Article
Multidisciplinary Sciences
Yuichi Shiraishi, Ai Okada, Kenichi Chiba, Asuka Kawachi, Ikuko Omori, Raul Nicolas Mateos, Naoko Iida, Hirofumi Yamauchi, Kenjiro Kosaki, Akihide Yoshimi
Summary: This study developed a method to detect genomic variants causing splicing changes using transcriptome data alone. By applying this method to a large dataset, the researchers identified a significant number of genomic variants associated with intron retention. Additionally, by exploring the positional relationships with known disease variants, they extracted potential disease-associated variants.
NATURE COMMUNICATIONS
(2022)
Article
Environmental Sciences
Valerio Sbragaglia, Salvatore Coco, Ricardo A. Correia, Marta Coll, Robert Arlinghaus
Summary: The study utilizes YouTube video data for digital analysis, finding that user-supplied data can help reveal the temporal and spatial ecological patterns of fish species and fill knowledge gaps in existing international datasets.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Engineering, Electrical & Electronic
Monier Habil, Fatih Anayi, Yiqin Xue, Khalefa Alnagasa
Summary: This paper describes the design and modeling of a DC linear stepper motor (DLSM) to investigate its magnetic flux density and static thrust force under DC current excitation while considering the nonlinearity of iron materials. A Finite Element Method (FEM) study using MagNet software was conducted to model and construct the motor. The simulations and measurements showed that the magnetic flux density had a sinusoidal shape, with a peak error of around 7.14%. Comparison of the thrust force at different armature currents and air gap lengths revealed differences between experimental and computed values of 8.07% and between measured and simulated values of 5.02%.
Article
Multidisciplinary Sciences
Rebecca F. Carlin, Benjamin Cornwell, Jichuan Wang, Yao Cheng, Anita Mathews, Rosalind P. Oden, Linda Y. Fu, Rachel Y. Moon
Summary: Recruiting new mothers using Respondent Driven Sampling (RDS) is challenging due to their limited contacts. Those recruited through RDS are more likely to be older, Caucasian, and of higher socioeconomic status, indicating that it is not an effective way to recruit a representative sample of new mothers.
Article
Clinical Neurology
Nicholas Markarian, Guillaume Kugener, Dhiraj J. Pangal, Vyom Unadkat, Aditya Sinha, Yichao Zhu, Arman Roshannai, Justin Chan, Andrew J. Hung, Bozena B. Wrobel, Animashree Anandkumar, Gabriel Zada, Daniel A. Donoho
Summary: This study demonstrates that surgical instruments in endoscopic endonasal intraoperative videos can be detected using a fully automated machine learning model. The development costs for manual video annotation were $130 and less than $100 for computation. Adding disparate surgical data sets did not improve the model performance, but may enhance the model's generalizability in other use cases.
OPERATIVE NEUROSURGERY
(2022)
Article
Agronomy
Muhammad Massub Tehseen, Rachael Claire Poore, Karen K. K. Fugate, Melvin D. D. Bolton, Vanitharani Ramachandran, Nathan A. A. Wyatt, Xuehui Li, Chenggen Chu
Summary: By analyzing the genetic diversity of 1936 publicly available germplasm lines of sugar beet, it was confirmed that the genetic base of sugar beet is narrow. However, wild accessions of sea beet were found to have greater diversity and potential for broadening the genetic base of sugar beet.
Article
Health Care Sciences & Services
Paula Martinez-Fernandez, Patricia Pose, Raquel Dolz-Gaiton, Arantxa Garcia, Inmaculada Trigo-Sanchez, Enrique Rodriguez-Zarco, MJose Garcia-Ruiz, Ibon Barba, Marta Izquierdo-Garcia, Jennifer Valero-Garcia, Carlos Ruiz, Marian Lazaro, Paula Carbonell, Pablo Gargallo, Carlos Mendez, Juan Jose Rios-Martin, Alberto Palmeiro-Uriach, Natalia Camarasa-Lillo, Jeronimo Forteza-Vila, Ines Calabria
Summary: The analytical and clinical feasibility study of the hybridization capture-based NGS panel (Action OncoKitDx) demonstrates its accuracy and robustness in identifying biomarkers in formalin-fixed paraffin-embedded (FFPE) tumor samples. The panel shows good specificity, sensitivity, reproducibility, and repeatability for all analyzed biomarkers, and can detect pathogenic genomic alterations and clinically relevant variants in a high percentage of patient cases across different tumor types. The validation supports the utility of Action OncoKitDx in adult solid tumors.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Neurosciences
Elizabeth A. Bartlett, R. Todd Ogden, J. John Mann, Francesca Zanderigo
Summary: A novel data-driven approach, STARE, is introduced for quantifying the net influx rate (Ki) of irreversible PET radiotracers using individual-level PET data without the need for blood data. Validation with human [F-18]FDG PET scans showed strong correlation with arterial blood-based Ki estimates and precise estimation. The method demonstrates feasibility for blood-free, data-driven quantification of Ki and shows robustness in simulations and potential applications with other radiotracers.
Article
Developmental Biology
Lucy A. Bartho, Jessica L. O'Callaghan, Joshua J. Fisher, James S. M. Cuffe, Tu'uhevaha J. Kaitu'u-Lino, Natalie J. Hannan, Vicki L. Clifton, Anthony V. Perkins
Summary: This study highlighted the importance of mitochondrial regulators in placental aging and pathophysiology through analyzing gene and protein expression levels in placental samples from pregnancies with different complications. Significant changes were observed in key mitochondrial transcripts, with MFN1, MFN2, and TOMM20 showing alterations in expression levels in pregnancies with FGR and post-term placenta.
Proceedings Paper
Computer Science, Artificial Intelligence
Michael Linortner, Andreas Uhl
Summary: This work presents a new open source software framework for vein recognition, supporting a complete tool chain for conducting biometric experiments. The software can be used on multiple publicly available databases and offers a convenient mechanism for configuring the tool chain. Implemented in C++, it works on Linux and Windows, providing an advantage over existing vein recognition libraries. The project aims to provide a valuable tool for vein recognition research and support reproducible research.
PROCEEDINGS OF THE 20TH INTERNATIONAL CONFERENCE OF THE BIOMETRICS SPECIAL INTEREST GROUP (BIOSIG 2021)
(2021)
Article
Oncology
Maya Dimitrova, Min Jae Kim, Iman Osman, George Jour
Summary: This study investigated the impact of panel size and mutation status on first-line treatment selection and outcomes in melanoma patients. The data showed differences in treatment information and mutation patterns among different panel size groups, highlighting the need for further research on data standardization.
Article
Respiratory System
Yoshihiko Raita, Marcos Perez-Losada, Robert J. Freishtat, Andrea Hahn, Eduardo Castro-Nallar, Ignacio Ramos-Tapia, Nathaniel Stearrett, Yury A. Bochkov, James E. Gern, Jonathan M. Mansbach, Zhaozhong Zhu, Carlos A. Camargo, Kohei Hasegawa
Summary: Through transcriptome and clustering analysis, we identified biologically distinct metatranscriptome profiles with differential risks of asthma in infant bronchiolitis.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Microbiology
Daniela Rosado, Marcos Perez-Losada, Manuel Aira, Jorge Dominguez
Summary: Vermicomposting is a process that uses earthworms and microbes to degrade organic waste, producing a nutrient-rich soil biofertilizer. This study investigated the bacterial succession during the vermicomposting of the invasive plant species, silver wattle, utilizing the earthworm species Eisenia andrei. The researchers observed significant changes in bacterial diversity and community composition during the first 28 days of vermicomposting, while the community seemed more stable between days 28 and 56. The study also identified a core microbiome and found significant changes in predicted functional profiles of genes involved in cellulose metabolism, nitrification, and salicylic acid.
Article
Immunology
Wei Li Adeline Koay, Jiayang Xiao, Marinella Temprosa, Lindsey P. Happ, Anne K. Monroe, Amanda D. Castel, Natella Y. Rakhmanina
Summary: This study investigated the virological outcomes of two-drug and three-drug antiretroviral regimens in adults with HIV. The results showed that adults receiving two-drug regimens had a slightly higher risk of virological failure at 24 months compared to those on three-drug regimens.
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2022)
Article
Microbiology
Manuel Aira, Marcos Perez-Losada, Keith A. Crandall, Jorge Dominguez
Summary: Earthworms heavily modify the soil microbiome as they pass through their guts, with unique bacterial populations present in the soil, gut, and casts. This study highlights the importance of understanding soil microbial communities and their dynamics in nutrient cycles.
Article
Cell & Tissue Engineering
Michael P. Gustafson, John A. Ligon, Alexey Bersenev, Chase D. McCann, Nirali N. Shah, Patrick J. Hanley
Summary: The field of cell and gene therapy in oncology has seen rapid progress since the approval of the first therapies in 2017. Multiple new products have been approved for additional indications, and efforts have been made to target different cancers, improve delivery logistics, and reduce costs. This review provides an overview of the current state of cell and gene therapy-based approaches for cancer treatment, discussing various effector cell types, genetic modifications, and promising approaches for improving therapeutic efficacy and persistence.
Article
Public, Environmental & Occupational Health
Hana Akselrod, Morgan Byrne, Jeannette Lundberg, Jonathan Mamber Czeresnia, Jose Lucar, Alessandra Secco, Matt Levy, Anne Monroe, Amanda Castel, Michael Horberg, Rupali Doshi, Heather Rivasplata, Leah Squires, David Parenti, Debra Benator
Summary: By using bacterial sexually transmitted infection as a surrogate for condomless sexual behavior, this study assessed the association between STI and uncontrolled HIV replication. The results showed that the correlation between STI occurrence and HIV viral load attenuated over time, possibly due to improvements in antiretroviral therapy and access to care, leading to population-wide virologic control and reduced risk of HIV transmission.
Article
Public, Environmental & Occupational Health
Maria Jaurretche, Morgan Byrne, Lindsey Powers Happ, Matt Levy, Michael Horberg, Alan Greenberg, Amanda D. Castel, Anne K. Monroe, C Cohort Execut Committee
Summary: The Ending the HIV Epidemic initiative aims to decrease new HIV infections and promote test-and-treat strategies. We conducted a study in Washington, DC, to establish a baseline of HIV outcomes among newly diagnosed individuals and identify factors associated with retention in care, antiretroviral therapy initiation, and viral suppression. Our findings demonstrated high rates of retention, ART initiation, and viral suppression among newly diagnosed individuals in DC. AIDS diagnosis was significantly associated with these outcomes. This analysis contributes to our understanding of HIV treatment dynamics in a city with a severe HIV epidemic.
EPIDEMIOLOGY AND INFECTION
(2023)
Article
Hematology
Hannah Kinoshita, Mamatha Mandava, Mariah Jensen-Wachspress, Haili Lang, Elisabeth Joy, Jay Tanna, Chase D. McCann, Samuel O'Brien, Sianna Burnett, Abeer Shibli, Fahmida Hoq, Monica Bhatia, Patrick J. Hanley, Blachy Davila Saldana, Kris M. Mahadeo, Catherine M. Bollard, Michael D. Keller, Allistair Abraham
Summary: Hematopoietic stem cell transplantation (HSCT) is increasingly used to treat sickle cell disease (SCD). However, this treatment increases the risk of viral infection. This study explores the use of virus-specific T-cell (VST) therapies after HSCT to prevent or treat viral infections in SCD patients.
Article
Health Policy & Services
Rachel Harp, Morgan Byrne, Anne Monroe, Amanda D. Castel
Summary: Housing instability can impede HIV patients' engagement in care, adherence to antiretroviral therapy, and achievement of viral suppression. This analysis found that unstable housing was associated with lower rates of viral suppression and higher rates of substance use and mental health disorders among HIV patients.
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2023)
Article
Infectious Diseases
Anne E. Monroe, Paige E. Kulie, Morgan C. Byrne, Brittany K. Wilbourn, Shannon B. Barth, Jenna M. Resnik, David A. Huebner, Michael D. Horberg, Amanda E. Castel, Alan Greenberg, DC Cohort Executive Comm
Summary: This study assessed the psychosocial impacts of COVID-19 on people with HIV in Washington DC and found that mental health and financial/employment were the most commonly reported impact categories. Older age was protective against adverse psychosocial impacts, while higher education was associated with fewer financial impacts but more mental health impacts, decreased social connection, and increased substance use. Males reported increased substance use compared to females.
AIDS RESEARCH AND THERAPY
(2023)
Article
Microbiology
Marcos Perez-Losada, Eduardo Castro-Nallar, Jose Laerte Boechat, Luis Delgado, Tiago Azenha Rama, Valentin Berrios-Farias, Manuela Oliveira
Summary: Allergic rhinitis and asthma lead to dysbiosis of nasal bacteriome, which can be potential biomarkers for diagnostics and therapeutics. This study provides insights into the distinct bacteriota in the nose during health and respiratory diseases.
Article
Nursing
Jessica L. Elf, Kimberly Horn, Lorien Abroms, Cassandra A. Stanton, Amy M. Cohn, Freya Spielberg, Tiffany Gray, Emily Harvey, Charles Debnam, Lexi Kierstead, Matthew E. Levy, Amanda Castel, Anne Monroe, Raymond Niaura
Summary: Using data from the D.C. Cohort Longitudinal HIV Study, this study explored the prevalence of diagnosed mental health and cardiovascular, pulmonary, or cancer comorbidity among adults with HIV who smoke. Non-Hispanic Black participants had a lower risk for mental health comorbidity, but a higher risk for CPC comorbidity. Male participants had a lower risk for both mental health and CPC comorbidity. Socioeconomic factors and housing status were associated with mental health and CPC comorbidity, while substance use showed no association.
JANAC-JOURNAL OF THE ASSOCIATION OF NURSES IN AIDS CARE
(2023)
Meeting Abstract
Oncology
Annie Coriolan Ciceron, Min (Jaime) Jeong Jeon, Michelle Elise Clausen, Anne Kress Monroe, Manya Magnus, Daisy Le
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Meeting Abstract
Oncology
Daisy Le, Annie Coriolan Ciceron, Min (Jaime) Jeong Jeon, Jose Bordon, Jeanne Jordan, Anne Monroe
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Public, Environmental & Occupational Health
Maria Jaurretche, Matthew Levy, Amanda D. Castel, Lindsey Powers Happ, Anne K. Monroe, Karen F. Wyche
Summary: Recruiting racial and ethnic minority persons living with HIV is crucial for inclusive research, requiring tailored strategies for different groups. Clinics with comprehensive services had higher consent rates; effective recruitment strategies involved culturally sensitive approaches and building rapport with patients.
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2022)
