Review
Oncology
Aysooda Hosseinzadeh, Parnaz Merikhian, Nazanin Naseri, Mohammad Reza Eisavand, Leila Farahmand
Summary: This article discusses the resistance mechanisms to trastuzumab in breast cancer and proposes MUC1 as a potential target to overcome this resistance. It has been found that silencing the MUC1-C proto-oncogene can increase the sensitivity of HER2(+) cells to trastuzumab.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Satoshi Takahashi, Rintaro Noro, Masahiro Seike, Chao Zeng, Masaru Matsumoto, Akiko Yoshikawa, Shinji Nakamichi, Teppei Sugano, Mariko Hirao, Kuniko Matsuda, Michiaki Hamada, Akihiko Gemma
Summary: This study identified that CRNDE is associated with the development of resistance to EGFR-TKIs in lung cancer cells. Inhibition of CRNDE activated the eIF4A3/MUC1/EGFR signaling pathway and apoptotic activity, restoring sensitivity to EGFR-TKIs. These findings suggest that CRNDE may be a potential therapeutic target for overcoming EGFR-mutant NSCLC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Yujia Zhao, Dai Xiao, Luwen Zhang, Daili Song, Rui Chen, Shiqian Li, Yijie Liao, Yimin Wen, Weizhe Liu, Enbo Yu, Yiping Wen, Rui Wu, Qin Zhao, Senyan Du, Xintian Wen, Sanjie Cao, Xiaobo Huang
Summary: This study evaluated three HSP90 inhibitors for their effects on Porcine deltacoronavirus (PDCoV) infection and found that 17-AAG and VER-82576 showed inhibitory effects on PDCoV replication, possibly by targeting the host cell factor HSP90AB1.
VETERINARY MICROBIOLOGY
(2022)
Review
Oncology
Talal El Zarif, Marcel Yibirin, Diana De Oliveira-Gomes, Marc Machaalani, Rashad Nawfal, Gianfranco Bittar, Hisham F. Bahmad, Nizar Bitar
Summary: Despite advances in screening and therapy for colorectal cancer (CRC), survival rates remain low. Drug repurposing offers a cost-effective solution for finding new uses for approved drugs in the treatment of CRC. This review summarizes the current data supporting drug repurposing as a feasible option for CRC patients, focusing on evidence and mechanisms of action for repurposed drugs such as anti-malarial, anti-helminthic, anti-inflammatory, anti-hypertensive, anti-hyperlipidemic, and anti-diabetic agents.
Article
Cell Biology
Yun Liu, Hao Zhuang, Fang Cao, Jie Li, Yan Guo, Jun Zhang, Qiang Zhao, Yuanyuan Liu
Summary: High expression of Shc3 was observed in patients with chemoresistant and recurrent HCCs. Shc3 overexpression increased MDR1/P-glycoprotein expression and reduced HCC cell sensitivity to doxorubicin and sorafenib. This study suggests a potential strategy to target the Shc3 pathway in conjunction with systemic chemotherapy for improved clinical treatment of HCC.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Reine Hanna, Jad Abdallah, Tamara Abou-Antoun
Summary: The study demonstrated that HSP90 inhibition can effectively suppress cellular proliferation, viability, and migration/invasion, while promoting apoptosis in neuroblastoma cells. The treatment also attenuated the stem-cell self-renewal potential in MYCN-amplified cells, showing a novel therapeutic mechanism to enhance therapeutic sensitivity.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Yu-Qiang Yu, Veronika Thonn, Jay Patankar, Oana-Maria Thoma, Maximilian Waldner, Marta Zielinska, Li-li Bao, Miguel Gonzalez-Acera, Stefan Wallmueller, Felix B. Engel, Michael Stuerzl, Markus F. Neurath, Eva Liebing, Christoph Becker
Summary: This study reveals that SMYD2 is overexpressed in colorectal cancer and plays a crucial role in tumor growth while inhibiting TNF-induced apoptosis and necroptosis.
CELL DEATH & DISEASE
(2022)
Article
Immunology
Mahdieh Shokrollahi Barough, Neda Jalili, Soodabe Shafiee, Malihe Salehi, Nazanin Naseri, Mohammad Amin Javidi, Aysooda Hosseinzadeh, Leila Farahmand
Summary: Blocking MUC1 resulted in overexpression of ER, PR, and HER2, leading to increased drug hypersensitization and reduced IC50 levels for Tamoxifen and Herceptin. MCF-7R cells showed positive response to Tamoxifen with decreased IC50 and enhanced apoptosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Retno Murwanti, Kaori Denda-Nagai, Daisuke Sugiura, Kaoru Mogushi, Sandra J. J. Gendler, Tatsuro Irimura
Summary: This study investigated the use of a DNA vaccine targeted at the commonly found tumor-associated antigen human MUC1 for the treatment of colorectal cancer. It was found that vaccination with MUC1 DNA mixed with bone-marrow-derived dendritic cells (BMDCs) reduced tumor burden in a mouse model of colon cancer induced by inflammation. The combination of MUC1 DNA and BMDCs showed an additive preventive effect on the development of colonic tumors.
Article
Microbiology
Antonio Luis de O. A. Petersen, Benjamin Cull, Beatriz R. S. Dias, Luana C. Palma, Yasmin da S. Luz, Juliana P. B. de Menezes, Jeremy C. Mottram, Patricia S. T. Veras
Summary: The Hsp90 inhibitor 17-AAG was shown to cause abnormal activation of the autophagic pathway, leading to the formation of immature autophagosomes and subsequent parasite death. This study provides evidence of the role of autophagy in 17-AAG-induced cell death, supporting the potential of Hsp90 as a drug target for parasitic diseases.
Review
Biochemistry & Molecular Biology
Maria Grazia Cerrito, Emanuela Grassilli
Summary: The development of high-throughput approaches has enabled the identification of novel actionable targets for colorectal cancer treatment and the development of specific inhibitors, leading to treatment innovations such as re-sensitizing drug-resistant tumors in combination with chemotherapy and inducing synthetic lethality in tumors with specific oncogenic mutations.
Article
Oncology
Tong Yu, Archana Chandrabhan Jadhav, Jiabao B. Xu, Adrian L. L. Harris, Venugopal Nair, Wei E. E. Huang
Summary: Understanding the development of cancer resistance to therapies is crucial. Newcastle disease virus (NDV) is a promising oncolytic agent, but some colon cancer cells show resistance to NDV reinfection. By using Raman spectroscopic and stable isotopic techniques, we found that the resistant cells slow down their replication and divert energy to protein and lipid synthesis. Understanding metabolic reprogramming could aid in developing precision cancer treatments that target resistant cells at the single-cell level.
Article
Multidisciplinary Sciences
Jinhyeon Kim, Hajung Kim, Yong Sik Yoon, Chan Wook Kim, Seung-Mo Hong, Sungjee Kim, Doowon Choi, Jihyun Chun, Seung Wook Hong, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Suk-Kyun Yang, Sun Young Kim, Seung-Jae Myung
Summary: This study evaluated the visualization ability of ICG fluorescence endoscopy in colitis-associated colon cancer and used a deep learning network to predict the development of colorectal cancer. The results showed that ICG could detect carcinoma, adenoma, and dysplasia with high accuracy, and there was a positive correlation between ICG and iNOS. The mechanism of ICG retention in cancer cells was related to intracellular nitric oxide concentration.
Article
Cell Biology
Shuo Zhang, Peng Wang, Binwu Hu, Weijian Liu, Xiao Lv, Songfeng Chen, Zengwu Shao
Summary: This study found that the HSP90 inhibitor 17-AAG can attenuate inflammation and catabolism induced by M1 macrophages in the nucleus pulposus. 17-AAG exerts anti-inflammatory and anti-catabolic effects by modulating the activities of macrophages and NPCs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Shudong Zhu, Yan Zhu, Qiuwen Wang, Yi Zhang, Xialing Guo
Summary: DNA methylation at the promoter CpG islands of CHK gene is increased in colon cancer cells and human colon cancer tissues compared to normal healthy counterparts, leading to decreased expression of CHK mRNA. Enhanced levels of DNMT in colon cancer cells and tissues contribute to this process, resulting in increased oncogenic properties in colon cancer cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)