Article
Oncology
Kyungsu Kim, Kook Nam Han, Byeong Hyeon Choi, Jiyun Rho, Jun Hee Lee, Jae Seon Eo, Chungyeul Kim, Beop-Min Kim, Ok Hwa Jeon, Hyun Koo Kim
Summary: The feasibility of using Indocyanine green (ICG) to detect metastatic lymph nodes and tumors was evaluated in both animal and clinical studies. ICG successfully detected metastatic lymph nodes and tumors. However, due to its low fluorescence, it may be challenging to detect tumors in vivo using ICG.
Review
Oncology
Julio Jimenez-Lillo, Eduardo Villegas-Tovar, Dulce Momblan-Garcia, Victor Turrado-Rodriguez, Ainitze Ibarzabal-Olano, Borja De Lacy, Alejandro Diaz-Giron-Gidi, Regina Faes-Petersen, Raigam J. Martinez-Portilla, Antonio Lacy
Summary: The study evaluated the detection rate of ICG imaging for sentinel lymph node mapping and lymph node metastases in esophageal cancer, with a detection rate of 89% for SLNM and a sensitivity of 84% for LNMs in the pooled analysis.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Materials Science, Biomaterials
Ye Ri Han, Da-Sol Lee, Sang Bong Lee, Hui-Jeon Jeon, Sijoon Lee, Soo-Eun Sung, Chang-Hee Lee, Sung Jin Cho, Kil Soo Kim, Dong-Su Kim, Yong Hyun Jeon
Summary: Novel phenaleno isoquinolinium-based fluorescent agents have been developed for sensitive detection of sentinel lymph nodes, showing potential for clinical applications.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Oncology
E. Kacmaz, M. D. Slooter, E. J. M. Nieveen van Dijkum, P. J. Tanis, A. F. Engelsman
Summary: This study evaluates the potential value of intraoperative fluorescence angiography in small bowel neuroendocrine neoplasm surgery. The results show that FA led to a management change in 80% of patients, aiding in better tailoring the extent of small bowel resection.
Article
Oncology
Gyung Mo Son, Mi Sook Yun, In Young Lee, Sun Bin Im, Kyung Hee Kim, Su Bum Park, Tae Un Kim, Dong-Hoon Shin, Armaan M. Nazir, Gi Won Ha
Summary: Fluorescence lymph node mapping (FLNM) is a promising method to improve the completeness and quality of D3 lymph node dissection in colon cancer surgery, by increasing the number of harvested D3 lymph nodes and enhancing the detection rate of metastatic lymph nodes.
Article
Surgery
Jens Osterkamp, Rune Strandby, Nikolaj Nerup, Morten-Bo Svendsen, Lars-Bo Svendsen, Michael Achiam
Summary: This study investigated the use of intraoperative ICG lymphography in robot-assisted resection of GEJ cancer. The results showed that this technique could aid in LN detection without increasing surgical risk. However, none of the dissected LNs were found to be metastatic. Therefore, the potential improvement in oncological outcomes with NIR lymphography remains uncertain.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Oncology
Yiqun Liao, Jiahao Zhao, Yuji Chen, Bin Zhao, Yongkun Fang, Fei Wang, Chen Wei, Yichao Ma, Hao Ji, Daorong Wang, Dong Tang
Summary: Indocyanine green enhanced fluorescence imaging has potential in gastric oncological surgery, but it is limited by false negative lymph nodes and loss of specificity. Current research aims to improve sensitivity and specificity, and quantify the intensity and distribution pattern of ICG.
Correction
Chemistry, Multidisciplinary
Long Wang, Yihe Hu, Qinghai Peng, Jiawei Zhou, Qichang Zhou, Senbo An, Chengcheng Niu
Summary: By loading indocyanine green dye into microbubbles and using near-infrared fluorescence/ultrasound imaging, Wang et al. successfully localized the sentinel lymph node. This study demonstrates good feasibility and potential for clinical application.
Article
Surgery
Kenjiro Jimbo, Uta Nakadaira, Chikashi Watase, Takeshi Murata, Sho Shiino, Shin Takayama, Akihiko Suto
Summary: The combination of radioisotopes and indocyanine green enables accurate detection of metastatic sentinel lymph nodes in breast cancer patients. However, there are discordances in sentinel lymph node reactivity between different tracers. Therefore, axillary lymph node dissection should be considered in these cases to ensure accurate nodal staging.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Cell Biology
Yaoping Zhu, Tao Xiao, Yijia He, Xiaowei Hong, Ting Zhou, Mingjie Da, Sumeng Ge, Diya Xie, Zhiyong Wang
Summary: This study successfully identified lingual lymph nodes and described the presence of lymphatic drainage channels in the floor of the mouth using intraoperative near-infrared fluorescence imaging with indocyanine green absorbed into human serum albumin. The technique could assist in determining metastatic lymph nodes in tongue carcinoma patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Meriem Koual, Louise Benoit, Huyen-Thu Nguyen-Xuan, Enrica Bentivegna, Henri Azais, Anne-Sophie Bats
Summary: The use of ICG coupled with NIR fluorescence imaging in SLN mapping for vulvar cancer shows good feasibility and accuracy, with a detection rate ranging from 89.7% to 100%. Studies with more metastatic lymph nodes tend to have lower SLN detection rates. There is no consensus on the optimal use of ICG.
GYNECOLOGIC ONCOLOGY
(2021)
Review
Medicine, General & Internal
Zoe Garoufalia, Steven D. D. Wexner
Summary: ICG imaging is increasingly used in colorectal surgery for perfusion assessment, ureteral and urethral assessment, lymphatic mapping, and assessment of hepatic and peritoneal metastases. Although evidence level is low, promising results have been observed, especially in reducing anastomotic leaks. ICG imaging is a safe and relatively cheap imaging modality in colorectal surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Manabu Kakizoe, Jun Watanabe, Yusuke Suwa, Kazuya Nakagawa, Hirokazu Suwa, Mayumi Ozawa, Atsushi Ishibe, Hidenobu Masui, Kaoru Nagahori
Summary: This study investigated the relationship between indocyanine green fluorescent imaging (ICG-FI) and histopathological findings of regional lymph node metastasis in splenic flexural colon cancer. The study found that occupied lymph nodes did not show fluorescence, but 80% of non-occupied lymph nodes did show fluorescence. Even non-occupied lymph nodes showing fluorescence did not have fluorescence at the cancer site, indicating that lymph node dissection should not be omitted even if intraoperative ICG-FI does not show fluorescence.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Oncology
Francesco Claps, Pedro de Pablos-Rodriguez, Alvaro Gomez-Ferrer, Juan Manuel Mascaros, Jose Marenco, Argimiro Collado Serra, Juan Casanova Ramon-Borja, Ana Calatrava Fons, Carlo Trombetta, Jose Rubio-Briones, Miguel Ramirez-Backhaus
Summary: This study confirms that F-ICG-guided lymphangiography correctly staged almost 98% of patients with high negative predictive value and safety. More conservative approaches might minimize perioperative morbidity during LNMs diagnosis in selected patients.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Surgery
Claudia A. Bargon, Anne Huibers, Danny A. Young-Afat, Britt A. M. Jansen, Inne H. M. Borel-Rinkes, Jules Lavalaye, Henk-Jan Van Slooten, Helena M. Verkooijen, Christiaan F. P. van Swol, Annemiek Doeksen
Summary: This study compared the detection rate of indocyanine green (ICG)-fluorescent imaging and Tc-99m-nanocoilloid for sentinel lymph node (SLN)-mapping in breast cancer patients. The results showed that ICG-fluorescence had a higher detection rate than Tc-99m-nanocoilloid, and both methods had equal detection rates for pathological lymph nodes. The study suggests that ICG-fluorescence may be a safe and effective alternative for SLNB in early-stage breast cancer patients.
Article
Oncology
Ali Bohlok, Camille Mercier, Fikri Bouazza, Maria Gomez Galdon, Luigi Moretti, Vincent Donckier, Issam El Nakadi, Gabriel Liberale
SUPPORTIVE CARE IN CANCER
(2020)
Article
Oncology
Valerio Lucidi, Ali Bohlok, Gabriel Liberale, Mattia Bez, Desislava Germanova, Fikri Bouazza, Pieter Demetter, Denis Larsimont, Philippe Aftimos, Nicolas Roydon Smoll, Vincent Donckier
Review
Oncology
G. Bregni, T. Akin Telli, S. Camera, C. Baratelli, L. Shaza, A. Deleporte, L. Moretti, M. A. Bali, G. Liberale, A. Hendlisz, F. Sclafani
CANCER TREATMENT REVIEWS
(2020)
Article
Surgery
G. Liberale, C-F Pop, L. Polastro, J. Kerger, M. Moreau, M. Chintinne, D. Larsimont, J. M. Nogaret, I Veys
JOURNAL OF VISCERAL SURGERY
(2020)
Letter
Oncology
Giacomo Bregni, Caroline Vandeputte, Andrea Pretta, Chiara Senti, Elena Trevisi, Elena Acedo Reina, Pashalina Kehagias, Gabriel Liberale, Luigi Moretti, Maria Antonietta Bali, Pieter Demetter, Patrick Flamen, Javier Carrasco, Lionel D'Hondt, Karen Geboes, Yeter Gokburun, Marc Peeters, Marc Van den Eynde, Jean-Luc Van Laethem, Philippe Vergauwe, Camille Anastasia Chapot, Marc Buyse, Amelie Deleporte, Alain Hendlisz, Francesco Sclafani
Article
Oncology
Deborah J. Repullo, Sandrine Barbois, Daniel Leonard, Ali Bohlok, Estelle T. Van den Audenaeren, Alain Hendlisz, Marc Van den Eynde, Vincent Donckier, Alex Kartheuser, Gabriel Liberale
Summary: The study compared the outcomes of patients with colorectal peritoneal metastasis treated with complete CRS and HIPEC with or without perioperative systemic chemotherapy (PCT). Results showed no clear benefit of PCT in terms of survival rates. Further research, including ongoing trials, is needed to clarify the role of PCT in patients with resectable PM.
Article
Surgery
Gabriel Liberale, Hans Van Veer, Jean Lemaitre, Marc Duinslager, Dirk Ysebaert, Arnaud De Roover, Charles de Gheldere, Niels Komen
Summary: The national survey in Belgium found that the COVID-19 outbreak severely impacted in-person consultations and surgical activities for benign and malignant disease, with procedures for benign disease being much more affected than those for malignancies.
ACTA CHIRURGICA BELGICA
(2022)
Article
Multidisciplinary Sciences
Yoon Penning, Antoine El Asmar, Michel Moreau, Julie Raspe, Lissandra Dal Lago, Thierry Pepersack, Vincent Donckier, Gabriel Liberale
Summary: The concept of frailty extends beyond chronological age. Using a two-step approach of screening with the G8 tool followed by comprehensive geriatric assessment (CGA) can guide treatment decisions and follow-up for oncogeriatric patients. This study found an association between G8 scores and CGA results, as well as the risk of postoperative complications. Identifying altered preoperative nutritional status can help optimize treatment decision making and improve outcomes.
Article
Oncology
Antoine El Asmar, Karim Hafez, Pauline Fauconnier, Michel Moreau, Lissandra Dal Lago, Thierry Pepersack, Vincent Donckier, Gabriel Liberale
Summary: This study evaluated the predictive performance of the ACS-SRC in patients undergoing surgery for abdominal malignancies. The results showed that the ACS-SRC had good predictive power for serious complications and pneumonia, but poor predictive power for sepsis, urinary tract infection, and surgical site infection.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Niels Komen, Hans van Veer, Gabriel Liberale, Arnaud Deroover, Dirk Ysebaert, Marc Duinslaeger, Jean Lemaitre, Charles de Gheldere
Summary: Due to COVID-19 restrictions, the 2020 Belgian Surgical Week was organized as a virtual congress. The event was successful, but attendees still preferred in-person meetings. However, there is potential in integrating the advantages of virtual meetings into live events.
ACTA CHIRURGICA BELGICA
(2023)
Article
Oncology
Fawaz Jade, Pocard Marc, Liberale Gabriel, Eveno Clarisse, Malgras Brice, Sideris Lucas, Huebner Martin, Sabbagh Charles, Sgarbura Olivia, Taibi Abdelkader, Hobeika Christian
Summary: A tool was created to refine the timing of early second-look laparoscopic exploration in patients at high risk of peritoneal metastasis recurrence after colon cancer surgery. The study found that synchronous limited peritoneal metastasis and/or ovarian metastasis were associated with very high-risk patients requiring early second-look laparoscopic exploration.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Antoine El Asmar, Isabelle Veys, Denis Larsimont, Vincent Donckier, Gabriel Liberale
Summary: This study reports a metastatic lymphatic pathway in patients with peritoneal carcinomatosis, which may represent a significant route for abdominal metastasis. Incidental findings of lymph nodes containing metastatic cancer cells were detected during surgery, which were not visible on preoperative imaging in some patients.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Health Care Sciences & Services
Gabriel Liberale, Sophie Vankerckhove, Fikri Bouazza, Maria Gomez Galdon, Denis Larsimont, Michel Moreau, Pierre Bourgeois, Vincent Donckier
JMIR RESEARCH PROTOCOLS
(2020)
Meeting Abstract
Oncology
Giacomo Bregni, Tugba Akin Telli, Silvia Camera, Chiara Baratelli, Leila Shaza, Amelie Deleporte, Luigi Moretti, Gabriel Liberale, Alain Hendlisz, Francesco Sclafani
JOURNAL OF CLINICAL ONCOLOGY
(2020)
