Journal
PLOS ONE
Volume 14, Issue 4, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0216304
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Funding
- Japan Society for the Promotion of Science KAKENHI [16K20313, 16K11265]
- Grants-in-Aid for Scientific Research [16K20313, 16K11265] Funding Source: KAKEN
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Purpose Vessel maturation is considered to proceed by pruning branches resulting in less branching vessels. This study investigated the vessel junction densities of type 1 and type 2 choroidal neovascularizations (CNVs) using optical coherence tomography angiography (OCTA). Methods We collected consecutive data from treatment-naive eyes diagnosed with typical age-related macular degeneration (AMD). The OCTA images with CNV were analyzed to calculate vessel areas, vessel lengths, and vessel junction densities. Results Of 60 eyes in 60 patients, type 1 CNV diagnoses had been made in 40 eyes, and type 2 CNV in 20 eyes. We found no significant difference in vessel areas between type 1 CNV and type 2 CNV (type 1 CNV, 0.44 +/- 0.37 mm 2; type 2 CNV, 0.37 +/- 0.48 mm(2)), and no significant difference in vessel lengths (type 1 CNV, 18.24 +/- 15.96 mm; type 2 CNV, 16.13 +/- 21.45 mm). However, the vessel junction density of type 1 CNV was significantly lower than that of type 2 CNV by 16.0% (P = 0.008). Conclusion OCTA revealed that the vessel junction densities of type 1 CNVs were lower than those of type 2 CNVs, suggesting type 1 CNV vessels are more mature than type 2 CNV vessels.
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