Applying computation biology and “big data” to develop multiplex diagnostics for complex chronic diseases such as osteoarthritis

Bioinformatics analysis of gene expression profiles of osteoarthritis

(2015) Qiang Wang et al.   ACTA HISTOCHEMICA

THU0455 Transcriptomics to Identify Synovial Genes and Pathways Associated with Disease Progression in A Cohort of Early Osteoarthritis Patients (CHECK)

(2014) A. Blom et al.   ANNALS OF THE RHEUMATIC DISEASES

Big Data and Large Sample Size: A Cautionary Note on the Potential for Bias

(2014) Robert M. Kaplan et al.   CTS-Clinical and Translational Science

Integration of gene expression data with network-based analysis to identify signaling and metabolic pathways regulated during the development of osteoarthritis

(2014) Amy L. Olex et al.   GENE

Usefulness of urinary CTX-II and NTX-I in evaluating radiological knee osteoarthritis : the Matsudai knee osteoarthritis survey

(2014) Nobuchika Tanishi et al.   JOURNAL OF ORTHOPAEDIC SCIENCE

A computational method to differentiate normal individuals, osteoarthritis and rheumatoid arthritis patients using serum biomarkers

(2014) B. J. Heard et al.   Journal of the Royal Society Interface

Biomarkers and proteomic analysis of osteoarthritis

(2014) Ming-Feng Hsueh et al.   MATRIX BIOLOGY

Expanding the computational toolbox for mining cancer genomes

(2014) Li Ding et al.   NATURE REVIEWS GENETICS

Discovery and analysis of rare coding variants for hipOA by exome-sequencing

(2014) C.G. Boer et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis Year in Review 2014: genetics and genomics

(2014) A. Tsezou   OSTEOARTHRITIS AND CARTILAGE

Network medicine analysis of chondrocyte proteins towards new treatments of osteoarthritis

(2014) J. C. Nacher et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Classification of osteoarthritis phenotypes by metabolomics analysis

(2014) Weidong Zhang et al.   BMJ Open

Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients

(2013) Juan Fernández-Tajes et al.   ANNALS OF THE RHEUMATIC DISEASES

Genes expressed in blood link osteoarthritis with apoptotic pathways

(2013) Yolande F M Ramos et al.   ANNALS OF THE RHEUMATIC DISEASES

Analysis of mass spectrometry data from the secretome of an explant model of articular cartilage exposed to pro-inflammatory and anti-inflammatory stimuli using machine learning

(2013) Anna L Swan et al.   BMC MUSCULOSKELETAL DISORDERS

Molecular Diagnosis of Eosinophilic Esophagitis by Gene Expression Profiling

(2013) Ting Wen et al.   GASTROENTEROLOGY

Whole-Transcriptome Profiling of Thyroid Nodules Identifies Expression-Based Signatures for Accurate Thyroid Cancer Diagnosis

(2013) Sam M. Wiseman et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Identification of Osteoarthritis Biomarkers by Proteomic Analysis of Synovial Fluid

(2013) My Han et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Intraarticular and Systemic Inflammatory Profiles May Identify Patients with Osteoarthritis

(2013) B. J. Heard et al.   JOURNAL OF RHEUMATOLOGY

The big challenges of big data

(2013) Vivien Marx   NATURE

TSG-6 activity as a novel biomarker of progression in knee osteoarthritis

(2013) H.-G. Wisniewski et al.   OSTEOARTHRITIS AND CARTILAGE

Identification and characterisation of osteoarthritis patients with inflammation derived tissue turnover

(2013) A.S. Siebuhr et al.   OSTEOARTHRITIS AND CARTILAGE

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide expression profiles of subchondral bone in osteoarthritis

(2013) Ching-Heng Chou et al.   ARTHRITIS RESEARCH & THERAPY

Assessment of Osteoarthritis Candidate Genes in a Meta-Analysis of Nine Genome-Wide Association Studies

(2013) Cristina Rodriguez-Fontenla et al.   Arthritis & Rheumatology

Five Years of GWAS Discovery

(2012) Peter M. Visscher et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data

(2012) Katherine S Elliott et al.   ANNALS OF THE RHEUMATIC DISEASES

Saliva Metabolomics Opens Door to Biomarker Discovery, Disease Diagnosis, and Treatment

(2012) Aihua Zhang et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Fibulin 3 peptides Fib3-1 and Fib3-2 are potential biomarkers of osteoarthritis

(2012) Yves Henrotin et al.   ARTHRITIS AND RHEUMATISM

Genome-wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis

(2012) Jesús Delgado-Calle et al.   ARTHRITIS AND RHEUMATISM

Pseudogenes

(2012) Yusuf Tutar   COMPARATIVE AND FUNCTIONAL GENOMICS

Urinary Proteomics for Early Diagnosis in Diabetic Nephropathy

(2012) P. Zurbig et al.   DIABETES

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

Chromosomal Microarray versus Karyotyping for Prenatal Diagnosis

(2012) Ronald J. Wapner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Principal Component Analysis of the Cytokine and Chemokine Response to Human Traumatic Brain Injury

(2012) Adel Helmy et al.   PLoS One

Experience with microarray-based comparative genomic hybridization for prenatal diagnosis in over 5000 pregnancies

(2012) Lisa G. Shaffer et al.   PRENATAL DIAGNOSIS

Unraveling the Regulatory Mechanisms Underlying Tissue-Dependent Genetic Variation of Gene Expression

(2012) Jingyuan Fu et al.   PLoS Genetics

Lung Cancer Diagnosis from Proteomic Analysis of Preinvasive Lesions

(2011) S. M. J. Rahman et al.   CANCER RESEARCH

Interactome Networks and Human Disease

(2011) Marc Vidal et al.   CELL

Status and Prospects for Discovery and Verification of New Biomarkers of Cardiovascular Disease by Proteomics

(2011) Robert E. Gerszten et al.   CIRCULATION RESEARCH

Deploying whole genome sequencing in clinical practice and public health: Meeting the challenge one bin at a time

(2011) Jonathan S Berg et al.   GENETICS IN MEDICINE

Algorithms for Detecting Significantly Mutated Pathways in Cancer

(2011) Fabio Vandin et al.   JOURNAL OF COMPUTATIONAL BIOLOGY

Next-generation transcriptome assembly

(2011) Jeffrey A. Martin et al.   NATURE REVIEWS GENETICS

Rare De Novo Variants Associated with Autism Implicate a Large Functional Network of Genes Involved in Formation and Function of Synapses

(2011) Sarah R. Gilman et al.   NEURON

Multiplexed Immunoassay Panel Identifies Novel CSF Biomarkers for Alzheimer's Disease Diagnosis and Prognosis

(2011) Rebecca Craig-Schapiro et al.   PLoS One

Noninvasive Prenatal Diagnosis of Fetal Trisomy 18 and Trisomy 13 by Maternal Plasma DNA Sequencing

(2011) Eric Z. Chen et al.   PLoS One

The future of Alzheimer's disease: The next 10 years

(2011) Harald Hampel et al.   PROGRESS IN NEUROBIOLOGY

Radioimmunotherapy of experimental head and neck squamous cell carcinoma (HNSCC) with E6-specific antibody using a novel HPV-16 positive HNSCC cell line

(2011) Matthew Harris et al.   Head and Neck Optical Diagnostics Society

Urinary proteomic diagnosis of coronary artery disease: identification and clinical validation in 623 individuals

(2010) Christian Delles et al.   JOURNAL OF HYPERTENSION

Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease

(2010) David M. Good et al.   MOLECULAR & CELLULAR PROTEOMICS

Computational solutions to large-scale data management and analysis

(2010) Eric E. Schadt et al.   NATURE REVIEWS GENETICS

Annotating non-coding regions of the genome

(2010) Roger P. Alexander et al.   NATURE REVIEWS GENETICS

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

The case for cloud computing in genome informatics

(2010) Lincoln D Stein   GENOME BIOLOGY

Chemometrics in metabolomics—A review in human disease diagnosis

(2009) Rasmus Madsen et al.   ANALYTICA CHIMICA ACTA

A neural network-based biomarker association information extraction approach for cancer classification

(2009) Hong-Qiang Wang et al.   JOURNAL OF BIOMEDICAL INFORMATICS

Applying mass spectrometry-based proteomics to genetics, genomics and network biology

(2009) Matthias Gstaiger et al.   NATURE REVIEWS GENETICS

Presymptomatic Prediction of Sepsis in Intensive Care Unit Patients

(2008) R. A. Lukaszewski et al.   Clinical and Vaccine Immunology

Metabolic syndrome: from epidemiology to systems biology

(2008) Aldons J. Lusis et al.   NATURE REVIEWS GENETICS