Article
Optics
Larry O'Connell, Brice Poirier, Oleksii Bratash, Charlene Pleniere, Loic Leroy, Yoann Roupioz, Pierre R. Marcoux
Summary: This study demonstrates the feasibility of using commercial laser direct writing equipment for rapid electrode patterning on glass substrates, particularly for electrokinetically active plasmonic sensors. The results show that using a commercial printed circuit board prototyper, interdigitated electrode arrays can be patterned on gold-coated glass slides and surface plasmon resonance prisms. These patterned surfaces can be used for trapping and electrokinetic manipulation of bacteria, as well as for sensing bacterial interactions using surface plasmon resonance imaging.
OPTICS AND LASER TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Tuhina Banerjee, Nilamben Panchal, Carissa Sutton, Rebekah Elliott, Truptiben Patel, Kajal Kajal, Eniola Arogunyo, Neelima Koti, Santimukul Santra
Summary: Frequent outbreaks of food-borne pathogens, particularly E. coli O157:H7, have significant effects on human health and the agricultural economy. Current detection methods for E. coli O157:H7 are sensitive but time-consuming and require extensive sample processing. To address these limitations, a novel magneto-plasmonic nanosensor (MPnS) was developed by integrating surface plasmon resonance (SPR) properties with spin-spin magnetic relaxation (T2 MR) technology. The MPnS exhibited rapid and ultrasensitive detection of E. coli O157:H7 using SPR, T2 MR, and colorimetric readout, with no cross-reactivity. It holds great potential for the detection of other foodborne pathogens, offering a simple and timely approach.
Article
Chemistry, Analytical
Pengfei Zhang, Rui Wang, Zijian Wan, Xinyu Zhou, Guangzhong Ma, Jayeeta Kolay, Jiapei Jiang, Shaopeng Wang
Summary: The article introduces a total internal reflection-based evanescent scattering microscopy technique that can detect single proteins without labeling and provides a high-precision measurement method for protein binding kinetics.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Malek G. Daher, Sofyan A. Taya, Ilhami Colak, Shobhit K. Patel, Melad M. Olaimat, Omar Ramahi
Summary: In this article, a highly sensitive surface plasmon resonance biosensor is proposed for rapid detection of waterborne bacteria. The sensor achieves high sensitivity in detecting Escherichia coli and Vibrio cholera bacteria, opening new opportunities in the field of microorganism detections.
JOURNAL OF BIOPHOTONICS
(2022)
Article
Optics
Soocheol Kim, Jin Hwa Ryu, Hoesung Yang, Kyuwon Han, Hyunseok Kim, Kwangsoo Cho, Soyoung Park, Sang Gi Hong, Kangbok Lee
Summary: This paper presents a spectrometer-based surface plasmon resonance imaging (SPRi) technique without mechanical scanning. A polarized broadband light source illuminates an object via a gold-coated prism, and the reflected light is spatially modulated by a digital mirror device (DMD) and measured with a spectrometer. Reflectance spectral images are reconstructed using the Hadamard transform (HT), and a refractive index (RI) map is visualized by analyzing the resonance peak shift at each image pixel. The method is demonstrated to have high resolution, sensitivity, and dynamic detection range, with experimental results validating the simulations.
Article
Chemistry, Analytical
Martina Vrablova, Katerina Smutna, Ivan Koutnik, Tomas Prostejovsky, Radim Zebrak
Summary: Glyphosate is a widely used pesticide. In order to tackle the issue of glyphosate removal, photocatalysis technology and a new sensor approach have been introduced. The aim of the research was to design and test an SPRi biosensor suitable for glyphosate degradation and the experimental results were recorded.
Article
Instruments & Instrumentation
Surjeet Raikwar, Y. K. Prajapati, D. K. Srivastava, J. B. Maurya, J. P. Saini
Summary: This paper presents the design of a graphene-coated surface plasmon resonance sensor for detecting Leptospirosis bacteria in Rodent urine, distinguishing between oliguria and polyuria based on different levels of sensitivity and detection accuracy.
Article
Chemistry, Analytical
Xin Gao, Haoran Xu, Zhuoyi Ye, Xin Chen, Xin Wang, Qi Chang, Yueqing Gu
Summary: The 5-year survival rate for pancreatic adenocarcinoma (PA) is less than 10%, but early-stage diagnosis and resection can increase the 4-year survival rate up to 78%. A novel PDGFR beta-targeting peptide (YQGX-10) was designed and coupled with a near-infrared fluorescent dye for precise detection of PA. The probe showed high affinity and specificity and could be used for NIRF-guided tumor resection of PA. A radioactive probe was also constructed for the diagnosis of PA with high specificity and sensitivity.
Article
Chemistry, Multidisciplinary
Stephan Kastner, Anne-Kathrin Dietel, Florian Seier, Shaunak Ghosh, Daniel Weiss, Oliwia Makarewicz, Andrea Csaki, Wolfgang Fritzsche
Summary: The need for rapid, simple, and accurate bioassays for nucleic acid detection has increased in recent years. This study utilized localized surface plasmon resonance (LSPR) spectroscopy to detect the antimicrobial resistance gene, sulfhydryl variable beta-lactamase (blaSHV), which confers resistance against a broad spectrum of beta-lactam antibiotics. The system was able to detect a 23 nucleotide DNA sequence at a limit of 25 nm, with signal intensity inversely correlated to sequence length. It was also capable of real-time monitoring and distinguishing single nucleotide polymorphism (SNP) variants of blaSHV.
Article
Microbiology
Laurence Van Moll, Jeroen De Smet, Anne Paas, Dorothee Tegtmeier, Andreas Vilcinskas, Paul Cos, Leen Van Campenhout
Summary: This study evaluated the activity of black soldier fly AMPs against human pathogens and a human cell line, and further explored the characteristics of two cecropins. The results showed that these AMPs exhibited high activity against various bacterial strains, rapid onset of action, and membrane-permeabilizing effects. They were also able to prevent biofilm formation in P. aeruginosa.
MICROBIOLOGY SPECTRUM
(2022)
Review
Food Science & Technology
Marco Marin, Maria Vesna Nikolic, Jasmina Vidic
Summary: This article introduces a new type of disposable colorimetric sensor based on gold nanoparticles for rapid measurement of bacteria and their toxins in food. Optimizations are needed to strengthen and improve the quality of devices for their application in the food industry.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2021)
Article
Chemistry, Analytical
Prerit Mathur, Anna Fomitcheva Khartchenko, Stavros Stavrakis, Govind V. Kaigala, Andrew J. deMello
Summary: We developed a method for monitoring localized antigen-antibody binding on cell and tissue sections using fluorescence lifetime imaging. By measuring the difference in fluorescence decay times of tagged antibodies in free solution and in the bound state, we can track the binding fraction over time and determine the binding kinetics. This method allows us to measure binding constants and observe biomarker expression effects on kinetics.
ANALYTICAL CHEMISTRY
(2022)
Article
Plant Sciences
Eric H-L Chen, Cheng-Wei Weng, Yi-Min Li, Ming-Chin Wu, Chien-Chih Yang, Kung-Ta Lee, Rita P-Y Chen, Chiu-Ping Cheng
Summary: This study designed a series of amphipathic helical peptides, finding that peptides with the special sequence pattern BBHBBHHBBH displayed excellent bactericidal and fungicidal activities in a wide range of economically important plant pathogens. Peptides with higher helical propensity had lower antimicrobial activity. Modifying the peptides with a long acyl chain at their N-terminus improved their plant protection effect.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biophysics
Abdelmonaim Azzouz, Lamia Hejji, Ki-Hyun Kim, Deepak Kukkar, Badredine Souhail, Neha Bhardwaj, Richard J. C. Brown, Wei Zhang
Summary: Surface plasmon resonance (SPR) technology is a valuable tool for the detection of cancer biomarkers, offering advantages such as low cost fabrication, sensitivity, label-free detection, and accuracy. Recent research has focused on utilizing SPR biosensing technology for diagnosing various cancer types, evaluating the performance of SPR biosensors in terms of quality assurance criteria. The limitations and future challenges associated with SPR biosensors for cancer biomarker detection are also discussed.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Wei Zhang, Tang Dang, Ying Li, Jiawei Liang, Hao Xu, Gang Logan Liu, Wenjun Hu
Summary: The study presents a highly sensitive imaging sensor and digital plasma immunosorbent assay based on a gold-titanium plasmonic nanopore array, which can quantitatively determine low concentrations of proteins and shows superior performance. The device was able to detect C-reactive protein and anti-CRP antibody binding information, with potential for future portable optical sensing for early disease detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Biochemistry & Molecular Biology
Eric Pardoux, Didier Boturyn, Yoann Roupioz
Article
Engineering, Biomedical
Julius Sefkow-Werner, Paul Machillot, Adria Sales, Elaine Castro-Ramirez, Melissa Degardin, Didier Boturyn, Elisabetta Ada Cavalcanti-Adam, Corinne Albiges-Rizo, Catherine Picart, Elisa Migliorini
ACTA BIOMATERIALIA
(2020)
Article
Chemistry, Analytical
Laure Bar, Christophe Nguyen, Mathieu Galibert, Francisco Santos-Schneider, Gudrun Aldrian, Jerome Dejeu, Remy Lartia, Liliane Coche-Guerente, Franck Molina, Didier Boturyn
Summary: Antibodies are not only important for clinical diagnostics and biopharmaceutical analysis, but also as drugs for treating various diseases. The identification of antibody-epitope binding sites, particularly for designing monoclonal antibody mimics like rituximab, is crucial for medical and bioanalytical applications. Rituximab, a monoclonal antibody used to treat cancers and autoimmune disorders, binds to targeted cells via the recognition of the CD20 epitope, with its binding area located on the surface of rituximab.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Enrique Sanchez Perez, Ritu Toor, Pierrick Bruyat, Celine Cepeda, Melissa Degardin, Jerome Dejeu, Didier Boturyn, Liliane Coche-Guerente
Summary: The study synthesized cyclodecapeptide scaffolds with two independent domains for multimeric presentation of guest molecules and potential grafting of biomolecules on solid surfaces. Using surface sensitive techniques, the influence of guest valency on the stability of inclusion complexes was quantified, showing a drastic enhancement of affinity with increasing guest valency. The results suggested that the multivalent model could be applied to extract intrinsic binding constants and effective concentrations of hosts.
Review
Chemistry, Analytical
Marielle El Kazzy, Jonathan S. Weerakkody, Charlotte Hurot, Raphael Mathey, Arnaud Buhot, Natale Scaramozzino, Yanxia Hou
Summary: The increasing demand for novel analytical tools for gases over the last three decades has led to the development of alternative technologies like artificial olfaction systems. These systems, including gas sensors, olfactory biosensors, and electronic noses, utilize various transducers such as chemiresistive, electrochemical, acoustic, and optical. Among optical transduction systems, surface plasmon resonance (SPR) has been extensively studied and found to have attractive features such as high sensitivity, label-free, and real-time measurements.
Article
Chemistry, Multidisciplinary
Jonathan S. Weerakkody, Marielle El Kazzy, Elise Jacquier, Pierre-Henri Elchinger, Raphael Mathey, Wai Li Ling, Cyril Herrier, Thierry Livache, Arnaud Buhot, Yanxia Hou
Summary: Electronic nose utilizes a multisensor array to differentiate volatile organic compounds. In this study, a biohybrid surface with hierarchical structures made of self-assembling peptides is used for VOCs detection and discrimination. By a simple design process, the biohybrid sensor array shows sufficient discriminatory capabilities for four VOCs, with benchmarked limit of detection.
Article
Chemistry, Inorganic & Nuclear
Celine Cepeda, Sergey A. Denisov, Didier Boturyn, Nathan D. McClenaghan, Olivier Seneque
Summary: This study presents a photoluminescent molecular chemosensor integrating lanthanide ions, tryptophan, and naphthalene antennas onto a polypeptide backbone for selective and sensitive detection of Cu(I) under pseudobiological conditions. The ion regulated modulation of lanthanide luminescence offers potential for ratiometric and time-gated detection of Cu(I), and the role of the bound ion in determining the photophysical properties is discussed with the aid of additional model compounds.
INORGANIC CHEMISTRY
(2021)
Article
Food Science & Technology
Oliver Brun, Claude Zoukimian, Barbara Oliveira-Mendes, Jerome Montnach, Benjamin Lauzier, Michel Ronjat, Remy Beroud, Frederic Lesage, Didier Boturyn, Michel De Waard
Summary: This study describes the chemical synthesis of a fluorescent-tagged alpha-bungarotoxin and demonstrates its binding properties on muscle nicotinic receptors using TE671 cells. The synthetic fluorescent alpha-bungarotoxin showed expected nanomolar affinity for the receptors and was able to label the cells.
Article
Medicine, Research & Experimental
Justyna Ciolek, Claude Zoukimian, Justine Dhot, Melanie Burban, Mathilde Triquigneaux, Benjamin Lauzier, Christelle Guimbert, Didier Boturyn, Marine Ferron, Lidia Ciccone, Livia Tepshi, Enrico Stura, Pierre Legrand, Philippe Robin, Gilles Mourier, Beatrice Schaack, Imen Fellah, Guillaume Blanchet, Chantal Gauthier-Erfanian, Remy Beroud, Denis Servent, Michel De Waard, Nicolas Gilles
Summary: This study identified a selective M2R ligand, MT9, from mamba snake venom and investigated its contribution to arterial contractions. MT9 exhibited a 100 times stronger affinity for M2R compared to other muscarinic receptors, and antagonized the M2R/Gi pathways in cell tests. It also acted as a non-competitive antagonist with low nM potency against acetylcholine or arecaine in isolated arteries.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Organic
Claude Zoukimian, Remy Beroud, Didier Boturyn
Summary: In this study, we utilized the Hmb(off/on) protecting group for directed disulfide bond formation. By combining it with classical Trt, Acm, and Mob groups, we successfully synthesized NMB-1 and phlotoxin-1 toxins, demonstrating new orthogonal strategies for directed disulfide bond formation.
Article
Optics
Loic Laplatine, Maryse Fournier, Nicolas Gaignebet, Yanxia Hou, Raphael Mathey, Cyril Herrier, Jie Liu, Delphine Descloux, Bertrand Gautheron, Thierry Livache
Summary: This study presents an olfactory sensor based on silicon photonics technology, capable of analyzing various volatile organic compounds at the ppm level.
Article
Biochemistry & Molecular Biology
Erenildo Ferreira de Macedo, Nivia Salles Santos, Lucca Silva Nascimento, Raphael Mathey, Sophie Brenet, Matheus Sacilotto de Moura, Yanxia Hou, Dayane Batista Tada
Summary: Despite the promising use of nanoparticles in biomedical applications, concerns about their safety have increased due to several toxic effects. This study aimed to develop a fast and accurate method using surface plasmon resonance imaging (SPRi) technique to characterize the interaction between nanoparticles, proteins, and lipidic membranes. The interaction of gold nanoparticles with mimetic membranes and blood proteins was evaluated, revealing differences in surface concentration density and preferential binding to specific proteins for gold and silver nanoparticles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Jordan Cossu, Fabien Thoreau, Didier Boturyn
Summary: RGD peptides have gained significant attention in the past two decades for their potential in improving tumor therapy by targeting the alpha V beta 3 integrin receptor. This review focuses on the molecular design of multimeric RGD compounds and suitable linkers for drug delivery. The use of RGD constructs in enhancing binding affinity and drug uptake in tumor cells, as well as their potential as theranostic systems, is highlighted. Furthermore, ongoing and future development in comparison with large molecules like monoclonal antibodies is addressed.
Review
Chemistry, Analytical
Vanessa Escobar, Natale Scaramozzino, Jasmina Vidic, Arnaud Buhot, Raphael Mathey, Carole Chaix, Yanxia Hou
Summary: Foodborne pathogens cause a significant number of illnesses worldwide. In recent decades, there has been a growing development of accurate biosensors for detecting bacterial pathogens in food, using peptides as recognition biomolecules. This review discusses strategies for designing and screening sensitive peptide bioreceptors, as well as advanced techniques for peptide-based biosensors and innovative approaches like electronic noses for food monitoring. These biosensors and electronic noses offer promising alternatives for highly sensitive, cost-effective, and rapid pathogen detection, some of which can be used as portable devices for on-site analysis.
Proceedings Paper
Optics
Jonathan S. Weerakkody, Charlotte Hurot, Sophie Brenet, Raphael Mathey, Cyril Herrier, Thierry Livache, Arnaud Buhot, Yanxia Hou
Summary: The study focuses on optimizing the prism metallization and testing the effect of humidity and temperature at different temperatures. Through a numerical model and experimental results, a fundamental understanding of the adsorption of water on gold surfaces was obtained to improve the system's stability and performance.
OPTICAL SENSING AND DETECTION VI
(2021)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).