Journal
BIOMARKERS
Volume 20, Issue 3, Pages 183-188Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2015.1061599
Keywords
Serum; stomach cancer; tissue microarray; tumor marker; UHRF1
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Funding
- National Natural Science Foundation of China [21475063]
- Jiangsu Provincial Special Program of Medical Science [BL2013036]
- Medicine Leading Talents of Jiangsu Province [LJ201131]
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Objective: To analyze the Ubiquitin-like with PHD and ring finger domains (UHRF) 1 expression in gastric cancer (GC). Methods: The concentrations of UHRF1 DNA in serum were compared between 187 GC patients and 56 healthy controls using real-time PCR. Immunohistochemical analysis using tissue microarrays was performed. Results: UHRF1 DNA levels were significantly higher in GC patients compared to healthy controls (p < 0.001) and have associations with age and lymph node metastasis (LNM). The UHRF1 expression was significantly higher in tumor tissue than matched normal tissues (p < 0.001). Conclusions: The UHRF1 expression in serum and tissue may represent a novel biomarker for GC diagnosis and prognosis.
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