Journal
POLYMER INTERNATIONAL
Volume 68, Issue 8, Pages 1468-1477Publisher
WILEY
DOI: 10.1002/pi.5852
Keywords
poly(N-isopropylacrylamide); collagen; self-assembly; thermo-responsiveness; pH-responsiveness; controlled release
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Funding
- National Natural Science Foundation of China [21606046, 21306024]
- Natural Science Foundation of Fujian Province [2016J01208]
- Special Fund for Science and Technology Innovation of FAFU [KFA17217A, KFA17476A]
- Fund for Outstanding Young Scientific Research Talents in Universities of Fujian Province [KLA18064A]
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Hydrogels with environment-sensitive properties have great potential applications in the controlled drug release field. In this paper, hybrid hydrogels with semi-interpenetrating polymer networks (semi-IPNs), composed of poly(N-isopropylacrylamide) (PNIPAM) as the thermo-sensitive component by in situ polymerization and self-assembled collagen nanofibrils as the pH-sensitive framework, were prepared for controlled release of methyl violet as a model drug. From Fourier transform infrared spectroscopy and scanning electron microscopy, it was indicated that the crosslinking of PNIPAM in the presence of collagen nanofibrils led to the formation of semi-IPNs with homogeneous porous structure, and the semi-IPNs showed improved thermal stability and elastic properties compared with the native collagen as determined using differential scanning calorimetry and rheologic measurements. Furthermore, the semi-IPNs possessed swelling behaviors quite different from those of neat collagen or PNIPAM hydrogel under various pH values and temperatures. Correspondingly, as expected, the drug release behavior in vitro for semi-IPNs performed variously compared with that for single-component semi-IPNs, which revealed the tunable performance of semi-IPNs for release ability. Finally the thermo- and pH-responsive mechanism of the semi-IPNs was illuminated to provide guidance for the application of the thermo- and pH-sensitive collagen-based hybrid hydrogels in controlled drug delivery systems. (c) 2019 Society of Chemical Industry
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