Article
Oncology
M. Reyes Oliver-Perez, Pablo Padilla-Iserte, Octavio Arencibia-Sanchez, Cristina Martin-Arriscado, Juan Carlos Muruzabal, Berta Diaz-Feijoo, Silvia Cabrera, Pluvio Coronado, M. Belen Martin-Salamanca, Manuel Pantoja-Garrido, Josefa Marcos-Sanmartin, Elena Cabezas-Lopez, Cristina Lorenzo, Duska Beric, Jose Ramon Rodriguez-Hernandez, Fernando Roldan-Rivas, Juan Gilabert-Estelles, Lourdes Sanchez, Maria Laseca-Modrego, Carmen Tauste-Rubio, Blanca Gil-Ibanez, Alvaro Tejerizo-Garcia
Summary: In patients with early-stage endometrioid endometrial cancer, the presence of lymph vascular space involvement (LVSI) is associated with nodal metastases, shorter disease-free survival and overall survival. However, the impact of LVSI on recurrence patterns and optimal adjuvant treatment is unclear. Our study aims to analyze oncological outcomes and recurrence patterns based on LVSI status in these patients, and determine preoperative predictors of positive LVSI.
Article
Obstetrics & Gynecology
Serhat Toprak, Eda Adeviye Sahin, Hanifi Sahin, Yusuf Aytac Tohma, Ercan Yilmaz, Mehmet Mutlu Meydanli
Summary: Lymphovascular space invasion, primary tumor diameter of at least 3 cm, and at least 50% deep myometrial invasion are independent predictors of cervical stromal involvement in patients with endometrioid-type endometrial cancer.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Biology
Eric M. Anderson, Michael Luu, Mitchell Kamrava
Summary: The presence of lymph node involvement in endometrial cancer patients guides treatment decisions. This study used a database of patients diagnosed between 2004 and 2016 to identify predictors of lymph node involvement. In addition to tumor characteristics, patient age and race were found to be associated with a higher risk of lymph node involvement.
Article
Oncology
Eric M. Anderson, Michael Luu, Diana J. Lu, Eric M. Chung, Mitchell Kamrava
Summary: This study aimed to investigate the risk factors for lymph node involvement in patients with less common histologies of endometrial cancer. The study found that predictors of lymph node positivity in non-endometrioid endometrial cancer patients are similar to endometrial adenocarcinoma, which could be helpful in making adjuvant treatment decisions for these less common histologies.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Beatriz Navarro, Chrysoula Margioula-Siarkou, Stamatios Petousis, Anne Floquet, Guillame Babin, Frederic Guyon
Summary: The study investigated the impact of surgical restaging on survival outcomes in early-stage endometrial cancer patients with positive lymphovascular space invasion (LVSI). The results showed that restaging with lymphadenectomy did not alter the prognosis of these patients, suggesting that it may be omitted as a treatment option.
Article
Oncology
Mathilde Maire, Aurelien Bourdon, Isabelle Soubeyran, Carlo Lucchesi, Frederic Guyon, Guillaume Babin, Anne Floquet, Adeline Petit, Jessica Baud, Valerie Velasco, Denis Querleu, Sabrina Croce
Summary: This study describes the transcriptomic landscape associated with lymph node metastases in endometroid endometrial carcinomas and generated a 54-gene expression signature that can predict lymph node invasion pre-operatively.
Review
Urology & Nephrology
Friedemann Zengerling, Dirk Beyersdorff, Jonas Busch, Julia Heinzelbecker, David Pfister, Christian Ruf, Christian Winter, Peter Albers, Sabine Kliesch, Stefanie Schmidt
Summary: In this study, a systematic evaluation of prognostic factors for tumor recurrence in clinical stage I nonseminoma patients was conducted. The results indicate that no additional factors were identified that have the same prognostic value as lymphovascular invasion (LVI). However, the presence of embryonal carcinoma (EC) may serve as a secondary prognostic factor, but further optimization and validation are required.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Pathology
Simona Stolnicu, Lien Hoang, Noorah Almadani, Louise De Brot, Glauco Baiocchi, Graziele Bovolim, Maria Jose Brito, Georgia Karpathiou, Antonio Ieni, Esther Guerra, Takako Kiyokawa, Pavel Dundr, Carlos Parra-Herran, Sofia Lerias, Ana Felix, Andres Roma, Anna Pesci, Esther Oliva, Kay J. Park, Robert A. Soslow, Nadeem R. Abu-Rustum
Summary: The Silva invasion pattern and lymphovascular invasion are important prognostic factors in stage IA1-IB1 endocervical adenocarcinomas. Patients can be categorized into low risk and high risk groups based on the binary Silva classification system.
Article
Oncology
Xue-Fei Liu, Bi-Cong Yan, Ying Li, Feng-Hua Ma, Jin-Wei Qiang
Summary: A radiomics nomogram based on MRI was established to predict LVSI in patients with early-stage EC, providing a new method for clinical prediction of LVSI.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Kaoru Okugawa, Hideaki Yahata, Kazuhisa Hachisuga, Hiroshi Tomonobe, Nobuko Yasutake, Keisuke Kodama, Hironori Kenjo, Hiroshi Yagi, Tatsuhiro Ohgami, Masafumi Yasunaga, Ichiro Onoyama, Kazuo Asanoma, Emiko Hori, Yoshihiro Ohishi, Yoshinao Oda, Kiyoko Kato
Summary: This study evaluated the clinical significance of lymphovascular space invasion (LVSI) in stage IA endometrial cancer. The results showed that LVSI was not a prognostic factor for both stage IA endometrial cancer and low-grade cancer.
Review
Oncology
Xiaoying Jin, Chunjuan Shen, Xiaodi Yang, Yayuan Yu, Jianzhang Wang, Xuan Che
Summary: This study conducted a meta-analysis and found that primary tumor size > 20 mm was significantly associated with depth of MI, positive LVSI, positive LNM, recurrence, and poor OS. Therefore, considering the value of tumor size is crucial in the clinicopathological staging of endometrial carcinoma, and tumor size > 20 mm should be integrated into the intraoperative algorithm for performing a full surgical staging.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Jianzhang Wang, Ping Xu, Xueying Yang, Qin Yu, Xinxin Xu, Gen Zou, Xinmei Zhang
Summary: This meta-analysis study found that deep myometrial invasion is positively associated with lymphovascular space invasion, lymph node metastasis, cancer recurrence, and overall survival in endometrial cancer patients. It suggests that myometrial invasion can be a useful evaluation criterion for clinical outcomes and prognosis of endometrial cancer, highlighting the importance of paying attention to myometrial invasion in clinical practice. Further investigation into the underlying mechanisms is warranted.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Sang Il Kim, Joo Hee Yoon, Sung Jong Lee, Min Jong Song, Jin Hwi Kim, Hae Nam Lee, Gyul Jung, Ji Geun Yoo
Summary: The study identified tumor size, depth of myometrial invasion, and presence of cervical stromal invasion as risk factors for lymphovascular space invasion (LVSI) in patients with endometrioid endometrial cancer. A simplified LVSI prediction model was developed and shown to have good predictive value for clinical use.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Rosemary Noel Senguttuvan, Christina Wei, Mustafa Raoof, Thanh H. Dellinger, Edward Wenge Wang
Summary: Treatment for endometrial cancer is evolving with the use of somatic tumor RNA sequencing. PARP inhibition is uncommon in endometrial cancer due to rare mutations, and no FDA approval exists. We present a case of a patient with stage IVB endometrial cancer who achieved a pathologic complete response following compassionate use of Olaparib.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Kevin X. Liu, Michael G. Milligan, Jonathan D. Schoenfeld, Roy B. Tishler, Andrea K. Ng, Phillip M. Devlin, Elliott Fite, Guilherme Rabinowits, Glenn J. Hanna, Ann W. Silk, Charles H. Yoon, Manisha Thakuria, Danielle N. Margalit
Summary: Limited data exists regarding the efficacy of curative hypofractionated radiotherapy (hypoRT) regimens compared to conventionally-fractionated radiotherapy (conv-RT) for Merkel cell carcinoma (MCC), but this retrospective analysis found no significant difference in in-field locoregional relapse rate and MCC-specific survival rate between the two treatment options.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Obstetrics & Gynecology
Ashley Veade, Caitlin Martin, Michael Dombrowski, Kennan Omurtag
Summary: There is a recent decrease in fertility rates among the general population in the United States, including female physicians. Despite the increasing number of female physicians seeking assisted reproductive technology, there is a lack of access to adequate insurance coverage for this higher-risk patient subset. Recent studies suggest that up to 25% of female physicians are seeking assisted reproductive technology.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)