Journal
POLYMER ENGINEERING AND SCIENCE
Volume 59, Issue 12, Pages 2479-2487Publisher
WILEY
DOI: 10.1002/pen.25122
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Funding
- Ministry of Science and Higher Education of the Russian Federation [AAAA-A19-119020890025-3]
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In this work, the preparation and characterization of a novel multifunctional collagen-chitosan material containing silver nanoparticles and nonsteroid anti-inflammatory drug ibuprofen is described. As a starting material, the commercially available collagen-chitosan scaffold was used. Drug-loading procedure was performed via supercritical CO2-assisted impregnation technique. Silver nanoparticles were prepared via metal vapor synthesis and introduced into the composite biopolymer matrix. An analysis of the small-angle X-ray scattering profiles revealed that silver nanoparticles are characterized by having a logarithmic normal size distribution with the maximum at 25 nm. The average size of particles determined from the broadening of diffraction peaks is in a good agreement with this result. The surface of the materials was characterized by X-ray photoelectron spectroscopy. The in vitro release kinetics of ibuprofen in phosphate buffer solution with pH = 7.4 from prepared materials was studied. The drug release to solution is governed by Fickian diffusion and can be described within the Ritger-Peppas model. Introduction of silver nanoparticles has no effect on the diffusion mechanism. The as-prepared materials are promising for the medical applications such as dressings for treatments of infected wounds and infection preventing. These materials can act as a matrix for transdermal drug administration. (C) 2019 Society of Plastics Engineers
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