Review
Rheumatology
Victoria Navarro-Compan, Alexandre Sepriano, Bassel El-Zorkany, Desiree van der Heijde
Summary: Axial spondyloarthritis is a chronic inflammatory disease primarily affecting the axial skeleton, leading to symptoms such as chronic back pain and spinal stiffness. Diagnosis relies on recognizing clinical patterns and utilizing clinical, laboratory, and imaging features. Treatment options include non-steroidal anti-inflammatory drugs as first-line therapy, with biologics as a second-line option, showing efficacy in improving disease symptoms.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Zhixiu Li, Mohammad Kazim Khan, Sjef M. van der Linden, Bjorn Winkens, Peter M. Villiger, Heinz Baumberger, Hermine van Zandwijk, Muhammad Asim Khan, Matthew A. Brown
Summary: This study found that patients with ankylosing spondylitis (AS) have a higher mortality rate compared to the general population, and healthy individuals carrying the HLA-B27 gene also have a similar risk. Additionally, female patients have a lower life expectancy. However, in the overall European population, the presence of the HLA-B27 gene does not affect survival or the risk of death from cardiovascular disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Liudan Tu, Churong Lin, Ya Xie, Xiaohong Wang, Qiujing Wei, Yanli Zhang, Jieruo Gu
Summary: This study found that patients with radiographic axial spondyloarthritis (r-axSpA) showed more active inflammatory and chronic structural damages on MRI compared to non-radiographic axial spondyloarthritis (nr-axSpA) patients, especially in terms of fat metaplasia and ankylosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Victoria Navarro-Compan, Diego Benavent, Dafne Capelusnik, Desiree van der Heijde, Robert B. M. Landewe, Denis Poddubnyy, Astrid van Tubergen, Xenofon Baraliakos, Filip E. van den Bosch, Floris A. van Gaalen, Lianne Gensler, Clementina Lopez-Medina, Helena Marzo-Ortega, Anna Molto, Rodolfo Perez-Alamino, Martin Rudwaleit, Marleen van de Sande, Raj Sengupta, Ulrich Weber, Sofia Ramiro
Summary: This study developed a consensual definition for 'early axial spondyloarthritis-axSpA' and 'early peripheral spondyloarthritis-pSpA' through a systematic literature review and Delphi survey. The results indicated that early axSpA should be based on symptom duration only, without considering the presence of radiographic damage.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Torsten Diekhoff, Iris Eshed, Felix Radny, Katharina Ziegeler, Fabian Proft, Juliane Greese, Dominik Deppe, Robert Biesen, Kay Geert Hermann, Denis Poddubnyy
Summary: The study found that compared to CT and MRI, X-ray had lower sensitivity and inferior specificity for axSpA. However, CT showed the best inter-rater reliability, highlighting the importance of structural lesions for the differential diagnosis in axSpA.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Rheumatology
Sizheng Steven Zhao, Bradley Pittam, Nicholas L. Harrison, Ashar E. Ahmed, Nicola J. Goodson, David M. Hughes
Summary: This study found that there is a significant global variation in delay to diagnosis for axial SpA patients, with longer delays reported in high-income countries compared to middle-income countries. Patient factors like lower education levels, younger age at symptom onset, and absence of extra-articular manifestations are associated with longer delays. In contrast, the diagnostic delay for PsA patients is significantly shorter.
Article
Rheumatology
Zhixiu Li, Sjef M. van der Linden, Muhammad Asim Khan, Heinz Baumberger, Hermine van Zandwijk, Mohammad Kazim Khan, Peter M. Villiger, Matthew A. Brown
Summary: The objective of this study is to assess heterogeneity in axial spondyloarthritis (axSpA) and its sources. The results suggest that women clinically diagnosed with axSpA but without radiographic sacroiliitis have distinct characteristics compared to men with non-radiographic axSpA.
Editorial Material
Rheumatology
Denis Poddubnyy, Torsten Diekhoff, Xenofon Baraliakos, Kay Geert A. Hermann, Joachim Sieper
Summary: This article discusses whether MRI can replace radiographs for diagnostic evaluation and classification of axial spondyloarthritis, and provides answers to specific questions based on current data.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Sizheng Steven Zhao, Gareth T. Jones, Gary J. Macfarlane, David M. Hughes, Robert J. Moots, Nicola J. Goodson
Summary: The study found that patients with multiple comorbidities in axSpA had poorer treatment outcomes when receiving TNFi therapy, with increased risk of treatment discontinuation, and poorer improvements in function and quality of life.
Article
Rheumatology
Robert D. Inman, Denis Choquette, Majed Khraishi, Dafna D. Gladman, Shamiza Hussein, Drew Neish, Patrick Leclerc
Summary: This study aimed to describe the real-world use of Secukinumab (SEC) in Canadian patients with axSpA. The results showed that SEC was effective in treating axSpA, with improvements in disease activity observed in patients after 12 months of treatment.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Immunology
Rick Wilbrink, Anneke Spoorenberg, Suzanne Arends, Kornelis S. M. van der Geest, Elisabeth Brouwer, Hendrika Bootsma, Frans G. M. Kroese, Gwenny M. Verstappen
Summary: This study compared the composition of peripheral B-cell compartment in axSpA patients and pSS patients, revealing a significant increase in the frequency of CD21(low) B cells compared to healthy donors. This suggests an active involvement of B-cells in the pathogenesis of axSpA, contradicting previous beliefs.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Rheumatology
Juergen Braun, Dietmar Krause, Uta Kiltz
Summary: This editorial discusses the impact evaluation of a nurse-led program for patient self-assessment and self-management in axial spondyloarthritis, presented in a prospective, multicenter, randomized, controlled trial (COMEDSPA) conducted by Anna Molto et al.
Article
Rheumatology
Adrian Ciurea, Andrea Gotschi, Seraphina Kissling, Alexander Bernatschek, Kristina Burki, Pascale Exer, Michael J. Nissen, Burkhard Moller, Almut Scherer, Raphael Micheroli
Summary: This study compared the characteristics of patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA), and found differences in demographic and clinical features between the two groups, but a similar disease burden.
Article
Health Care Sciences & Services
Julie Soulard, Jacques Vaillant, Athan Baillet, Philippe Gaudin, Nicolas Vuillerme
Summary: Patients with axSpA show significant changes in gait parameters, including slower speed, lower cadence, shorter stride length and swing time, and increased double support and stance time. Pain intensity may play a role in influencing gait in patients with axSpA.
JMIR MHEALTH AND UHEALTH
(2021)
Article
Multidisciplinary Sciences
Luca Franco, Raj Sengupta, Logan Wade, Dario Cazzola
Summary: The study introduced a wearable sensor protocol for assessing spinal ROM and kinematics, showing low error in measurements and high level of agreement in reliability analysis. The protocol demonstrated potential for clinical application, but further validation on Axial Spondyloarthritis patients is needed.
Article
Rheumatology
Sizheng Steven Zhao, Houchen Lyu, Chao Zeng, Guanghua Lei, Jie Wei, Sarah L. Mackie
Summary: Initiation of ARBs is associated with a higher risk of GCA compared with ACEis or other antihypertensives. Mechanistic studies of angiotensin receptor biology will provide further clarity for our findings.
Letter
Rheumatology
Sizheng Steven Zhao, Anne Barton, John Bowes
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Deepak R. Jadon, Nadia Corp, Danielle A. van der Windt, Laura C. Coates, Enrique R. Soriano, Arthur Kavanaugh, Tim Raine, Florian Rieder, Stefan Siebert, Michel Zummer, Sergio Schwartzman, James T. Rosenbaum, Brigitte Michelsen, Ramasharan Laxminarayan, Dongze Wu, Latika Gupta, Beverly Ng, Hannah Jethwa, Nick De Windt, Tania Gudu, Joseph Hutton, Denis O'Sullivan, Michele M. Luchetti, Matthew Stoll, Jasvinder A. Singh, Rosario Peluso, Judith Rademacher, M. Elaine Husni
Summary: This study summarizes the efficacy and safety of advanced therapies for psoriatic arthritis in patients with related conditions, including Crohn's disease, ulcerative colitis, and noninfectious uveitis. The tumor necrosis factor inhibitor (TNFi) class appears to be effective and safe, while interleukin 12/23 inhibitors (IL-12/23i) show efficacy in Crohn's disease and ulcerative colitis. However, caution should be exercised when using interleukin 17 inhibitors (IL-17i) in patients with psoriatic arthritis at high risk of inflammatory bowel disease.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Jonathan Kennedy, Natasha Kennedy, Roxanne Cooksey, Ernest Choy, Stefan Siebert, Muhammad Rahman, Sinead Brophy
Summary: This study used machine learning to develop a profile of individuals who are likely to be diagnosed with ankylosing spondylitis (AS) in the future. The models showed that lower back pain, uveitis, and NSAID use under age 20 are associated with AS development in men, while women tend to have an older age of symptom presentation, along with back pain and multiple pain relief medications. However, when applied to a general population with low prevalence rates, the positive predictive value of these models would be very low.
Article
Rheumatology
Lianne Kearsley-Fleet, Aasiyah Rokad, Man-Fung Tsoi, Sizheng Steven Zhao, Mark Lunt, Kath D. Watson, Kimme L. Hyrich
Summary: Etanercept biosimilars have shown comparable efficacy to their originators in treating biologic-naive patients with rheumatoid arthritis (RA), resulting in significant cost savings. This study aimed to compare the effectiveness of etanercept originator vs etanercept biosimilar in routine clinical practice in the UK among biologic-naive RA patients.
Article
Rheumatology
Arno W. R. Van Kuijk, Mike T. Nurmohamed, Stefan Siebert, Paul Bergmans, Kurt de Vlam, Elisa Gremese, Beatriz Joven-Ibanez, T. Korotaeva, Frederic Lavie, Mohamed Sharaf, Wim Noel, Elke Theander, Josef S. Smolen, Laure Gossec, Irene E. van der Horst-bruinsma
Summary: The study found that female PsA patients had more severe disease characteristics before starting bDMARD treatment compared to males, with less improvement and lower treatment persistence. Further understanding of these differences may help improve therapeutic management in female PsA patients.
Letter
Rheumatology
Sizheng Steven Zhao, Sarah Dyball
Article
Rheumatology
Hanna Johnsson, John Cole, Iain B. McInnes, Gerard Graham, Stefan Siebert
Summary: This study compares transcriptional changes in psoriasis and PsA skin for the first time, finding that immunoglobulin genes are upregulated in PsA skin lesions, which may have implications for its spread to other tissues.
Article
Rheumatology
Sizheng Steven Zhao, Michael Holmes, Uazman Alam
Summary: A bidirectional causal relationship between depression and chronic widespread pain was found in this study using genetic data. The study demonstrated that an increased genetic liability to depression leads to an increased risk of chronic widespread pain, and vice versa.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Biochemistry & Molecular Biology
Eleanor Barnes, Carl S. Goodyear, Michelle Willicombe, Charlotte Gaskell, Stefan Siebert, Thushan I. de Silva, Sam M. Murray, Daniel Rea, John A. Snowden, Miles Carroll, Sarah Pirrie, Sarah J. Bowden, Susanna J. Dunachie, Alex Richter, Zixiang Lim, Jack Satsangi, Gordon Cook, Ann Pope, Ana Hughes, Molly Harrison, Sean H. Lim, Paul Miller, Paul Klenerman, Pitch Consortium, Neil Basu, Ashley Gilmour, Sophie Irwin, Georgina Meacham, Thomas Marjot, Stavros Dimitriadis, Peter Kelleher, Maria Prendecki, Candice Clarke, Paige Mortimer, Stacey McIntyre, Rachael Selby, Naomi Meardon, Dung Nguyen, Tom Tipton, Stephanie Longet, Stephen Laidlaw, Kim Orchard, Georgina Ireland, David Thomas, Pamela Kearns, Amanda Kirkham, Iain B. McInnes
Summary: Serological analysis and infection outcomes of 2,686 participants with immune-suppressive diseases who received two COVID-19 vaccines revealed specific clinical phenotypes that might benefit from targeted COVID-19 therapeutic strategies. Some patients failed to develop anti-SARS-CoV-2 antibodies, with the highest vaccine failure rates observed in ANCA-associated vasculitis, hemodialysis, and solid organ transplant recipients. Decreased serological and T cell responses were associated with severe COVID-19. In summary, we identified clinical phenotypes that may benefit from targeted COVID-19 therapeutic strategies.
Article
Rheumatology
Lianne Kearsley-Fleet, Aasiyah Rokad, Man-Fung Tsoi, Sizheng Steven Zhao, Mark Lunt, Kath D. Watson, Kimme L. Hyrich
Summary: This study investigated the outcomes of adults with rheumatoid arthritis who switched from etanercept originator to a biosimilar. The results showed that patients who switched to the biosimilar had similar drug survival and disease activity compared to those who remained on the originator.
Article
Rheumatology
Sizheng Steven Zhao, Stephen Burgess
Article
Medicine, General & Internal
Baraka Moshi, Nateiya Yongolo, Sanjura Mandela Biswaro, Hans Maro, Sakanda Linus, Stefan Siebert, William Nkenguye, Emma McIntosh, Febronia Shirima, Rosalia E. Njau, Alice A. Andongolile, Manasseh Joel Mwanswila, Jo E. B. Halliday, Stefanie Krauth, Kajiru Kilonzo, Richard William Walker, Gloria August Temu, Blandina T. Mmbaga
Summary: This study aimed to determine the number of stroke admissions and associated comorbidities at a referral hospital in Northern Tanzania. Results showed that 12.2% of the admissions between 2017 and 2019 were stroke patients, with a high proportion of hypertension and diabetes mellitus among them. The in-hospital mortality related to stroke was also high, highlighting the need for interventions to reduce non-communicable diseases and their complications.
Article
Rheumatology
Georg Schett, Warner Chen, Sheng Gao, Soumya D. Chakravarty, May Shawi, Frederic Lavie, Miriam Zimmermann, Mohamed Sharaf, Laura C. Coates, Stefan Siebert
Summary: In the COSMOS trial, guselkumab demonstrated efficacy in treating TNFi-IR PsA patients by reducing levels of effector cytokines associated with the IL-23/IL-17 pathway.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Rheumatology
Laure Gossec, Stefan Siebert, Paul Bergmans, Kurt de Vlam, Elisa Gremese, Beatriz Joven-Ibanez, Tatiana V. Korotaeva, Frederic Lavie, Wim Noel, Michael T. Nurmohamed, Petros P. Sfikakis, Mohamed Sharaf, Elke Theander, Josef S. Smolen
Summary: This study evaluated the effects of ustekinumab or TNFi on patient-reported outcomes (PRO) and their association with effectiveness endpoints in PsA patients over a 3-year period. The results showed that both treatments led to improvements in PROs, with TNFi showing a greater improvement in work productivity.
ARTHRITIS RESEARCH & THERAPY
(2023)