Article
Engineering, Environmental
Kaiyi Wu, Merve Atasoy, Hans Zweers, Huub Rijnaarts, Alette Langenhoff, Tania V. Fernandes
Summary: Microalgae-based technologies can effectively remove organic micropollutants (OMPs) from wastewater, but the impact of wastewater characteristics on the removal is not well understood. This study evaluated the removal of sixteen OMPs by Chlorella sorokiniana cultivated in three types of wastewater. The results showed that the removal efficiency varied depending on the wastewater type, with longer retention time enhancing the removal of some OMPs. Wastewater soluble COD and biomass concentration were found to be the major factors affecting OMPs removal.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Engineering, Environmental
Jiaqi Tan, Hao Yi, Zijia Zhang, Delong Meng, Yinta Li, Ling Xia, Shaoxian Song, Li Wu, Rosa Maria Torres Sancheze, Maria E. Farias
Summary: This study found that adding montmorillonite in soil can facilitate Chlorella sorokiniana FK's biomineralization of lead, increasing the algae's tolerance to lead poisoning. The montmorillonite promotes photosynthesis and urea hydrolysis in Chlorella, enhancing the biomineralization process of lead.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Agricultural Engineering
Jin-Long Zhou, Lei Yang, Kai-Xuan Huang, Dong-Zhi Chen, Feng Gao
Summary: This study reviews the development of microalgae's ability to remove emerging contaminants from wastewater. It proposes three methods to improve the removal performance of contaminants by microalgae and recommends three types of algal-bacterial consortia applications. However, further research is needed to understand the applicability and cost-effectiveness of these hybrid processes.
BIORESOURCE TECHNOLOGY
(2022)
Article
Agricultural Engineering
Abdul-Wahab Abbew, Shuang Qiu, Ayesha Algade Amadu, Muhammed Zeeshan Qasim, Zhipeng Chen, Zhengshuai Wu, Lingfeng Wang, Shijian Ge
Summary: This study revealed the multi-targeted responses of the model wastewater microalgae, Chlorella sorokiniana, to FNA exposure. The findings showed that FNA negatively influenced microalgal growth and photosynthesis, increased oxidative stress, and altered gene expression. These results are crucial for understanding the stability of the MBCP system and its potential application in wastewater treatment.
BIORESOURCE TECHNOLOGY
(2022)
Article
Agricultural Engineering
Chengfeng Xue, I. -Son Ng
Summary: By optimizing the process with in situ CO2 adaptation and citrate feeding strategies, biorefineries have successfully achieved efficient production of GABA and sequestered the CO2 generated in sodium hydroxide. Supplying GABA to the culture further improved biomass and lipid content.
BIORESOURCE TECHNOLOGY
(2022)
Article
Agricultural Engineering
Charles B. Felix, Wei-Hsin Chen, Jo-Shu Chang, Young -Kwon Park, Samrand Saeidi, Gopalakrishnan Kumar
Summary: Oxidative torrefaction is recommended for improving the fuel properties of microalgae as solid biofuels. Temperature, time, and O2 concentration have significant effects on various parameters such as solid yield, energy yield, and higher heating value. The optimal conditions for this process are 200°C, 10.6 min, and 12% O2, resulting in an energy yield of 98.73% and an enhancement factor of 1.08. Furthermore, it shows higher reactivity under an air environment compared to inert torrefaction conditions.
BIORESOURCE TECHNOLOGY
(2023)
Article
Environmental Sciences
Antonio Leon-Vaz, Luis C. Romero, Cecilia Gotor, Rosa Leon, Javier Vigara
Summary: This study investigated the effect of cadmium on the microalga Chlorella sorokiniana through a proteomic approach, revealing adjustments in various metabolic pathways and an increase in pathways such as photorespiration and antioxidant enzymes. Additionally, it was found that Chlorella sorokiniana exhibits high tolerance to cadmium exposure, suggesting its potential use in bioremediation processes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Chemistry, Multidisciplinary
Aline C. C. Pena, Lucas Manique Raymundo, Luciane F. Trierweiler, Mariliz Gutterres
Summary: In this study, microalgae biochar was used to synthesize carbon dots (CDs) for detecting toxic metal ions. The synthesized CDs showed high fluorescence intensity and stability. The results demonstrated selective quenching ability of the CDs towards Cr (VI), indicating their potential for metal ion detection.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Tingting Li, Na Pang, Lian He, Yuan Xu, Xinyu Fu, Yinjie Tang, Yair Shachar-Hill, Shulin Chen
Summary: The microalga Chlorella sorokiniana adjusts metabolic flux and biomass synthesis to adapt to light conditions. Under light conditions, the microalga reduces fluxes in glucose catabolism, the tricarboxylic acid cycle, and anaplerotic reaction, while activating the RuBisCO reaction.
Article
Engineering, Environmental
Najmeh Hamidian, Hajar Zamani
Summary: This study investigates the integration of treatment of dairy wastewater and bioactive-rich biomass production by cultivating Chlorella sorokiniana in undiluted and diluted wastewater. The results demonstrate that C. sorokiniana can effectively reduce the pollutant content of undiluted wastewater and achieve high biomass production. Additionally, the biomass obtained from mixotrophic cultivation shows potential for biofuel production and contains high levels of antioxidant compounds. The findings highlight the effectiveness of mixotrophic cultivation using dairy wastewater in reducing production costs and obtaining high-quality microalgal biomass.
JOURNAL OF WATER PROCESS ENGINEERING
(2022)
Article
Agricultural Engineering
Yuhao Chu, Shengnan Li, Peng Xie, Xi Chen, Xue Li, Shih-Hsin Ho
Summary: This study investigates the removal of tetracycline (TET), sulfathiazole (STZ), and ciprofloxacin (CIP) by Chlorella sorokiniana at different concentrations and finds that microalgae have a concentration-dependent effect on antibiotic removal. TET shows nearly 100% removal efficiency at any concentration. High concentrations of STZ inhibit microalgal photosynthesis and induce the production of reactive oxygen species (ROS), leading to antioxidant damage and reduced removal efficiency. On the other hand, CIP enhances the ability of microalgae to remove CIP by inducing a dual peroxidase and cytochrome P450 enzyme response. Economic analysis shows that microalgae treatment of antibiotics is cheaper compared to other microalgae water treatment processes.
BIORESOURCE TECHNOLOGY
(2023)
Article
Energy & Fuels
B. Namitha, Asha Sathish, P. Senthil Kumar, K. Nithya, Shyam Sundar
Summary: This study compared the performance of Monoraphidium sp. and Chlorella sorokiniana in the energy conversion process, finding that Chlorella sorokiniana has higher yield and more favorable fatty acid profile. The use of biodiesel showed high lipid recovery and lower CO and HC emissions, but slightly higher nitrogen oxides and carbon dioxide emissions.
Article
Agricultural Engineering
Anil Kumar Patel, Akash Pralhad Vadrale, Reeta-Rani Singhania, Chiu-Wen Chen, Jo Shu Chang, Cheng-Di Dong
Summary: The aim of this study was to isolate microalgae with high lutein production and maximize lutein yield through a sustainable lutein-lipid biorefinery scheme. Lutein reduces the risk of retinitis and macular degeneration and improves eye health. An effective bioprocess design optimized nutrients, temperature, light, and salinity to enhance biomass and lutein yield. The identified Chlorella sorokiniana C16 exhibited one of the highest lutein yields reported, making it a promising candidate for commercial lutein production under a biorefinery scheme.
BIORESOURCE TECHNOLOGY
(2023)
Article
Engineering, Environmental
Di Zhou, Shuang Qiu, Mengting Li, Wenju Shan, Zhipeng Chen, Zhengshuai Wu, Shijian Ge
Summary: This study investigated the effects of surgical mask exudates (SMEs) in wastewater on microalgal cellular responses. The findings showed that SMEs significantly inhibited nutrient uptake and photosynthetic activities, disrupted peroxisome biogenesis, induced oxidative stress, and destroyed the structure of cell membrane. The exposure to SMEs also affected carbon fixation pathways, suppressed ABC transporters, and promoted oxidative phosphorylation processes. These findings contribute to our understanding of the effects of SMEs in wastewater on microalgae and improve the practical relevance of microalgae wastewater bioremediation technology.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Chemistry, Applied
J. T. Mary Leema, T. Persia Jothy, G. Dharani
Summary: The study focuses on the rapid green microwave-assisted extraction of lutein from marine microalgae, optimizing the process parameters for higher lutein yield with less energy intensity. The results show that the optimized conditions for microwave-assisted alkali pre-treatment significantly increased lutein extraction yield and improved the quality of the extracted lutein. This innovative method can be a suitable process for lutein extraction from marine microalgae due to its efficiency and high extraction yield.
Article
Engineering, Environmental
Elianta Kora, Danai Theodorelou, Georgia Gatidou, Michail S. Fountoulakis, Athanasios S. Stasinakis
CHEMICAL ENGINEERING JOURNAL
(2020)
Article
Environmental Sciences
Georgia Gatidou, Niki Vazaiou, Nikolaos S. Thomaidis, Athanasios S. Stasinakis
Article
Environmental Sciences
Chrysanthi Michelaki, Nikolaos M. Fyllas, Alexandros Galanidis, Maria Aloupi, Eleftherios Evangelou, Margarita Arianoutsou, Panayiotis G. Dimitrakopoulos
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Environmental Sciences
Maria Aloupi, Elpida Ferentinou, Olga-Maria Zaharaki, Triantafyllos Akriotis
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2020)
Correction
Environmental Sciences
Chrysanthi Michelaki, Nikolaos M. Fyllas, Alexandros Galanidis, Maria Aloupi, Eleftherios Evangelou, Margarita Arianoutsou, Panayiotis G. Dimitrakopoulos
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Biochemistry & Molecular Biology
Georgios Theodoridis, Alexandros Pechlivanis, Nikolaos S. Thomaidis, Apostolos Spyros, Constantinos A. Georgiou, Triantafyllos Albanis, Ioannis Skoufos, Stavros Kalogiannis, George Th. Tsangaris, Athanasios S. Stasinakis, Ioannis Konstantinou, Alexander Triantafyllidis, Konstantinos Gkagkavouzis, Anastasia S. Kritikou, Marilena E. Dasenaki, Helen Gika, Christina Virgiliou, Dritan Kodra, Nikolaos Nenadis, Ioannis Sampsonidis, Georgios Arsenos, Maria Halabalaki, Emmanuel Mikros
Summary: FoodOmicsGR_RI coordinates research efforts from eight Greek Universities and Research Centers to support the agri-food sector through omics technologies, aiming at comprehensive characterization of foods and dietary/nutrition studies. The network combines expertise in omics with a range of other scientific fields to cover a broad spectrum of the Greek agri-food sector.
Article
Agricultural Engineering
Eirini Zkeri, Athanasia Iliopoulou, Alexandra Katsara, Angeliki Korda, Maria Aloupi, Georgia Gatidou, Michail S. Fountoulakis, Athanasios S. Stasinakis
Summary: Two systems were compared for medium-strength dairy wastewater treatment, with one achieving energy autonomy through a combination of a methanogenic reactor and an aerobic reactor, effectively removing COD, NH4-N, TKN, and PO4-P. The other system, using a reactor and Chlorella sorokiniana, completely removed COD but only partially removed other pollutants.
BIORESOURCE TECHNOLOGY
(2021)
Article
Plant Sciences
Panayiotis G. Dimitrakopoulos, Maria Aloupi, Georgios Tetradis, George C. Adamidis
Summary: The study investigates the interaction between Odontarrhena lesbiaca and parasitic species, with a focus on the defense hypothesis of metal hyperaccumulation. It was found that parasitic plants can attack O. lesbiaca individuals and still hyperaccumulate metals in their tissues despite elevated leaf nickel concentrations, contrary to the elemental defense hypothesis.
Article
Environmental Sciences
Ana Miralles-Marco, Miaomiao Wang, June-Soo Park, Georgia Gatidou, Maria-Christina Nika, Samantha Bialorucki, Olga-Ioanna Kalantzi, Nikolaos S. Thomaidis, Athanasios S. Stasinakis, Myrto Petreas
Summary: This study evaluated the effects of shipping and handling on PFAS in environmental samples, indicating that storage time may impact the recovery of PFAS. Additionally, analysis of local and international wastewater samples identified six PFAS and quantified their concentrations accordingly.
Article
Biotechnology & Applied Microbiology
Athanasia Iliopoulou, Eirini Zkeri, Anthi Panara, Marilena Dasenaki, Michail S. Fountoulakis, Nikolaos S. Thomaidis, Athanasios S. Stasinakis
Summary: This study found that Chlorella sorokiniana can efficiently remove pollutants from dairy industry effluents and produce biomass rich in proteins, carbohydrates, and lipids. Additionally, the biomass contains significant amounts of pigments, phenolic compounds, and amino acids.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2022)
Article
Green & Sustainable Science & Technology
Petros Mastoras, Stergios Vakalis, Michail S. Fountoulakis, Georgia Gatidou, Panagiota Katsianou, Georgios Koulis, Nikolaos S. Thomaidis, Dias Haralambopoulos, Athanasios S. Stasinakis
Summary: This study evaluated the use of solar distillation for olive mill wastewater management by constructing a pilot-scale solar still. The results showed that higher temperatures in the distillation process led to increased concentrations of total phenols, tyrosol, and hydroxytyrosol in the distillates. Additionally, the use of a heated underfloor system in the pilot system improved the average and maximum daily temperatures in the still and increased the production rates of the distillates. Liquid chromatography - high resolution mass spectrometry analysis detected concentrations of tyrosol and 4- hydroxybenzoic acid in the collected distillates. Economic evaluation showed that the operational and overall costs for upscaling the pilot system were estimated to 0.60 and 1.21 euro/m3, respectively, considering the reuse of the distillate for washing and malaxation of olive fruits and selling the solid residue as biofuel.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Agricultural Engineering
Demetrios Kalantzis, Ioannis Daskaloudis, Tim Lacoere, Athanasios S. Stasinakis, Demetris F. Lekkas, Jo De Vrieze, Michail S. Fountoulakis
Summary: This study examined the continuous addition of conductive GAC in an integrated pilot-scale unit for the treatment of agro-industrial wastewater. The addition of GAC increased biogas production by 32% and the relative abundance of Methanosaeta in the digester. The final effluent after treatment had a low total solids content and a moderate chemical oxygen demand, showing the potential profitability of GAC addition.
BIORESOURCE TECHNOLOGY
(2023)
Article
Energy & Fuels
Konstantinos Tsompanoglou, Olga P. Koutsou, Athanasios S. Stasinakis
Summary: This study evaluates the energy consumption and greenhouse gas emissions of landfill leachate treatment systems. The results show that biological treatment and reverse osmosis are effective in pollutant removal. Mechanical vapor recompression evaporation contributes significantly to both energy consumption and greenhouse gas emissions.
Article
Environmental Sciences
Athanasia Iliopoulou, Olga S. Arvaniti, Michalis Deligiannis, Georgia Gatidou, Ioannis Vyrides, Michalis S. Fountoulakis, Athanasios S. Stasinakis
Summary: An integrated lab-scale wastewater treatment system was used to study the removal and fate of pharmaceuticals during wastewater treatment. The removal of major pollutants and target pharmaceuticals was not affected by the temperature of the anaerobic Moving Bed Biofilm Reactor (AnMBBR). Biotransformation was the predominant mechanism for the removal of pharmaceuticals, while sorption played a minor role.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Environmental Sciences
Olga P. Koutsou, Christoforos Mandylas, Michail S. Fountoulakis, Athanasios S. Stasinakis
Summary: The sustainable management of landfill leachates is an important concern for many countries. The study found that the use of constructed wetlands is a treatment method with lower operational costs, energy requirements, and greenhouse gas emissions.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)