob, Jacqueline Palace, Silvia Messina, Friedemann Paul, Jens Wuerfel, Romain Marignier, Francoise Durand-Dubief, Carolina de Medeiros Rimkus, Dagoberto Callegaro, Douglas Kazutoshi Sato, Massimo Filippi, Maria Assunta Rocca, Laura Cacciaguerra, Alex Rovira, Jaume Sastre-Garriga, Georgina Arrambide, Yaou Liu, Yunyun Duan, Claudio Gasperini, Carla Tortorella, Serena Ruggieri, Maria Pia Amato, Monica Ulivelli, Sergiu Groppa, Matthias Grothe, Sara Llufriu, Maria Sepulveda, Carsten Lukas, Barbara Bellenberg, Ruth Schneider, Piotr Sowa, Elisabeth G. Celius, Anne-Katrin Proebstel, Ozgur Yaldizli, Jannis Mueller, Bruno Stankoff, Benedetta Bodini, Luca Carmisciano, Maria Pia Sormani, Frederik Barkhof, Nicola De Stefano, Olga Ciccarelli
Summary: The study aimed to differentiate non-acute MOG-antibody disease from AQP4-neuromyelitis optica spectrum disorder and multiple sclerosis using MRI and clinical markers. The findings provide guidance for identifying patients with MOG-antibody disease in clinical practice.
Article
Clinical Neurology
Brenda Banwell, Jeffrey L. Bennett, Romain Marignier, Ho Jin Kim, Fabienne Brilot, Eoin P. Flanagan, Sudarshini Ramanathan, Patrick Waters, Silvia Tenembaum, Jennifer S. Graves, Tanuja Chitnis, Alexander U. Brandt, Cheryl Hemingway, Rinze Neuteboom, Lekha Pandit, Markus Reindl, Albert Saiz, Douglas Kazutoshi Sato, Kevin Rostasy, Friedemann Paul, Sean J. Pittock, Kazuo Fujihara, Jacqueline Palace
Summary: Serum antibodies against MOG can help diagnose MOGAD, which is distinct from multiple sclerosis and neuromyelitis optica. The presence of MOG-IgG is a core criterion for the diagnosis. MOGAD can present with various symptoms and can be either monophasic or relapsing, and diagnostic accuracy relies on MOG-IgG cell-based assays.
Article
Information Science & Library Science
Carolina Bittencourt Gomes, Luciana Calabro, Suzana Rachel de Oliveira, Leo Anderson Meira Martins, Diogo Onofre Souza, Ediane Maria Gheno
Summary: This article evaluated the characteristics of grantees in the Health Sciences area of the National Council for Scientific and Technological Development. Various indicators were used to assess 1,634 researchers with current grants in 2021. The study found differences in the distribution of articles among Committees and the influence of article numbers on the level of grants. It provides important insights for public policies in Science and Technology and contributes to the field by evaluating the Health Sciences area using diverse indicators.
Review
Neurosciences
Renata Barbosa Paolilo, Jose Albino da Paz, Samira Luisa Apostolos-Pereira, Carolina de Medeiros Rimkus, Dagoberto Callegaro, Douglas Kazutoshi Sato
Summary: Neuromyelitis optica spectrum disorder (NMOSD) is a rare and severe inflammatory disorder of the central nervous system (CNS) that mainly affects young women from non-white ethnicities. Children and adolescents with NMOSD have similar clinical, radiologic, and laboratory presentation as adults. However, data on NMOSD in pediatric patients is limited and there is a need for more clinical trials to evaluate the safety and efficacy of drugs in this population.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2023)
Article
Clinical Neurology
Cibele Ferreira Teixeira, Veronica Farina Azzolin, Giordani Rodrigues dos Passos, Barbara Osmarin Turra, Audrei de Oliveira Alves, Augusto Cesar Morioka Bressanim, Luiz Eduardo Leal Canton, Aline de Cassia Vieira dos Santos, Moises Henrique Mastella, Fernanda Barbisan, Euler Esteves Ribeiro, Thiago Duarte, Marta Maria Medeiros Frescura Duarte, Nathalia Cardoso de Afonso Bonotto, Douglas Kazutoshi Sato, Ivana Beatrice Manica da Cruz
Summary: This pilot study aimed to investigate the effects of a guarana, selenium, and L-carnitine (GSC) based multi supplement on oxidative and inflammatory markers in patients with relapsing-remitting multiple sclerosis (RRMS). The results showed that a low concentration of GSC could decrease the levels of oxidized DNA and pro-inflammatory cytokines in RRMS patients. These findings support further research on the potential clinical benefits of GSC in not only MS patients, but also in other neurological conditions.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Neurosciences
Diego Cardoso Fragoso, Luana Michelli Oliveira de Paula Salles, Samira Luisa Apostolos Pereira, Dagoberto Callegaro, Douglas Kazutoshi Sato, Carolina de Medeiros Rimkus
Summary: This study analyzed the MRI features of patients with MOGAD, AQP4-IgG NMOSD, and double-seronegative patients, and found differences in clinical presentation and imaging features among these diseases, providing critical information for a timely differential diagnosis.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2023)
Article
Biochemistry & Molecular Biology
Blessing A. Obafemi, Isaac A. Adedara, Ana L. A. Segatto, Diogo O. Souza, Joao B. T. da Rocha, Olawande C. Olagoke
Summary: In this study, the mechanism of inflammatory response to organometallic cation methylmercury, common cooking seasoning (NaCl and MSG), and their crosstalk with redox signaling were investigated using the lobster cockroach as a model. The activation of Nox/Duox NADPH oxidases, along with JNK and Rel signaling pathways, was found to play crucial roles during methylmercury and MSG exposure.
JOURNAL OF FOOD BIOCHEMISTRY
(2023)
Article
Clinical Neurology
Bruna Klein da Costa, Paula de Oliveira Pinto, Lia Staub, Gisele Hansel, Guilherme Vanik Pinto, Lucas Porcello Schilling, Giordani Rodrigues dos Passos, William Alves Martins, Jefferson Becker, Raphael Machado Castilhos, Andre Palmini, Douglas Kazutoshi Sato
Summary: This study described the phenotype and environmental associations of patients with neurological syndromes associated with antibodies against neuronal surface antigens. The results showed that most patients had disease onset in spring and summer, and observed a different pattern of brain lesions in NMDAr-IgG encephalitis following herpes encephalitis, as well as an association with Rosai-Dorfman-Destombe disease. Importantly, most patients improved with immunotherapy, even when initiated later in the disease course.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Meeting Abstract
Clinical Neurology
R. Cortese, M. Battaglini, F. Prados, G. Gentile, L. Luchetti, A. Bianchi, L. Haider, A. Jacob, J. Palace, S. Messina, F. Paul, J. Wuerfel, R. Marignier, F. Durand-Dubief, C. De Medeiros Rimkus, D. Callegaro, D. Kazutoshi Sato, M. Filippi, M. A. Rocca, L. Cacciaguerra, A. Rovira, J. Sastre-Garriga, G. Arrambide, Y. Liu, Y. Duan, C. Gasperini, C. Tortorella, S. Ruggieri, M. P. Amato, M. Ulivelli, S. Groppa, M. Grothe, S. Llufriu, M. Sepulveda, C. Lukas, B. Bellenberg, R. Schneider, P. Sowa, E. G. Celius, A. -K. Proebstel, O. Yaldizli, J. Muller, B. Stankoff, B. Bodini, L. Carmisciano, M. P. Sormani, F. Barkhof, N. De Stefano, O. Ciccarelli
MULTIPLE SCLEROSIS JOURNAL
(2022)
Correction
Clinical Neurology
Romain Marignier, Yael Hacohen, Alvaro Cobo-Calvo, Anne-Katrin Probstel, Orhan Aktas, Harry Alexopoulos, Maria-Pia Amato, Nasrin Asgari, Brenda Banwell, Jeffrey Bennett, Fabienne Brilot, Marco Capobianco, Tanuja Chitnis, Olga Ciccarelli, Kumaran Deiva, Jerome De Seze, Kazuo Fujihara, Anu Jacob, Ho Jin Kim, Ingo Kleiter, Hans Lassmann, Maria-Isabel Leite, Christopher Linington, Edgar Meinl, Jacqueline Palace, Friedemann Paul, Axel Petzold, Sean Pittock, Markus Reindl, Douglas Kazutoshi Sato, Krzysztof Selmaj, Aksel Siva, Bruno Stankoff, Mar Tintore, Anthony Traboulsee, Patrick Waters, Emmanuelle Waubant, Brian Weinshenker, Tobias Derfuss, Sandra Vukusic, Bernhard Hemmer
Meeting Abstract
Clinical Neurology
R. Cortese, M. Battaglini, F. Prados, L. Haider, A. Jacob, J. Palace, F. Paul, R. Marignier, D. Kazutoshi Sato, M. Filippi, A. Rovira, Y. Liu, C. Gasperini, M. Amato, S. Groppa, S. Llufriu, C. Lukas, P. Sowa, A. Proebstel, B. Stankoff, M. Sormani, F. Barkhof, N. De Stefano, O. Ciccarelli
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Julia D. Moreira, Leticia Vicari Siqueira, Alexandre P. Muller, Lisiane O. Porciuncula, Lucia Vinade, Diogo O. Souza
Summary: Dietary omega-3 polyunsaturated fatty acids (n-3 PUFAs) can positively influence the glutamatergic system and prevent seizure-related memory deficits.
NUTRITIONAL NEUROSCIENCE
(2022)