Article
Clinical Neurology
Sokratis Charisis, Eva Ntanasi, Maria Stamelou, Georgia Xiromerisiou, Maria Maraki, Aristidis S. Veskoukis, Mary Yannakoulia, Mary H. Kosmidis, Costas A. Anastasiou, Nikolaos Giagkou, Efthimios Dardiotis, Georgios Hadjigeorgiou, Paraskevi Sakka, Demetrios Kouretas, Leonidas Stefanis, Nikolaos Scarmeas
Summary: The study explores the potential role of plasma GSH as a risk/susceptibility biomarker for prodromal PD and finds that higher plasma GSH levels are associated with slower increases in pPD probability, potentially aiding in the identification of individuals likely to be diagnosed with pPD more rapidly.
MOVEMENT DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Ana Freitas, Miguel Aroso, Antonio Barros, Miriam Fernandez, Eduardo Conde-Sousa, Marina Leite, Eva Daniela Carvalho, Cristina C. Ribeiro, Rita Ferreira, Ana Paula Pego, Rui Vitorino, Maria Gomez-Lazaro
Summary: The extracellular matrix in the brains of Parkinson's disease patients shows increased oxalate content and oxidative modifications, affecting microglial survival, morphology, and cytoskeletal tension. Thorough investigation into these modifications may lead to new therapies for Parkinson's disease.
Article
Biochemistry & Molecular Biology
Carmen Pena-Bautista, Lourdes alvarez, Miguel Baquero, Ines Ferrer, Lorena Garcia, David Hervas-Marin, Consuelo Chafer-Pericas
Summary: The study analyzed the utility of lipid peroxidation biomarkers in evaluating Alzheimer's Disease progression, with some analytes showing an increasing trend over time. A regression model developed based on baseline values could predict long-term cognitive status.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Jesus D. Melendez-Flores, Alexandra Carolina Cavazos-Benitez, Ingrid Estrada-Bellmann
Summary: Parkinson's disease is a neurodegenerative condition associated with various metabolic factors, such as proteinuria. Microalbuminuria may serve as a potential marker for evaluating PD severity, reflecting common pathological mechanisms including oxidative stress, insulin resistance, and endothelial dysfunction. Further evidence from white matter lesions suggests that microalbuminuria could provide insight into PD status and further research is needed to confirm this hypothesis.
MEDICAL HYPOTHESES
(2021)
Article
Clinical Neurology
Ji-tian Guan, Xin Zheng, Lingfeng Lai, Shuyi Sun, Yiqun Geng, Xiaolei Zhang, Teng Zhou, Huan-ze Wu, Jia-qing Chen, Zhong-xian Yang, Xiao-hong Zheng, Jia-xu Wang, Wei Chen, You-qiao Zhang
Summary: This study investigated the alteration of metabolites in patients with Parkinson's disease (PD) and non-motor symptoms using 1H-MRS. The results suggest that Cr, NAA/Cr, and mI/Cr may serve as potential biomarkers for the progression of PD. Furthermore, MRS of the thalamus may be a sensitive region for the detection of cognitive decline in PD.
FRONTIERS IN NEUROLOGY
(2022)
Article
Engineering, Environmental
Jiapei Yang, Lei Wang, Yue Su, Lingyue Shen, Xihui Gao, Leilei Shi, Xinyuan Zhu
Summary: A color-convertible fluorescent nanoprobe was designed for the diagnosis of Parkinson's disease based on the high level of iron and reactive oxygen species in PD. The nanoprobe can detect dual biomarkers with high sensitivity and specificity, providing a valuable tool for PD detection in vitro and in vivo.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Chen Dong, Chandrashekhar Honrao, Leonardo O. Rodrigues, Josephine Wolf, Keri B. Sheehan, Matthew Surface, Roy N. Alcalay, Elizabeth M. O'Day
Summary: Parkinson's disease is a progressive neurodegenerative disease with motor and nonmotor function loss. This study identified metabolic markers of PD in plasma and developed a machine learning model for PD diagnosis with high accuracy. The findings provide insights for the development of diagnostic tools for PD.
Article
Chemistry, Analytical
Hao Kang, Wei Shu, Jin Yu, Mengxu Gao, Rubing Han, Jing Jing, Rubo Zhang, Xiaoling Zhang
Summary: Parkinson's disease is a common neurodegenerative disease that causes great pain and economic burden. Peroxynitrite (ONOO-) plays a significant role in the development of Parkinson's disease, but effective detection methods are currently lacking. This study design a highly sensitive and selective near-infrared ratiometric fluorescent probe to track ONOO- and successfully observe its changes in a Parkinson's disease model.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Review
Chemistry, Medicinal
Claudia Bento-Pereira, Albena T. Dinkova-Kostova
Summary: Parkinson's disease is a progressive neurodegenerative disorder for which no disease-modifying therapies are available. Factors like age, genetic predisposition, and environmental stressors are known to increase the risk of developing PD. Activation of Nrf2 has shown to be beneficial in cellular and animal models of PD.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Clinical Neurology
Yasuaki Mizutani, Reiko Ohdake, Harutsugu Tatebe, Atsuhiro Higashi, Sayuri Shima, Akihiro Ueda, Mizuki Ito, Takahiko Tokuda, Hirohisa Watanabe
Summary: This study aimed to investigate the association between Alzheimer's disease (AD)-related plasma biomarkers and cognitive decline in Parkinson's disease (PD) patients. The results showed that plasma neurofilament light chain was associated with cognitive decline and disease severity, while plasma beta-amyloid 42/40 showed an increasing trend in PD patients without dementia compared to healthy controls. These findings suggest astrocytic pathologies related to cognitive decline and provide potential biomarkers for predicting cognitive decline in PD.
JOURNAL OF NEUROLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Amanda Li, Joel Tyson, Shivni Patel, Meer Patel, Sruthi Katakam, Xiaobo Mao, Weiwei He
Summary: With the aging population, the prevalence of neurodegenerative diseases such as PD and AD is expected to rise. These diseases are classified as proteinopathies with misfolded proteins like alpha-synuclein, amyloid-beta, and tau. Nanomaterials offer advantages over traditional therapies in targeting specific mechanisms, such as reducing oxidative stress or disaggregating fibrils.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Xin-xing Yang, Rong Yang, Feng Zhang
Summary: Parkinson's disease is a common and chronic degenerative disease in the central nervous system. The main pathology involves the loss of dopaminergic neurons and the formation of Lewy bodies. The pathogenesis of PD is influenced by various independent factors, and regulating the Nrf2 pathway may be a promising strategy for preventing and treating PD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Daniel L. D. Freitas, Ana F. S. Peres, Lidiane G. Silva, Joao V. M. Mariz, Marcos G. Santos, Rayanne S. P. Morais, Camilo L. M. Morais, Francis L. Martin, Daniel A. Pascoal, Juliana D. de A. S. Camargo, Janaina C. O. Crispim, Kassio M. G. Lima
Summary: The prevention of mother-to-child transmission programs in Brazil have seen success, as access to antiretroviral therapy during pregnancy has led to a reduction in new infections among children. By utilizing near-infrared spectroscopy, pregnant women with and without HIV infection can be quickly and accurately differentiated, offering a new perspective on investigating vertical transmission and providing a potential low-cost screening tool for fast HIV detection.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Andreas Daiber, Omar Hahad, Ioanna Andreadou, Sebastian Steven, Steffen Daub, Thomas Muenzel
Summary: Global epidemiological studies highlight the significance of chronic non-communicable diseases like atherosclerosis and metabolic disorders in premature mortality and morbidity, with cardiovascular diseases such as ischemic heart disease contributing significantly to the global disease burden and socioeconomic health costs. Research demonstrates a link between oxidative stress markers and major cardiovascular diseases, emphasizing the role of reactive oxygen and nitrogen species in conditions like hyperlipidemia, hypertension, and diabetes. In vivo redox biomarkers are discussed for their clinical relevance, while the potential prognostic value and limitations of these markers are critically examined.
Review
Biochemistry & Molecular Biology
Yasir Hasan Siddique
Summary: Parkinson's disease is the second most common neurodegenerative disorder affecting elderly people worldwide. While there is no permanent cure for the disease, symptomatic relief can be obtained through the use of dopamine agonists. Researchers are now focusing on the development of neuroprotective agents from plants to combat the side effects associated with long-term drug use.
Letter
Clinical Neurology
Ivan Martinez-Valbuena, Naomi P. Visanji, Diana A. Olszewska, Mario Sousa, Puja Bhakta, Anna Vasilevskaya, Chloe Anastassiadis, Maria Carmela Tartaglia, Gabor G. Kovacs, Anthony E. Lang
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Anne Weissbach, Annika Steinmeier, Martje Pauly, Duha M. Al-Shorafat, Gerard Saranza, Anthony Lang, Norbert Brueggemann, Vera Tadic, Christine Klein, Alexander Muenchau, Tobias Baeumer, Matt J. N. Brown
Summary: This study examined sensorimotor inhibition in GCH1 mutation carriers and found that their short-latency afferent inhibition (SAI) and dual-site transcranial magnetic stimulation (ds-TMS) levels were not significantly different from the control group. However, SAI decreased over time in mutation carriers off dopamine replacement therapy (DRT). These results suggest changes in plasticity in the sensorimotor networks.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Clinical Neurology
Diana A. Olszewska, Rajesh Shetty, Thenral S. Geetha, Vedam L. Ramprasad, Anthony E. Lang, Prashanth Lingappa Kukkle
MOVEMENT DISORDERS CLINICAL PRACTICE
(2022)
Letter
Clinical Neurology
Irene Litvan, Anthony E. Lang, Melissa Armstrong
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Letter
Clinical Neurology
Nikolai Gil D. Reyes, Daniel G. Di Luca, Vanda McNiven, Anthony E. Lang
Summary: GNB1 encephalopathy is a rare neuro-developmental syndrome caused by pathogenic variants in the GNB1 gene. It is characterized by global developmental delay and co-occurrence of movement disorders, with dystonia being the most common. Other rare phenomenologies include myoclonus, tics, chorea, ataxia, and oculomotor abnormalities. This case report presents a unique phenotype of GNB1 encephalopathy caused by a de novo mutation in exon 11, with symptoms of dystonia, myoclonus, and vertical supranuclear gaze palsy.
PARKINSONISM & RELATED DISORDERS
(2023)
Letter
Clinical Neurology
Daniel G. Di Luca, Dilinuer Wubuli, Vanda McNiven, Anthony E. Lang
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Antigony Rigas, Tina Mainka, Tamara Pringsheim, Alexander Muenchau, Irene Malaty, Yulia Worbe, Andrea E. Cavanna, Andrew John Lees, Anthony E. Lang, Davide Martino, Christos Ganos
Summary: This study revealed that the diagnostic distinction between primary and functional tics is often difficult, even for expert clinicians, in the absence of clinical information.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Tiago A. Mestre, Michael P. McDermott, Raquel Lobo, Joaquim J. Ferreira, Anthony E. E. Lang
Summary: This study evaluated the "lessebo effect" in disease modification trials in Parkinson's disease and found that it did not exist in these trials. However, the use of placebo instead of an active comparator was a limitation. Prospective measurement of expectation of benefit could help assess the various impacts of placebo use.
MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Anthony E. Lang
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Donald C. Brien, Heidi C. Riek, Rachel Yep, Jeff Huang, Brian Coe, Corson Areshenkoff, David Grimes, Mandar Jog, Anthony Lang, Connie Marras, Mario Masellis, Paula McLaughlin, Alicia Peltsch, Angela Roberts, Brian Tan, Derek Beaton, Wendy Lou, Richard Swartz, Douglas P. Munoz
Summary: A simple and non-invasive test was developed using video-based eye tracking and machine learning, which showed high sensitivity in detecting the stages of Parkinson's Disease and cognitive impairment. The classifier reached a sensitivity of 83% and a specificity of 78%.
PARKINSONISM & RELATED DISORDERS
(2023)
Editorial Material
Clinical Neurology
Nikolai Gil D. Reyes, Anthony E. Lang
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Letter
Clinical Neurology
Seyedeh Narges Tabatabaee, Sajjad Effat Nejad, Ali Nikkhah, Narges Hashemi, Afagh Alavi, Anthony E. E. Lang, Mohammad Rohani, Maziar Emamikhah
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Daniel G. Di Luca, Carolina Ramirez-Gomez, Jurgen Germann, Brendan Santyr, Alexandre Boutet, Luka Milosevic, Anthony E. Lang, Suneil K. Kalia, Andres M. Lozano, Alfonso Fasano
Summary: This study aimed to evaluate the safety and efficacy of deep brain stimulation on the globus pallidus pars interna and externa in MSA-P patients. The surgery did not result in major complications, but did not provide significant clinical benefit as measured by MDS-UPDRS III.
MOVEMENT DISORDERS
(2023)
Review
Clinical Neurology
Iris Lin, Laura Armengou-Garcia, Sanskriti Sasikumar, Greg Kuhlman, Susan H. Fox, Anthony E. Lang, Alberto J. Espay
Summary: Speech-induced craniofacial myoclonus with stuttering-like dysarthria and speech arrests is a disabling iatrogenic complication in Parkinson's disease that resolves upon amantadine discontinuation. Four of the patients with renal insufficiency were identified as a risk factor.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Elahe Amini, Mohammad Rohani, Anthony E. Lang, Zahra Azad, Seyed Amir Hassan Habibi, Afagh Alavi, Gholamali Shahidi, Maziar Emamikhah, Ahmad Chitsaz
Summary: Among 122 genetically confirmed NBIA patients, KRS had the best survival and longest preservation of ambulation ability, while classical PKAN and MPAN patients showed similar progression patterns in loss of ambulation ability, with MPAN patients having a slower progression to death. Spasticity was identified as the most significant factor associated with death.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
