Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 44, Issue 9, Pages 752-764Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2019.03.011
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Funding
- European Research Council (DYNACOMP)
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Strict regulation of DNA replication is of fundamental significance for the maintenance of genome stability. Licensing of origins of DNA replication is a critical event for timely genome duplication. Errors in replication licensing control lead to genomic instability across evolution. Here, we present accumulating evidence that aberrant replication licensing is linked to oncogene-induced replication stress and poses a major threat to genome stability, promoting tumorigenesis. Oncogene activation can lead to defects in where along the genome and when during the cell cycle licensing takes place, resulting in replication stress. We also discuss the potential of replication licensing as a specific target for novel anticancer therapies.
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