Association between polymorphisms in IL27 gene and renal cell carcinoma

Context: Interleukin-27 is a new member of the IL-12 family which plays an important role in human carcinogenesis. Objective: To investigate whether polymorphisms in IL27 contribute to renal cell carcinoma (RCC) risk. Materials and methods: These two polymorphisms were genotyped in 329 RCC patients and 386 healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: Significantly increased RCC risk was associated the G allele of both rs153109 and rs17855750 (rs153109: p = 0.006, OR = 1.364, 95% CI = 1.095-1.700; rs17855750: p = 0.001, OR = 1.768, 95% CI = 1.245-2.511). Conclusion: The present study provided evidence that rs153109 and rs17855750 were associated with increased risk for RCC, suggesting an important role IL-27 may play in nephrocarcinogenesis.