A new therapeutic target: the CD69-Myl9 system in immune responses

CD103+Tumor-Resident CD8+T Cells Are Associated with Improved Survival in Immunotherapy-Naïve Melanoma Patients and Expand Significantly During Anti–PD-1 Treatment

(2018) Jarem Edwards et al.   CLINICAL CANCER RESEARCH

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

(2018) Daniele V. F. Tauriello et al.   NATURE

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

(2018) Thomas Duhen et al.   Nature Communications

Crucial role of CD69 in anti-tumor immunity through regulating the exhaustion of tumor-infiltrating T cells

(2018) Yukiyoshi Mita et al.   INTERNATIONAL IMMUNOLOGY

Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates

(2018) Yannick Simoni et al.   NATURE

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

CD69 prevents PLZFhi innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation

(2018) Motoko Y. Kimura et al.   Nature Communications

Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin

(2018) Simone L. Park et al.   NATURE

Crucial role for CD69 in allergic inflammatory responses: CD69-Myl9 system in the pathogenesis of airway inflammation

(2017) Motoko Y. Kimura et al.   IMMUNOLOGICAL REVIEWS

Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment

(2017) Sadna Budhu et al.   Science Signaling

Combination therapy with dendritic cell-based vaccine and anti-CD69 antibody enhances antitumor efficacy in renal cell carcinoma-bearing mice

(2017) Si-Ming WEI et al.   Turkish Journal Of Medical Sciences

Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment

(2017) Sadna Budhu et al.   Science Signaling

Thy1+IL-7+lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation

(2016) Kenta Shinoda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycosylation-dependent interaction between CD69 and S100A8/S100A9 complex is required for regulatory T-cell differentiation

(2015) Chih-Ru Lin et al.   FASEB JOURNAL

CD8+CD103+Tumor–Infiltrating Lymphocytes Are Tumor-Specific Tissue-Resident Memory T Cells and a Prognostic Factor for Survival in Lung Cancer Patients

(2015) Fayçal Djenidi et al.   JOURNAL OF IMMUNOLOGY

CD103+ Tumor Infiltrating Lymphocytes Predict a Favorable Prognosis in Urothelial Cell Carcinoma of the Bladder

(2015) Bo Wang et al.   JOURNAL OF UROLOGY

Anti-CD69 monoclonal antibody treatment inhibits airway inflammation in a mouse model of asthma

(2015) Hui-ying Wang et al.   Journal of Zhejiang University-SCIENCE B

Pre-B cell receptor binding to galectin-1 modifies galectin-1/carbohydrate affinity to modulate specific galectin-1/glycan lattice interactions

(2015) Jeremy Bonzi et al.   Nature Communications

Tissue-Resident Memory T Cells

(2014) Jason M. Schenkel et al.   IMMUNITY

Maintenance of immune tolerance by Foxp3+ regulatory T cells requires CD69 expression

(2014) José R. Cortés et al.   JOURNAL OF AUTOIMMUNITY

TGF-β upregulates CD70 expression and induces exhaustion of effector memory T cells in B-cell non-Hodgkin’s lymphoma

(2014) Z-Z Yang et al.   LEUKEMIA

The Leukocyte Activation Receptor CD69 Controls T Cell Differentiation through Its Interaction with Galectin-1

(2014) H. de la Fuente et al.   MOLECULAR AND CELLULAR BIOLOGY

Tumor-Infiltrating Lymphocytes Expressing the Tissue Resident Memory Marker CD103 Are Associated with Increased Survival in High-Grade Serous Ovarian Cancer

(2013) J. R. Webb et al.   CLINICAL CANCER RESEARCH

Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells

(2013) Cara N Skon et al.   NATURE IMMUNOLOGY

Crucial Role for CD69 in the Pathogenesis of Dextran Sulphate Sodium-Induced Colitis

(2013) Akihiro Hasegawa et al.   PLoS One

The Early Activation Marker CD69 Regulates the Expression of Chemokines and CD4 T Cell Accumulation in Intestine

(2013) Katarina Radulovic et al.   PLoS One

Is CD69 an effective brake to control inflammatory diseases?

(2013) Roberto González-Amaro et al.   TRENDS IN MOLECULAR MEDICINE

Sphingosine-1-Phosphate and Lymphocyte Egress from Lymphoid Organs

(2012) Jason G. Cyster et al.   Annual Review of Immunology

Galectin-1 Deactivates Classically Activated Microglia and Protects from Inflammation-Induced Neurodegeneration

(2012) Sarah C. Starossom et al.   IMMUNITY

CD69 Regulates Type I IFN-Induced Tolerogenic Signals to Mucosal CD4 T Cells That Attenuate Their Colitogenic Potential

(2012) K. Radulovic et al.   JOURNAL OF IMMUNOLOGY

Antigen-Independent Differentiation and Maintenance of Effector-like Resident Memory T Cells in Tissues

(2012) K. A. Casey et al.   JOURNAL OF IMMUNOLOGY

Type II membrane protein CD69 regulates the formation of resting T-helper memory

(2012) K. Shinoda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cigarette smoke-induced pulmonary inflammation is attenuated in CD69-deficient mice

(2011) Junichi Tsuyusaki et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

CD69 Suppresses Sphingosine 1-Phosophate Receptor-1 (S1P1) Function through Interaction with Membrane Helix 4

(2010) Alexander J. Bankovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The route of priming influences the ability of respiratory virus–specific memory CD8+T cells to be activated by residual antigen

(2010) Shiki Takamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD69 Association with Jak3/Stat5 Proteins Regulates Th17 Cell Differentiation

(2010) P. Martin et al.   MOLECULAR AND CELLULAR BIOLOGY

Lymph node cortical sinus organization and relationship to lymphocyte egress dynamics and antigen exposure

(2010) I. L. Grigorova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neural Crest-Derived Pericytes Promote Egress of Mature Thymocytes at the Corticomedullary Junction

(2010) M. A. Zachariah et al.   SCIENCE

MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9

(2009) L. Gilles et al.   BLOOD

CD69 Controls the Pathogenesis of Allergic Airway Inflammation

(2009) T. Miki-Hosokawa et al.   JOURNAL OF IMMUNOLOGY