VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure

Protective Role of mPGES-1 (Microsomal Prostaglandin E Synthase-1)–Derived PGE2(Prostaglandin E2) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to InjuryHighlights

(2018) Huifeng Hao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Abdominal aortic aneurysms

(2018) Natzi Sakalihasan et al.   Nature Reviews Disease Primers

TRPV1 attenuates intracranial arteriole remodeling through inhibiting VSMC phenotypic modulation in hypertension

(2016) Ming-Jie Zhang et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation

(2016) Henrick Horita et al.   Nature Communications

Disruption of prostaglandin E2 receptor EP4 impairs urinary concentration via decreasing aquaporin 2 in renal collecting ducts

(2015) Min Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prostaglandin E2 impairs osteogenic and facilitates adipogenic differentiation of human bone marrow stromal cells

(2015) Carolin Noack et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Prostaglandin E 2 Inhibits Elastogenesis in the Ductus Arteriosus via EP4 Signaling

(2013) Utako Yokoyama et al.   CIRCULATION

Prostaglandin Receptor EP4 in Abdominal Aortic Aneurysms

(2012) Richard Y. Cao et al.   AMERICAN JOURNAL OF PATHOLOGY

Inactivation of the E-Prostanoid 3 Receptor Attenuates the Angiotensin II Pressor Response via Decreasing Arterial Contractility

(2012) Lihong Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

EP1 Disruption Attenuates End-Organ Damage in a Mouse Model of Hypertension

(2012) Christina S. Bartlett et al.   HYPERTENSION

Inhibition of EP4 Signaling Attenuates Aortic Aneurysm Formation

(2012) Utako Yokoyama et al.   PLoS One

Signaling Mechanisms That Regulate Smooth Muscle Cell Differentiation

(2011) Christopher P. Mack   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Targeted Disruption of the Prostaglandin E 2 E-Prostanoid 2 Receptor Exacerbates Vascular Neointimal Formation in Mice

(2011) Sen Zhu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Prostaglandin E2-EP4 signaling suppresses adipocyte differentiation in mouse embryonic fibroblasts via an autocrine mechanism

(2011) Tomoaki Inazumi et al.   JOURNAL OF LIPID RESEARCH

Deletion of EP4 on Bone Marrow–Derived Cells Enhances Inflammation and Angiotensin II–Induced Abdominal Aortic Aneurysm Formation

(2010) Eva H.C. Tang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammatory cytokines in vascular dysfunction and vascular disease

(2009) Alexander H. Sprague et al.   BIOCHEMICAL PHARMACOLOGY

Smooth muscle phenotypic modulation is an early event in aortic aneurysms

(2009) Gorav Ailawadi et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Aortic Aneurysms

(2008) Helena Kuivaniemi et al.   CIRCULATION