Antiviral RNAi in Insects and Mammals: Parallels and Differences

Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids

(2019) Yan-Peng Xu et al.   CELL RESEARCH

MicroRNA-deficient mouse embryonic stem cells acquire a functional interferon response

(2019) Jeroen Witteveldt et al.   eLife

Intrinsic Immunity Shapes Viral Resistance of Stem Cells

(2018) Xianfang Wu et al.   CELL

Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate

(2018) Zhongmin Liu et al.   CELL

The RIG‐I‐like receptor LGP2 inhibits Dicer‐dependent processing of long double‐stranded RNA and blocks RNA interference in mammalian cells

(2018) Annemarthe G van der Veen et al.   EMBO JOURNAL

LGP2 virus sensor regulates gene expression network mediated by TRBP-bound microRNAs

(2018) Tomoko Takahashi et al.   NUCLEIC ACIDS RESEARCH

Influenza A virus-derived siRNAs increase in the absence of NS1 yet fail to inhibit virus replication

(2018) Kevin Tsai et al.   RNA

Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals

(2017) Yang Qiu et al.   IMMUNITY

The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination

(2017) Yong Hu et al.   JOURNAL OF VIROLOGY

Dicer uses distinct modules for recognizing dsRNA termini

(2017) Niladri K. Sinha et al.   SCIENCE

Deletion of Cytoplasmic Double-Stranded RNA Sensors Does Not Uncover Viral Small Interfering RNA Production in Human Cells

(2017) Susan Schuster et al.   mSphere

Filament assemblies in foreign nucleic acid sensors

(2016) Jungsan Sohn et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The impact of transposable elements on mammalian development

(2016) Jose L. Garcia-Perez et al.   DEVELOPMENT

Inactivation of the type I interferon pathway reveals long double‐stranded RNA‐mediated RNA interference in mammalian cells

(2016) Pierre V Maillard et al.   EMBO JOURNAL

Structural Analysis of Human Argonaute-2 Bound to a Modified siRNA Guide

(2016) Nicole T. Schirle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Production of small RNAs by mammalian Dicer

(2016) Eliska Svobodova et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Yellow fever virus capsid protein is a potent suppressor of RNA silencing that binds double-stranded RNA

(2016) Glady Hazitha Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virus-derived DNA drives mosquito vector tolerance to arboviral infection

(2016) Bertsy Goic et al.   Nature Communications

PIWIs Go Viral: Arbovirus-Derived piRNAs in Vector Mosquitoes

(2016) Pascal Miesen et al.   PLoS Pathogens

Induction and suppression of antiviral RNA interference by influenza A virus in mammalian cells

(2016) Yang Li et al.   Nature Microbiology

Influenza Virus Adaptation PB2-627K Modulates Nucleocapsid Inhibition by the Pathogen Sensor RIG-I

(2015) Michaela Weber et al.   Cell Host & Microbe

LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling

(2015) Annie M. Bruns et al.   CYTOKINE

The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus

(2015) Seiichi Sato et al.   IMMUNITY

The Nucleocapsid Protein of Coronaviruses Acts as a Viral Suppressor of RNA Silencing in Mammalian Cells

(2015) Lei Cui et al.   JOURNAL OF VIROLOGY

Production of functional small interfering RNAs by an amino-terminal deletion mutant of human Dicer

(2015) Edward M. Kennedy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered Mammalian RNAi Can Elicit Antiviral Protection that Negates the Requirement for the Interferon Response

(2015) Asiel Arturo Benitez et al.   Cell Reports

RNA interference-mediated antiviral defense in insects

(2015) Don B Gammon et al.   Current Opinion in Insect Science

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

YASARA View—molecular graphics for all devices—from smartphones to workstations

(2014) Elmar Krieger et al.   BIOINFORMATICS

The Interferon Signaling Antagonist Function of Yellow Fever Virus NS5 Protein Is Activated by Type I Interferon

(2014) Maudry Laurent-Rolle et al.   Cell Host & Microbe

Protective Role of LGP2 in Influenza Virus Pathogenesis

(2014) Mustapha Si-Tahar et al.   JOURNAL OF INFECTIOUS DISEASES

Replication of Many Human Viruses Is Refractory to Inhibition by Endogenous Cellular MicroRNAs

(2014) Hal P. Bogerd et al.   JOURNAL OF VIROLOGY

The Innate Immune Sensor LGP2 Activates Antiviral Signaling by Regulating MDA5-RNA Interaction and Filament Assembly

(2014) Annie M. Bruns et al.   MOLECULAR CELL

mRNA Destabilization Is the Dominant Effect of Mammalian MicroRNAs by the Time Substantial Repression Ensues

(2014) Stephen W. Eichhorn et al.   MOLECULAR CELL

Mosquito andDrosophilaentomobirnaviruses suppress dsRNA- and siRNA-induced RNAi

(2014) Koen W.R. van Cleef et al.   NUCLEIC ACIDS RESEARCH

Small RNA Analysis in Sindbis Virus Infected Human HEK293 Cells

(2014) Andras Donaszi-Ivanov et al.   PLoS One

Derivation and characterization of Dicer- and microRNA-deficient human cells

(2014) H. P. Bogerd et al.   RNA

The Mammalian Response to Virus Infection Is Independent of Small RNA Silencing

(2014) Simone Backes et al.   Cell Reports

The long and short of antiviral defense: small RNA-based immunity in insects

(2014) Alfred W Bronkhorst et al.   Current Opinion in Virology

Novel Drosophila Viruses Encode Host-Specific Suppressors of RNAi

(2014) Joël T. van Mierlo et al.   PLoS Pathogens

Distinct Antiviral Responses in Pluripotent versus Differentiated Cells

(2014) Justin M. Pare et al.   PLoS Pathogens

G3BP1, G3BP2 and CAPRIN1 Are Required for Translation of Interferon Stimulated mRNAs and Are Targeted by a Dengue Virus Non-coding RNA

(2014) Katell Bidet et al.   PLoS Pathogens

IFITM-Family Proteins: The Cell's First Line of Antiviral Defense

(2014) Charles C. Bailey et al.   Annual Review of Virology

Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5

(2014) Stephanie Reikine et al.   Frontiers in Immunology

A Retrotransposon-Driven Dicer Isoform Directs Endogenous Small Interfering RNA Production in Mouse Oocytes

(2013) Matyas Flemr et al.   CELL

Mutual Antagonism between the Ebola Virus VP35 Protein and the RIG-I Activator PACT Determines Infection Outcome

(2013) Priya Luthra et al.   Cell Host & Microbe

Reciprocal Inhibition between Intracellular Antiviral Signaling and the RNAi Machinery in Mammalian Cells

(2013) Gil Ju Seo et al.   Cell Host & Microbe

Cytosolic Sensing of Viruses

(2013) Delphine Goubau et al.   IMMUNITY

MicroRNA-based strategy to mitigate the risk of gain-of-function influenza studies

(2013) Ryan A Langlois et al.   NATURE BIOTECHNOLOGY

RNA-mediated interference and reverse transcription control the persistence of RNA viruses in the insect model Drosophila

(2013) Bertsy Goic et al.   NATURE IMMUNOLOGY

Diversifying microRNA sequence and function

(2013) Stefan L. Ameres et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Homeostatic control of Argonaute stability by microRNA availability

(2013) Peter Smibert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dicer-2 Processes Diverse Viral RNA Species

(2013) Leah R. Sabin et al.   PLoS One

RNA Interference Functions as an Antiviral Immunity Mechanism in Mammals

(2013) Y. Li et al.   SCIENCE

Antiviral RNA Interference in Mammalian Cells

(2013) P. V. Maillard et al.   SCIENCE

Identification of RNase L-Dependent, 3'-End-Modified, Viral Small RNAs in Sindbis Virus-Infected Mammalian Cells

(2013) E. Girardi et al.   mBio

The Making of a Slicer: Activation of Human Argonaute-1

(2013) Christopher R. Faehnle et al.   Cell Reports

Correction: Functional Specialization of the Small Interfering RNA Pathway in Response to Virus Infection

(2013) Joao Trindade Marques et al.   PLoS Pathogens

The Structure of Human Argonaute-2 in Complex with miR-20a

(2012) Elad Elkayam et al.   CELL

Degradation of Host MicroRNAs by Poxvirus Poly(A) Polymerase Reveals Terminal RNA Methylation as a Protective Antiviral Mechanism

(2012) Simone Backes et al.   Cell Host & Microbe

MicroRNA biogenesis: regulating the regulators

(2012) Emily F. Finnegan et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Intracellular Localization and Routing of miRNA and RNAi Pathway Components

(2012) Thomas Ohrt et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The RIG-I-like Receptor LGP2 Controls CD8+ T Cell Survival and Fitness

(2012) Mehul S. Suthar et al.   IMMUNITY

Broad RNA Interference-Mediated Antiviral Immunity and Virus-Specific Inducible Responses in Drosophila

(2012) C. Kemp et al.   JOURNAL OF IMMUNOLOGY

Regulation of Human RNase-L by the miR-29 Family Reveals a Novel Oncogenic Role in Chronic Myelogenous Leukemia

(2012) Teresa Y. Lee et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Noncoding Flavivirus RNA Displays RNA Interference Suppressor Activity in Insect and Mammalian Cells

(2012) E. Schnettler et al.   JOURNAL OF VIROLOGY

Dicer-dependent and -independent Argonaute2 Protein Interaction Networks in Mammalian Cells

(2012) Anne Frohn et al.   MOLECULAR & CELLULAR PROTEOMICS

Structure of yeast Argonaute with guide RNA

(2012) Kotaro Nakanishi et al.   NATURE

microRNAs associated with the different human Argonaute proteins

(2012) A. Dueck et al.   NUCLEIC ACIDS RESEARCH

Deregulation of Type I IFN-Dependent Genes Correlates with Increased Susceptibility to Cytomegalovirus Acute Infection of Dicer Mutant Mice

(2012) Eleonore Ostermann et al.   PLoS One

Hematopoietic-specific targeting of influenza A virus reveals replication requirements for induction of antiviral immune responses

(2012) Ryan A. Langlois et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DNA virus Invertebrate iridescent virus 6 is a target of the Drosophila RNAi machinery

(2012) A. W. Bronkhorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Duplex RNA activated ATPases (DRAs)

(2012) Dahai Luo et al.   RNA Biology

Association of Argonaute proteins and microRNAs can occur after cell lysis

(2012) K. J. Riley et al.   RNA

The Crystal Structure of Human Argonaute2

(2012) N. T. Schirle et al.   SCIENCE

Productive Hepatitis C Virus Infection of Stem Cell-Derived Hepatocytes Reveals a Critical Transition to Viral Permissiveness during Differentiation

(2012) Xianfang Wu et al.   PLoS Pathogens

Convergent Evolution of Argonaute-2 Slicer Antagonism in Two Distinct Insect RNA Viruses

(2012) Joël T. van Mierlo et al.   PLoS Pathogens

The Many Faces of RNAi

(2011) René F. Ketting   DEVELOPMENTAL CELL

RNA Interference in Fungi: Pathways, Functions, and Applications

(2011) Yunkun Dang et al.   EUKARYOTIC CELL

Mapping a Dynamic Innate Immunity Protein Interaction Network Regulating Type I Interferon Production

(2011) Shitao Li et al.   IMMUNITY

Ambivalent Role of the Innate Immune Response in Rabies Virus Pathogenesis

(2011) D. Chopy et al.   JOURNAL OF VIROLOGY

Ebolavirus Proteins Suppress the Effects of Small Interfering RNA by Direct Interaction with the Mammalian RNA Interference Pathway

(2011) G. Fabozzi et al.   JOURNAL OF VIROLOGY

RNA-Based Immunity Terminates Viral Infection in Adult Drosophila in the Absence of Viral Suppression of RNA Interference: Characterization of Viral Small Interfering RNA Populations in Wild-Type and Mutant Flies

(2011) Y.-H. Han et al.   JOURNAL OF VIROLOGY

Identification of human miRNA precursors that resemble box C/D snoRNAs

(2011) Motoharu Ono et al.   NUCLEIC ACIDS RESEARCH

Interferon-stimulated genes and their antiviral effector functions

(2011) John W Schoggins et al.   Current Opinion in Virology

Natural and Experimental Infection of Caenorhabditis Nematodes by Novel Viruses Related to Nodaviruses

(2011) Marie-Anne Félix et al.   PLOS BIOLOGY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

microRNAs regulate human embryonic stem cell division

(2010) Junlin Qi et al.   CELL CYCLE

Molecular basis for an attenuated cytoplasmic dsRNA response in human embryonic stem cells

(2010) Ling-Ling Chen et al.   CELL CYCLE

Viral tricks to grid-lock the type I interferon system

(2010) Gijs A Versteeg et al.   CURRENT OPINION IN MICROBIOLOGY

Canonical and alternate functions of the microRNA biogenesis machinery

(2010) M. M. W. Chong et al.   GENES & DEVELOPMENT

Argonaute proteins at a glance

(2010) C. Ender et al.   JOURNAL OF CELL SCIENCE

Mutations Abrogating VP35 Interaction with Double-Stranded RNA Render Ebola Virus Avirulent in Guinea Pigs

(2010) K. C. Prins et al.   JOURNAL OF VIROLOGY

Hsc70/Hsp90 Chaperone Machinery Mediates ATP-Dependent RISC Loading of Small RNA Duplexes

(2010) Shintaro Iwasaki et al.   MOLECULAR CELL

A direct role for Hsp90 in pre-RISC formation in Drosophila

(2010) Tomohiro Miyoshi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cricket paralysis virus antagonizes Argonaute 2 to modulate antiviral defense in Drosophila

(2010) Arabinda Nayak et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human box C/D snoRNAs with miRNA like functions: expanding the range of regulatory RNAs

(2010) Markus Brameier et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-145 Targets YES and STAT1 in Colon Cancer Cells

(2010) Lea H. Gregersen et al.   PLoS One

Engineered RNA viral synthesis of microRNAs

(2010) A. Varble et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila

(2010) S. Mueller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

(2010) T. Satoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small RNA profiling reveals antisense transcription throughout the KSHV genome and novel small RNAs

(2010) Y.-T. Lin et al.   RNA

Six RNA Viruses and Forty-One Hosts: Viral Small RNAs and Modulation of Small RNA Repertoires in Vertebrate and Invertebrate Systems

(2010) Poornima Parameswaran et al.   PLoS Pathogens

Ars2 Regulates Both miRNA- and siRNA- Dependent Silencing and Suppresses RNA Virus Infection in Drosophila

(2009) Leah R. Sabin et al.   CELL

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I

(2009) Michaela Ulrike Gack et al.   Cell Host & Microbe

Suppression of RNA silencing by Flock house virus B2 protein is mediated through its interaction with the PAZ domain of Dicer

(2009) Gatikrushna Singh et al.   FASEB JOURNAL

Essential and overlapping functions for mammalian Argonautes in microRNA silencing

(2009) H. Su et al.   GENES & DEVELOPMENT

The role of RNAi and microRNAs in animal virus replication and antiviral immunity

(2009) J. L. Umbach et al.   GENES & DEVELOPMENT

Antiviral immunity in Drosophila requires systemic RNA interference spread

(2009) Maria-Carla Saleh et al.   NATURE

MicroRNA-mediated species-specific attenuation of influenza A virus

(2009) Jasmine T Perez et al.   NATURE BIOTECHNOLOGY

Small silencing RNAs: an expanding universe

(2009) Megha Ghildiyal et al.   NATURE REVIEWS GENETICS

Loqs and R2D2 act sequentially in the siRNA pathway in Drosophila

(2009) João Trindade Marques et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs

(2009) C. Cole et al.   RNA

C3PO, an Endoribonuclease That Promotes RNAi by Facilitating RISC Activation

(2009) Y. Liu et al.   SCIENCE

Human miRNA Precursors with Box H/ACA snoRNA Features

(2009) Michelle S. Scott et al.   PLoS Computational Biology

Dengue Virus Type 2 Infections of Aedes aegypti Are Modulated by the Mosquito's RNA Interference Pathway

(2009) Irma Sánchez-Vargas et al.   PLoS Pathogens

Aedes aegypti uses RNA interference in defense against Sindbis virus infection

(2008) Corey L Campbell et al.   BMC MICROBIOLOGY

A Highly Structured, Nuclease-Resistant, Noncoding RNA Produced by Flaviviruses Is Required for Pathogenicity

(2008) Gorben P. Pijlman et al.   Cell Host & Microbe

Mechanism of Induction and Suppression of Antiviral Immunity Directed by Virus-Derived Small RNAs in Drosophila

(2008) Roghiyh Aliyari et al.   Cell Host & Microbe

Endogenous RNA Interference Provides a Somatic Defense against Drosophila Transposons

(2008) Wei-Jen Chung et al.   CURRENT BIOLOGY

Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs

(2008) J. E. Babiarz et al.   GENES & DEVELOPMENT

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Autoinhibition of Human Dicer by Its Internal Helicase Domain

(2008) Enbo Ma et al.   JOURNAL OF MOLECULAR BIOLOGY

A Human snoRNA with MicroRNA-Like Functions

(2008) Christine Ender et al.   MOLECULAR CELL

The C-Terminal Regulatory Domain Is the RNA 5′-Triphosphate Sensor of RIG-I

(2008) Sheng Cui et al.   MOLECULAR CELL

Nonself RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses

(2008) Kiyohiro Takahasi et al.   MOLECULAR CELL

Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells

(2008) Yoshinori Kawamura et al.   NATURE

The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs

(2008) Katsutomo Okamura et al.   NATURE

Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes

(2008) Oliver H. Tam et al.   NATURE

An endogenous small interfering RNA pathway in Drosophila

(2008) Benjamin Czech et al.   NATURE

The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila

(2008) Safia Deddouche et al.   NATURE IMMUNOLOGY

Endogenous siRNAs Derived from Transposons and mRNAs in Drosophila Somatic Cells

(2008) M. Ghildiyal et al.   SCIENCE

The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition

(2008) Nicole Cloonan et al.   GENOME BIOLOGY