Journal
ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 9
Volume 9, Issue -, Pages 1-25Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-anchem-071015-041742
Keywords
whispering gallery mode; biosensing; chemical sensing
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Funding
- NCI NIH HHS [R33 CA177462] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R33CA177462] Funding Source: NIH RePORTER
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Optical resonator sensors are an emerging class of analytical technologies that use recirculating light confined within a microcavity to sensitively measure the surrounding environment. Bolstered by advances in microfabrication, these devices can be configured for a wide variety of chemical or biomolecular sensing applications. We begin with a brief description of optical resonator sensor operation, followed by discussions regarding sensor design, including different geometries, choices of material systems, methods of sensor interrogation, and new approaches to sensor operation. Throughout, key developments are highlighted, including advancements in biosensing and other applications of optical sensors. We discuss the potential of alternative sensing mechanisms and hybrid sensing devices for more sensitive and rapid analyses. We conclude with our perspective on the future of optical microcavity sensors and their promise as versatile detection elements within analytical chemistry.
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