Article
Immunology
Zetao Ding, Haoyu Pan, Zhixia Yang, Chengde Yang, Hui Shi
Summary: Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the presence of antiphospholipid antibodies. Anti-phosphatidylserine/prothrombin antibodies (aPS/PT) have proven valuable in identifying APS patients and stratifying their risk. However, challenges remain in the laboratory testing of aPS/PT.
CLINICAL IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Daniele Roselli, Maria Addolorata Bonifacio, Giovanna Barbuti, Maria Rosaria Rossiello, Prudenza Ranieri, Maria Addolorata Mariggio
Summary: This real life study aimed to explore the connections between laboratory criteria and the prevalence of non-criteria antiphospholipid antibodies (aPL) in antiphospholipid syndrome (APS). The study found a significant association between aPS and aCL as well as aβ(2)GPI, while the association with LA was less significant. Therefore, measuring aPT and aA5 autoantibodies may be useful, particularly in aCL/aβ(2)GPI-negative patients or in cases of isolated LA positivity.
Article
Hematology
Arne Vandevelde, Walid Chayoua, Bas de Laat, Gary W. Moore, Jacek Musial, Stephane Zuily, Denis Wahl, Katrien M. J. Devreese
Summary: The presence of antiphosphatidylserine/prothrombin antibodies (aPS/PT), especially with high antibody titer, is associated with the diagnosis of thrombotic antiphospholipid syndrome (TAPS).
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Medicine, General & Internal
Savino Sciascia, Massimo Radin, Irene Cecchi, Elena Rubini, Silvia Grazietta Foddai, Alice Barinotti, Antonella Vaccarino, Daniela Rossi, Dario Roccatello
Summary: This study prospectively investigated the incidence of first thromboembolic events in SLE patients positive for aPS/PT antibodies, finding that the cumulative incidence of TEs increased over time and patients with IgG aPS/PT positivity were at significantly higher risk for TEs.
FRONTIERS IN MEDICINE
(2021)
Article
Medical Laboratory Technology
Yuncong Zhang, Yang Su, Han Guo, Lu Wang, Aiwei Li, Chanjuan Wang, Jie Zhang, Rui Qiao
Summary: This study aimed to investigate whether aPS/PT antibodies could prolong phospholipid (PL)-dependent clotting time and increase the risk of thrombosis or pregnancy complications based on LA positivity. The results showed that PT was longer in aPS/PT IgG-positive patients, and there was a significant association between aPS/PT antibodies and SCT-S or dRVVT-S. The incidence of thrombosis was also higher in the aPS/PT IgG-positive group. Thus, aPS/PT antibodies prolong PL-dependent clotting time and increase the risk of thrombosis in LA positivity.
CLINICAL BIOCHEMISTRY
(2023)
Article
Immunology
Natalia Egri, Chelsea Bentow, Laura Rubio, Gary L. Norman, Susana Lopez-Sanudo, Michael Mahler, Albert Perez-Isidro, Ricard Cervera, Odette Vinas, Gerard Espinosa, Estibaliz Ruiz-Ortiz
Summary: The study found that persistently positive results for aPS/PT IgG antibodies were significantly associated with APS classification, thrombosis, triple aPL positivity, LA positive result, and the Global APS Score (GAPSS) > than 9 points, but not with pregnancy morbidity and SLE.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Chaojun Hu, Siting Li, Zhijuan Xie, Hanxiao You, Hui Jiang, Yu Shi, Wanting Qi, Jiuliang Zhao, Qian Wang, Xinping Tian, Mengtao Li, Yan Zhao, Xiaofeng Zeng
Summary: This study found that detecting aCL IgA, aβ2GPI IgA, aAnxV IgG/M, and aPS/PT IgG/M as biomarkers provides additive value in APS diagnosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Katja Perdan-Pirkmajer, Polona Zigon, Anja Boc, Eva Podovsovnik, Sasa Cucnik, Alenka Mavri, Ziga Rotar, Ales Ambrozic
Summary: This study suggests that negative aCL and/or anti-beta 2GPI at the time of acute DVT may not require further aPL testing, while LA should be checked after discontinuation of anticoagulant therapy. Positive aCL and/or anti-beta 2GPI at the time of acute DVT have a strong positive predictive value for APS and may impact therapeutic decisions.
Article
Biochemistry & Molecular Biology
Jaume Alijotas-Reig, Ariadna Anunciacion-Llunell, Stephanie Morales-Perez, Jaume Trape, Enrique Esteve-Valverde, Francesc Miro-Mur
Summary: APLAs are present in approximately one-third of hospitalized COVID-19 patients. IgM positivity in anti-phosphatidylserine is associated with thrombosis, while IgM positivity in anti-phosphatidylinositol is associated with inflammation. Therefore, testing for non-criteria APLAs in hospitalized COVID-19 patients can help assess the risk of clinical complications.
Article
Immunology
Savino Sciascia, Massimo Radin, Mario Bazzan, Barbara Montaruli, Domenico Cosseddu, Claudio Norbiato, Maria Tiziana Bertero, Renato Carignola, Beatrice Bacco, Silvia Gallo Cassarino, Dario Roccatello
Summary: The presence of antiphospholipid antibodies in COVID-19 patients may contribute to a pro-coagulant state, but differs from patients with overt APS. Therefore, caution is needed in interpreting and generalizing the role of aPL in the management of COVID-19 patients. Additional well-designed clinical studies are necessary before introducing aPL testing as routine in COVID-19 patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Francisco Javier Gil-Etayo, Sara Garcinuno, Antonio Lalueza, Raquel Diaz-Simon, Ana Garcia-Reyne, Daniel Enrique Pleguezuelo, Oscar Cabrera-Marante, Edgard Alfonso Rodriguez-Frias, Alfredo Perez-Rivilla, Manuel Serrano, Antonio Serrano
Summary: The presence of aPL in COVID-19 patients is significantly associated with thrombosis, with potential mechanisms including early immune dysregulation and delayed aPL-mediated thrombosis. Additionally, aPL found in COVID-19 patients may preexist before the infection.
Article
Hematology
Arne Vandevelde, Jean-Christophe Gris, Gary W. Moore, Jacek Musial, Stephane Zuily, Denis Wahl, Katrien M. J. Devreese
Summary: Currently, the added value of antiphosphatidylserine/prothrombin antibodies testing in the diagnosis of obstetric antiphospholipid syndrome seems limited compared with other antibodies. However, it may be useful in specific subsets of patients.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Immunology
Massimo Radin, Alice Barinotti, Silvia Grazietta Foddai, Irene Cecchi, Elena Rubini, Dario Roccatello, Elisa Menegatti, Savino Sciascia
Summary: This study evaluated the clinical utility of aPS/PT antibody testing in identifying APS patients who developed cerebrovascular events (CVE) in patients negative for Beta2-Glycoprotein 1(beta 2GPI)-dependent tests. It was found that patients with a positive Lupus anticoagulant (LA) test were more likely to have CVE, and these patients exhibited significantly different TGA profiles.
IMMUNOLOGIC RESEARCH
(2021)
Article
Rheumatology
Medha Barbhaiya, Stephane Zuily, Ray Naden, Alison Hendry, Florian Manneville, Mary-Carmen Amigo, Zahir Amoura, Danieli Andrade, Laura Andreoli, Bahar Artim-Esen, Tatsuya Atsumi, Tadej Avcin, Michael H. Belmont, Maria Laura Bertolaccini, D. Ware Branch, Graziela Carvalheiras, Alessandro Casini, Ricard Cervera, Hannah Cohen, Nathalie Costedoat-Chalumeau, Mark Crowther, Guilherme de Jesus, Aurelien Delluc, Sheetal Desai, Maria De Sancho, Katrien M. Devreese, Reyhan Diz-Kucukkaya, Ali Duarte-Garcia, Camille Frances, David Garcia, Jean-Christophe Gris, Natasha Jordan, Rebecca K. Leaf, Nina Kello, Jason S. Knight, Carl Laskin, Alfred I. Lee, Kimberly Legault, Steve R. Levine, Roger A. Levy, Maarten Limper, Michael D. Lockshin, Karoline Mayer-Pickel, Jack Musial, Pier Luigi Meroni, Giovanni Orsolini, Thomas L. Ortel, Vittorio Pengo, Michelle Petri, Guillermo Pons-Estel, Jose A. Gomez-Puerta, Quentin Raimboug, Robert Roubey, Giovanni Sanna, Surya V. Seshan, Savino Sciascia, Maria G. Tektonidou, Angela Tincani, Denis Wahl, Rohan Willis, Cecile Yelnik, Catherine Zuily, Francis Guillemin, Karen Costenbader, Doruk Erkan
Summary: This study developed new APS classification criteria with high specificity, including clinical and laboratory domains, and improved classification accuracy through weighting and stratification.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Xiangjun Liu, Lei Zhu, Hongjiang Liu, Qingmeng Cai, Zelin Yun, Feng Sun, Yuan Jia, Jianping Guo, Chun Li
Summary: Non-criteria antiphospholipid antibodies have a high prevalence in patients with antiphospholipid syndrome, and their inclusion can improve the diagnostic accuracy of APS. APhL IgG, aPS/PT, and aPS IgG may serve as potential biomarkers for predicting thrombotic risk in APS patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Letter
Immunology
Amelia Ruffatti, Vincenzo Tarzia, Marry Fedrigo, Antonia Calligaro, Maria Favaro, Paolo Macor, Tiziana Tison, Umberto Cucchini, Erich Cosmi, Francesco Tedesco, Annalisa Angelini, Gino Gerosa
AUTOIMMUNITY REVIEWS
(2019)
Article
Rheumatology
Jaume Alijotas-Reig, Enrique Esteve-Valverde, Raquel Ferrer-Oliveras, Luis Saez-Comet, Elmina Lefkou, Arsene Mekinian, Cristina Belizna, Amelia Ruffatti, Ariela Hoxha, Angela Tincani, Cecilia Nalli, Luca Marozio, Aldo Maina, Gerard Espinosa, Roberto Rios-Garces, Ricard Cervera, Sara De Carolis, Giuseppina Monteleone, Omar Latino, Sebastian Udry, Elisa LLurba, Carmen Garrido-Gimenez, Laura Trespidi, Maria Gerosa, Cecilia Beatrice Chighizola, Patrizia Rovere-Querini, Valentina Canti, Karoline Mayer-Pickel, Sara Tabacco, Anna Arnau, Jaume Trape, Domingo Ruiz-Hidalgo, Laia Sos, Inmaculada Farran-Codina
Article
Hematology
Ariela Hoxha, Maria Favaro, Antonia Calligaro, Teresa Del Ross, Alessandra Teresa Ruffatti, Chiara Infantolino, Marta Tonello, Elena Mattia, Amelia Ruffatti
THROMBOSIS AND HAEMOSTASIS
(2020)
Review
Rheumatology
Amelia Ruffatti, Antonia Calligaro, Carmelo S. Lacognata, Anna D'Odorico, Anna Colpo, Fabrizio Cardin, Fiorella Calabrese
CLINICAL RHEUMATOLOGY
(2020)
Article
Obstetrics & Gynecology
Marta Tonello, Antonia Calligaro, Maria Favaro, Teresa Del Ross, Paola Veronese, Elisa Salvan, Maria Teresa Gervasi, Amelia Ruffatti
Summary: The study aimed to evaluate the long-term risk of thrombosis after pregnancy in women with purely obstetric antiphospholipid syndrome (OAPS) and identify the risk factors for thrombosis in OAPS patients. The incidence of thrombotic events was not significantly different between OAPS patients and aPL carriers, with arterial thrombosis and cerebrovascular events being the most frequent types of vascular involvement. The presence of lupus anticoagulant was a significant risk factor for thrombosis in both OAPS patients and aPL carriers who developed thrombosis.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Review
Immunology
Roberto Giacomelli, Antonella Afeltra, Elena Bartoloni, Onorina Berardicurti, Michele Bombardieri, Alessandra Bortoluzzi, Francesco Carubbi, Francesco Caso, Ricard Cervera, Francesco Ciccia, Paola Cipriani, Emmanuel Coloma-Bazan, Fabrizio Conti, Luisa Costa, Salvatore D'Angelo, Oliver Distler, Eugen Feist, Nathan Foulquier, Marco Gabini, Vanessa Gerber, Roberto Gerli, Rosa Daniela Grembiale, Giuliana Guggino, Ariela Hoxha, Annamaria Iagnocco, Suzana Jordan, Bashar Kahaleh, Kim Lauper, Vasiliki Liakouli, Ennio Lubrano, Domenico Margiotta, Saverio Naty, Luca Navarini, Federico Perosa, Carlo Perricone, Roberto Perricone, Marcella Prete, Jacques-Olivier Pers, Costantino Pitzalis, Roberta Priori, Felice Rivellese, Amelia Ruffatti, Piero Ruscitti, Raffaele Scarpa, Yehuda Shoenfeld, Giovanni Triolo, Athanasios Tzioufas
Summary: Autoimmune diseases share common clinical features but have different pathogenic mechanisms and targeted organs. Applying precision medicine principles may improve treatment success by tailoring therapy to individual characteristics and reducing adverse events.
AUTOIMMUNITY REVIEWS
(2021)
Review
Rheumatology
Amelia Ruffatti, Marta Tonello, Maria Favaro, Teresa Del Ross, Antonia Calligaro, Alessandra Teresa Ruffatti, Maria Teresa Gervasi, Ariela Hoxha
Summary: A systematic review was conducted to evaluate second-line treatments for pregnant women with antiphospholipid syndrome (APS), and it was found that using IVIG, HCQ, pravastatin, PE+IVIG, and PE+LDS significantly increased the live birth rate and/or reduced the occurrence of severe complications.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Article
Allergy
Laura Andreoli, Cecilia Nalli, Maria Grazia Lazzaroni, Chiara Carini, Francesca Dall'Ara, Rossella Reggia, Marilia Rodrigues, Carolina Benigno, Elena Baldissera, Elena Bartoloni, Fabio Basta, Francesca Bellisai, Alessandra Bortoluzzi, Corrado Campochiaro, Francesco Paolo Cantatore, Roberto Caporali, Angela Ceribelli, Cecilia B. Chighizola, Paola Conigliaro, Addolorata Corrado, Maurizio Cutolo, Salvatore D'Angelo, Elena De Stefani, Andrea Doria, Maria Favaro, Colomba Fischetti, Rosario Foti, Armando Gabrielli, Elena Generali, Roberto Gerli, Maria Gerosa, Maddalena Larosa, Armin Maier, Nazzarena Malavolta, Marianna Meroni, Pier Luigi Meroni, Carlomaurizio Montecucco, Marta Mosca, Melissa Padovan, Giuseppe Paolazzi, Giulia Pazzola, Susanna Peccatori, Roberto Perricone, Giorgio Pettiti, Valentina Picerno, Immacolata Prevete, Veronique Ramoni, Nicoletta Romeo, Amelia Ruffatti, Carlo Salvarani, Gian Domenico Sebastiani, Carlo Selmi, Francesca Serale, Luigi Sinigaglia, Chiara Tani, Marica Trevisani, Marta Vadacca, Eleonora Valentini, Guido Valesini, Elisa Visalli, Ester Vivaldelli, Lucia Zuliani, Angela Tincani
Summary: Concerns about the health of offspring are one reason for reduced family sizes among women with rheumatic diseases (RD). However, data gathered from a survey of 398 patients diagnosed with RD during childbearing age indicate that the risk of autoimmune diseases (AD) and neurodevelopmental disorders (ND) in their children is relatively low.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2022)
Article
Anesthesiology
Jaume Alijotas-Reig, Enrique Esteve-Valverde, Raquel Ferrer-Oliveras, Luis Saez-Comet, Elmina Lefkou, Arsene Mekinian, Cristina Belizna, Amelia Ruffatti, Angela Tincani, Josep Pardos-Gea, Cecilia Nalli, Luca Marozio, Gerard Espinosa, Sara De Carolis, Omar Latino, Udry Sebastian, Elisa LLurba, Laura Trespidi, Cecilia Chighizola, Vittorio Pengo, Patrizia Rovere-Querini, Valentina Canti, Karoline Mayer-Pickel, Tatiana Reshetnyak, Sara Tabacco, Anna Arnau
Summary: This study evaluated the haemostatic safety of using LDA and LMWH during pregnancy in women with full-blown or noncriteria antiphospholipid syndrome. The results showed that these medications were safe overall, with a slight increase in bleeding risk noted in instrumental deliveries. No bleeding complications were observed in cases where HCQ was added to standard therapy.
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2021)
Correction
Rheumatology
Jaume Alijotas-Reig, Enrique Esteve-Valverde, Raquel Ferrer-Oliveras, Luis Saez-Comet, Elmina Lefkou, Arsene Mekinian, Cristina Belizna, Amelia Ruffatti, Ariela Hoxha, Angela Tincani, Cecilia Nalli, Luca Marozio, Aldo Maina, Gerard Espinosa, Roberto Rios-Garces, Ricard Cervera, Sara De Carolis, Giuseppina Monteleone, Omar Latino, Sebastian Udry, Elisa LLurba, Carmen Garrido-Gimenez, Laura Trespidi, Maria Gerosa, Cecilia Beatrice Chighizola, Patrizia Rovere-Querini, Valentina Canti, Karoline Mayer-Pickel, Sara Tabacco, Anna Arnau, Jaume Trape, Domingo Ruiz-Hidalgo, Laia Sos, Inmaculada Farran-Codina
Article
Obstetrics & Gynecology
Amelia Ruffatti, Alessia Cerutti, Marta Tonello, Maria Favaro, Teresa Del Ross, Antonia Calligaro, Chiara Grava, Margherita Zen, Ariela Hoxha, Giovanni Di Salvo
Summary: This study compared the short and long-term outcomes of children with anti-Ro/La-related congenital heart block treated with a combined maternal-neonatal therapy protocol with those treated with other therapies. The combined therapy group showed a lower progression rate of block, higher heart rate at birth, and fewer pacemaker implants during post-natal follow-up compared to the control group.
JOURNAL OF PERINATOLOGY
(2022)
Article
Rheumatology
A. Ruffatti, M. Tonello, A. Calligaro, T. Del Ross, M. Favaro, M. Zen, A. Carletto, V. Lotti, E. Bertoldo, F. Tedesco, A. Hoxha, D. Biasi
Summary: This study aimed to evaluate the clinical significance of complement activation products C5a and C5b-9 in quiescent phases of thrombotic antiphospholipid syndrome (APS). The results showed that TAPS patients had significantly lower levels of both complement activation products compared to RAPS and CAPS patients, and C5a and C5b-9 were significantly increased in patients with small-vessel thrombosis.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Letter
Hematology
Amelia Ruffatti, Marta Tonello, Paolo Macor, Antonia Calligaro, Teresa Del Ross, Maria Favaro, Virginia Lotti, Antonio Carletto, Ariela Hoxha, Domenico Biasi
Article
Rheumatology
Maddalena Larosa, Veronique Le Guern, Nathalie Morel, Meriem Belhocine, Amelia Ruffatti, Nicolas Martin Silva, Romain Paule, Luc Mouthon, Michel Dreyfus, Jean-Charles Piette, Odile Souchaud-Debouverie, Catherine Deneux-Tharaux, Gaelle Guettrot-Imbert, Vassilis Tsatsaris, Emmanuelle Pannier-Metzger, Anne Murarasu, Andrea Doria, Nathalie Costedoat-Chalumeau
Summary: Severe preeclampsia in patients with APS led to high mortality in offspring. Almost half of the women experienced other APS features, but not three consecutive miscarriages.
ARTHRITIS RESEARCH & THERAPY
(2021)
Review
Rheumatology
A. Hoxha, E. Mattia, A. Zanetti, G. Carrara, N. Morel, N. Costedoat-Chalumeau, A. L. Brucato, A. Ruffatti
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2020)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)