Review
Oncology
Zuxi Li, Meijuan Song, Shangjun Han, Chuanwei Jin, Jing Yang
Summary: Circulating tumor cells (CTC) are associated with the prognosis of patients with gastric cancer. Gastric cancer patients with positive CTC may have a poorer prognosis compared to those with CTC-negative tumors. CTC-positive patients have more advanced TNM staging, poorer tumor differentiation, and earlier distant metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Jinwu Wei, Mingxia Wang, Guixiang Li
Summary: This study systematically evaluated the relationship between cancer-associated fibroblasts (CAFs) and the clinicopathological characteristics and prognosis of gastric cancer, providing new directions and clinical evidence for the diagnosis and treatment of this disease. The results showed that high expression of CAFs was associated with advanced stages of gastric cancer, lymph node metastasis, infiltration, and poor prognosis.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Ye Qiu, Zongxin Zhang, Ying Chen
Summary: By conducting meta-analysis, this study found that a high pretreatment SII is associated with poor overall survival in gastric cancer patients and several clinical characteristics. Monitoring SII could be valuable for guiding prognostication in GC.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Guo Zu, Jiacheng Gao, Tingting Zhou
Summary: The expression of SOX9 is associated with depth of tumor invasion, TNM stage, and poorer overall survival in gastric cancer patients. High expression of SOX9 is also correlated with shorter survival in GC patients. TCGA analysis indicates that SOX9 is upregulated in STAD patients compared to normal patients, and high expression of SOX9 is associated with poorer overall survival, although the statistical difference is not significant.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, General & Internal
Qian Wang, Hao Chen, Congying Yang, Yi Liu, Feng Li, Chunfang Zhang
Summary: This meta-analysis reveals that higher expression of SOX9 is associated with gastric cancer, and it is closely related to age, tumor size, histological differentiation, tumor stage, lymph node metastasis, and TNM stage. Higher expression of SOX9 also indicates poorer overall survival.
Review
Medicine, General & Internal
Kaifeng Tang, Jingting Liu, Baoqing Liu, Chunyan Meng, Jianhua Liao
Summary: This meta-analysis study indicates that high SOX2 expression is associated with poor prognosis in gastric cancer patients, serving as an independent prognostic marker. Moreover, SOX2 expression is also correlated with increased tumor invasion depth and positive vascular invasion.
Article
Oncology
Jing Sun, Yang-Kai Bai, Zhi-Gang Fan
Summary: In this study, systematic meta-analysis and bioinformatics analysis were conducted to determine the expression levels of FBXW7 as a prognostic marker in gastric cancer. The meta-analysis included six studies and revealed that FBXW7 expression was significantly downregulated in gastric cancer. According to the Oncomine database, FBXW7 mRNA expression was higher in gastric cancer than in normal tissue. Kaplan-Meier plots showed that FBXW7 mRNA expression was positively associated with the overall and progression-free survival of patients with gastric cancer.
Review
Oncology
Chengzhi Wei, Zhu Yu, Gonghe Wang, Yiming Zhou, Lei Tian
Summary: This meta-analysis revealed that low albumin-to-globulin ratio (AGR) is associated with worse overall survival and disease-free survival/progression-free survival in gastric cancer patients, and this association remains consistent across different conditions.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, General & Internal
Xikai Wang, Qinghe Meng, Yuanyuan Wang, Yanlu Gao
Summary: High expression of MMP14 is associated with shorter overall survival and worse clinicopathological features in patients with gastric cancer. MMP14 could serve as a prognostic factor and potential therapeutic target for gastric cancer. Data from TCGA and GEO further support the association of MMP14 expression with poor prognosis in gastric cancer.
Article
Oncology
Jing Sun, Yang-Kai Bai, Zhi-Gang Fan
Summary: In this study, the relationship between SPARC expression in gastric cancer tissues and the clinicopathological characteristics and prognosis of patients with gastric cancer was evaluated. The results showed that SPARC expression was higher in gastric cancer tissues compared to normal tissues and was associated with the degree of differentiation and distant metastasis. High SPARC expression was negatively associated with patient survival rates, indicating its potential as a biomarker for tumorigenesis and metastasis in gastric cancer.
Review
Medicine, General & Internal
Ning Li, Yu Pang, Jing Sang, Yong Sun, Weiwei Hou
Summary: This study analyzed the relationship between SOX2 expression and baseline data, clinicopathological parameters, prognosis, and Helicobacter pylori infection in patients with gastric cancer. The results showed that downregulation expression of SOX2 is related to clinicopathological parameters in gastric cancer, but not correlated with prognosis.
Article
Oncology
Xiaohong He, Sicheng Zhou, Hongjun Li, Yue Gou, Dan Jia
Summary: This meta-analysis study found that there is an association between pretreatment skeletal muscle index (SMI) and long-term survival of gastric cancer patients. Lower pretreatment SMI is associated with poorer survival rates. However, more prospective high-quality studies are needed to confirm these findings.
PATHOLOGY & ONCOLOGY RESEARCH
(2023)
Review
Medicine, General & Internal
Dailong Li, Wanqiang Li, Yaqi Pang, Siqi Liu, Lu Xu, Xinhua Xu
Summary: This study using meta-analysis showed that lymphovascular invasion is an independent risk factor affecting the prognosis of stage I gastric cancer, and it is significantly associated with overall survival and relapse-free survival.
Article
Cell Biology
Shaohua Huang, Liping Ma, Biyang Lan, Ning Liu, Wenwei Nong, Zhihu Huang
Summary: Through bioinformatic analyses, key dysregulated genes associated with the development of gastric cancer were identified, showing potential prognostic value. High expression of LRFN4 and LOC100506388 was linked to a higher risk of gastric cancer, while tumor infiltration levels were associated with overall survival in patients.
Review
Oncology
Jiuzhou Chen, Yaru Guo, Miao Fang, Yan Yuan, Youqi Zhu, Yong Xin, Longzhen Zhang
Summary: This study evaluated the clinical curative effects and toxicity of neoadjuvant chemoradiotherapy compared to neoadjuvant chemotherapy for resectable gastric cancer. The results showed that neoadjuvant chemoradiotherapy had better efficacy, improved survival rates, and fewer adverse effects compared to neoadjuvant chemotherapy. Therefore, neoadjuvant chemoradiotherapy has great potential as an effective therapy for resectable gastric cancers.
FRONTIERS IN ONCOLOGY
(2022)