Journal
PHYTOCHEMISTRY
Volume 161, Issue -, Pages 86-96Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2019.02.008
Keywords
Metasequoia glyptostroboides Hu & WC Cheng; Cupressaceae; Sesquiterpenoids; Diterpenoids; Cytotoxicity
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Funding
- project of the Science and Technology Program of Yunnan province, China [2015FB173]
- Natural Science Foundation of China [81773611, 21602227, 21778059]
- NSFC-Joint Foundation of Yunnan Province [U1502223]
- CAS Light of West China Program
- Youth Innovation Promotion Association CAS
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A phytochemical study on the stem bark of Metasequoia glyptostroboides led to the isolation of sixty-one diterpenoids and sesquiterpenoids, including seventeen previously undescribed compounds, metaglyptins A-Q. Their structures were elucidated by extensive analysis of spectroscopic data (IR, UV, HRESIMS, and H-1, C-13 and 2D NMR). The absolute configurations of metaglyptins I, J, and O were determined by the ECD data and single-crystal X-ray diffraction analysis. The undescribed compounds were evaluated for their cytotoxicity against HeLa, AGS, and MDA-MB-231 cancer cell lines. The results revealed that metaglyptin A exhibited moderate cytotoxicity against MDA-MB-231 cell line with IC50 value of 20.02 mu M.
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