Review
Biochemistry & Molecular Biology
Furong Zhao, Siying Xie, Bingzhi Li, Xing Zhang
Summary: This review discusses the roles of carbohydrates and glycoconjugates in organisms and the applications of FNAs-based biosensors in detecting disease-related substances. By summarizing construction strategies and biosensing applications, challenges and development opportunities in this area are highlighted.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Analytical
Xiuen Cao, Chuanpin Chen, Qubo Zhu
Summary: This review summarizes the applications of functional nucleic acids and isothermal amplification techniques in biosensing, highlighting their important contributions to the field. These technologies have great potential to enhance the performance of biosensors.
Review
Chemistry, Analytical
Xinhong Yu, Shiqi Zhang, Wenqiang Guo, Boxi Li, Yang Yang, Bingqing Xie, Ke Li, Li Zhang
Summary: Biosensors have been developed for rapid detection of human diseases, while functional nucleic-acid (FNA) biosensors have gained attention recently due to their stability and specificity. However, there is a lack of comprehensive summaries on their working principles, classification, and applications.
Review
Chemistry, Analytical
Bingyang Huo, Yuling Hu, Zhixian Gao, Gongke Li
Summary: This article reviewed the application of functional nucleic acid-based biosensors in food safety analysis, including their programmability, structural switches, and detection methods for various food contaminants.
Review
Food Science & Technology
Jie Zhou, Teng-Yu Wang, Zhi Lan, Han-Jie Yang, Xing-Jian Ye, Rui Min, Zhao-Hui Wang, Qing Huang, Jing Cao, Yu-E Gao, Wen-Long Wang, Xiu-Lan Sun, Yi Zhang
Summary: Foodborne microbial contamination (FMC) is the primary cause of food poisoning and illness. Isothermal amplification methods with functional nucleic acids (FNAs) have enabled the detection of mycotoxins, making biosensors for FMC more sensitive, cost-effective, and less reliant on nanomaterials for signal output.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Chemistry, Analytical
Chenlan Shen, Liang Zhong, Peng Wan, Hengke Jia, Beizhong Liu
Summary: This study successfully constructed a novel biosensor for rapid enzyme-free detection of the specific fusion gene PML/RAR & alpha; in acute promyelocytic leukemia (APL). Through the use of DNAzyme and carbon dots/cobalt oxhydroxide nanosheet complex (CDs/CoOOH), the detection of PML/RAR & alpha; was achieved quickly and sensitively, showing potential clinical application value in the diagnosis and treatment of leukemia.
ANALYTICA CHIMICA ACTA
(2023)
Article
Biophysics
Zhuoer Zeng, Rong Zhou, Ruowei Sun, Xun Zhang, Zeneng Cheng, Chuanpin Chen, Qubo Zhu
Summary: Hybridization chain reaction (HCR) can be categorized into linear and nonlinear types. Traditional linear HCR is limited by slow kinetics and low sensitivity, while nonlinear HCR, triggered by an initiator, can self-assemble into dendritic or branched DNA nanostructures with exponential growth kinetics, offering advantages such as rapid growth, high sensitivity, and ease of operation.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Engineering, Biomedical
Ying Chen, Yonglin Wang, Xianfang Jiang, Jinhong Cai, Yuting Chen, Hanji Huang, Yuan Yang, Li Zheng, Jinmin Zhao, Ming Gao
Summary: This study developed cationic nanoparticles with favorable biocompatibility and high scavenging efficacy for the treatment of rheumatoid arthritis (RA). The nanoparticles effectively bound to excessive cfDNA, resulting in the inhibition of inflammation and the alleviation of joint swelling and cartilage destruction. Nanoparticles with higher bis dimethylamino group content exhibited stronger therapeutic effects.
BIOACTIVE MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Pooja Bhardwaj, Rajni Kant, Sthita Pragnya Behera, Gaurav Raj Dwivedi, Rajeev Singh
Summary: This article emphasizes the importance of CRISPR/Cas technology as a diagnostic tool for early management, diagnosis, and treatment of infections and diseases, and explores its detection capabilities for non-nucleic acid targets as well as the technical challenges and improvements in clinical assessment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Jiuxing Li, Shadman Khan, Jimmy Gu, Carlos D. M. Filipe, Tohid F. Didar, Yingfu Li
Summary: An Au-on-Au tip sensor is developed for the detection of Salmonella using a new synthetic nucleic acid probe as a linker. The sensor can visually detect the presence of Salmonella by cleaving the probe and detecting the freed DNA-conjugated Au nanoparticle. It has a portable design without requiring any electronic, electrochemical or optical equipment, and shows a high detection limit and no cross-reactivity with control bacteria.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Food Science & Technology
Tai-Yong Kim, Xiaoning Zhu, Se-Min Kim, Jeong-A Lim, Min-Cheol Lim, Ke Luo
Summary: Viruses are major pathogens in food poisoning, and the development of foodborne virus detection technologies for the entire food distribution chain is crucial for food safety. Polymerase chain reaction (PCR) is the gold standard method for monitoring food contamination by viruses, but it is time-consuming and vulnerable to inhibitors in food samples. Optical and electrical readout biosensors based on nucleic acid isothermal amplification technology and nanomaterials have emerged as alternatives, offering portability and on-site operation. However, the complexity of food components and lack of stability studies on residual food components limit the practical application of biosensors as a universal detection method.
FOOD RESEARCH INTERNATIONAL
(2023)
Review
Biotechnology & Applied Microbiology
Kun Chen, Ziyi Shen, Guanzhen Wang, Wei Gu, Shengchao Zhao, Zihan Lin, Wei Liu, Yi Cai, Gohar Mushtaq, Jia Jia, Chunpeng (Craig) Wan, Tingdong Yan
Summary: CRISPR/Cas technology, awarded the Nobel Prize in Chemistry in 2020, has gained attention for its success in gene editing and its potential in molecular diagnostics. By integrating with biosensors and bioassays, CRISPR-based detection shows high specificity and sensitivity, making it a promising tool for detecting biomarkers.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Loredana Mereuta, Alina Asandei, Irina Schiopu, Jonggwan Park, Yoonkyung Park, Tudor Luchian
Summary: Nanopores offer sensitive and cost-effective single-molecule sensing capabilities, and the advent of nanopore-based DNA detection and sequencing technologies has had a significant societal impact. To address the challenge of forming stable, long-lasting single nanopores, we have developed a new approach for detecting small single-stranded DNA using dynamic hybrid constructs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Seetha Lakshmy, Gopal Sanyal, Antara Vaidyanathan, Saju Joseph, Nandakumar Kalarikkal, Brahmananda Chakraborty
Summary: The research investigates the sensing capabilities of Ti-decorated MoS2 for catechol through DFT simulation, revealing that Ti-decorated MoS2 has higher binding energy and may be a promising nanomaterial for catechol detection.
APPLIED SURFACE SCIENCE
(2021)
Review
Biotechnology & Applied Microbiology
Jingwen Wang, Han Jiang, Leiming Pan, Xiuying Gu, Chaogeng Xiao, Pengpeng Liu, Yulong Tang, Jiehong Fang, Xiaoqian Li, Chenze Lu
Summary: As nucleic acid testing becomes crucial in various research fields, there is an increasing demand for rapid on-site testing methods. This review discusses recent advances in on-chip methods for sample preparation, amplification, and detection in the nucleic acid testing procedure. It covers integration strategies for sample preparation, various on-chip amplification methods, and evaluation of potential detection methods. The review also highlights the importance of improving the speed and integration of all steps onto a single chip for future developments in nucleic acid testing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Florika C. Macazo, Richard L. Karpel, Ryan J. White
Article
Chemistry, Multidisciplinary
Florika C. Macazo, Ryan J. White
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2016)
Article
Chemistry, Multidisciplinary
Sofiene Abdellaoui, Florika C. Macazo, Rong Cai, Antonio L. De lacey, Marcos Pita, Shelley D. Minteer
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2018)
Meeting Abstract
Biophysics
Ronald L. Koder, Jonathan M. Preston, Bernard H. Everson, Emma Bjerkefeldt, Florika C. Macazo, Fabien Giroud, Shelly D. Minteer, David J. Vinyard, Gary W. Brudvig
BIOPHYSICAL JOURNAL
(2018)
Correction
Engineering, Environmental
Yimin Huang, Xinqing Lee, Florika C. Macazo, Matteo Grattieri, Rong Cai, Shelley D. Minteer
CHEMICAL ENGINEERING JOURNAL
(2018)
Article
Materials Science, Multidisciplinary
Yimin Huang, Xinqing Lee, Matteo Grattieri, Florika C. Macazo, Rong Cai, Shelley D. Minteer
JOURNAL OF MATERIALS SCIENCE
(2018)
Article
Electrochemistry
Selmihan Sahin, Rong Cai, Ross D. Milton, Sofiene Abdellaoui, Florika C. Macazo, Shelley D. Minteer
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2018)
Article
Chemistry, Analytical
Florika C. Macazo, Ryan J. White
ANALYTICAL CHEMISTRY
(2014)
Article
Electrochemistry
Juan Liu, Melissa Davila Morris, Florika C. Macazo, Lauren R. Schoukroun-Barnes, Ryan J. White
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2014)
Article
Nanoscience & Nanotechnology
Beyza Bulutoglu, Florika C. Macazo, Jacob Bale, Neil King, David Baker, Shelley D. Minteer, Scott Banta
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Nanoscience & Nanotechnology
Koun Lim, Florika C. Macazo, Connor Scholes, Hui Chen, Kirsten Sumampong, Shelley D. Minteer
ACS APPLIED BIO MATERIALS
(2020)
Review
Chemistry, Physical
Florika C. Macazo, Shelley D. Minteer
CURRENT OPINION IN ELECTROCHEMISTRY
(2017)
Article
Chemistry, Multidisciplinary
Florika C. Macazo, David P. Hickey, Sofiene Abdellaoui, Matthew S. Sigman, Shelley D. Minteer
CHEMICAL COMMUNICATIONS
(2017)
Article
Chemistry, Analytical
Robert A. Lazenby, Florika C. Macazo, Richard F. Wormsbecher, Ryan J. White
ANALYTICAL CHEMISTRY
(2018)