Article
Biochemistry & Molecular Biology
Katrin Radeloff, Dorothee Weiss, Rudolf Hagen, Norbert Kleinsasser, Andreas Radeloff
Summary: Adipose-derived stromal cells show chondrogenic differentiation capacity in vitro and have potential for cartilage replacement. Implantation of predifferentiated cell-seeded constructs into rabbit ear cartilage defects resulted in deposition of cartilage-like structures with evidence of endochondral ossification.
Article
Orthopedics
Xing Guo, Denghua Huang, Dan Li, Longfei Zou, Hui Lv, Yuanhui Wang, Meiyun Tan
Summary: This study found that hypoxia preconditioning attenuates the proliferation and migration ability of ADSCs, but has positive impact on tenogenic differentiation through HIF-1 alpha signaling pathway.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Cell & Tissue Engineering
Shan-Chuang Chen, Tao Jiang, Qi-Yu Liu, Zi-Tao Liu, Yu-Fei Su, Hai-Tao Su
Summary: This study demonstrates that hsa_circ_0001485 plays a crucial role in osteogenic differentiation. The circRNA activates the TGF beta-BMP pathway by targeting BMPR2, thereby positively regulating osteogenic differentiation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
John P. Gleeson, Namit Chaudhary, Katherine C. Fein, Rose Doerfler, Patricia Hredzak-Showalter, Kathryn A. Whitehead
Summary: Breast milk contains cells that are beneficial for infant development, but little is known about these cells. This study characterized the cells in mature breast milk from healthy donors and identified the main cell population as epithelial cells, with several subpopulations including previously unidentified ones. These findings provide insights into the potential applications of breast milk cells in maternal and infant medicine.
Article
Cell & Tissue Engineering
Sophia K. Theodossiou, Jett B. Murray, LeeAnn A. Hold, Jeff M. Courtright, Anne M. Carper, Nathan R. Schiele
Summary: The study found that Akt signaling plays a role in TGF beta 2-induced tenogenesis, and that tenogenesis of MSCs can still be initiated by TGF beta 2 during inhibition of Smad3.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Ana L. Graca, Rui M. A. Domingues, Manuel Gomez-Florit, Manuela E. Gomes
Summary: In this study, the role of platelet-derived extracellular vesicles (EVs) in stem cells' tenogenic commitment was assessed using a 3D bioengineered in vitro tendon model. The findings showed that platelet-derived EVs boosted the tenogenic commitment of stem cells and enhanced the deposition of tendon-like extracellular matrix. These results suggest that platelet-derived EVs have promising applications in tissue engineering and regenerative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Biomaterials
Shuai Chen, Juan Wang, Yini Chen, Xiumei Mo, Cunyi Fan
Summary: Tissue engineering using GDF-5-induced ASCs cell sheets for tendon repair shows promise in enhancing tenogenesis-related markers expression. Combining cell sheets with nanoyarn scaffolds demonstrates potential in tendon regeneration in rabbit models.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Cell & Tissue Engineering
Ying Rao, Chenxian Zhu, Hoi Ching Suen, Shuting Huang, Jinyue Liao, Dai Fei Elmer Ker, Rocky S. Tuan, Dan Wang
Summary: This study demonstrates that urea-extracted tECM contains abundant protein components and can enhance the proliferation and tenogenic differentiation of hASCs. Comparative analysis with Col1 reveals the potential mechanism of tECM's pro-tenogenic bioactivity.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Feikun Yang, Dean W. Richardson
Summary: The study demonstrates that BMSCs and teno-iPSCs respond differently to tenogenic stimuli, potentially affecting their application in tendon repair or regeneration in terms of tenocyte-lineage-specific gene expression.
STEM CELLS INTERNATIONAL
(2021)
Article
Biotechnology & Applied Microbiology
Jing Li, Zhiyu Li, Song Wang, Jianhai Bi, Ran Huo
Summary: This study investigated the effects of exosomes from human adipose-derived mesenchymal stem cells (adMSC-Exos) on extracellular matrix (ECM) remodeling in keloids. The results showed that adMSC-Exos inhibited the expression of collagen and fibronectin, disrupted collagen production and microvessel structure, and had an impact on the protein expression of certain factors involved in ECM production. These findings provide a new potential alternative for the treatment of keloids by targeting ECM production.
Article
Cell Biology
Huina Liu, Xiao Han, Haoqing Yang, Yangyang Cao, Chen Zhang, Juan Du, Shu Diao, Zhipeng Fan
Summary: Different expression levels of GREM1 in ADSCs have diverse effects on osteogenic differentiation and senescence, mainly achieved through regulating the expression of corresponding genes.
CONNECTIVE TISSUE RESEARCH
(2021)
Article
Endocrinology & Metabolism
Tao Liang, Zheng-hao Dai, Hang Guo, Li-chang Zhong, Bin Zhang, Xiang Li, Wei-guo Chen
Summary: This study investigated the effect of adipose-derived stem cell (ADSC) exosomes on TGF-beta 1-induced urethral fibrosis in rats. The results showed that ADSC-exos significantly reduced the expression of fibrosis-related proteins in the urethral tissues by inhibiting the TGF-beta 1/Smad3 signaling pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Cell Biology
Liang-Ju Ning, Ya-Jing Zhang, Yan-Jing Zhang, Min Zhu, Wei Ding, Yan-Lin Jiang, Yi Zhang, Jing-Cong Luo, Ting-Wu Qin
Summary: A new decellularized tendon hydrogel from Macaca mulatta was developed in this study, which was found to promote proliferation, migration, and tenogenic differentiation of tendon-derived stem cells. The retained nanofibrous structure and bioactive factors make this hydrogel a promising candidate for tendon regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Ying Li, Chenyang Xiao, Ruihua Li, Weiliang Zhong, Gang Xu, Weiguo Zhang
Summary: In this study, it was found that YAP is a key mediator in tenogenic differentiation of C3H10T1/2 cells, and the induction of BMP-12 leads to a significant increase of tendon-related proteins Scleraxis, Tenascin C, and Tenomodulin.
JOURNAL OF MOLECULAR HISTOLOGY
(2022)
Article
Chemistry, Physical
Chunhui Sheng, Xiaodong Guo, Zhuqing Wan, Xiaoqiang Bai, Hao Liu, Xiao Zhang, Ping Zhang, Yunsong Liu, Wenyue Li, Yongsheng Zhou, Longwei Lv
Summary: This study investigated the potential of exosomes derived from human adipose-derived stem cells (hASCs) in promoting osteogenic differentiation for osteoporosis treatment. The study identified the key differentially expressed microRNA between two exosomes and their potential target gene. Results showed that exosomes from osteogenic induction medium had a better effect on promoting osteogenic differentiation than those from proliferation medium. Moreover, miR-335-3p inhibitor-optimized exosomes enhanced osteogenic differentiation in vitro and bone density in vivo, suggesting the potential of engineered exosomes in optimizing exosome-based therapy for osteoporosis.
Article
Cell & Tissue Engineering
Veronika Hruschka, Aram Saeed, Paul Slezak, Racha Cheikh Al Ghanami, Georg Alexander Feichtinger, Cameron Alexander, Heinz Redl, Kevin Shakesheff, Susanne Wolbank
TISSUE ENGINEERING PART A
(2015)
Article
Polymer Science
Xin Liao, Grace Walden, Noelia D. Falcon, Simon Donell, Michael J. Raxworthy, Michael Wormstone, Graham P. Riley, Aram Saeed
EUROPEAN POLYMER JOURNAL
(2017)
Review
Cell & Tissue Engineering
Grace Walden, Xin Liao, Simon Donell, Mike J. Raxworthy, Graham P. Riley, Aram Saeed
TISSUE ENGINEERING PART B-REVIEWS
(2017)
Article
Chemistry, Multidisciplinary
Aram Saeed, Nora Francini, Lisa White, James Dixon, Toby Gould, Hassan Rashidi, Racha Cheikh Al Ghanami, Veronika Hruschka, Heinz Redl, Brian R. Saunders, Cameron Alexander, Kevin M. Shakesheff
ADVANCED MATERIALS
(2015)
Article
Engineering, Biomedical
Veronika Hruschka, Alexandra Meinl, Aram Saeed, Racha Cheikh Al Ghanami, Heinz Redl, Kevin Shakesheff, Susanne Wolbank
BIOMEDICAL MATERIALS
(2013)
Article
Chemistry, Multidisciplinary
Aram O. Saeed, Ben Newland, Abhay Pandit, Wenxin Wang
CHEMICAL COMMUNICATIONS
(2012)
Article
Immunology
A. Saeed, K. Baloch, R. J. P. Brown, R. Wallis, L. Chen, L. Dexter, C. P. McClure, K. Shakesheff, B. J. Thomson
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2013)
Article
Engineering, Biomedical
Yixiao Dong, Waqar Hassan, Yu Zheng, Aram Omer Saeed, Hongliang Cao, Hongyun Tai, Abhay Pandit, Wenxin Wang
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2012)
Article
Polymer Science
Yixiao Dong, Aram Omer Saeed, Waqar Hassan, Catherine Keigher, Yu Zheng, Hongyun Tai, Abhay Pandit, Wenxin Wang
MACROMOLECULAR RAPID COMMUNICATIONS
(2012)
Article
Materials Science, Biomaterials
Giovanna Sicilia, Christine Grainger-Boultby, Nora Francini, Johannes P. Magnusson, Aram O. Saeed, Francisco Fernandez-Trillo, Sebastian G. Spain, Cameron Alexander
BIOMATERIALS SCIENCE
(2014)
Article
Biochemical Research Methods
Grace Walden, Xin Liao, Graham Riley, Simon Donell, Michael J. Raxworthy, Aram Saeed
BIOCONJUGATE CHEMISTRY
(2019)
Article
Cell & Tissue Engineering
Arabella Baird, Noelia Dominguez Falcon, Aram Saeed, Deborah Jane Guest
TISSUE ENGINEERING PART C-METHODS
(2019)
Article
Chemistry, Multidisciplinary
Xin Liao, Noelia D. Falcon, Ali A. Mohammed, Yasmin Z. Paterson, Andrew Geoffrey Mayes, Deborah J. Guest, Aram Saeed
Article
Polymer Science
Noelia D. Falcon, Aram Saeed
Summary: This study introduces a novel approach to prefunctionalize polymer microparticles with adhesion moieties, enhancing their adhesive properties in applications such as cell and tissue engineering.
EUROPEAN POLYMER JOURNAL
(2021)