Review
Physiology
Jea Giezl Niedo Solidum, Youngjae Jeong, Francisco Heralde III, Dongsu Park
Summary: Skeletal stem/progenitor cells (SSPCs) play crucial roles in skeletal development, bone remodeling, and repair. Recent studies have revealed the presence of distinct SSPC populations in various skeletal compartments. The regulatory mechanisms for these cells differ based on their cellular and matrix environment, embryonic origin, and adjacent tissue structures. Understanding these regulatory differences is important for discovering novel treatment approaches for bone repair.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Oncology
Ziyi Zhao, Yingwei Sun, Jing Tang, Yuting Yang, Xiaochao Xu
Summary: LRPPRC plays critical roles in regulating mitochondrial homeostasis, mitochondrial function, and tumorigenesis in osteosarcomas and osteosarcoma-derived CSCs, suggesting it may be a promising therapeutic target for osteosarcomas.
Article
Biochemistry & Molecular Biology
Hyewon Jang, Jiyeon Ham, Jisoo Song, Gwonhwa Song, Whasun Lim
Summary: Alpinumisoflavone is a natural compound with beneficial properties such as antioxidant, anti-inflammatory, antibacterial, osteoprotective, and neuroprotective effects. This study demonstrates the anti-cancer effects of alpinumisoflavone on hepatocellular carcinoma (HCC), showing its inhibition on cell viability, regulation of the MAPK/PI3K pathway, depolarization of mitochondrial membrane potential, suppression of mitochondrial respiration, dysregulation of mitochondrial complexes, accumulation of calcium ions in the mitochondria, and induction of mitochondria-mediated apoptosis.
Article
Biochemistry & Molecular Biology
Austin C. Boese, Sumin Kang
Summary: Cancer cells exhibit abnormal metabolic activity, often preferring aerobic glycolysis, and mitochondrial metabolic pathways are also reprogrammed in cancer. Cancer cells have higher levels of reactive oxygen species compared to non-cancerous cells and must employ diverse metabolic strategies to prevent oxidative stress.
Review
Endocrinology & Metabolism
Ila Tewari Jasra, Nerea Cuesta-Gomez, Kevin Verhoeff, Braulio A. Marfil-Garza, Nidheesh Dadheech, A. M. James Shapiro
Summary: This review summarizes the roles and mechanisms of mitochondria in somatic cell reprogramming to iPSCs and the metabolic shift associated with directed differentiation into pancreatic beta-like cells.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Chengxiang Li, Guofu Pi, Feng Li
Summary: The intestinal flora, considered as the second gene pool of the human body, has a complex symbiotic relationship with the host and can regulate bone homeostasis through the host immune, metabolic, and endocrine systems. Changing the composition and function of the intestinal flora using probiotics, prebiotics, and fecal microbiota transplantation is being explored as a potential novel approach for regulating bone homeostasis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Chujiao Lin, Qiyuan Yang, Dongsheng Guo, Jun Xie, Yeon-Suk Yang, Sachin Chaugule, Ngoc DeSouza, Won-Taek Oh, Rui Li, Zhihao Chen, Aijaz A. John, Qiang Qiu, Lihua Julie Zhu, Matthew B. Greenblatt, Sankar Ghosh, Shaoguang Li, Guangping Gao, Cole Haynes, Charles P. Emerson, Jae-Hyuck Shim
Summary: This study demonstrates that mitochondrial oxidative phosphorylation is the major energy source for osteogenesis of skeletal progenitors. Deletion of ECSIT hinders bone formation and regeneration, resulting in skeletal deformity and defects in the bone marrow niche.
NATURE COMMUNICATIONS
(2022)
Review
Endocrinology & Metabolism
Siyuan Zhu, Yidan Pang, Jun Xu, Xiaoyi Chen, Changqing Zhang, Bo Wu, Junjie Gao
Summary: Thyroid hormones play significant roles in bone growth and development, and an imbalance of thyroid hormones can impair bone homeostasis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Hongyu Liao, Yan Qi, Yida Ye, Peng Yue, Donghui Zhang, Yifei Li
Summary: Mitochondria play a crucial role in cardiomyocytes and maintaining mitochondrial homeostasis is essential for normal heart function. Mechanotransduction pathways are involved in regulating physiological and pathophysiological states of cardiomyocytes, influencing mitochondrial function by modulating mitochondrial-related genes. Restoring mitochondrial function by shutting down excessive mechanotransduction pathways is a promising therapeutic strategy for cardiovascular diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Editorial Material
Cell Biology
Louis Gervais, Allison J. Bardin
Summary: The vascular system is a crucial regulator of adult stem cells, as demonstrated by two studies showing that the vascular-like Drosophila trachea undergoes reshaping after intestinal damage or tumor formation, which is necessary for compensatory intestinal stem cell proliferation and tumor growth.
NATURE CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Won Dong Yu, Yu Jin Kim, Min Jeong Cho, Gi Jin Kim, Soon Ha Kim, Myung Joo Kim, Jung Jae Ko, Jae Ho Lee
Summary: This study found that MIT-001 can protect the altered phenotypes and mitochondrial features of MSCs exposed to inflammatory cytokines, improving mitochondrial quiescence and cellular phenotypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Zhenya Tan, Chen Kan, Mandy Wong, Minqiong Sun, Yakun Liu, Fan Yang, Siying Wang, Hong Zheng
Summary: The bone marrow microenvironment plays a crucial role in both normal hematopoietic stem cells and pathological leukemic stem cells. Mesenchymal stem cells (MSCs) are particularly involved in leukemia progression, chemoresistance, and relapse. The abnormal behavior of MSCs can contribute to the initiation and development of leukemia. This article summarizes the detailed relationship between MSCs and leukemia, including how MSCs actively and passively regulate leukemia progression through various mechanisms. The recent advances in therapy targeting MSCs are also discussed, aiming to provide new perspectives and therapeutic strategies for leukemia treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Kangyi Hu, Zhengya Shang, Xiaorui Yang, Yongjie Zhang, Linzhong Cao
Summary: Bone immunity is the intersection between the skeletal and immune systems, involving various signaling pathways and the interaction between immune cells and bone cells. Macrophages, as key cell types in bone immunity, can polarize into pro-inflammatory M1 macrophages and anti-inflammatory M2 macrophages, playing different roles in bone metabolism. Imbalanced polarization of macrophages can lead to immune dysregulation and release of inflammatory factors, affecting bone metabolism and causing diseases such as osteoporosis and rheumatoid arthritis.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Medicine, Research & Experimental
Xiaoya Zhou, Li Huang, Jieying Wu, Yuhua Qu, Hua Jiang, Jinqiu Zhang, SiYuan Qiu, Can Liao, Xiang Xu, Jianchuan Xia, Qizhou Lian
Summary: Beta-thalassemia is a hereditary disease that can lead to ineffective erythropoiesis. Patients with the condition often require long-term blood transfusions, which can result in iron overload and various complications. Iron overload affects the bone marrow microenvironment, impacting the function of stem cells and leading to pathologies associated with beta-thalassemia.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Linlin Zhang, Jingyi Qi, Xu Zhang, Xiya Zhao, Peng An, Yongting Luo, Junjie Luo
Summary: Mitochondria are essential for cellular energy metabolism and the generation of oxygen free radicals, and also play a crucial role in cell death. Ca2+ acts as a messenger for cell proliferation and death, and is involved in the energy metabolism, physiology, and pathology of mitochondria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chun-Lei Deng, Cheng-Biao Hu, Sheng-Tao Ling, Na Zhao, Li-Hui Bao, Feng Zhou, Ye-Cheng Xiong, Tao Chen, Bing-Dong Sui, Xiao-Rui Yu, Cheng-Hu Hu
Summary: The study revealed the therapeutic effects and mechanisms of mesenchymal stem cell transplantation and exosomal transplantation on photoreceptor injuries, with a focus on miR-21 mediation for photoreceptor viability. These methods demonstrated long-lasting efficacy in treating retinal degenerative diseases, highlighting their potential as a therapeutic approach.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Cell & Tissue Engineering
Na Zhao, Ying-Feng Gao, Lei Bao, Jing Lei, Huan-Xiao An, Feng-Xing Pu, Rui-Ping Cheng, Ji Chen, Hua Ni, Bing-Dong Sui, Fan-Pu Ji, Cheng-Hu Hu
Summary: The study compared the efficacy of FMD and UC-MSC infusion in treating T2D, finding that the combined use of both improved hyperglycemia and lipid metabolism. While UC-MSCs were effective in improving hyperglycemia, FMD was effective in restoring lipid metabolism, and their combined effects showed potential in T2D therapy.
STEM CELL RESEARCH & THERAPY
(2021)
Correction
Cell & Tissue Engineering
Xiaoyao Huang, Zihan Li, Peisheng Liu, Meiling Wu, An-qi Liu, Chenghu Hu, Xuemei Liu, Hao Guo, Xiaoxue Yang, Xiaohe Guo, Bei Li, Xiaoning He, Kun Xuan, Yan Jin
STEM CELLS INTERNATIONAL
(2021)
Article
Chemistry, Physical
Cheng-Hu Hu, Bing-Dong Sui, Jin Liu, Lei Dang, Ji Chen, Chen-Xi Zheng, Songtao Shi, Na Zhao, Min-Yan Dang, Xiao-Ning He, Li-Qiang Zhang, Ping-Ping Gao, Nan Chen, Hui-Juan Kuang, Kai Chen, Xiao-Lin Xu, Xiao-Rui Yu, Ge Zhang, Yan Jin
Summary: Sympathetic neurostimulation through beta(1/2)-adrenergic receptor signaling triggers the transcription of miR-21 in osteoblasts, which is then transferred to osteoclast progenitors via exosomes to dictate osteoclastogenesis. Pharmacological inhibition of exosome release can suppress this miR-21 transfer and ameliorate bone loss under stress-induced depression conditions.
Article
Dentistry, Oral Surgery & Medicine
Bingdong Sui, Jin Liu, Chenxi Zheng, Lei Dang, Ji Chen, Yuan Cao, Kaichao Zhang, Lu Liu, Minyan Dang, Liqiang Zhang, Nan Chen, Tao He, Kun Xuan, Fang Jin, Ge Zhang, Yan Jin, Chenghu Hu
Summary: This study reveals the crucial role of sympathetic cues in regulating bone homeostasis and neurostress-induced bone loss. The research focuses on the impact of sympatho-adrenergic activation on osteoclastogenesis and identifies miR-21 as a key regulator in this process. Targeted inhibition of miR-21 or suppression of osteoclastogenesis using drugs can protect bone against stress-induced osteopenias.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Article
Engineering, Biomedical
Runci Wang, Meng Hao, Xiaoxing Kou, Bingdong Sui, Maria Laura Sanmillan, Xiao Zhang, Dawei Liu, Jun Tian, Wenjing Yu, Chider Chen, Ruili Yang, Lingyun Sun, Yi Liu, Claudio Giraudo, Deepak A. Rao, Nan Shen, Songtao Shi
Summary: Mesenchymal stem cells influence T cells through extracellular vesicles, and in this study, we demonstrate the immunomodulatory potential of apoptotic vesicles generated by MSCs. Replenishing apoVs in Fas mutant mice rescued the deficiency and improved inflammation and lupus activity. ApoVs directly interacted with CD4+ T cells, inhibiting CD25 expression and IL-2 production.
BIOACTIVE MATERIALS
(2023)
Article
Cell Biology
Jia Guo, Feng Zhou, Zhi Liu, Yuan Cao, Wanming Zhao, Zheru Zhang, Qiming Zhai, Yan Jin, Bei Li, Fang Jin
Summary: Combining exosomes with dental pulp stem cells (DPSCs) has a remarkable effect on bone regeneration. Exosomes promote osteogenic differentiation of DPSCs by transferring mitochondrial transcription factor A (TFAM) mRNA and enhancing glutamate metabolism and oxidative phosphorylation (OXPHOS) activity. This study provides a new potential strategy to improve DPSC-based bone regenerative treatment.
CELL PROLIFERATION
(2022)
Review
Physiology
Bing-Dong Sui, Chen -Xi Zheng, Wan -Min Zhao, Kun Xuan, Bei Li, Yan Jin
Summary: Teeth are highly specialized organs that perform important functions for humans. However, they have limited ability to repair themselves, leading to a high prevalence of tooth loss and defects worldwide. Regenerative medicine offers the potential for restoring lost or damaged teeth, and recent advancements in developmental engineering have made tooth regeneration possible. Mesenchymal condensation, a key process in tooth development, has been studied and utilized for regenerative purposes, resulting in successful tooth regeneration in animals and humans. This review summarizes the process of mesenchymal condensation and highlights the achievements and mechanisms of tooth regeneration through condensation-mimetic engineering using dental stem cells.
PHYSIOLOGICAL REVIEWS
(2023)
Correction
Multidisciplinary Sciences
Cheng-Hu Hu, Bing-Dong Sui, Fang-Ying Du, Yi Shuai, Chen-Xi Zheng, Pan Zhao, Xiao-Rui Yu, Yan Jin
SCIENTIFIC REPORTS
(2022)
Review
Medicine, General & Internal
C. Ma, Y. Zhang, Y. Cao, C-H Hu, C-X Zheng, Y. Jin, B-D Sui
Summary: Efficient bone regeneration is a major challenge in medicine, especially under the emerging psychological stress in modern society. The brain-bone axis and autonomic nerves play important roles in bone homeostasis and degenerative diseases. This review summarizes the distribution characteristics and regulatory effects of autonomic nerves on bone stem cell lineages, and highlights their crucial role in bone physiology and pathology. It also discusses the autonomic neural basis of psychological stress-induced bone loss and potential pharmaceutical therapeutic strategies for bone regeneration.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Cell Biology
Tao Jiang, Yanmin Xia, Wenzhe Wang, Jinbo Zhao, Wenhao Liu, Shiyu Liu, Songtao Shi, Bei Li, Xiaoning He, Yan Jin
Summary: Apoptotic bodies (ABs) released by transplanted human umbilical cord MSCs (UC-MSCs) convert macrophages from a pro-inflammatory to an anti-inflammatory state, ameliorating acute lung injury (ALI) in a mouse model. This effect is mediated by the interaction between programmed cell death 1 ligand 1 (PDL1) on UC-MSCs-derived ABs and programmed cell death protein 1 (PD1) on host macrophages, leading to the reprogramming of macrophage metabolism. The potential clinical implications of developing therapeutic strategies for ALI patients are suggested.
CELL PROLIFERATION
(2023)
Correction
Medicine, Research & Experimental
Ya-Jie Lv, Yi Yang, Bing-Dong Sui, Cheng-Hu Hu, Pan Zhao, Li Li, Ji Chen, Li-Qiang Zhang, Tong-Tao Yang, Shao-Feng Zhang, Yan Jin
Correction
Cell Biology
Pan Zhao, Bing-Dong Sui, Nu Liu, Ya-Jie Lv, Chen-Xi Zheng, Yong-Bo Lu, Wen-Tao Huang, Cui-Hong Zhou, Ji Chen, Dan-Lin Pang, Dong-Dong Fei, Kun Xuan, Cheng-Hu Hu, Yan Jin
Review
Cell & Tissue Engineering
Ji Chen, Chen-Xi Zheng, Yan Jin, Cheng-Hu Hu
Summary: Type 2 diabetes mellitus (T2DM) poses a major threat to global public health, with immune dysfunction recognized as a crucial contributor to its pathogenesis. Mesenchymal stromal cells (MSCs) have emerged as promising therapeutic agents for T2DM, with their immunomodulatory effects mediated through paracrine mechanisms and extracellular vesicles (EVs). Preclinical studies have shown the benefits of MSCs in improving islet function and insulin resistance, while clinical trials have further supported their therapeutic potential for T2DM.
