Review
Biochemistry & Molecular Biology
Federico Biscetti, Elisabetta Nardella, Maria Margherita Rando, Andrea Leonardo Cecchini, Antonio Gasbarrini, Massimo Massetti, Andrea Flex
Summary: PAD is a manifestation of atherosclerosis affecting lower extremity arteries. CLTI, the most dangerous complication, often leads to limb loss without revascularization. EVT has become the primary approach for CLTI, but unsolved issues exist due to different clinical outcomes among patients with similar comorbidities undergoing the same procedure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Surgery
Jean Jacob-Brassard, Mohammed Al-Omran, Therese A. Stukel, Muhammad Mamdani, Douglas S. Lee, Charles de Mestral
Summary: The study aimed to quantify the regional variation in revascularization and amputation rates for peripheral artery disease (PAD). A repeated cross-sectional analysis of Ontarians aged 40 years and older between 2002 and 2019 was conducted. The results showed significant regional differences in demographics, comorbidities, and rates of revascularization and amputation for PAD.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Surgery
Maha H. Haqqani, Louis P. Kester, Brenda Lin, Alik Farber, Elizabeth G. King, Thomas W. Cheng, Andrea Alonso, Karan Garg, Mohammad H. Eslami, Denis Rybin, Jeffrey J. Siracuse, New York
Summary: This study aimed to evaluate the outcomes of interventions for intermittent claudication in different age groups. The results showed that patients aged 80 years and above had higher rates of perioperative hematoma and 30-day mortality, as well as fewer independently ambulatory patients at 1 year post-intervention. Risk-adjusted analysis demonstrated that this age group had higher risks of reintervention/amputation/death, amputation/death, and mortality. Similar findings were observed in the octogenarian and nonagenarian group undergoing infrainguinal bypass. Therefore, the risks and benefits of revascularization should be carefully assessed in elderly patients with intermittent claudication, and medical and exercise therapy should be maximized.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Qingyuan Yu, Cheng Chen, Jinyan Xu, Yu Xiao, Junmin Bao, Liangxi Yuan
Summary: This study compared the efficacy and safety of rivaroxaban and warfarin in patients with atrial fibrillation undergoing lower-extremity revascularization. The results showed that there were no significant differences in efficacy and safety outcomes between the two drugs.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Eric Kaplovitch, John W. Eikelboom, Leanne Dyal, Victor Aboyans, Maria Teresa Abola, Peter Verhamme, Alvaro Avezum, Keith A. A. Fox, Scott D. Berkowitz, Shrikant I. Bangdiwala, Salim Yusuf, Sonia S. Anand
Summary: This study aimed to quantify the risk of major vascular events among patients with symptomatic LE-PAD and investigate the response to treatment with low-dose rivaroxaban and aspirin. The analysis found that high-risk limb presentations or comorbidities could benefit from combination treatment with rivaroxaban and aspirin, showing a significant reduction in vascular risk.
Article
Surgery
Cassandra J. Beck, Emidio Germano, Amanda S. Artis, Lee Kirksey, Christopher J. Smolock, Sean P. Lyden, Faisal G. Bakaeen, Venu Menon, Eric E. Roselli, Behzad S. Farivar
Summary: This study aims to analyze the characteristics, treatment methods, and outcomes of patients undergoing proximal aortic repair for TAAD with ALI. The study found that ALI can be resolved after proximal aortic repair of TAAD in most cases. The extent of aortic dissection into zone 11 and iliac thrombosis were identified as risk factors for additional peripheral revascularization. True lumen collapse at the renovisceral aorta and TAAD with concomitant ALI and renovisceral malperfusion were associated with a poor prognosis. A multi-disciplinary team approach is recommended to improve outcomes in patients with ascending aortic dissection and distal malperfusion.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Medicine, General & Internal
Kirsten F. Ma, Stef Levolger, Issi R. Vedder, Mostafa El Moumni, Jean-Paul P. M. de Vries, Reinoud P. H. Bokkers, Alain R. Viddeleer
Summary: This study found that lower extremity muscle atrophy and myosteatosis increased in PAD patients with increasing disease severity. Additionally, lower extremity muscle atrophy and myosteatosis were associated with amputation rate and amputation-free survival in PAD patients, but not with reintervention rate or reintervention-free survival.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Hyunsuk P. Suh, Daniel J. Kedar, Yeon Hoon Lee, Pil Hyung Lee, Seung-Whan Lee, Joon Pio Hong
Summary: This study examined the outcomes of reconstruction of ischemic diabetic foot according to the severity of vessel occlusion and found that using recanalized vessels after percutaneous transluminal angioplasty (PTA) can be safe and improve flap survival for partially occluded arteries.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Review
Medicine, General & Internal
Tamar S. Polonsky, Mary M. McDermott
Summary: Peripheral artery disease affects approximately 230 million people worldwide and can be diagnosed noninvasively with ABI, although some patients may not exhibit typical symptoms. PAD patients not only have an increased risk of cardiovascular events, but also a greater risk of functional decline compared to those without PAD.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sienna Li, Diego B. Lopez Gonzalez, John Di Capua, Nicholas J. Reid, Thomas An, Avik Som, Dania Daye, T. Gregory Walker
Summary: The purpose of this study was to identify variables associated with patient discharge disposition following lower extremity arterial interventions for peripheral artery disease. The study found that prolonged procedural time, the presence of preprocedural wound, patient comorbidities, symptom severity, and baseline functional status were associated with nonhome discharge.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Nipun Bhandari, Jonathan D. Newman, Jeffrey S. Berger, Nathaniel R. Smilowitz
Summary: This study examines the impact of diabetes mellitus on outcomes of lower extremity revascularization for peripheral artery disease and finds that diabetes is an independent risk factor for major limb amputation and 6-month hospital readmission.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2022)
Article
Surgery
Jaclyn Derieux, Dina Obed, Arianne Johnson, Michael J. Paisley, Michelle Wang, Kevin M. Casey
Summary: Endovascular procedures in nonagenarians have low mortality and amputation rates. Patients with early amputation are at significantly higher risk of death at 12 months. Frailty, as measured by a validated index, was not associated with early or late outcomes.
ANNALS OF VASCULAR SURGERY
(2023)
Review
Cardiac & Cardiovascular Systems
Hongxin Shu, Xiaowei Xiong, Xiaomei Chen, Xiaolei Sun, Rong Zhang, Ruihua Wang, Qun Huang, Jun Zhu
Summary: This review provides comprehensive and recent evidence for the treatment of lower extremity artery disease (LEAD). The study found that there are differences in short-term and long-term outcomes between endovascular revascularization (EVR) and open surgical revascularization (OSR), with EVR showing lower short-term risk and OSR showing lower long-term risk.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Clayton Busch, Olivia Smith, Tristan Weaver, Jayesh Vallabh, Alaa Abd-Elsayed
Summary: Peripheral nerve stimulation (PNS) is a widely used interventional pain treatment modality for chronic lower extremity pain. Despite the lack of large prospective evidence, PNS has shown potential for improving pain scores, functionality, and opioid consumption, making it a viable option for patients with chronic lower extremity pain.
Article
Surgery
Nadia K. Palte, Lily S. F. Adler, Justin W. Ady, Huong Truong, Saum A. Rahimi, William E. Beckerman
Summary: The study found that socioeconomic status (SES) was not associated with increased risk of mortality or major adverse limb events (MALE) in patients undergoing open lower extremity revascularization. However, uninsured patients were at a higher risk of mortality after revascularization. There was no difference in the distribution of revascularizations or amputations by SES, but a higher proportion of uninsured patients underwent amputation compared with revascularization.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Surgery
Yeju Kang, Halbert Bai, Jason B. Storch, Jenny Chen, Pavel Kibrik, Windsor Ting
Summary: Diabetes, hypertension, and smoking were common among CVI patients, but unlike in PAD patients, they had little to no impact on long-term outcomes or reinterventions after IVS.
ANNALS OF VASCULAR SURGERY
(2024)