sGC stimulator praliciguat suppresses stellate cell fibrotic transformation and inhibits fibrosis and inflammation in models of NASH

The soluble guanylate cyclase stimulator IW-1973 prevents inflammation and fibrosis in experimental non-alcoholic steatohepatitis

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Real-World Improvement in Above-Target Estimated A1c with Sequential Use of Professional Flash Continuous Glucose Monitoring for Individuals with Diabetes

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Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in Preclinical Models of Disease

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Discovery and development of next generation sGC stimulators with diverse multidimensional pharmacology and broad therapeutic potential

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The soluble guanylate cyclase stimulator riociguat reduces fibrogenesis and portal pressure in cirrhotic rats

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AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis

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Renin angiotensin system in liver diseases: Friend or foe?

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AMP-activated protein kinase inhibits transforming growth factor-β-mediated vascular smooth muscle cell growth: implications for a Smad-3-dependent mechanism

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Activators and stimulators of soluble guanylate cyclase counteract myofibroblast differentiation of prostatic and dermal stromal cells

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Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue

(2015) Linda S. Hoffmann et al.   Nature Communications

Stimulation of the soluble guanylate cyclase (sGC) inhibits fibrosis by blocking non-canonical TGFβ signalling

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A murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma

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Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

(2013) Ingmar Mederacke et al.   Nature Communications

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

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Structure and Regulation of Soluble Guanylate Cyclase

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Role of Oxidative Stress and Molecular Changes in Liver Fibrosis: A Review

(2012) V. Sanchez-Valle et al.   CURRENT MEDICINAL CHEMISTRY

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(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

Soluble Guanylate Cyclase Stimulation Prevents Fibrotic Tissue Remodeling and Improves Survival in Salt-Sensitive Dahl Rats

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