Editorial Material
Neurosciences
Brian M. Andersen, Francisco J. Quintana
Summary: Using single-cell analysis, Kumar et al. have identified pro-inflammatory interactions between microglia and T cells in individuals with drug-resistant childhood epilepsy. This finding may contribute to the identification of therapeutic targets for this condition.
NATURE NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Lai Yee Cheong, Baile Wang, Qin Wang, Leigang Jin, Kelvin H. M. Kwok, Xiaoping Wu, Lingling Shu, Huige Lin, Sookja Kim Chung, Kenneth K. Y. Cheng, Ruby L. C. Hoo, Aimin Xu
Summary: This study reveals the role of fibroblastic reticular cells (FRCs) in releasing IL-33 and mediating cold-induced beiging of white adipose tissue (WAT) through neuro-immune interaction. The findings highlight the importance of FRCs in maintaining energy homeostasis.
NATURE COMMUNICATIONS
(2023)
Review
Immunology
Jianheng Luo, Ke Liu, Yong Wang, Hongge Li
Summary: This review briefly describes the immune response during I/R injury and how PD-L1 is involved in its regulation, focusing on findings from various I/R models. Despite the limited number of studies, PD-L1 has shown sufficient potential as a clinical therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Belinda Camp, Sabine Stegemann-Koniszewski, Jens Schreiber
Summary: Chronic obstructive airway diseases such as asthma and COPD cause significant morbidity and mortality worldwide, with a lack of effective cures. There is growing awareness of the role of neurological and neuro-immunological processes in the development and outcome of these diseases, as well as the impact of respiratory tract microorganisms. However, the underlying mechanisms of their roles remain poorly understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Laura Tarnawski, Peder S. Olofsson
Summary: Inflammation is a crucial process in antimicrobial defense and tissue repair, with neural circuits playing important roles throughout this process. However, the neurophysiological and molecular mechanisms involved are not fully understood. Advances in technology are being used to further investigate and utilize this neural regulation in inflammation neuroscience.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Review
Immunology
Lena Bourhy, Aurelien Mazeraud, Fernando A. Bozza, Guillaume Turc, Pierre-Marie Lledo, Tarek Sharshar
Summary: This article discusses the interaction between stroke and the immune system, with a focus on the modulatory role of peripheral inflammatory signaling in post-stroke inflammation and the impact of peripheral inflammatory response on the central nervous system.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Amanda Jacobson, Daping Yang, Madeleine Vella, Isaac M. Chiu
Summary: The gastrointestinal tract is regulated by a dense network of interconnected neurons that coordinate important physiological functions. Studies have shown complex interactions between gut neurons, immune cells, and epithelial cells, highlighting their roles in immune regulation and intestinal function. Integration of intestinal microbiota into the neuro-immune axis through tuning neuronal and immune interactions may offer new therapeutic targets for inflammatory diseases.
MUCOSAL IMMUNOLOGY
(2021)
Review
Oncology
Alessandra Dimino, Chiara Brando, Laura Algeri, Valerio Gristina, Erika Pedone, Marta Peri, Alessandro Perez, Ida De Luca, Roberta Sciacchitano, Luigi Magrin, Tancredi Didier Bazan Russo, Marco Bono, Nadia Barraco, Silvia Contino, Maria La Mantia, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia
Summary: The effect of genetic alteration on the prognosis of GIST patients has been extensively studied. However, not all GISTs can benefit from targeted therapies, highlighting the need to understand other predictive mechanisms. The relationship between immune checkpoints, tumor microenvironment, and clinical behavior of GIST with different driver mutations is being investigated and could lead to improved prognostication in GIST.
Review
Obstetrics & Gynecology
Sulagna Dutta, Narpal Sandhu, Pallav Sengupta, Marco G. Alves, Ralf Henkel, Ashok Agarwal
Summary: The development of antibodies to antigens involved in sperm production can lead to autoimmune responses affecting sperm motility, functions, and fertility. The testes need to establish an immune-privileged microenvironment to protect germ cells through various mechanisms.
REPRODUCTIVE SCIENCES
(2022)
Review
Oncology
Defne Bayik, Justin D. Lathia
Summary: The development of tumors is affected by cellular heterogeneity and an immunosuppressive tumor microenvironment, which interact with each other and lead to therapeutic resistance. The interaction between cancer stem cells and infiltrating immune cell populations in the tumor microenvironment promotes tumor development and immune evasion.
NATURE REVIEWS CANCER
(2021)
Article
Cell Biology
Shukkur M. Farooq, Hossam M. Ashour
Summary: The study demonstrates that CII-specific ACAID B cells can induce peripheral tolerance, and the adoptively transferred B cells have the ability to suppress immune responses after challenges with CII. This effect was replicated in multiple strains of mice, indicating potential therapeutic implications for the treatment of CII-mediated autoimmune diseases.
Article
Multidisciplinary Sciences
Munetoyo Toda, Morio Ueno, Jun Yamada, Asako Hiraga, Kazuko Asada, Junji Hamuro, Chie Sotozono, Shigeru Kinoshita
Summary: This study found that injection of cultured human corneal endothelial cell suspension into the anterior chamber can induce immune tolerance that contributes to the survival of reconstituted endothelium, and no signs of immune rejection were observed during the 5-8 years of postoperative follow-up.
SCIENTIFIC REPORTS
(2022)
Review
Chemistry, Medicinal
Hei Jung Kim, Young Rae Ji, You Mie Lee
Summary: Understanding and overcoming the complexity and heterogeneity within the tumor microenvironment (TME) is crucial for the development of anti-cancer combination therapies. This review investigates the crosstalk between immunity and angiogenesis in the TME and explores strategies to enhance anti-cancer immunity, convert immune suppressive tumors into immune activating tumors, and improve effector immune cell infiltration.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Oncology
Yi Shao, Xinru Gui, Yuxin Wang, Lei Sheng, Dong Sun, Qingdong Zeng, Huayang Wang
Summary: This study analyzed the association between serum levels of soluble immune checkpoints (sICs) and cervical lymph node metastasis (CLNM) in patients with differentiated thyroid carcinoma (DTC). The results showed that higher sTIM-3 levels were associated with CLNM and postoperative sTIM-3 levels decreased. This provides evidence for predicting CLNM and surgical decision-making in DTC.
Review
Immunology
Monrat Chulanetra, Wanpen Chaicumpa
Summary: Parasites employ various strategies to counteract host immune defenses, which can be beneficial for the development of diagnostics, therapeutics, and vaccines against parasitic infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Ophthalmology
Takehiro Matsumura, Takefumi Yamaguchi, Kazunari Higa, Masaru Intani, Jun Shimazaki
Summary: The study investigated the etiology and long-term surgical prognosis of abnormal epithelium in partial limbal stem cell deficiency following superficial keratectomy. Patients showed corneal reepithelialization and transparency postoperatively, with recurrence observed in 37% of cases. Postoperative delayed epithelialization and extensive limbal involvement were identified as risk factors for recurrence.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yusuke Nishio, Hiroko Taniguchi, Ayaka Takeda, Junko Hori
Summary: Scleritis is an inflammation of the eye's sclera, and is associated with systemic inflammatory diseases. Through animal models and case series studies, the role of macrophages and factors such as TNF, IL-6, and CD20 in the pathogenesis of scleritis have been identified, providing potential targets for molecularly targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Kenichi Namba, Hiroshi Takase, Yoshihiko Usui, Fumihiko Nitta, Kazuichi Maruyama, Sentaro Kusuhara, Masaki Takeuchi, Atsushi Azumi, Ryoji Yanai, Yutaka Kaneko, Eiichi Hasegawa, Kei Nakai, Hidekazu Tsuruga, Kazuo Morita, Toshikatsu Kaburaki
Summary: In Japanese clinical practice, many patients with recurrent non-infectious uveitis accompanying VKH disease or sarcoidosis require long-term use of systemic corticosteroids, suggesting that reducing corticosteroids is challenging in patients with difficulty suppressing inflammation.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Kazuichi Maruyama, Chiharu Iwahashi, Noriyasu Hashida, Nobuyuki Ohguro, Kohji Nishida
Summary: The study investigated diffuse large B-cell lymphoma lesions with CNS involvement in patients with VRL during long-term clinical courses. Over 60% of the VRL patients had CNS lesions, which were not associated with the optic pathway or visual cortex. Clinicians should carefully examine CNS lesions occurring in both forebrain- and hindbrain-originating tissues during a patient's clinical course.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Takashi Ono, Hiroshi Goto, Tsutomu Sakai, Fumihiko Nitta, Nobuhisa Mizuki, Hiroshi Takase, Yutaka Kaneko, Junko Hori, Satoko Nakano, Nobuhisa Nao-I, Nobuyuki Ohguro, Kazunori Miyata, Makoto Tomita, Manabu Mochizuki
Summary: This study compared the efficacy and safety of a combination therapy of prednisolone and cyclosporine with corticosteroid pulse therapy in treating VKH disease. The combination therapy was found to be noninferior to corticosteroid therapy and showed better performance in preventing recurrence and worsening of the disease.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Cell & Tissue Engineering
Nobuhiko Shiraki, Kazuichi Maruyama, Ryuhei Hayashi, Akiko Oguchi, Yasuhiro Murakawa, Tomohiko Katayama, Toru Takigawa, Susumu Sakimoto, Andrew J. Quantock, Motokazu Tsujikawa, Kohji Nishida
Summary: The study found that cells with characteristics resembling microglia naturally develop in eye-like SEAM organoids derived from human-induced pluripotent stem cells. These unique cells are PAX6-positive and possess some mesoderm characteristics.
Article
Ophthalmology
Kazuichi Maruyama, Song Mei, Hirokazu Sakaguchi, Chikako Hara, Atsuya Miki, Zaixing Mao, Ryo Kawasaki, Zhenguo Wang, Susumu Sakimoto, Noriyasu Hashida, Andrew J. Quantock, Kinpui Chan, Kohji Nishida
Summary: This study quantifies choroidal vessels in pathological eyes using optical coherence tomography and deep-learning analysis. The 3D visualization and quantification provided by this method allows for the diagnosis and differentiation of choroidal diseases. The results show high sensitivity and specificity in distinguishing between pathological and healthy choroids.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Ophthalmology
Yuki Hamano, Kazuichi Maruyama, Yoshinori Oie, Naoyuki Maeda, Shizuka Koh, Noriyasu Hashida, Kohji Nishida
Summary: This study used CASIA-2 to investigate for the first time the morphological changes in the anterior segment of the eye in VKH patients, revealing that these changes may affect visual acuity and the astigmatic axis. Assessing corneal morphology is essential in determining the cause of visual function deterioration in VKH patients.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Kosuke Miyazawa, Susumu Sakimoto, Masanori Kanai, Akihiko Shiraki, Shizuka Takahashi, Nobuhiko Shiraki, Kazuichi Maruyama, Hirokazu Sakaguchi, Kohji Nishida
Summary: This study evaluated the macular vessel tortuosity using OCTA after ERM surgery and found that the change in vessels around the macula becoming more linear was associated with visual outcomes postoperatively.
Article
Cell & Tissue Engineering
Yu Yoshinaga, Takeshi Soma, Shohei Azuma, Kazuichi Maruyama, Yoshiko Hashikawa, Tomohiko Katayama, Yuzuru Sasamoto, Hiroshi Takayanagi, Naoki Hosen, Takashi Shiina, Kazumasa Ogasawara, Ryuhei Hayashi, Kohji Nishida
Summary: This study investigated the impact of human leukocyte antigen (HLA) on corneal epithelial cell sheet (CEPS) transplantation. The results showed that there was no difference in immune response to CEPS between HLA-matched and -unmatched peripheral blood mononuclear cells. Additionally, programmed death ligand 1 was identified to have an immunosuppressive effect on CEPS under inflammatory conditions.
Article
Medicine, General & Internal
Hiroyuki Komatsu, Yoshihiko Usui, Kinya Tsubota, Risa Fujii, Takefumi Yamaguchi, Kazuichi Maruyama, Ryo Wakita, Masaki Asakage, Hiroyuki Shimizu, Naoyuki Yamakawa, Naoya Nezu, Koji Ueda, Hiroshi Goto
Summary: Comprehensive proteomic analysis revealed altered vitreous protein expression levels that can discriminate ocular sarcoidosis from other forms of uveitis. Neutrophil gelatinase-associated lipocalin (NGAL) and junctional adhesion molecules B (JAMB) were identified as potential biomarkers for ocular sarcoidosis, serving as an auxiliary tool for its diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Noriyasu Hashida, Kazunobu Asao, Chikako Hara, Andrew J. Quantock, Ryotaro Saita, Hiroyuki Kurakami, Kazuichi Maruyama, Kohji Nishida
Summary: The study demonstrated that elevated serum levels of mtDNA and HMGB1 were associated with the clinical activities of CSC, indicating that serum mtDNA and HMGB1 could serve as biomarkers for the acute phase of the disease, allowing for the prediction of disease onset and determination of disease severity.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Reiko Kobayashi, Noriyasu Hashida, Kazuichi Maruyama, Kohji Nishida
Summary: The aim of this study was to evaluate the usefulness of specular microscopy as a diagnostic tool for CMV corneal endotheliitis. Through the study of 104 patients with infectious corneal endotheliitis, iridocyclitis, and retinitis, it was found that 22% of the cases observed owl's eye cells through specular microscopy, which was related to the occurrence of CMV endotheliitis. Specular microscopy can be used as a useful tool for diagnosing and monitoring CMV corneal endotheliitis.
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2022)
Meeting Abstract
Ophthalmology
Atsuya Miki, Xin Sui, Kazuichi Maruyama, Zaixing Mao, Song Mei, Zhenguo Wang, Shinichi Usui, Kenji Matsushita, Ryo Kawasaki, Kinpui Chan, Kohji Nishida
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Letter
Ophthalmology
Ayaka Kimura, Ayaka Takeda, Toyo Ikebukuro, Junko Hori
JOURNAL OF OPHTHALMIC INFLAMMATION AND INFECTION
(2021)
