Article
Microbiology
Barbara Van der Pol, Arundhati Rao, Melinda B. Nye, Steven Chavoustie, Aaron Ermel, Clair Kaplan, David Eisenberg, Philip A. Chan, Leandro Mena, Sixto Pacheco, Ken B. Waites, Li Xiao, Smitha Krishnamurthy, Ruchika Mohan, Rasa Bertuzis, Chris L. McGowin, Rodney Arcenas, Elizabeth M. Marlowe, Stephanie N. Taylor
Summary: Trichomonas vaginalis is a prevalent sexually transmitted infection, with nucleic acid amplification tests showing higher sensitivity in diagnosis compared to microscopic analysis or culture. Men are often asymptomatic carriers of the organism, transmitting it to their female sexual partners. The cobas T. vaginalis/Mycoplasma genitalium assay demonstrates high sensitivity for detecting T. vaginalis DNA in both male and female patients, making it a suitable diagnostic tool for infection control efforts.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Engineering, Biomedical
Adrian Cervero-Varona, Angelo Canciello, Alessia Peserico, Arlette Alina Haidar Montes, Maria Rita Citeroni, Annunziata Mauro, Valentina Russo, Samanta Moffa, Serena Pilato, Stefano Di Giacomo, Beatrice Dufrusine, Enrico Dainese, Antonella Fontana, Barbara Barboni
Summary: The use of biomaterials in immune regenerative strategies for unresolved pathologies is gaining attention in tissue engineering. Graphene oxide (GO) has been proposed as an immune-mimetic material for stem cell-based regenerative therapies, influencing stem cell behavior and immune response. Amniotic epithelial stem cells (AECs) are also of interest due to their plasticity and immunomodulatory paracrine activities, and the effects of GO on AECs are explored in this study. GO-coating induced and accelerated the Epithelial-Mesenchymal Transition (EMT) in AECs, leading to changes in cytokine secretion and enhanced activation of macrophages. Adhesion of AECs on GO-functionalized surfaces could create a tailored microenvironment for the regenerative process.
MATERIALS TODAY BIO
(2023)
Article
Chemistry, Multidisciplinary
Iroda Saydullaeva, Bilge Debelec Butuner, Kemal Sami Korkmaz
Summary: Studies have shown that inflammation plays a role in the development and spread of aggressive prostate tumors, but the exact mechanism of how inflammation contributes to prostate cancer is still unclear. Previous research has indicated that the loss of tumor suppressor NKX3.1 is partially correlated with cell migration in response to conditioned media. This study investigates the role of inflammation in prostate cancer cell migration and the involvement of NKX3.1 in this process.
Article
Chemistry, Multidisciplinary
Iroda Saydullaeva, Bilge Debelec Butuner, Kemal Sami Korkmaz
Summary: Inflammation plays a synergistic role in the development and metastatic spread of aggressive prostate tumors. However, the exact mechanism by which inflammation promotes prostate cancer remains unclear. This study used the CRISPR/Cas9 system to suppress the expression of the tumor suppressor gene NKX3.1 and observed phenotypic changes in cell migration. Furthermore, quantitative proteomic analysis revealed that different cell subpopulations exhibited distinct phenotypes and genetic compositions during the process of cellular migration.
Article
Biochemistry & Molecular Biology
Rabiatul Adawiyah Razali, Muhammad Dain Yazid, Aminuddin Saim, Ruszymah Bt Hj Idrus, Yogeswaran Lokanathan
Summary: The study investigated the effect of Hydroxytyrosol (HT) on epithelial-mesenchymal transition (EMT) in primary human respiratory epithelial cells (RECs). Various approaches of HT treatment and TGF beta 1 induction were studied, evaluating the morphology and migration ability of RECs. Immunofluorescence staining and Western blotting were performed to analyze protein expression. In silico analysis showed the potential of HT to bind with the TGF beta receptor. The results indicated that HT could suppress EMT and modulate the related signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Sara Lovisa
Summary: EMT, a process crucial in wound healing, fibrosis, and cancer, has gained significant attention from researchers since its discovery in the seventies. Despite advances in understanding its functional role, targeting EMT in fibrotic diseases remains a challenge at an early stage of development.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Iveta Yotova, Quanah J. Hudson, Florian M. Pauler, Katharina Proestling, Isabella Haslinger, Lorenz Kuessel, Alexandra Perricos, Heinrich Husslein, Rene Wenzl
Summary: LINC01133 is upregulated in endometriosis and may affect pathogenesis through cellular proliferation and migration pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Samantha Gogola, Michael Rejzer, Hisham F. Bahmad, Wassim Abou-Kheir, Yumna Omarzai, Robert Poppiti
Summary: Prostate cancer is the second most common cancer in men worldwide, and treatment options include radiation therapy, surgery, and active surveillance. However, in most cases, the cancer eventually becomes castration-resistant. The transition from androgen-dependent to androgen-independent state is not well understood, but epithelial-to-non-epithelial transition plays a crucial role. This review summarizes the factors and pathways involved in this transition, as well as the diagnostic and prognostic biomarkers.
Article
Immunology
Sarthak Sahoo, Sonali Priyadarshini Nayak, Kishore Hari, Prithu Purkait, Susmita Mandal, Akash Kishore, Herbert Levine, Mohit Kumar Jolly
Summary: Recent research shows that cells with hybrid epithelial/mesenchymal characteristics can have high levels of PD-L1, important for immune evasion, without needing to fully undergo epithelial-mesenchymal transition. This cellular state in breast cancer is associated with resistance to anti-estrogen therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Lei Chen, Hailong Liu, Yiyi Ji, Zehua Ma, Kai Shen, Xun Shangguan, Hongyang Qian, Yu Zhao, Chun-Wu Pan, Wei Xue
Summary: The study reveals that SHMT2 plays a role as a tumor proliferation suppressor and negatively regulates aggressive behavior in prostate cancer. Downregulation of SHMT2 is observed in advanced prostate cancer, and its depletion promotes proliferation and migration in prostate cancer cell lines. These findings highlight the importance of SHMT2 in prostate cancer and its potential for the development of new therapeutic strategies.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Oncology
Chongqing Gao, Jing Li, Fuling Zeng, Lijuan Wang, Kaiyun Chen, Dong Chen, Jian Hong, Chen Qu
Summary: MCM6, a novel diagnostic biomarker, is upregulated in intrahepatic cholangiocarcinoma (ICC) and associated with poor prognosis. It promotes ICC progression by activating the E2F1-mediated epithelial-mesenchymal transition (EMT) and enhances the proliferation and migration of ICC cells.
Review
Biochemistry & Molecular Biology
Dexin Shen, Hongwei Peng, Caixia Xia, Zhao Deng, Xi Tong, Gang Wang, Kaiyu Qian
Summary: This study summarizes the detailed mechanisms and modes of long non-coding RNAs (lncRNAs) participating in the epithelial-mesenchymal transition (EMT) process of prostate cancer (PCa) by regulating multiple signaling pathways.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Immunology
Ningyue Gong, Lei Shi, Xin Bing, Hui Li, Houyang Hu, Pan Zhang, Huiming Yang, Na Guo, Hongjie Du, Ming Xia, Chengcheng Liu
Summary: This study identified the increased expression of S100A4 during the progressive EMT process of CRS mucosal epithelial cells and revealed the important role of transcriptional regulation of S100A4 in the occurrence and development of EMT. This finding helps us better understand the pathogenesis behind remodeling in CRS patients and provides potential target molecules for the treatment of CRS.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Lili Liang, Andreas M. Kaufmann
Summary: Cancer stem cells (CSCs) have been identified and characterized in both hematopoietic and solid tumors. They possess unique properties, including slow proliferation, self-renewal, differentiation, and the ability to undergo epithelial-mesenchymal transition (EMT) and its reverse process. CSCs play a crucial role in tumor growth, therapy resistance, and cancer metastasis. Strategies targeting CSCs are being developed for novel anti-metastasis treatments, aiming to improve therapeutic efficiency and prognosis with fewer side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Zahra Salemi, Reza Azizi, Faranak Fallahian, Mahmoud Aghaei
Summary: The study explores the effects of selective inhibition of integrin alpha 2 beta 1 on prostate cancer cells, showing that suppression of integrin alpha 2 beta 1 can inhibit EMT, decrease cell migration capacity, reduce cell proliferation, induce G1 cell cycle arrest, and promote apoptosis. These findings suggest a critical role for integrin alpha 2 beta 1 in the proliferation of prostate cancer cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Otorhinolaryngology
Seon Min Jung, Hye Ryoung Koo, Ki Seok Jang, Min Sung Chung, Chang Myeon Song, Yong Bae Ji, Jeong Seon Park, Kyung Tae
Summary: Ultrasound-guided CNB is more effective than rFNA for repeat biopsy of thyroid nodules with inconclusive initial FNA results, especially for patients with categories I and III, but showed no significant differences for category IV nodules.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Minwoo Hong, Ik-Hwan Han, Ilseob Choi, Nari Cha, Woojin Kim, Sun Kwang Kim, Hyunsu Bae
Summary: This study demonstrated that oral administration of Magnoliae Cortex (M.C) can effectively alleviate cisplatin-induced sarcopenia by modulating M2 macrophage polarization in mice. M.C increased M2 macrophage markers in skeletal muscle, reduced M1-specific markers, and increased the number of M2a and M2c macrophages, without interfering with the anticancer effect of cisplatin in colon cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Chang-Suk Noh, Hyo-Yeoung Chung, Ik-Hwan Han, Jung-Hyun Kim, Yu-Mi Kim, Jae-Sook Ryu
Summary: The interaction between prostate stromal cells stimulated with Tv and mast cells promotes the proliferation of prostate stromal cells through the tryptase-PAR2 pathway. This pathway involves signaling molecules such as PAR2, p-ERK, COX-2, 15d-PGJ(2), and PPAR gamma, with inhibition of tryptase and PAR2 leading to reduced expression of these molecules.
PARASITE IMMUNOLOGY
(2021)
Article
Parasitology
Jung-Hyun Kim, Ik-Hwan Han, Su-Jin Shin, Sung-Yul Park, Hyo-Yeoung Chung, Jae-Sook Ryu
Summary: This study showed that inflamed BPH-1 cells infected with T vaginalis induce prostate cell proliferation through the leptin-OBR signaling pathway. It suggests that T vaginalis likely contributes to prostate enlargement in BPH via adipocyte leptin released as a result of prostate inflammation.
KOREAN JOURNAL OF PARASITOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiham Sung, Yura Kim, Pei Fu Yu, Younsub Kim, Ik-Hwan Han, Hyunsu Bae
Summary: The potential toxicity of melittin-dKLA in ICR mice is limited to 20 mg/kg, both with single and repeated subcutaneous administration, providing important data for the development of new drugs.
MOLECULAR & CELLULAR TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chanju Lee, Soyoung Kim, Chanmi Jeong, Inhee Cho, Juyeon Jo, Ik-Hwan Han, Hyunsu Bae
Summary: The study suggests that targeting M2-like tumor-associated macrophages (TAMs) could be a potential therapeutic strategy for inhibiting breast cancer metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Parasitology
Sang-Su Kim, Kyu-Shik Kim, Ik-Hwan Han, Yeseul Kim, Seong Sik Bang, Jung-Hyun Kim, Yong-Suk Kim, Soo-Yeon Choi, Jae-Sook Ryu
Summary: The inflammatory microenvironment induced by Trichomonas vaginalis infection can stimulate proliferation and invasion of prostate cancer cells through cytokine-cytokine receptor signaling pathways.
KOREAN JOURNAL OF PARASITOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chanju Lee, Mi Jung Kang, Soyoung Kim, Ik-Hwan Han, Hyunsu Bae
Summary: This study demonstrated the protective effects of three phytochemicals against cisplatin-induced muscle atrophy in vitro. The compounds, magnolol, fisetin, and sclareol, showed significant inhibition of IL-6 and myostatin expression, along with improvement in myotube diameter. Further investigation into their in vivo potential in cachexia mice model is warranted.
MOLECULAR & CELLULAR TOXICOLOGY
(2022)
Letter
Oncology
Chanju Lee, Hyunji Lee, Hayoon Cho, Soyoung Kim, Ilseob Choi, Young-Sik Hwang, Hyunju Jeong, Hogi Jang, Sehyun Pak, Deok-Sang Hwang, Ik-Hwan Han, Hyunsu Bae
CANCER COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Minwoo Hong, Mi Jung Kang, Sehyun Pak, Ik-Hwan Han, Hyunsu Bae
Summary: The aim of this study was to investigate whether bvPLA2 alleviates the pathological features of ALS by affecting Tregs in SOD1 mice. The results demonstrated that bvPLA2 treatment improved the body weight, motor function, and motor neuron survival in SOD1 mice, while increasing the level of Tregs and reducing the expression of inflammatory factors.
ADVANCES IN TRADITIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ik-Hwan Han, Chanmi Jeong, Juwon Yang, Seung-Hyeok Park, Deok-Sang Hwang, Hyunsu Bae
Summary: This study found that melittin-dKLA inhibits the growth of melanoma by inducing apoptosis of M2-like macrophages. In in vitro and in vivo studies, melittin-dKLA effectively reduced the proliferation and migration of M2 macrophages, resulting in a decrease in melanoma tumor growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Soyoung Kim, Ilseob Choi, Ik-Hwan Han, Hyunsu Bae
Summary: Triple-negative breast cancer (TNBC) is highly likely to metastasize, and tumor-associated macrophages (TAMs) play a crucial role in this process. A peptide called PEG-melittin-dKLA8-26 has been found to reduce TNBC metastasis by targeting M2 macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Keun-Tae Park, Suyong Kim, Ilseob Choi, Ik-Hwan Han, Hyunsu Bae, Woojin Kim
Summary: In this study, the researchers evaluated the effect of cucurbitacins B and D on paclitaxel-induced neuropathic pain. The results showed that cucurbitacin D attenuated the cold and mechanical allodynia caused by paclitaxel. Additionally, cucurbitacin D did not diminish the anticancer effect of chemotherapeutic drugs. Therefore, cucurbitacin D could be considered as a treatment option for paclitaxel-induced neuropathic pain.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Chanmi Jeong, Jeongdong Kim, Ik-Hwan Han, Soyoung Kim, Ilseob Choi, Hongsung Kim, Jin-Hyun Jeong, Hyunsu Bae
Summary: This study evaluates the therapeutic effects of M-DM1 on melanoma. The results show that M-DM1 can specifically reduce M2-like tumor-associated macrophages, inhibit tumor growth and invasion, and improve survival rates. Additionally, M-DM1 enhances the infiltration of CD8+ cytotoxic T cells and natural killer cells in the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Parasitology
Ik-Hwan Han, Jung-Hyun Kim, Jae-Sook Ryu
Summary: Trichomonas vaginalis is a protozoan that causes trichomoniasis, a common sexually transmitted infection. Infection with T. vaginalis is often asymptomatic in men but can lead to chronic infection. Studies show that T. vaginalis infection may contribute to prostatic diseases such as prostatitis and benign prostatic hyperplasia.
PARASITES HOSTS AND DISEASES
(2023)