Article
Biochemistry & Molecular Biology
Martyna Nowak-Perlak, Mariusz A. Bromke, Piotr Ziolkowski, Marta Wozniak
Summary: This study investigated the potential of emodin and aloe-emodin as photosensitizers in photodynamic therapy for skin cancer. The results showed that these two substances can affect skin cancer cells and normal skin cells in different ways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Yuting Xiang, Min Liu, Yunrong Yang, Yubo Wang, Yige Qiu, Shiqi Tu, Yitian Jiang, Yayun Nan, Xiaojie Zhang, Qiong Huang
Summary: This article summarizes the latest developments in using nanodrugs to manipulate ER stress for cancer treatment. The prospects of nanodrugs enhancing ER stress for cancer treatment are discussed, providing insights for novel therapeutic approaches and the design of nanodrugs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Applied
Ke Xue, Pengfei Wei, Wentong Qi, Lin Jia, Lei Tong, Zhengjian Qi
Summary: This study designed and synthesized a photosensitizer named TTQ-ER with aggregation-induced emission (AIE) characteristics to specifically target the endoplasmic reticulum (ER) and promote oxidative stress, disrupting the normal function of ER and inducing apoptosis in cancer cells. This work provides valuable insights for designing a new generation of photosensitizers.
Article
Biochemistry & Molecular Biology
Li Yang, Xing Wang, Yongfei Zhao, Ke Xue, Jiankang Liang, Xiaohan Wang, Jing Deng, Zhengjian Qi
Summary: In this study, an AIE-type strong endoplasmic reticulum-targeted luminogen (MTOQS) was developed. MTOQS efficiently produced reactive oxygen species (ROS) in cellular and non-cellular environments, effectively reducing levels of GSH and MDA in cancer cells. Through dual organelle oxidative stress, MTOQS altered cancer cell metabolism and culture environment, leading to apoptosis by damaging endoplasmic reticulum and mitochondria.
BIOORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Ernesto Martinez-Martinez, Joaquin Fernandez-Irigoyen, Enrique Santamaria, Maria Luisa Nieto, Jose Manuel Bravo-San Pedro, Victoria Cachofeiro
Summary: This study used a proteomic approach to investigate the potential mediators involved in the improvement of cardiac fibrosis in obese rats treated with the mitochondrial antioxidant MitoQ. The results showed that obesity altered the expression of 33 proteins, including those related to ER stress and oxidative stress. Treatment with MitoQ prevented the increase of cardiac transthyretin (TTR) levels in obese animals, which was associated with the levels of endoplasmic reticulum stress marker BiP and fibrosis. TTR was found to stimulate collagen I production and BiP in cardiac fibroblasts, and this upregulation was prevented by MitoQ.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Francisco V. Souza-Neto, Sara Jimenez-Gonzalez, Beatriz Delgado-Valero, Raquel Jurado-Lopez, Marie Genty, Ana Romero-Miranda, Cristina Rodriguez, Maria Luisa Nieto, Ernesto Martinez-Martinez, Victoria Cachofeiro
Summary: The study revealed the significant role of mitochondrial oxidative stress and endoplasmic reticulum stress activation in the progression of obesity-related cardiovascular fibrosis. MitoQ and ER stress inhibitors were found to effectively block the harmful effects of Ang II in cardiac and vascular cells, thus preventing the development of cardiovascular fibrosis.
Article
Biochemistry & Molecular Biology
Francisco Souza-Neto, Fabian Islas, Sara Jimenez-Gonzalez, Maria Luaces, Bunty Ramchandani, Ana Romero-Miranda, Beatriz Delgado-Valero, Elena Roldan-Molina, Melchor Saiz-Pardo, Ma Angeles Ceron-Nieto, Luis Ortega-Medina, Ernesto Martinez-Martinez, Victoria Cachofeiro
Summary: This study evaluated the cardiac function and fibrosis in infarcted rats treated with MitoQ and in patients with acute myocardial infarction. The results showed that MitoQ reduced oxidative stress and improved cardiac function, and also decreased fibrosis by inhibiting endoplasmic reticulum stress.
Article
Engineering, Biomedical
Jianqing Li, Jun Dai, Zeyan Zhuang, Zijuan Meng, Jing-Jing Hu, Xiaoding Lou, Fan Xia, Zujin Zhao, Ben Zhong Tang
Summary: This study presents a novel photosensitizer that can trigger endoplasmic reticulum stress and induce effective immunogenic cell death. Combining with immune checkpoint blockade, it can significantly inhibit tumor growth and provoke a systemic antitumor immune response.
Article
Engineering, Biomedical
Xiang Zhou, Yanmei Li, Xinyu Li, Jiaqi Huang, Renjiang Kong, Lingshan Liu, Hong Cheng
Summary: In this study, a self-delivery nanomedicine (GosCe) was developed based on a Bcl-2 inhibitor and photosensitizer. GosCe exhibited favorable size distribution, high drug contents, and improved drug delivery efficiency. It increased the efficacy of PDT by inhibiting Bcl-2 and inducing endoplasmic reticulum stress, leading to significant inhibition of tumor growth with reduced side effects in vivo.
ACTA BIOMATERIALIA
(2022)
Article
Immunology
Ting-Ting Yu, Jun Hu, Qi-Rui Li, Xing-Chun Peng, Hua-Zhen Xu, Ning Han, Liu-Gen Li, Xiao-Xin Yang, Xiang Xu, Zi-Yi Yang, Hao Chen, Xiao Chen, Mei-Fang Wang, Tong-Fei Li
Summary: Photodynamic therapy (PDT) can enhance the immunogenicity of lung cancer cells by inducing apoptosis and generating reactive oxygen species (ROS). It promotes endoplasmic reticulum stress and DNA damage, leading to the release of immunoregulatory proteins and enhancing the immunogenicity of lung cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Hao Zhang, Yang Liu, Yue Cao, Peizhe Song, Wanying Li, Zhijia Lv, Shuyan Song, Yinghui Wang, Hongjie Zhang
Summary: With the development of oncology, immunotherapy holds great promise for tumor treatment. However, immunogenic cell death often fails to trigger effective immunotherapy. In this study, a nanoplatform based on a porous organic framework is developed to cause endoplasmic reticulum stress and amplify immunogenic cell death, thereby enhancing immunotherapy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Yifan Zhao, Bai Lv, Guanghe Xue, Yong Sun, Jie Cao
Summary: In this study, a nanosystem (named CyI & Met-Liposome, LCM) was designed to co-encapsulate the photosensitizer CyI and mitochondrial respiration inhibitor metformin (Met) for enhanced photodynamic therapy (PDT) efficiency. The results showed that LCM alleviated tumor hypoxia, enhanced PDT efficiency, and promoted antitumor immunity through oxygen-boosted PDT.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Medicinal
Shijia Su, Jiarui Wang, Jing Wang, Ruili Yu, Likang Sun, Yue Zhang, Lei Song, Weiling Pu, Yi Tang, Yingli Yu, Kun Zhou
Summary: In this study, it was found that GP-17 can prevent myocardial ischemia/reperfusion injury by inhibiting endoplasmic reticulum stress, reducing cell apoptosis, autophagy, and oxidative stress. GP-17 also regulates the balance of mitochondrial fusion and fission, protecting mitochondrial function and improving cardiac function.
PHYTOTHERAPY RESEARCH
(2022)
Article
Toxicology
Ying-Huan Hu, Zheng-Yang Quan, Deng-Ke Li, Cheng-Yu Wang, Zhen-Xiao Sun
Summary: Aloe-emodin is a natural hydroxyanthraquinone derivative with various pharmacological activities, but it may have hepatotoxic effects. Studies have shown that the metabolism of aloe-emodin in liver microsomes can lead to hepatocyte apoptosis, mitochondrial injury, and oxidative stress imbalance. The inhibition of CYP3A4 enhances the hepatocyte injury caused by aloe-emodin.
TOXICOLOGY IN VITRO
(2022)
Review
Biochemistry & Molecular Biology
Yan Zhou, Dharmani Devi Murugan, Haroon Khan, Yu Huang, Wai San Cheang
Summary: ER stress is closely associated with the pathogenesis of diabetes and obesity, with excess nutrients and inflammatory cytokines as triggers. It not only induces endothelial dysfunction and atherosclerosis, but also contributes to oxidative stress.
Review
Pharmacology & Pharmacy
Ying Zhang, Jinyan Li, Tinghe Yu
EXPERT OPINION ON DRUG DELIVERY
(2017)
Article
Oncology
Biao Wan, Leheyi Dai, Li Wang, Ying Zhang, Hong Huang, Guanhua Qian, Tinghe Yu
ENDOCRINE-RELATED CANCER
(2018)
Article
Biochemistry & Molecular Biology
Jinyan Li, Guanhua Qian, Xiaocui Zhong, Tinghe Yu
DNA AND CELL BIOLOGY
(2018)
Article
Oncology
Qing Chen, Kai-Ting Li, Si Tian, Ting-He Yu, Le-Hu Yu, Hai-Dan Lin, Ding-Qun Bai
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2018)
Article
Cell Biology
Jianguo Hu, Li Hu, Yangyang Gong, Lei Zhang, Xiaoling Gan, Xiaodong Luo, Tinghe Yu, Xiaocui Zhong, Xinru Deng, Lina Hu, Zhanyu Zhang, Xiaojing Dong
CELL DEATH & DISEASE
(2018)
Article
Biotechnology & Applied Microbiology
Guanhua Qian, Tinghe Yu
BIOMED RESEARCH INTERNATIONAL
(2018)
Article
Biochemistry & Molecular Biology
Guanhua Qian, Leheyi Dai, Tinghe Yu
DNA AND CELL BIOLOGY
(2019)
Article
Medicine, Research & Experimental
Qianfen Liu, Xiaocui Zhong, Ying Zhang, Xinya Li, Guanhua Qian, Tinghe Yu
MOLECULAR PHARMACEUTICS
(2020)
Article
Cell Biology
Shanyu Fang, Yuanyuan Luo, Ying Zhang, Houmei Wang, Qianfen Liu, Xinya Li, Tinghe Yu
Summary: In the treatment of epithelial ovarian cancer, a high level of NTNG1 has been found to lead to cisplatin resistance through the GAS6/AXL/Akt pathway, affecting cell apoptosis and survival. NTNG1 may serve as a useful target to overcome drug resistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Integrative & Complementary Medicine
Yuanyuan Luo, Tinghe Yu, Xinya Li, Guanhua Qian
Summary: Thioridazine enhances the sensitivity of cisplatin-resistant human lung cancer cells to cisplatin by reducing detoxification and DNA repair capacity, thereby increasing cisplatin-induced DNA damage in resistant cells.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Houmei Wang, Yuanyuan Luo, Rui Ran, Xinya Li, Hongjian Ling, Fang Wen, Tinghe Yu
Summary: This study found that IDO1 is associated with cisplatin resistance in ovarian cancer, and high IDO1 levels are correlated with poor prognosis. In experiments, up-regulating IDO1 weakened DDP-induced apoptosis, while silencing IDO1 enhanced apoptosis and the effect of DDP. These results indicate that targeting IDO1 could modulate the efficacy of platinum-based chemotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Qianfen Liu, Xinya Li, Yuanyuan Luo, Houmei Wang, Ying Zhang, Tinghe Yu
Summary: In this study, ultrasound was used to enhance the effects of ZD2767P+CPG2 against cisplatin-resistant lung cancer cells. The combination of ZD2767P+CPG2+US induced cell death and apoptosis, with stronger effects compared to ZD2767P+CPG2 alone. It also caused DNA double-strand breaks and altered the levels of transferrin, ferroportin, and GPX4. The intracellular pharmacokinetics and xenograft tumor experiments confirmed the effectiveness of ZD2767P+CPG2+US as a potential therapy for cisplatin-resistant lung cancer.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Editorial Material
Oncology
Tinghe Yu, Xinya Li
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ling Liu, Jianguo Hu, Tinghe Yu, Shuang You, Yulin Zhang, Lina Hu
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2019)
Article
Oncology
Guanhua Qian, Li Wang, Xueling Zheng, Tinghe Yu
CANCER BIOLOGY & THERAPY
(2017)