Article
Food Science & Technology
Beatriz Nunes Silva, Vasco Cadavez, Cristina Caleja, Eliana Pereira, Ricardo C. Calhelha, Mikel Anibarro-Ortega, Tiane Finimundy, Marina Kostic, Marina Sokovic, Jose Antonio Teixeira, Lillian Barros, Ursula Gonzales-Barron
Summary: This study aimed to characterize the polyphenolic profile and bioactive properties of lemon balm, sage, and spearmint extracts. The results showed that some of these extracts may have the ability to prevent food spoilage and promote health benefits while not displaying toxicity against healthy cells. Although sage extracts did not exhibit anti-inflammatory capacity, they often showed the best outcomes in terms of other bioactivities. Overall, the research provides insight into the potential of plant extracts as a source of active phytochemicals and as natural food additives.
Article
Agricultural Engineering
Maria Stasinska-Jakubas, Barbara Hawrylak-Nowak, Slawomir Dresler, Magdalena Wojciak, Katarzyna Rubinowska
Summary: Plant elicitors, such as chitosan lactate and salicylic acid, have been extensively used to increase the production of secondary metabolites in vitro. In vivo studies are still needed to fully understand the biological basis of elicitation. Among the compounds studied, chitosan lactate and salicylic acid showed the strongest elicitation effects on phenolic metabolites in lemon balm, while a mixture of elicitors did not significantly change metabolite levels. Additionally, the highest concentrations of metabolites were observed on the 8th day of elicitation, and the elicitors also increased antioxidant activity in plant extracts.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Barbara Hawrylak-Nowak, Slawomir Dresler, Maria Stasinska-Jakubas, Magdalena Wojciak, Ireneusz Sowa, Renata Matraszek-Gawron
Summary: In this study, the application of NaCl as an abiotic elicitor enhanced the biosynthesis and accumulation of phenolic secondary metabolites in lemon balm plants. Despite inhibiting plant growth, salt stress did not disturb the accumulation of photosynthetic pigments or the proper functioning of the PS II photosystem. This method represents a cost-effective and convenient alternative for improving the quality of lemon balm and increasing health-promoting phytochemicals in herbal products.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Barbara Hawrylak-Nowak, Slawomir Dresler, Katarzyna Rubinowska, Renata Matraszek-Gawron
Summary: The study showed that the foliar spray of chitosan lactate can enhance the accumulation of certain important compounds in herbal plants. For basil, a concentration of 100 mg/L of ChL increased the content of rosmarinic acid, while for lemon balm, both 100 mg/L and 500 mg/L of ChL increased the accumulation of certain phenolics and anthocyanins.
Article
Agricultural Engineering
Woon Yao Chai, Joo Kheng Goh, Vineetha Kalavally, Sadequr Rahman, Yau Yan Lim, Wee Sim Choo
Summary: This study aimed to enhance the medicinal characteristics of Melissa officinalis by increasing the production of phenolic compounds, particularly rosmarinic acid (RA), and evaluating the activities of RA-regulatory enzymes using different light treatments. The results showed that a blue-enriched light treatment significantly increased the total phenolic content, RA, and antioxidant capacity of M. officinalis. The application of spectrally tunable LEDs also induced changes in malondialdehyde level and sugar concentration, with minimal effect on chlorophyll content and antimicrobial activity. The findings suggest that spectrally tunable LEDs have the potential to promote phenolic compounds production in M. officinalis.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Plant Sciences
Fahima Abdellatif, Muhammad Akram, Samir Begaa, Mohammed Messaoudi, Adel Benarfa, Chukwuebuka Egbuna, Hamza Ouakouak, Aicha Hassani, Barbara Sawicka, Walaa Fikry Mohammed Elbossaty, Jesus Simal-Gandara
Summary: This study describes the mineral elements, chemical composition, antioxidant, and antimicrobial activities of Algerian Melissa officinalis plant. The research identified 18 mineral elements and 78 compounds in the plant, with major components being geranial, neral, and citronellal in the essential oil. The essential oil showed high antimicrobial activity against various microorganisms.
Review
Physiology
Nevena Draginic, Vladimir Jakovljevic, Marijana Andjic, Jovana Jeremic, Ivan Srejovic, Marina Rankovic, Marina Tomovic, Tamara Nikolic Turnic, Andrey Svistunov, Sergey Bolevich, Isidora Milosavljevic
Summary: Melissa officinalis, commonly known as lemon balm, has been traditionally used for memory, cognition, anxiety, depression, and heart palpitations. Studies have shown that it has beneficial cardiovascular effects, including antiarrhythmic, hypotensive, and vasorelaxant properties. The main active compounds, such as rosmarinic acid, exhibit antioxidant and anti-inflammatory effects in protecting the cardiovascular system. Further investigation is needed to explore its potential as a cardioprotective agent in patients with cardiovascular diseases.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Agricultural Engineering
Hamid Mohammadi, Zahra Mousavi, Saeid Hazrati, Ahmad Aghaee, Fatemeh Bovand, Marian Brestic
Summary: Lemon balm is a valuable medicinal plant with various uses. The study found that foliar application of 100 mg/L titanium dioxide nanoparticles under shading conditions can improve the yield and quality of lemon balm.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Horticulture
Arvish Maharaj, Yougasphree Naidoo, Yaser Hassan Dewir, Hail Rihan
Summary: This study investigated the bioconstituents and biological properties of Mangifera indica leaves during summer and winter seasons. The leaves were found to contain various metabolites, including phenols, flavonoids, tannins, terpenoids, alkaloids, phytosterol, saponins, steroids, and carbohydrates. Methanolic extracts showed antibacterial activity, while hexane and methanolic extracts exhibited significant antioxidant activity. Summer extracts showed stronger antibacterial and radical scavenging effects than winter extracts.
Article
Plant Sciences
Rubi Julieta Ortega-Medrano, Luis Fernando Ceja-Torres, Monserrat Vazquez-Sanchez, Guillermo Cristian Guadalupe Martinez-Avila, Jose Roberto Medina-Medrano
Summary: The phytochemical composition, phenolic content, and antioxidant activity of ethanolic and methanolic extracts from leaves and flowers of Cosmos sulphureus were determined. The extracts were found to have high contents of phenolic, flavonoid, and condensed tannins, and showed relevant antioxidant activities. This research highlights the phytochemical profile and antioxidant activity of phenolic compounds-rich extracts from C. sulphureus.
Article
Chemistry, Applied
Maria del Pilar Fernandez-Poyatos, Antonio Ruiz-Medina, Eulogio J. Llorent-Martinez
Summary: The study found that the phenolic content of Royal variety olive fruits reached its peak in January as the olives ripened, while there was no clear trend observed regarding the mineral content.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2021)
Article
Plant Sciences
Thais C. Silva, Suzan K. Bertolucci, Alexandre A. Carvalho, Wesley N. Tostes, Ivan C. A. Alvarenga, Fernanda Pacheco, Rafael M. A. de Assis, Alan da Cunha Honorato, Jose E. B. P. Pinto
Summary: The study evaluated the growth and chemical composition of Melissa officinalis L. essential oil in plants subjected to mineral omission. The results showed that nutrient omission affected plant growth and the quality of essential oil produced.
JOURNAL OF APPLIED RESEARCH ON MEDICINAL AND AROMATIC PLANTS
(2021)
Article
Biochemistry & Molecular Biology
Dorota Adamczyk-Szabela, Ewa Chrzescijanska, Piotr Zielenkiewicz, Wojciech M. M. Wolf
Summary: The aim of this study was to assess the influence of cadmium and zinc treatments on antioxidant activity and photosynthesis efficiency in lemon balm. The results showed a reduction in net photosynthesis for plants subjected to both zinc and cadmium treatments. The herbal extracts had exceptional antioxidant capacities and were good scavengers of free radicals and reactive oxygen species. In addition, the structural similarity of cadmium and zinc facilitated their mutual structural exchange and led to an expansion of phenolics under mixed zinc and cadmium treatments.
Article
Biology
Maryam Mohammadi-Cheraghabadi, Seyed Ali Mohammad Modarres-Sanavy, Fatemeh Sefidkon, Ali Mokhtassi-Bidgoli, Saeid Hazrati
Summary: This study investigated the effect of putrescine on Salvia officinalis under different irrigation regimes, revealing significant differences in plant response to various treatments and correlations between different parameters.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Engineering, Chemical
Asmaa Saleh, Omkulthom Al Kamaly, Ashwag S. Alanazi, Omar Noman
Summary: In this study, the phytochemical composition and antimicrobial activity of Rosmarinus officinalis essential oil were investigated. The GC-MS analysis revealed the presence of 18 constituents, with Bornyl acetate, Eucalyptol, and Camphor being the major compounds. The essential oil showed strong antimicrobial activity against S. aureus and E. coli. Molecular docking experiments suggested that the oil has potential affinities with microbial proteins, indicating its potential use in the development of synthetic drugs.
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).